5-[4-(3,3-Dimethylbutoxycarbonyl)phenyl]-4-pentynoic acid and its derivatives inhibit ionotropic γ-aminobutyric acid receptors by binding to the 4'-ethynyl-4-n-propylbicycloorthobenzoate site

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 3, 2000, Pages 665-674

  Hamano, Hiroshi ^a   Nagata, Keiichi ^b   Fukada, Nobuo ^a   Shimotahira, Hiroshi ^a   Ju, Xiu Lian ^a   Ozoe, Yoshihisa ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4' ETHYNYL 4 PROPYLBICYCLOORTHOBENZOATE; 5 [4 (3,3 DIMETHYLBUTOXYCARBONYL)PHENYL] 4 PENTYNOIC ACID; 5 [4 (3,3 DIMETHYLBUTOXYCARBONYL)PHENYL] 4 PENTYNOIC ACID DERIVATIVE; RADIOLIGAND; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; BINDING SITE; BRAIN MEMBRANE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HOUSE FLY; ION CURRENT; MASS SPECTROMETRY; MEMBRANE CURRENT; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PATCH CLAMP; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOASSAY; RAT; SPINAL GANGLION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; BINDING, COMPETITIVE; BRAIN CHEMISTRY; CARDIOTONIC AGENTS; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC CONDUCTIVITY; FATTY ACIDS, UNSATURATED; GABA ANTAGONISTS; GANGLIA, SPINAL; HOUSEFLIES; INHIBITORY CONCENTRATION 50; INSECTICIDES; MEMBRANE POTENTIALS; MODELS, CHEMICAL; MOLECULAR PROBES; NEURONS; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 0033998230     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00009-2     Document Type: Article

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