메뉴 건너뛰기




Volumn 21, Issue 10, 2007, Pages 2181-2191

A new xenograft model of myeloma bone disease demonstrating the efficacy of human mesenchymal stem cells expressing osteoprotegerin by lentiviral gene transfer

Author keywords

[No Author keywords available]

Indexed keywords

LENTIVIRUS VECTOR; OSTEOPROTEGERIN;

EID: 34548802420     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404814     Document Type: Article
Times cited : (37)

References (40)
  • 1
    • 0030791806 scopus 로고    scopus 로고
    • Mechanisms of bone lesions in multiple myeloma and lymphoma
    • Roodman GD. Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer 1997; 80 (8 Suppl): 1557-1563.
    • (1997) Cancer , vol.80 , Issue.8 SUPPL. , pp. 1557-1563
    • Roodman, G.D.1
  • 2
    • 0025783336 scopus 로고
    • Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma
    • Bataille R, Chappard D, Marcelli C, Dessauw P, Baldet P, Sany J et al. Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J Clin Invest 1991;88: 62-66.
    • (1991) J Clin Invest , vol.88 , pp. 62-66
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3    Dessauw, P.4    Baldet, P.5    Sany, J.6
  • 3
    • 0026690115 scopus 로고
    • Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption
    • Taube T, Beneton MN, McCloskey EV, Rogers S, Greaves M, Kanis JA. Abnormal bone remodelling in patients with myelomatosis and normal biochemical indices of bone resorption. Eur J Haematol 1992; 49 192-198.
    • (1992) Eur J Haematol , vol.49 , pp. 192-198
    • Taube, T.1    Beneton, M.N.2    McCloskey, E.V.3    Rogers, S.4    Greaves, M.5    Kanis, J.A.6
  • 4
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I, Tan HL, Timms E, Capparelli C et al. OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature 1999; 397: 315-323.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3    Tan, H.L.4    Timms, E.5    Capparelli, C.6
  • 6
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 1997; 89: 309-319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3    Kelley, M.4    Chang, M.S.5    Luthy, R.6
  • 7
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse RN, Sordillo EM, Yaccoby S, Wong BR, Liau DF, Colman N et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 2001; 98: 11581-11586.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3    Wong, B.R.4    Liau, D.F.5    Colman, N.6
  • 8
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N, Bataille R, Mancini C, Lazzaretti M, Barille S. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 2001; 98: 3527-3533.
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3    Lazzaretti, M.4    Barille, S.5
  • 9
    • 0035496947 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
    • Seidel C, Hjertner O, Abildgaard N, Heickendorff L, Hjorth M, Westin J et al. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood 2001; 98: 2269-2271.
    • (2001) Blood , vol.98 , pp. 2269-2271
    • Seidel, C.1    Hjertner, O.2    Abildgaard, N.3    Heickendorff, L.4    Hjorth, M.5    Westin, J.6
  • 10
    • 0342322717 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma
    • Choi SJ, Cruz JC, Craig F, Chung H, Devlin RD, Roodman GD et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood 2000;96: 671-675.
    • (2000) Blood , vol.96 , pp. 671-675
    • Choi, S.J.1    Cruz, J.C.2    Craig, F.3    Chung, H.4    Devlin, R.D.5    Roodman, G.D.6
  • 11
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
    • Giuliani N, Colla S, Morandi F, Lazzaretti M, Sala R, Bonomini S et al. Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Blood 2005; 106: 2472-2483.
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3    Lazzaretti, M.4    Sala, R.5    Bonomini, S.6
  • 12
