-
1
-
-
27244434788
-
-
Calin, G.A., Ferracin, M., Cimmino, A. et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N. Engl. J. Med. 353, 1793-1801 (2005). The first description of miRNA signatures as progostic markers in CLL.
-
Calin, G.A., Ferracin, M., Cimmino, A. et al. A microRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N. Engl. J. Med. 353, 1793-1801 (2005). The first description of miRNA signatures as progostic markers in CLL.
-
-
-
-
2
-
-
20444460289
-
-
Lu, J., Getz, G., Miska, E.A. et al. MicroRNA expression profiles classify human cancers. Nature 435, 834-838 (2005). The first demonstration that miRNA profiling, rather than mRNA profiling, is better at defining the tissue origin of poorly differentiated cancers.
-
Lu, J., Getz, G., Miska, E.A. et al. MicroRNA expression profiles classify human cancers. Nature 435, 834-838 (2005). The first demonstration that miRNA profiling, rather than mRNA profiling, is better at defining the tissue origin of poorly differentiated cancers.
-
-
-
-
3
-
-
33748624597
-
Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies
-
Mattie, M.D., Benz, C.C., Bowers, J. et al. Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies. Mol. Cancer 5, 24 (2006).
-
(2006)
Mol. Cancer
, vol.5
, pp. 24
-
-
Mattie, M.D.1
Benz, C.C.2
Bowers, J.3
-
4
-
-
33144490646
-
A microRNA expression signature of human solid tumors defines cancer gene targets
-
Volinia, S., Calin, G.A., Liu, C.G. et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc. Natl. Acad. Sci. U.S.A. 103, 2257-2261 (2006).
-
(2006)
Proc. Natl. Acad. Sci. U.S.A
, vol.103
, pp. 2257-2261
-
-
Volinia, S.1
Calin, G.A.2
Liu, C.G.3
-
5
-
-
23944514849
-
-
Bagga, S., Bracht, J., Hunter, S., Massirer, K., Holtz, J., Eachus, R., and Pasquinelli, A.E. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122, 553-563 (2005). Dispelled the widely held belief that miRNAs function solely by decreasing translation.
-
Bagga, S., Bracht, J., Hunter, S., Massirer, K., Holtz, J., Eachus, R., and Pasquinelli, A.E. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122, 553-563 (2005). Dispelled the widely held belief that miRNAs function solely by decreasing translation.
-
-
-
-
6
-
-
0037423845
-
Vertebrate microRNA genes
-
Lim, L.P., Glasner, M.E., Yekta, S., Burge, C.B., and Bartel, D.P. Vertebrate microRNA genes. Science 299, 1540 (2003).
-
(2003)
Science
, vol.299
, pp. 1540
-
-
Lim, L.P.1
Glasner, M.E.2
Yekta, S.3
Burge, C.B.4
Bartel, D.P.5
-
7
-
-
0346094457
-
Prediction of mammalian microRNA targets
-
Lewis, B.P., Shih, I.H., Jones-Rhoades, M.W., Bartel, D.P., and Burge, C.B. Prediction of mammalian microRNA targets. Cell 115, 787-98 (2003).
-
(2003)
Cell
, vol.115
, pp. 787-798
-
-
Lewis, B.P.1
Shih, I.H.2
Jones-Rhoades, M.W.3
Bartel, D.P.4
Burge, C.B.5
-
8
-
-
20444467290
-
-
He, L., et al., A microRNA polycistron as a potential human oncogene. Nature 435, 828-833 (2005). Description of the first oncomir cluster and demonstration of cooperation with MYC for tumor formation.
-
He, L., et al., A microRNA polycistron as a potential human oncogene. Nature 435, 828-833 (2005). Description of the first "oncomir" cluster and demonstration of cooperation with MYC for tumor formation.
-
-
-
-
9
-
-
23844555119
-
MicroRNA gene expression deregulation in human breast cancer
-
Iorio, M.V., Ferracin, M., Liu, C.G. et al. MicroRNA gene expression deregulation in human breast cancer. Cancer Res. 65, 7065-7070 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 7065-7070
-
-
Iorio, M.V.1
Ferracin, M.2
Liu, C.G.3
-
10
-
-
20044395613
-
-
Johnson, S.M., Grosshans, H., Shingara, J. et al. RAS is regulated by the let-7 microRNA family. Cell 120, 635-647 (2005). Landmark paper demonstrating conservation of gene-miRNA pairing between C. elegans and humans.
-
Johnson, S.M., Grosshans, H., Shingara, J. et al. RAS is regulated by the let-7 microRNA family. Cell 120, 635-647 (2005). Landmark paper demonstrating conservation of gene-miRNA pairing between C. elegans and humans.
-
-
-
-
11
-
-
20444479428
-
-
O'Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V., and Mendell, J.T. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435, 839-843 (2005). Copublished with (8), the authors showed that MYC can induce miRNA 17-92b cluster expression.
-
O'Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V., and Mendell, J.T. c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435, 839-843 (2005). Copublished with (8), the authors showed that MYC can induce miRNA 17-92b cluster expression.
-
-
-
-
12
-
-
33646056975
-
-
Voorhoeve, P.M., le Sage, C., Schrier, M. et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124, 1169-1181 (2006). Largest published screen, to date, of miRNAs that functionally cooperate for tumor formation.
-
Voorhoeve, P.M., le Sage, C., Schrier, M. et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 124, 1169-1181 (2006). Largest published screen, to date, of miRNAs that functionally cooperate for tumor formation.
