Impact of preoperative steroids administration on ischemia-reperfusion injury and systemic responses in liver surgery: A prospective randomized study

Liver Transplantation

Volumn 12, Issue 6, 2006, Pages 941-949

  Aldrighetti, Luca ^a   Pulitanò, Carlo ^a   Arru, Marcella ^a   Finazzi, Renato ^a   Catena, Marco ^a   Soldini, Laura ^a   Comotti, Laura ^a   Ferla, Gianfranco ^a  

^a VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; INTERLEUKIN 6; METHYLPREDNISOLONE; NADROPARIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANEMIA; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; BLOOD CLOTTING; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG RESPONSE; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOSTASIS; HEPATITIS B; HEPATITIS C; HUMAN; INCIDENCE; LENGTH OF STAY; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; LIVER ISCHEMIA; LIVER METASTASIS; LIVER PROTECTION; LIVER RESECTION; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREOPERATIVE CARE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; REPERFUSION INJURY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THROMBOEMBOLISM;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS; FEMALE; HUMANS; LIVER; MALE; METHYLPREDNISOLONE; MIDDLE AGED; REPERFUSION INJURY;

EID: 33745489247     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.20745     Document Type: Article

References (60)

1. Desborough JP. The stress response to trauma and surgery. Br J Anaesth 2000;85:109-117.
2. Baigrie RJ, Lamont PM, Kwiatkowski D, Dallman MJ, Morris PJ. Systemic cytokine response after major surgery. Br J Surg 1992;79:757-760.
3. Biffl WL, Moore EE, Moore FA, Peterson VM. Interleukin-6 in the injured patients. Marker of injury or mediator of inflammation? Ann Surg 1996;224:647-664.
4. Rangel-Frausto MS, Pittet D, Costigan M, Hwang T, Davis CS, Wenzel RP. The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA 1995;273:117-123.
5. Davies MG, Hagen PO. Systemic inflammatory response syndrome. Br J Surg 1997:84:920-935.
6. Oka Y, Murata A, Nishijima J, Yasuda T, Hiraoka N, Ohmachi Y, et al. Circulating interleukin 6 as useful marker for predicting postoperative complications. Cytokine 1992; 4:298-304.
7. Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci 1998;94:557-572.
8. Sapolsky RM, Romero LM, Munck AU. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000;21:55-89.
9. Holte K, Kehlet H. Perioperative single dose glucocorticoid administration - pathophysiological effects and clinical implications. J Am Coll Surg 2002;195:694-712.
10. Sauerland S, Nagelschmidt M, Mallmann P, Neugebauer EA. Risks and benefits of preoperative high-dose methyl-prednisolone in surgical patients. Drug Saf 2000;23:449-461.
11. Muratore A, Ribero D, Ferrero A, Berbero R, Capussotti L. Prospective randomized study of steroids in the prevention of ischaemic injury during hepatic resection with pedicle clamping. Br J Surg 2003;90:17-22.
12. Yamashita Y, Shimada M, Hamatsu T, Rikimaru T, Tanaka S, Shirabe K, Sugimachi K. Effects of preoperative steroid administration on surgical stress in hepatic resection. Arch Surg 2001;136:328-333.
13. Shimada M, Saitoh A, Kano T, Takenaka K, Sugimachi K. The effects of a perioperative steroid pulse on surgical stress in hepatic resection. Int Surg 1996;81:49-51.
14. Emori TG, Culver DH, Horan TC, Janis WR, White JW, Olson DR, et al. National nosocomial infections surveillance system (NNIS): description of surveillance methods. Am J Infect Control 1991;19:19-35.
15. Moshage H. Cytokines and the hepatic acute phase response. J Pathol 1997;181:25.
16. Livingston DH, Mosenthal AC, Deitch EA. Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview. New Horiz 1995;3:276-287.
17. Selzman CH, Shames BD, Miller SA, Pulido EJ, Meng X, McIntyre RC Jr, Harken AH. Therapeutic implications of interleukin-10 in surgical disease. Shock 1998;10:309-318.
