Investigation of structural requirements for inhibitory activity at the rat and housefly picrotoxinin binding sites in ionotropic GABA receptors using DISCOtech and CoMFA

Chemosphere

Volumn 69, Issue 6, 2007, Pages 864-871

  Ju, Xiu Lian ^a   Hao, Yan Li ^a   Pei, Jan Feng ^b   Ozoe, Yoshihisa ^c  

^a WUHAN INSTITUTE OF TECHNOLOGY   (China)

^b PEKING UNIVERSITY   (China)

^c SHIMANE UNIVERSITY   (Japan)

Author keywords

CoMFA; DISCOtech; GABA receptor; Noncompetitive antagonist; Pharmacophore

Indexed keywords

CATALYST SELECTIVITY; HYDROGEN BONDS; MOLECULAR MODELING; RATS; STATISTICAL METHODS;

COMPARATIVE MOLECULAR FIELD ANALYSIS; GABA RECEPTOR; INHIBITORY ACTIVITIES; NONCOMPETITIVE ANTAGONIST; PICROTOXININ BINDING SITES;

BIOCHEMICAL ENGINEERING;

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BICYCLO COMPOUND; BRAIN RECEPTOR; CYCLOOCTANE DERIVATIVE; FIPRONIL; IONOTROPIC RECEPTOR; PICRODENDRIN; PICROTOXININ; TERPENOID DERIVATIVE; TRIOXABICYCLOOCTANE DERIVATIVE; UNCLASSIFIED DRUG;

BIOCHEMICAL ENGINEERING; CATALYST SELECTIVITY; HYDROGEN BONDS; MOLECULAR MODELING; RATS; STATISTICAL METHODS;

ANTAGONISM; FLY; INHIBITOR; ORGANIC POLLUTANT; RODENT;

ARTICLE; BINDING SITE; COMPARATIVE MOLECULAR FIELD ANALYSIS; DISTANCE COMPARISON TECHNIQUE; DRUG ACTIVITY; DRUG SELECTIVITY; HOUSE FLY; HYDROGEN BOND; MOLECULAR MODEL; NONHUMAN; PHARMACOPHORE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT STRAIN; RECEPTOR BINDING; STATISTICAL PARAMETERS; THREE DIMENSIONAL IMAGING;

RATTUS;

EID: 34548654980     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2007.06.040     Document Type: Article

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