Back to the beginning - The quest for thymic epithelial stem cells

European Journal of Immunology

Volumn 37, Issue 9, 2007, Pages 2364-2366

  Swann, Jeremy B ^a   Boehm, Thomas ^a  

^a MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

Author keywords

Epithelium; Stem cells; Stroma; Thymus

Indexed keywords

ALPHA6 INTEGRIN; BIOLOGICAL MARKER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; OCTAMER TRANSCRIPTION FACTOR 4; THYMOCYTE ANTIBODY; TRANSCRIPTION FACTOR;

ANTIGEN EXPRESSION; AUTOIMMUNE DISEASE; CELL AGGREGATION; CELL ISOLATION; CELL MATURATION; CELL POPULATION; CELL RENEWAL; EPITHELIUM CELL; HUMAN; IMMUNOLOGICAL TOLERANCE; NOTE; PRIORITY JOURNAL; STEM CELL; STROMA CELL; THYMOCYTE; THYMUS; THYMUS FUNCTION; THYMUS TRANSPLANTATION;

ANIMALS; CELL DIFFERENTIATION; EPITHELIAL CELLS; HUMANS; STEM CELLS; THYMUS GLAND;

EID: 34548760932     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200737709     Document Type: Note

References (20)

1. Kondo, M., Wagers, A. J., Manz, M. G., Prohaska, S. S., Scherer, D. C., Beilhack G. F., Shizuru, J. A. and Weissman, I. L., Biology of hematopoietic stem cells and progenitors: Implications for clinical application. Annu. Rev. Immunol. 2003. 21: 759-806.
2. Lorenz, E., Uphoff, D., Reid, T. R. and Shelton, E., Modification of irradiation injury in mice and guinea pigs by bone marrow injections. J. Natl. Cancer Inst. 1951. 12: 197-201.
3. Jacobson, L. O., Simmons, E. L., Marks, E. K. and Eldredge, J. H., Recovery from radiation injury. Science 1951. 113: 510-511.
4. Becker, A. J., Mc, C. E. and Till, J. E., Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow Nature 1963. 197: 452-454.
5. Jordan, C. T. and Lemischka, I. R., Clonal and systemic analysis of longterm hematopoiesis in the mouse. Genes Dev. 1990. 4: 220-232.
6. Uchida, N. and Weissman, I. L., Searching for hematopoietic stem cells: Evidence that Thy-1.1lo Lin-Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow. J. Exp. Med. 1992. 175: 175-184.
7. Smith, L. G., Weissman, I. L. and Heimfeld, S., Clonal analysis of hematopoietic stem-cell differentiation in vivo. Proc. Natl. Acad. Sci. USA 1991. 88: 2788-2792.
8. Wagers, A. J., Sherwood, R. I., Christensen, J. L. and Weissman, I. L., Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 2002. 297: 2256-2259.
9. Rossi, S. W., Chidgey, A. P., Parnell, S. M., Jenkinson, W. E., Boyd, R. L., Jenkinson E. J. and Anderson, G. A., Redefining epithelial progenitor potential in the developing thymus. Eur. J. Immunol. 2007. 37: DOI 10.1002/eji.200737275
10. Lampert, I. A., Ritter, M. A., The origin of the diverse epithelial cells of the thymus: Is there a common stem cell? Thymus Update 1998. 1: 2-25.
11. Rossi, S. W., Jenkinson, W. E., Anderson, G. and Jenkinson, E. J., Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium. Nature 2006. 441: 988-991.
12. Bleul, C. C., Corbeaux, T., Reuter, A., Fisch, P., Monting, J. S. and Boehm, T., Formation of a functional thymus initiated by a postnatal epithelial progenitor cell. Nature 2006. 441: 992-996.
13. Rodewald, H. R., Paul, S., Haller, C., Bluethmann, H. and Blum, C., Thymus medulla consisting of epithelial islets each derived from a single progenitor. Nature 2001. 414: 763-768.
14. Bennett, A. R., Farley, A., Blair, N. F., Gordon, J., Sharp, L. and Blackburn, C. C., Identification and characterization of thymic epithelial progenitor cells. Immunity 2002. 16: 803-814.
15. Gill, J., Malin, M., Hollander, G. A. and Boyd, R., Generation of a complete thymic microenvironment by MTS24(+) thymic epithelial cells. Nat. Immunol. 2002. 3: 635-642.
16. Shackleton, M., Vaillant, F., Simpson, K. J., Stingl, J., Smyth, G. K. Asselin-Labat, M. L., Wu, L. et al., Generation of a functional mammary gland from a single stem cell. Nature 2006. 439: 84-88.
17. Lawson, D. A., Xin, L., Lukacs, R. U., Cheng, D. and Witte, O. N., Isolation and functional characterization of murine prostate stem cells. Proc. Natl. Acad. Sci USA 2007. 104: 181-186.
18. Boyer, L. A., Mathur, D. and Jaenisch, R., Molecular control of pluripotency. Curr. Opin. Genet. Dev. 2006. 16: 455-462.
19. Beltrami, A. P., Cesselli, D., Bergamin, N., Marcon, P., Rigo, S., Puppato, E., D'Aurizio, F. et al., Multipotent cells can be generated in vitro from several adult human organs (heart, liver and bone marrow). Blood 2007. DOI: 10.1182/blood-2006-11-055566.
20. Gillard, G. O., Dooley, J., Erickson, M., Peltonen, L. and Farr, A. G., Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation. J. Immunol. 2007. 178: 3007-3015.