18. De Maio A, Mooney ML, Matesic LE, Paidas CN, Reeves RH. Genetic component in the inflammatory response induced by bacteria] lipopolysaccharide. Shock 1998;10: 319-323.
19. Fong YM, Marano MA, Moldawer LL, Wei H, Calvano SE, Kenney JS, et al. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest 1990;85:1896-1904.
20. Teoh NC, Farrell GC. Hepatic ischemia reperfusion injury: pathogenic mechanisms and basis for hepatoprotection. J Gastroenterol Hepatol 2003;18:891-902.
21. Esmon CT. The impact of the inflammatory response on coagulation. Thromb Res 2004;114:321-327
22. Ogawa K, Hirai M, Katsube T, Murayama M, Hamaguchi K, Shimakawa T, et al. Suppression of cellular immunity by surgical stress. Surgery 2000;127:329-336.
23. Lederer JA, Rodrick ML, Mannick JA. The effects of injury on the adaptive immune response. Shock 1999;11:153-159.
24. Shimada M, Harimoto N, Maehara S, Tsujita E, Rikimaru T, Yamashita Y, et al. Minimally invasive hepatectomy: modulation of systemic reactions to operation or laparoscopic approach? Surgery 2002;131(suppl):S312-S317.
25. Badia JM, Ayton LC, Evans TJ, Carpenter AJ, Nawfal G, Kinderman H, et al. Systemic cytoktne response to hepatic resections under total vascular exclusion. Eur J Surg 1998:164:185-190.
26. Figueroa I, Santiago-Delpin EA. Steroid protection of the liver during experimental ischemia. Surg Gynecol Obstet 1975;140:368-370.
27. Wang M, Sakon M, Umeshita K, Okuyama M, Shiozaki K, Nagano H, et al. Prednisolone suppresses ischemia-reperfusion injury of the rat liver by reducing cytokine production and calpain μ activation. J Hepatol 2001;34:278-283.
28. Glanemann M, Strenziok R, Kuntze R, Munchow S, Dikopoulos N, Lippek F, et al. Ischemic preconditioning and methylprednisolone both equally reduce hepatic ischemia/reperfusion injury. Surgery 2004;135:203-214.
29. Chiappa AC, Makuuchi M, Zbar AP, Biella F, Vezzoni A, Torzilli G, Andreoni B. Protective effect of methylprednisolone and of intermittent hepatic pedicle clamping during liver vascular inflow occlusion in the rat. Hepatogastroenterology 2004;51:1439-1444.
30. Glanemann M, Munchow S, Schirmeier A, Al-Abadi H, Lippek F, Langrehr JM, et al. Steroid administration before partial hepatectomy with temporary inflow occlusion does not influence cyclin D1 and Ki-67 related liver regeneration. Langenbecks Arch Surg 2004;389:380-386.
31. Torzilli G, Makuuchi M, Inoue K, Takayama T, Sakamoto Y, Sugawara Y, et al. No-mortality liver resection for hepatocellular carcinoma in cirrhotic and non-cirrhotic patients: is there a way? A prospective analysis of our approach. Arch Surg 1999;134:984-992.
32. Torzilli G, Makuuchi M, Midorikawa Y, Sano K, Inoue K, Takayama T, Kubota K. Liver resection without total vascular exclusion: hazardous or beneficial? An analysis of our experience. Ann Surg 2001:233:167-175.
33. Wallenius V, Wallenius K, Jansson JO. Normal pharmacologically-induced, but decreased regenerative liver growth in interleukin-6-deficient "IL-6 knockout" mice. J Hepatol 2000;33:967-974.
34. Peters M, Blinn G, Jostock T, Schirmacher P, Meyer zum Buschenfelde KH, Galle PR, Rose-John S. Combined interleukin 6 and soluble interleukin 6 receptor accelerates murine liver regeneration. Gastroenterology 2000;119: 1663-1671.
35. Wustefeld T, Rakemann T, Kubicka S, Maims MP, Trautwein C. Hyperstimulation with interleukin 6 inhibits cell cycle progression after hepatectomy in mice. Hepatology 2000;32:514-522.
36. Man K, Lo CM, Ng IO, Wong YC, Qin LF, Fan ST, Wong J. Liver transplantation in rats using small-for-size grafts: A study of hemodynamic and morphological changes. Arch Surg 2001;136:280-285.
37. Man K, Lo CM, Lee TK, Li XL, Ng IO, Fan ST. Intragraft gene expression profiles by cDNA microarray in small-for-size liver grafts. Liver Transpl 2003;9:425-432.
38. Clavien PA, Yadav S, Sindram D, Bentley RC. Protective effects of ischemic preconditioning for liver resection performed under inflow occlusion in humans. Ann Surg 2000;232:155-162.
