Preoperative methylprednisolone administration maintains coagulation homeostasis in patients undergoing liver resection: Importance of inflammatory cytokine modulation

Shock

Volumn 28, Issue 4, 2007, Pages 401-405

  Pulitanò, Carlo ^a,b   Aldrighetti, Luca ^a   Arru, Marcella ^a   Finazzi, Renato ^a   Catena, Marco ^a   Guzzetti, Eleonora ^a   Soldini, Laura ^a   Comotti, Laura ^a   Ferla, Gianfranco ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Coagulation homeostasis; Corticosteroid administration; Liver surgery; Randomized clinical trial; Surgical stress

Indexed keywords

ANTITHROMBIN III; CYTOKINE; D DIMER; FIBRIN DEGRADATION PRODUCT; FIBRINOGEN; INTERLEUKIN 6; METHYLPREDNISOLONE; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; BLOOD CLOTTING; BLOOD CLOTTING DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CYTOKINE RELEASE; FEMALE; HEMANGIOENDOTHELIOMA; HOMEOSTASIS; HUMAN; INFLAMMATION; LIVER CELL CARCINOMA; LIVER DISEASE; LIVER SURGERY; LIVER TUMOR; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROTEIN BLOOD LEVEL; PROTHROMBIN TIME; RANDOMIZED CONTROLLED TRIAL; SURGICAL STRESS; SURGICAL TECHNIQUE; THROMBOCYTE;

ADRENAL CORTEX HORMONES; ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; ANTITHROMBIN III; BLOOD COAGULATION; CYTOKINES; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HEPATECTOMY; HUMANS; INTERLEUKIN-6; METHYLPREDNISOLONE; MIDDLE AGED; PREOPERATIVE CARE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34548662631     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/shk.0b013e318063ed11     Document Type: Article

References (27)

1. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, Corvera C, Weber S, Blumgart LH: Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 236(4):397-406, 2002.
2. Nagino M, Nimura Y, Hayakawa N, Kamiya J, Kondo S, Miyachi M, Kanai M: Disseminated intravascular coagulation after liver resection: retrospective study in patients with biliary tract carcinoma. Surgery 117(5):581-585, 1995.
3. Siniscalchi A, Begliomini B, De Pietri L, Braglia V, Gazzi M, Masetti M, Di Benedetto F, Pinna AD, Miller CM, Pasetto A: Increased prothrombin time and platelet counts in living donor right hepatectomy: implications for epidural anesthesia. Liver Transpl 10:1144-1149, 2004.
4. Mammem EF. Coagulopathies of liver disease. Clin Lab Med 14(4):769-780, 1994.
5. Meijer C, Wiezer MJ, Hack CE, Boelens PG, Wedel NI, Meijer S, Nijveldt RJ, Statius Muller MG, Wiggers T, Zoetmulder FA, et al.: Coagulopathy following major liver resection: the effect of rBPI21 and the role of decreased synthesis of regulating proteins by the liver. Shock 15:261-271, 2001.
6. Pulitanò C, Sitia G, Aldrighetti L, Finazzi R, Arru M, Catena M, Guidotti LG, Ferla G: Reduced severity of liver ischemia/reperfusion injury following hepatic resection in humans is associated with enhanced intrahepatic expression of T2 cytokine. Hepatol Res 36:20-26, 2006.
7. Lederer JA, Rodrick ML, Mannick JA: The effects of injury on the adaptive immune response. Shock 11:153-159, 1999.
8. Iba T, Kidokoro A, Fukunaga M, Sugiyama K, Sawada T, Kato H: Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers. Shock 23(1):25-29, 2005.
9. Oberholzer A, Souza SM, Tschoeke SK, Oberholzer C, Abouhamze A, Pribble JP, Moldawer LL: Plasma cytokine measurements augment prognostic scores as indicators of outcome in patients with severe sepsis. Shock 23(6):488-493, 2005.
10. Aldrighetti L, Pulitano C, Arru M, Finazzi R, Catena M, Soldini L, Comotti L, Ferla G: Impact of preoperative corticosteroids administration on ischemia-reperfusion injury and systemic responses in liver surgery: a prospective randomized trial. Liver Transpl 12:941-949, 2006.
11. Holte K, Kehler H: Perioperative single dose glucocorticoid administration: pathophysiologic effects and clinical implications. J Am Coll Surg 195:694-712, 2002.
12. Annane D, Cavaillon JM: Corticosteroids in sepsis: from bench to bedside? Shock 320:197-207, 2000.
13. Berger D, Bolke E, Seidelmann M, Beger HG: Time-scale of interleukin-6, myeloid related proteins (MRP), C reactive protein (CRP), and endotoxin plasma levels during the postoperative acute phase reaction. Shock 7(6):422-426, 1997.
14. van der Poll T, Buller HR, ten Cate H, Wortel CH, Bauer KA, van Deventer SJ, Hack CE, Sauerwein HP, Rosenberg RD, ten Cate JW: Activation of coagulation after administration of tumor necrosis factor to normal subjects. N Engl J Med 322:1622-1627, 1990.
15. Stouthard JM, Levi M, Hack CE, Veenhof CH, Romijn HA, Sauerwein HP, van der Poll T: Interleukin-6 stimulates coagulation, not fibrinolysis, in humans. Thromb Haemost 76(5):738-742, 1996.
16. Pajkrt D, van der Poll T, Levi M, Cutler DL, Affrime MB, van den Ende A, ten Cate JW, van Deventer SJ: Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia. Blood 89:2701-2705, 1997.
17. Sapolsky RM, Romero LM, Munck AU: How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21:55-89, 2000.
18. Yamazaki M, Aoshima K, Mizutani T, Ontachi Y, Saito M, Morishita E, Asakura H, Matsuda T, Triplett DA: Prednisolone inhibits endotoxin-induced disseminated intravascular coagulation and improves mortality in rats: importance of inflammatory cytokine suppression. Blood Coag Fibrinol 10:321-332, 1999.
19. Yoshikawa T, Murakami M, Furukawa Y, Takemura S, Kondo M: Prevention by methylprednisolone of disseminated intravascular coagulation induced by sustained infusion of endotoxin in rats. Haemostasis 13(4):268-273, 1983.
20. Shimada M, Itasaka H, Suehiro T, Wakiyama S, Soejima Y, Yanaga K, Sugimachi K: The significance of tissue-type plasminogen activator for pretransplant assessment of liver graft viability: analysis of effluent from the graft in rats. Transplant Int 7:233-236, 1994.
21. Matsutani T, Onda M, Sasajima K, Miyashita M: Glucocorticoid attenuates a decrease of antithrombin III following major surgery. Surg Res 79(2):158-163, 1998.
22. Inthorn D, Hoffmann JN, Hartl WH, Muhlbayer D, Jochum M: Effect of antithrombin III supplementation on inflammatory response in patients with severe sepsis. Shock 10(2):90-96, 1998.
23. Harada N, Okajima K, Uchiba M, Kushimoto S, Isobe H: Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1. Thromb Haemost 92:550-558, 2004.
24. Pulitanò C, Aldrighetti L, Finazzi R, Arru M, Catena M, Ferla G: Inhibition of cytokine response by methylprednisolone attenuates antithrombin reduction following hepatic resection. Thromb Haemost 93:1199-1200, 2005.
25. Sauerland S, Nagelschmidt M, Mallmann P, Neugebauer EA: Risks and benefits of preoperative high dose methylprednisolone in surgical patients: a systematic review. Drug Saf 23:449-461, 2000.
26. Shimada M, Harimoto N, Maehara S, Tsujita E, Rikimura T, Yamashita Y, Tanaka S, Shirabe K: Minimally invasive hepatectomy: modulation of systemic reactions to operation or laparoscopic approach? Surgery 131:s312-s317, 2002.
27. Shimada H, Ochiai T, Okazumi S, Matsubara H, Nabeya Y, Miyazawa Y, Arima M, Funami Y, Hayashi H, Takeda A, et al.: Clinical benefits of steroid therapy on surgical stress in patients with esophageal cancer. Surgery 128:791-798, 2000.