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003; 349 2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6
  • 13
    • 33751193178 scopus 로고    scopus 로고
    • Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition
    • Giuliani N, Rizzoli V, Roodman GD. Multiple myeloma bone disease: pathophysiology of osteoblast inhibition. Blood 2006; 108: 3992-3996.
    • (2006) Blood , vol.108 , pp. 3992-3996
    • Giuliani, N.1    Rizzoli, V.2    Roodman, G.D.3
  • 14
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma
    • Croucher PI, Shipman CM, Lippitt J, Perry M, Asosingh K, Hijzen A et al. Osteoprotegerin inhibits the development of osteolytic bone disease in multiple myeloma. Blood 2001; 98: 3534-3540.
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1    Shipman, C.M.2    Lippitt, J.3    Perry, M.4    Asosingh, K.5    Hijzen, A.6
  • 15
    • 0035664488 scopus 로고    scopus 로고
    • Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease
    • Choi SJ, Oba Y, Gazitt Y, Alsina M, Cruz J, Anderson J et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 2001; 108: 1833-1841.
    • (2001) J Clin Invest , vol.108 , pp. 1833-1841
    • Choi, S.J.1    Oba, Y.2    Gazitt, Y.3    Alsina, M.4    Cruz, J.5    Anderson, J.6
  • 16
    • 0027534880 scopus 로고
    • Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease
    • Huang YW, Richardson JA, Tong AW, Zhang BQ, Stone MJ, Vitetta ES. Disseminated growth of a human multiple myeloma cell line in mice with severe combined immunodeficiency disease. Cancer Res 1993; 53 1392-1396.
    • (1993) Cancer Res , vol.53 , pp. 1392-1396
    • Huang, Y.W.1    Richardson, J.A.2    Tong, A.W.3    Zhang, B.Q.4    Stone, M.J.5    Vitetta, E.S.6
  • 17
    • 0030019981 scopus 로고    scopus 로고
    • Development of an in vivo model of human multiple myeloma bone disease
    • Allsina M, Boyce B, Devlin RD, Anderson JL, Craig F, Mundy GR et al. Development of an in vivo model of human multiple myeloma bone disease. Blood 1996; 87: 1495-1501.
    • (1996) Blood , vol.87 , pp. 1495-1501
    • Allsina, M.1    Boyce, B.2    Devlin, R.D.3    Anderson, J.L.4    Craig, F.5    Mundy, G.R.6
  • 18
    • 0030821607 scopus 로고    scopus 로고
    • New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin-6 receptor
    • Tsunenari T, Koishihara Y, Nakamura A, Moriya M, Ohkawa H, Goto H et al. New xenograft model of multiple myeloma and efficacy of a humanized antibody against human interleukin-6 receptor. Blood 1997; 90: 2437-2444.
    • (1997) Blood , vol.90 , pp. 2437-2444
    • Tsunenari, T.1    Koishihara, Y.2    Nakamura, A.3    Moriya, M.4    Ohkawa, H.5    Goto, H.6
  • 19
    • 0032930729 scopus 로고    scopus 로고
    • Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice
    • Hjorth-Hansen H, Seifert MF, Borset M, Aarset H, Ostlie A, Sundan A et al. Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice. J Bone Miner Res 1999;14: 256-263.
    • (1999) J Bone Miner Res , vol.14 , pp. 256-263
    • Hjorth-Hansen, H.1    Seifert, M.F.2    Borset, M.3    Aarset, H.4    Ostlie, A.5    Sundan, A.6
  • 20
    • 0032532608 scopus 로고    scopus 로고
    • Primary myeloma cells growing in SCID-hu mice: A model for studying the biology and treatment of myeloma and its manifestations
    • Yaccoby S, Barlogie B, Epstein J. Primary myeloma cells growing in SCID-hu mice: A model for studying the biology and treatment of myeloma and its manifestations. Blood 1998; 92: 2908-2913.
    • (1998) Blood , vol.92 , pp. 2908-2913
    • Yaccoby, S.1    Barlogie, B.2    Epstein, J.3
  • 21
    • 8844264524 scopus 로고    scopus 로고
    • The SCID-rab model: A novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells
    • Yata K, Yaccoby S. The SCID-rab model: A novel in vivo system for primary human myeloma demonstrating growth of CD138-expressing malignant cells. Leukemia 2004; 18: 1891-1897.
    • (2004) Leukemia , vol.18 , pp. 1891-1897
    • Yata, K.1    Yaccoby, S.2
  • 22
    • 0028356380 scopus 로고
    • VS38: A new monoclonal antibody for detecting plasma cell differentiation in routine sections
    • Turley H, Jones M, Erber W, Mayne K, de Waele M, Gatter K. VS38: A new monoclonal antibody for detecting plasma cell differentiation in routine sections.J Clin Pathol 1994; 47: 418-422.
    • (1994) J Clin Pathol , vol.47 , pp. 418-422
    • Turley, H.1    Jones, M.2    Erber, W.3    Mayne, K.4    de Waele, M.5    Gatter, K.6
  • 23
    • 0036200735 scopus 로고    scopus 로고
    • Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood
    • Hanawa H, Kelly PF, Nathwani AC, Persons DA, Vandergriff JA, Hargrove P et al. Comparison of various envelope proteins for their ability to pseudotype lentiviral vectors and transduce primitive hematopoietic cells from human blood. Mol Ther 2002; 5: 242-251.
    • (2002) Mol Ther , vol.5 , pp. 242-251
    • Hanawa, H.1    Kelly, P.F.2    Nathwani, A.C.3    Persons, D.A.4    Vandergriff, J.A.5    Hargrove, P.6
  • 24
    • 1542373663 scopus 로고    scopus 로고
    • Impaired bone marrow homing of cytokine-activated CD34+cells in the NOD/SCID model
    • Ahmed F, Ings SJ, Pizzey AR, Blundell MP, Thrasher AJ, Ye HT et al. Impaired bone marrow homing of cytokine-activated CD34+cells in the NOD/SCID model. Blood 2004; 103: 2079-2087.
    • (2004) Blood , vol.103 , pp. 2079-2087
    • Ahmed, F.1    Ings, S.J.2    Pizzey, A.R.3    Blundell, M.P.4    Thrasher, A.J.5    Ye, H.T.6
  • 25
    • 0024359185 scopus 로고
    • Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(ql3;q32)
    • Ohtsuki T, Yawata Y, Wada H, Sugihara T, Mori M, Namba M. Two human myeloma cell lines, amylase-producing KMS-12-PE and amylase-non-producing KMS-12-BM, were established from a patient, having the same chromosome marker, t(11;14)(ql3;q32). Br J Haematol 1989; 73: 199-204.
    • (1989) Br J Haematol , vol.73 , pp. 199-204
    • Ohtsuki, T.1    Yawata, Y.2    Wada, H.3    Sugihara, T.4    Mori, M.5    Namba, M.6
  • 26
    • 33645211749 scopus 로고    scopus 로고
    • Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFIk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model
    • Kyriakou CA, Yong KL, Benjamin R, Pizzey A, Dogan A, Singh N et al. Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFIk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt's lymphoma in a murine model. J Gene Med 2006; 8: 253-264.
    • (2006) J Gene Med , vol.8 , pp. 253-264
    • Kyriakou, C.A.1    Yong, K.L.2    Benjamin, R.3    Pizzey, A.4    Dogan, A.5    Singh, N.6
  • 28
    • 0037439916 scopus 로고    scopus 로고
    • Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma
    • Vanderkerken K, De Leenheer E, Shipman C, Asosingh K, Willems A, Van Camp B et al. Recombinant osteoprotegerin decreases tumor burden and increases survival in a murine model of multiple myeloma. Cancer Res 2003; 63: 287-289.
    • (2003) Cancer Res , vol.63 , pp. 287-289
    • Vanderkerken, K.1    De Leenheer, E.2    Shipman, C.3    Asosingh, K.4    Willems, A.5    Van Camp, B.6
  • 29
    • 0037303260 scopus 로고    scopus 로고
    • Sordillo EM, Pearse RN. RANK-Fc: A therapeutic antagonist for RANK-L in myeloma. Cancer 2003; 97 (3 Suppl): 802-812.
    • Sordillo EM, Pearse RN. RANK-Fc: A therapeutic antagonist for RANK-L in myeloma. Cancer 2003; 97 (3 Suppl): 802-812.
  • 30
    • 0346837985 scopus 로고    scopus 로고
    • A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body JJ, Greipp P, Coleman RE, Facon T, Geurs F, Fermand JP et al. A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 2003; 97 (3 Suppl): 887-892.