39. Mammen EF. Coagulation abnormalities in liver disease. Hematol Oncol Clin North Am 1992;6:1247-1257.
40. Shimada M, Matsumata T, Kamakura T, Suehiro T, Itasaka H, Sugimachi K. Changes of regulating blood coagulation in hepatic resection with special references to soluble thrombomodulin and protein C. J Am Coll Surg 1994;178:65-68.
41. Nagino M, Nimura Y, Hayakawa N, Kamiya J, Kondo S, Miyachi M, et al. Disseminated intravascular coagulation after liver resection: retrospective study in patients with biliary tract carcinoma. Surgery 1995;117:581-585.
42. Dhainaut JF, Marin N, Mignon A, Visonneau C. Hepatic response to sepsis. Interaction between coagulation and inflammatory processes. Crit Care Med 2001;29(suppl): S42-S47.
43. van der Poll T, Buller HR, ten Cate H, Wortel CH, Bauer KA, van Deventer SJ, et al. Activation of coagulation after administration of tumor necrosis factor to normal subjects. N EngI J Med 1990;322:1622-1627.
44. Stouthard JM, Levi M, Hack CE, Veenhof CH, Romijn HA, Sauerwein HP, van der Poll T. Interleukin-6 stimulates coagulation, not fibrinolysis, in humans. Thromb Haemost 1996;76:738-742.
45. Esmon CT. Role of coagulation inhibitors in inflammation. Thromb Haemost 2001;86:51-56.
46. Opal SM. Therapeutic rationale for antithrombin III in sepsis. Crit Care Med 2000;28(suppl):S34-S37.
47. Harada N, Okajima K, Uchiba M, Kushimoto S, Isobe H. Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1. Thromb Haemost 2004;92:550-558.
48. Pulitano C, Aldrighetti L, Finazzi R, Arru M, Catena M, Ferla G. Inhibition of cytokine response by methylprednisolone attenuates antithrombin reduction following hepatic resection. Thromb Haemost 2005;93:1199-1200.
49. Siniscalchi A, Begliomini B, De Pietri L, Braglia V, Gazzi M, Masetti M, et al. Increased prothrombin time and platelet counts in living donor right hepatectomy: implications for epidural anesthesia. Liver Transpl 2004;10:1144-1149.
50. Tsuji K, Eguchi Y, Kodama M. Postoperative hypercoagulable state followed by hyperfibrinolysis related to wound healing after hepatic resection. J Am Coll Surg 1996;183: 230-238.
51. Tsuzuki T, Toyama K, Nakayasu K, Iida S, Ueda M, Toizumi A. Disseminated intravascular coagulation after hepatic resection. Surgery 1990;107:172-176.
52. Yamazaki M, Aoshima K, Mizutani T, Ontachi Y, Saito M, Morishita E, et al. Prednisolone inhibits endotoxin-induced disseminated intravascular coagulation and improves mortality in rats: importance of inflammatory cytokine suppression. Blood Coagul Fibrinolysis 1999;10: 321-332.
53. Yoshikawa T, Murakami M, Furukawa Y, Takemura S, Kondo M. Prevention by methylprednisolone of disseminated intravascular coagulation induced by sustained infusion of endotoxin in rats. Haemostasis 1983;13:268-273.
54. Imamura H, Seyama Y, Kokudo N, Maema A, Sugawara Y, Sano K, Takayama T, Makuuchi M. One thousand fifty-six hepatectomies without mortality in 8 years. Arch Surg 2003;138:1198-1206.
55. Jarnagin WR, Gonen M, Fong Y, DeMatteo RP, Ben-Porat L, Little S, et al. Improvement in perioperative outcome after hepatic resection: analysis of 1,803 consecutive cases over the past decade. Ann Surg 2002;236:397-406.
56. Shirabe K, Takenaka K, Yamatomto K, Kawahara N, Itasaka H, Nishizaki T, et al. Impaired systemic immunity and frequent infection in patients with candida antigen fter hepatectomy. Hepatogastroenterology 1997;44:199-204.
57. Shimada H, Ochiai T, Okazumi S, Matsubara H, Nabeya Y, Miyazawa Y, et al. Clinical benefits of steroid therapy on surgical stress in patients with esophageal cancer. Surgery 2000;128:791-798.
58. Staubbs SS. Corticosteroids and bioavailability. Trans Proc 1975;7:11-19.
59. Serracino-Inglott F, Habib N, Mathie R. Hepatic ischemia-reperfusion injury. Am J Surg 2001;181:160-166.
60. Webel ML, Ritts RE Jr, Taswell HF, Danadio JV Jr, Woods JE. Cellular Immunity after intravenous administration of methylprednisolone. J Lab Clin Med 1974;83:383-392.