Prophylactic antibiotics for the prevention of preterm birth in women at risk: A meta-analysis

Australian and New Zealand Journal of Obstetrics and Gynaecology

Volumn 47, Issue 5, 2007, Pages 368-377

  Simcox, Rachael ^a   Sin, Wing To A ^a   Seed, Paul T ^a   Briley, Annette ^a   Shennan, Andrew H ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Antibiotic; Antimicrobial; Bacterial vaginosis; Meta analysis; Preterm birth

Indexed keywords

ANTIBIOTIC AGENT; CLINDAMYCIN; ERYTHROMYCIN; FIBRONECTIN; METRONIDAZOLE; PLACEBO;

ANTIBIOTIC THERAPY; ARTICLE; BACTERIAL INFECTION; CLINICAL TRIAL; COCHRANE LIBRARY; COMBINATION CHEMOTHERAPY; CONTROLLED CLINICAL TRIAL; GESTATIONAL AGE; HIGH RISK PATIENT; HUMAN; MEDICAL LITERATURE; MEDLINE; META ANALYSIS; MONOTHERAPY; OUTCOMES RESEARCH; PERINATAL MORTALITY; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGRESSION ANALYSIS; RISK ASSESSMENT; RISK REDUCTION; SYSTEMATIC REVIEW; VAGINA FLORA; VAGINITIS;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; BIOLOGICAL MARKERS; FEMALE; FETAL BLOOD; FIBRONECTINS; HUMANS; PREGNANCY; PREMATURE BIRTH; RISK FACTORS; VAGINA; VAGINOSIS, BACTERIAL;

EID: 34548787310     PISSN: 00048666     EISSN: 1479828X     Source Type: Journal    
DOI: 10.1111/j.1479-828X.2007.00759.x     Document Type: Article

References (37)