    • (2003) Cancer , vol.97 , Issue.3 SUPPL. , pp. 887-892
    • Body, J.J.1    Greipp, P.2    Coleman, R.E.3    Facon, T.4    Geurs, F.5    Fermand, J.P.6
  • 31
    • 1642634597 scopus 로고    scopus 로고
    • Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts
    • Doran PM, Turner RT, Chen D, Facteau SM, Ludvigson. JM, Khosla S et al. Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts. Exp Hematol 2004; 32: 351-359.
    • (2004) Exp Hematol , vol.32 , pp. 351-359
    • Doran, P.M.1    Turner, R.T.2    Chen, D.3    Facteau, S.M.4    Ludvigson, J.M.5    Khosla, S.6
  • 32
    • 0034700846 scopus 로고    scopus 로고
    • New insights into role of microenvironment in multiple myeloma
    • Tricot G. New insights into role of microenvironment in multiple myeloma. Lancet 2000; 355: 248-250.
    • (2000) Lancet , vol.355 , pp. 248-250
    • Tricot, G.1
  • 34
    • 0033678140 scopus 로고    scopus 로고
    • Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep
    • Liechty KW, MacKenzie TC, Shaaban AF, Radu A, Moseley AM, Deans R et al. Human mesenchymal stem cells engraft and demonstrate site-specific differentiation after in utero transplantation in sheep. Nat Med 2000; 6: 1282-1286.
    • (2000) Nat Med , vol.6 , pp. 1282-1286
    • Liechty, K.W.1    MacKenzie, T.C.2    Shaaban, A.F.3    Radu, A.4    Moseley, A.M.5    Deans, R.6
  • 35
    • 0032976690 scopus 로고    scopus 로고
    • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
    • Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med 1999; 5: 309-313.
    • (1999) Nat Med , vol.5 , pp. 309-313
    • Horwitz, E.M.1    Prockop, D.J.2    Fitzpatrick, L.A.3    Koo, W.W.4    Gordon, P.L.5    Neel, M.6
  • 36
    • 0032697409 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases
    • Koc ON, Peters C, Aubourg P, Raghavan S, Dyhouse S, DeGasperi R et al. Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases. Exp Hematol 1999; 27: 1675-1681.
    • (1999) Exp Hematol , vol.27 , pp. 1675-1681
    • Koc, O.N.1    Peters, C.2    Aubourg, P.3    Raghavan, S.4    Dyhouse, S.5    DeGasperi, R.6
  • 37
    • 33646690027 scopus 로고    scopus 로고
    • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma
    • Khakoo AY, Pati S, Anderson SA, Reid W, Elshal MF, Rovira II et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 2006; 203: 1235-1247.
    • (2006) J Exp Med , vol.203 , pp. 1235-1247
    • Khakoo, A.Y.1    Pati, S.2    Anderson, S.A.3    Reid, W.4    Elshal, M.F.5    Rovira II6
  • 38
    • 0036644833 scopus 로고    scopus 로고
    • Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors
    • Studeny M, Marini FC, Champlin RE, Zompetta C, Fidler IJ, Andreeff M. Bone marrow-derived mesenchymal stem cells as vehicles for interferon-beta delivery into tumors. Cancer Res 2002; 62: 3603-3608.
    • (2002) Cancer Res , vol.62 , pp. 3603-3608
    • Studeny, M.1    Marini, F.C.2    Champlin, R.E.3    Zompetta, C.4    Fidler, I.J.5    Andreeff, M.6
  • 39
    • 20244374417 scopus 로고    scopus 로고
    • Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas
    • Nakamizo A, Marini F, Amano T, Khan A, Studeny M, Gumin J et al. Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas. Cancer Res 2005; 65: 3307-3318.
    • (2005) Cancer Res , vol.65 , pp. 3307-3318
    • Nakamizo, A.1    Marini, F.2    Amano, T.3    Khan, A.4    Studeny, M.5    Gumin, J.6
  • 40
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S, Wezeman MJ, Zangari M, Walker R, Cottler-Fox M, Gaddy D et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006; 91: 192-199.
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3    Walker, R.4    Cottler-Fox, M.5    Gaddy, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.