-
-
-
-
13
-
-
34247593034
-
-
Kumar, M.S., Lu, J., Mercer, K.L., Golub, T.R., and Jacks, T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat. Genet. 39, 673-677 (2007). The authors were the first to demonstrate that loss of Dicer expression cooperates for tumor formation in a transgenic animal lung cancer model.
-
Kumar, M.S., Lu, J., Mercer, K.L., Golub, T.R., and Jacks, T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat. Genet. 39, 673-677 (2007). The authors were the first to demonstrate that loss of Dicer expression cooperates for tumor formation in a transgenic animal lung cancer model.
-
-
-
-
14
-
-
33847323881
-
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
-
Wang, Y., Medvid, R., Melton, C., Jaenisch, R., and Blelloch, R. DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 39, 380-385 (2007).
-
(2007)
Nat. Genet
, vol.39
, pp. 380-385
-
-
Wang, Y.1
Medvid, R.2
Melton, C.3
Jaenisch, R.4
Blelloch, R.5
-
15
-
-
33748302836
-
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
-
Dews, M., Homayouni, A., Yu, D. et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat. Genet. 38, 1060-1065 (2006).
-
(2006)
Nat. Genet
, vol.38
, pp. 1060-1065
-
-
Dews, M.1
Homayouni, A.2
Yu, D.3
-
16
-
-
25444520537
-
miR-15 and miR-16 induce apoptosis by targeting BCL2
-
Cimmino, A., Calin, G.A., Fabbri, M. et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc. Natl. Acad. Sci. U.S.A. 102, 13944-13949 (2005).
-
(2005)
Proc. Natl. Acad. Sci. U.S.A
, vol.102
, pp. 13944-13949
-
-
Cimmino, A.1
Calin, G.A.2
Fabbri, M.3
-
17
-
-
33847738628
-
-
Scott, G.K., Goga, A., Bhaumik, D., Berger, C.E., Sullivan, C.S., and Benz, C.C. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J. Biol. Chem. 282, 1479-1486 (2007). First article to show that two genes in the same signaling pathway can be regulated by the same miRNA.
-
Scott, G.K., Goga, A., Bhaumik, D., Berger, C.E., Sullivan, C.S., and Benz, C.C. Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b. J. Biol. Chem. 282, 1479-1486 (2007). First article to show that two genes in the same signaling pathway can be regulated by the same miRNA.
-
-
-
-
18
-
-
33846190181
-
Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181
-
Pekarsky, Y., Santanam, U., Cimmino, A. et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res. 66, 11590-11593 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 11590-11593
-
-
Pekarsky, Y.1
Santanam, U.2
Cimmino, A.3
-
19
-
-
0028587370
-
Identification of the TCL1 gene involved in T-cell malignancies
-
Virgilio, L., Narducci, M.G., Isobe, M., Billips, L.G., Cooper, M.D., Croce, C.M., and Russo, G. Identification of the TCL1 gene involved in T-cell malignancies. Proc. Natl. Acad. Sci. U.S.A. 91, 12530-12534 (1994).
-
(1994)
Proc. Natl. Acad. Sci. U.S.A
, vol.91
, pp. 12530-12534
-
-
Virgilio, L.1
Narducci, M.G.2
Isobe, M.3
Billips, L.G.4
Cooper, M.D.5
Croce, C.M.6
Russo, G.7
-
20
-
-
1842328565
-
11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis
-
Döhner, H., Stilgenbauer, S., James, M.R., Benner, A., Weilguni, T., Bentz, M., Fischer, K., Hunstein, W., and Lichter, P. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood 89, 2516-2522 (1997).
-
(1997)
Blood
, vol.89
, pp. 2516-2522
-
-
Döhner, H.1
Stilgenbauer, S.2
James, M.R.3
Benner, A.4
Weilguni, T.5
Bentz, M.6
Fischer, K.7
Hunstein, W.8
Lichter, P.9
-
21
-
-
31444446831
-
TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state
-
Herling, M., Patel, K.A., Khalili, J., Schlette, E., Kobayashi, R., Medeiros, L.J., and Jones, D. TCL1 shows a regulated expression pattern in chronic lymphocytic leukemia that correlates with molecular subtypes and proliferative state. Leukemia 20, 280-285 (2006).
-
(2006)
Leukemia
, vol.20
, pp. 280-285
-
-
Herling, M.1
Patel, K.A.2
Khalili, J.3
Schlette, E.4
Kobayashi, R.5
Medeiros, L.J.6
Jones, D.7
-
22
-
-
9144247189
-
-
Soutschek, J., Akinc, A., Bramlage, B. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004). First paper to demonstrate knock down of liver-expressed genes in vivo by modified siRNAs.
-
Soutschek, J., Akinc, A., Bramlage, B. et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 432, 173-178 (2004). First paper to demonstrate "knock down" of liver-expressed genes in vivo by modified siRNAs.
-
-
-
-
23
-
-
32944462300
-
-
Scott, G.K., Mattie, M.D., Berger, C.E., Benz, S.C., and Benz, C.C. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 66, 1277-12781 (2006). First article to show that pharmacologic treatment with HDAC inhibitors alters miRNA expression.
-
Scott, G.K., Mattie, M.D., Berger, C.E., Benz, S.C., and Benz, C.C. Rapid alteration of microRNA levels by histone deacetylase inhibition. Cancer Res. 66, 1277-12781 (2006). First article to show that pharmacologic treatment with HDAC inhibitors alters miRNA expression.
-
-
-
|