1. Lettieri L, Vintzileos AM, Rodis JF, Albini SM, Salafia CM. Does 'idiopathic' preterm labor resulting in preterm birth exist? Am J Obstet Gynecol 1993; 168: 1480-1485.
2. Leitich H, Bodner-Adler B, Brunbauer M, Kaider A, Egarter C, Husslein P. Bacterial vaginosis as a risk factor for preterm delivery: A meta-analysis. Am J Obstet Gynecol 2003; 189: 139-147.
3. Lamont RF. Antibiotics for the prevention of preterm birth. N Engl J Med 2000; 342: 581-583.
4. Klebanoff MA, Hillier SL, Nugent RP et al. Is bacterial vaginosis a stronger risk factor for preterm birth when it is diagnosed earlier in gestation? Am J Obstet Gynecol 2005; 192: 470-477.
5. McDonald H, Brocklehurst P, Parsons J. Antibiotics for treating bacterial vaginosis in pregnancy. Cochrane Database Syst Rev 2005; (1): CD000262.
6. Leitich H, Brunbauer M, Bodner-Adler B, Kaider A, Egarter C, Husslein P. Antibiotic treatment of bacterial vaginosis in pregnancy: A meta-analysis. Am J Obstet Gynecol 2003; 188: 752-758.
7. Guise JM, Mahon SM, Aickin M, Helfand M, Peipert JF, Westhoff C. Screening for bacterial vaginosis in pregnancy. Am J Prev Med 2001; 20 (3 Suppl.): 62-72.
8. Shennan A, Crawshaw S, Briley A et al. A randomised controlled trial of metronidazole for the prevention of preterm birth in women positive for cervicovaginal fetal fibronectin: The PREMET study. Br J Obstet Gynaecol 2006; 113: 65-74.
9. Carey JC, Klebanoff MA, Hauth JC et al. Metronidazole to prevent preterm delivery in pregnant women with asymptomatic bacterial vaginosis. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 2000; 342: 534-540.
10. Eschenbach DA, Nugent RP, Rao AV et al. A randomized placebo-controlled trial of erythromycin for the treatment of ureaplasma urealyticum to prevent premature delivery. The Vaginal Infections and Prematurity Study Group. Am J Obstet Gynecol 1991; 164: 734-742.
11. Klebanoff MA, Carey JC, Hauth JC et al. Failure of metronidazole to prevent preterm delivery among pregnant women with asymptomatic Trichomonas vaginalis infection. N Engl J Med 2001; 345: 487-493.
12. Joesoef MR, Hillier SL, Wiknjosastro G et al. Intravaginal clindamycin treatment for bacterial vaginosis: Effects on preterm delivery and low birth weight. Am J Obstet Gynecol 1995; 173: 1527-1531.
13. Kekki M, Kurki T, Pelkonen J, Kurkinen-Raty M, Cacciatore B, Paavonen J. Vaginal clindamycin in preventing preterm birth and peripartal infections in asymptomatic women with bacterial vaginosis: A randomized, controlled trial. Obstet Gynecol 2001; 97 (5 Part 1): 643-648.
14. Kurkinen-Raty M, Vuopala S, Koskela M et al. A randomised controlled trial of vaginal clindamycin for early pregnancy bacterial vaginosis. BJOG 2000; 107: 1427-1432.
15. Lamont RF, Duncan SL, Mandal D, Bassett P. Intravaginal clindamycin to reduce preterm birth in women with abnormal genital tract flora. Obstet Gynecol 2003; 101: 516-522.
16. McDonald HM, O'Loughlin JA, Vigneswaran R. et al. Impact of metronidazole therapy on preterm birth in women with bacterial vaginosis flora (Gardnerella vaginalis): A randomised, placebo controlled trial. Br J Obstet Gynaecol 1997; 104: 1391-1397.
17. McGregor JA, French JI, Jones W et al. Bacterial vaginosis is associated with prematurity and vaginal fluid mucinase and sialidase: Results of a controlled trial of topical clindamycin cream. Am J Obstet Gynecol 1994; 170: 1048-1059.
18. Klebanoff MA, Regan JA, Rao AV et al. Outcome of the Vaginal Infections and Prematurity Study: Results of a clinical trial of erythromycin among pregnant women colonized with group B streptococci. Am J Obstet Gynecol 1995; 172: 1540-1545.
19. Odendaal HJ, Popov I, Schoeman J, Smith M, Grove D. Preterm labour - is bacterial vaginosis involved? S Afr Med J 2002; 92: 231-234.
20. Ugwumadu A, Manyonda I, Reid F, Hay P. Effect of early oral clindamycin on late miscarriage and preterm delivery in asymptomatic women with abnormal vaginal flora and bacterial vaginosis: A randomised controlled trial. Lancet 2003; 361: 983-988.
21. Andrews WW, Sibai BM, Thom EA et al. Randomized clinical trial of metronidazole plus erythromycin to prevent spontaneous preterm delivery in fetal fibronectin-positive women. Obstet Gynecol 2003; 101 (5 Part 1): 847-855.
22. Vermeulen GM, Bruinse HW. Prophylactic administration of clindamycin 2% vaginal cream to reduce the incidence of spontaneous preterm birth in women with an increased recurrence risk: A randomised placebo-controlled double-blind trial. Br J Obstet Gynaecol 1999; 106: 652-657.
23. Morales WJ, Schorr S, Albritton J. Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: A placebo-controlled, double-blind study. Am J Obstet Gynecol 1994; 171: 345-347.
24. Hauth JC, Goldenberg RL, Andrews WW, DuBard MB, Copper RL. Reduced incidence of preterm delivery with metronidazole and erythromycin in women with bacterial vaginosis. N Engl J Med 1995; 333: 1732-1736.
25. Klein LL, Gibbs RS. Use of microbial cultures and antibiotics in the prevention of infection-associated preterm birth. Am J Obstet Gynecol 2004; 190: 1493-1502.
26. Beigi RH, Austin MN, Meyn LA, Krohn MA, Hillier SL. Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am J Obstet Gynecol 2004; 191: 1124-1129.
27. Porter K, Rambo D, Jazayeri M, Prien S. Prospective randomised trial of once versus twice daily metronidazole-vaginal in obstetrical population identified with bacterial vaginosis. Am J Obstet Gynecol 2005; 184 (1 Part 2): S166.
28. Duff P, Lee ML, Hillier SL, Herd LM, Krohn MA, Eschenbach DA. Amoxicillin treatment of bacterial vaginosis during pregnancy. Obstet Gynecol 1991; 77: 431-435.
29. Guaschino S, Ricci E, Franchi M et al. Treatment of asymptomatic bacterial vaginosis to prevent pre-term delivery: A randomised trial. Eur J Obstet Gynecol Reprod Biol 2003; 110: 149-152.
30. McGregor JA, French JI, Seo K. Adjunctive clindamycin therapy for preterm labor: Results of a double-blind, placebo-controlled trial. Am J Obstet Gynecol 1991; 165 (4 Part 1): 867-875.
31. Okun N, Gronau KA, Hannah ME. Antibiotics for bacterial vaginosis or Trichomonas vaginalis in pregnancy: A systematic review. Obstet Gynecol 2005; 105: 857-868.
32. Kiss H, Petricevic L, Husslein P. Prospective randomised controlled trial of an infection screening programme to reduce the rate of preterm delivery. BMJ 2004; 329: 371.
33. Wilks M, Wiggins R, Whiley A et al. Identification and H(2) O(2) production of vaginal lactobacilli from pregnant women at high risk of preterm birth and relation with outcome. J Clin Microbiol 2004; 42: 713-717.
34. Romero R, Espinoza J, Chaiworapongsa T, Kalache K. Infection and prematurity and the role of preventive strategies. Semin Neonatol 2002; 7: 259-274.
35. Lamont RF. Infection in the prediction and antibiotics in the prevention of spontaneous preterm labour and preterm birth. BJOG 2003; 110 (Suppl. 20): 71-75.
36. Loren ZE, Hallman M, Marttila R, Haataja R, Schwartz DA. Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population. Pediatr Res 2002; 52: 373-376.
37. Ferrand PE, Parry S, Sammel M et al. A polymorphism in the matrix metalloproteinase-9 promoter is associated with increased risk of preterm premature rupture of membranes in African Americans. Mol Hum Reprod 2002; 8: 494-501.