Validation of the comet-X assay as a pharmacodynamic assay for measuring DNA cross-linking produced by the novel anticancer agent RH1 during a phase I clinical trial

Cancer Chemotherapy and Pharmacology

Volumn 60, Issue 6, 2007, Pages 851-861

  Danson, S ^a   Ranson, M ^a   Denneny, O ^a   Cummings, J ^a   Ward, T H ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Comet X assay; DNA cross linking; RH1; SCGE; Validation

Indexed keywords

ANTINEOPLASTIC AGENT; RH1; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL TRIAL; COMET ASSAY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DNA CROSS LINKING; DNA DAMAGE; ELECTROPHORESIS; HUMAN; HUMAN CELL; IRRADIATION; PERIPHERAL BLOOD MONONUCLEAR CELL; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; QUALITY CONTROL; RADIATION DOSE; TECHNIQUE;

ANTINEOPLASTIC AGENTS; AZIRIDINES; BENZOQUINONES; CALIBRATION; COMBINED MODALITY THERAPY; COMET ASSAY; CROSS-LINKING REAGENTS; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOSE-RESPONSE RELATIONSHIP, RADIATION; FREEZING; HUMANS; K562 CELLS; LEUKOCYTES, MONONUCLEAR; QUALITY CONTROL; RADIOTHERAPY; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SPECIMEN HANDLING; TIME FACTORS;

EID: 34548572724     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-007-0432-9     Document Type: Article

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