The in vitro transport of dihydroergotamine across porcine nasal respiratory and olfactory mucosa and the effect of a novel powder formulation

Journal of Drug Delivery Science and Technology

Volumn 17, Issue 4, 2007, Pages 267-271

  Fransen N ^a   Espefalt Westin U ^a   Nystrom C ^a   Bjork E ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Dihydroergotamine; Horizontal ussing chambers; In vitro transport; Interactive mixture; Nasal drug delivery; Olfactory mucosa; Sodium starch glycolate

Indexed keywords

DIHYDROERGOTAMINE; STARCH GLYCOLATE SODIUM;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG TRANSPORT; DRY POWDER; IN VITRO STUDY; NONHUMAN; NOSE MUCOSA; OLFACTORY EPITHELIUM; PARTICLE SIZE;

EID: 34548578978     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(07)50094-8     Document Type: Article

References (20)

1. Mathison S., Nagilla R., Kompella U.B. - Nasal route for direct delivery of solutes to the central nervous system: Fact or fiction? - J Drug Target, 5, 415-441, 1998.
2. Dahlin M., Bergman U., Jansson B., Björk E., Brittebo E. - Transfer of dopamine in the olfactory pathway following nasal administration in mice. - Pharm Res, 17, 737-42, 2000.
3. Westin U.E., Bostrom E., grasjo J., Hammarlund-Udenaes M., Bjork E. - Direct nose-to-brain transfer of morphine after nasal administration to rats. - Pharm Res, 23, 565-72, 2006.
4. Marini S., Longo V., Mazzaccaro A., gervasi P.G. - Xenobiotic- metabolizing enzymes in pig nasal and hepatic tissues. - Xenobiotica, 28, 923-35, 1998
5. Thornton-Manning J.R., Dahl A.R. - Metabolic capacity of nasal tissue interspecies comparisons of xenobiotic-metabolizing enzymes. - Mutat Res, 380, 43-59, 1997.
6. Östh K., Gråsjö J., Björk E. - A new method for drug transport studies on pig nasal mucosa using a horizontal Ussing chamber. - J Pharm Sci, 91, 1259-1273, 2002.
7. Larsson P., Tjalve H. - Bioactivation of aflatoxin B1 in the nasal and tracheal mucosa in swine. - J Anim Sci, 74, 1672-80, 1996.
8. Fransén N., Björk E., Nyström C. - Development and characterization of mucoadhesive interactive mixtures for nasal delivery. - Eur. J. Pharm. Biopharm., accepted.
9. Björk E., Isaksson U., Edman P., Artursson P. - Starch microspheres induce pulsatile delivery of drugs and peptides across the epithelial barrier by reversible separation of the tight junctions. - J Drug Target, 2, 501-507, 1995.
10. Pereswetoff-Morath L., Edman P. - Dextran microspheres as a potential nasal drug delivery system for insulin - in vitro and in vivo properties. - Int J Pharm, 124, 37-44, 1995.
11. Kaye B.H. - Permeability techniques for characterizing fine powders. - Powder Technol, 1, 11-22, 1967.
12. Alderborn G., Duberg M., Nyström C. - Studies on direct compression of tablets X. Measurement of tablet surface area by permeametry. - Powder Technol, 41, 49-56, 1985.
13. Williams J.C. -The mixing of dry powders. - Powder Technology, 2, 13-20, 1968.
14. Östh K. - The horizontal Ussing chamber method in studies of nasal drug delivery. - In: Department of Pharmacy, Uppsala, Uppsala University, 2002.
15. Wikman-Larhed A., Artursson P. - Co-cultures of human intestinal goblet (HT29-H) and absorptive (Caco-2) cells for studies of drug and peptide absorption. - Eur J Pharm Sci, 3, 171-183, 1995.
16. Palm K., Luthman K., Ros J., Gråsjö J., Artursson P. - Effect of molecular charge on intestinal epithelial drug transport: pH-dependent transport of cationic drugs. - J Pharmacol Exp Ther, 291, 435-443, 1999.
17. Malmqvist K., Nyström C. - Studies on direct compression of tablets. IX. The effect of scaling-up on the preparation of ordered mixtures in double-cone mixers. - Acta Pharm. Suec., 21, 21-30, 1984.
18. Wang Y., Aun R., Tse F.L. - Brain uptake of dihydroergotamine after intravenous and nasal administration in the rat. - Biopharm Drug Dispos, 19, 571-5, 1998.
19. Cassidy M.M., Tidball C.S. - Cellular mechanism of intestinal permeability alterations produced by chelation depletion. - J Cell Biol, 32, 685-98, 1967.
20. Jansson B. - Models for the transfer of drugs from the nasal cavity to the central nervous system. - In: Department of Pharmacy, Uppsala, Uppsala University, 2004.