Digoxin and mortality in atrial fibrillation: A prospective cohort study

European Journal of Clinical Pharmacology

Volumn 63, Issue 10, 2007, Pages 959-971

  Hallberg, Pär ^a   Lindbäck, Johan ^b   Lindahl, Bertil ^b   Stenestrand, Ulf ^c   Melhus, Håkan ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b UPPSALA CLINICAL RESEARCH CENTER   (Sweden)

^c LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Atrial fibrillation; Digoxin; Heart failure; Mortality; RIKS HIA

Indexed keywords

ACETYLSALICYLIC ACID; ANTICOAGULANT AGENT; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIGOXIN; DIURETIC AGENT; LONG ACTING DRUG; NITRATE;

AGED; ARTICLE; CONFIDENCE INTERVAL; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; CORONARY CARE UNIT; DATA ANALYSIS; FEMALE; HEART ATRIUM FIBRILLATION; HOSPITAL ADMISSION; HOSPITAL DISCHARGE; HOSPITALIZATION; HUMAN; INTENSIVE CARE UNIT; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MORTALITY; PACEMAKER; POSITIVE END EXPIRATORY PRESSURE; PRESCRIPTION; PRIORITY JOURNAL; SCORING SYSTEM; SURVIVAL RATE;

AGED; AGED, 80 AND OVER; ANTI-ARRHYTHMIA AGENTS; ATRIAL FIBRILLATION; CREATININE; DIGOXIN; FEMALE; HEART FAILURE; HUMANS; MALE; MYOCARDIAL INFARCTION; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; REGISTRIES; RESEARCH DESIGN; RISK ASSESSMENT; RISK FACTORS; STROKE VOLUME; SWEDEN; TIME FACTORS; TREATMENT OUTCOME; VENTRICULAR FUNCTION, LEFT;

EID: 34548544807     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-007-0346-9     Document Type: Article

References (41)

1. Garg R, Gorlin R, Smith T, Yusuf S, on behalf of the Digitalis Investigation Group (1997) The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336(8):525-533
2. Hornestam B, on behalf of the Digitalis in Acute Atrial Fibrillation (DAAF) Trial Group (1997) Intravenous digoxin in acute atrial fibrillation. Results of a randomized, placebo-controlled multicentre trial in 239 patients. Eur Heart J 18(4):649-654
3. Adams KF Jr, Patterson JH, Gattis WA, O'Connor CM, Lee CR, Schwartz TA, Gheorghiade M (2005) Relationship of serum digoxin concentration to mortality and morbidity in women in the digitalis investigation group trial: a retrospective analysis. J Am Coll Cardiol 46(3):497-504
4. Brener SJ, Lytle BW, Casserly IP, Schneider JP, Topol EJ, Lauer MS (2004) Propensity analysis of long-term survival after surgical or percutaneous revascularization in patients with multivessel coronary artery disease and high-risk features. Circulation 109(19):2290-2295
5. Corley SD, Epstein AE, DiMarco JP, Domanski MJ, Geller N, Greene HL, Josephson RA, Kellen JC, Klein RC, Krahn AD, Mickel M, Mitchell LB, Nelson JD, Rosenberg Y, Schron E, Shemanski L, Waldo AL, Wyse DG (2004) Relationships between sinus rhythm, treatment, and survival in the Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study. Circulation 109(12):1509-1513
6. Eichhorn EJ, Gheorghiade M (2002) Digoxin. Prog Cardiovasc Dis 44(4):251-266
7. Falk RH, Knowlton AA, Bernard SA, Gotlieb NE, Battinelli NJ (1987) Digoxin for converting recent-onset atrial fibrillation to sinus rhythm. A randomized, double-blinded trial. Ann Intern Med 106(4):503-506
8. Fuster V, Ryden LE, Asinger RW, Cannom DS, Crijns HJ, Frye RL, Halperin JL, Kay GN, Klein WW, Levy S, McNamara RL, Prystowsky EN, Wann LS, Wyse DG (2001) ACC/AHA/ESC guidelines for the management of patients with atrial fibrillation. A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for Practice Guidelines and Policy Conferences (Committee to develop guidelines for the management of patients with atrial fibrillation) developed in collaboration with the North American Society of Pacing and Electrophysiology. Eur Heart J 22(20):1852-1923
9. Gheorghiade M, Ferguson D (1991) Digoxin. A neurohormonal modulator in heart failure? Circulation 84(5):2181-2186
10. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY (2004) Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 351(13):1296-1305
11. Gold H, Cattell M, Greiner T (1953) Clinical pharmacology of digoxin. J Pharmacol Exp Ther (109):45-47
12. Hou ZY, Chang MS, Chen CY, Tu MS, Lin SL, Chiang HT, Woosley RL (1995) Acute treatment of recent-onset atrial fibrillation and flutter with a tailored dosing regimen of intravenous amiodarone. A randomized, digoxin-controlled study. Eur Heart J 16(4):521-528
13. Jaeschke R, Oxman AD, Guyatt GH (1990) To what extent do congestive heart failure patients in sinus rhythm benefit from digoxin therapy? A systematic overview and meta-analysis. Am J Med 88(3):279-286
14. Joffe MM, Rosenbaum PR (1999) Invited commentary: propensity scores. Am J Epidemiol 150(4):327-333
15. Jordaens L, Trouerbach J, Calle P, Tavernier R, Derycke E, Vertongen P, Bergez B, Vandekerckhove Y (1997) Conversion of atrial fibrillation to sinus rhythm and rate control by digoxin in comparison to placebo. Eur Heart J 18(4):643-648
16. Khairy P, Nattel S (2002) New insights into the mechanisms and management of atrial fibrillation. Cmaj 167(9):1012-1020
17. Koh KK, Kwon KS, Park HB, Baik SH, Park SJ, Lee KH, Kim EJ, Kim SH, Cho SK, Kim SS (1995) Efficacy and safety of digoxin alone and in combination with low-dose diltiazem or betaxolol to control ventricular rate in chronic atrial fibrillation. Am J Cardiol 75(1):88-90
18. Lader E, Egan D, Hunsberger S, Garg R, Czajkowski S, McSherry F (2003) The effect of digoxin on the quality of life in patients with heart failure. J Card Fail 9(1):4-12
19. Lindenauer PK, Pekow P, Wang K, Gutierrez B, Benjamin EM (2004) Lipid-lowering therapy and in-hospital mortality following major noncardiac surgery. JAMA 291(17):2092-2099
20. Macaubas C, de Klerk NH, Holt BJ, Wee C, Kendall G, Firth M, Sly PD, Holt PG (2003) Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. Lancet 362(9391):1192-1197
21. Norgaard A, Bagger JP, Bjerregaard P, Baandrup U, Kjeldsen K, Thomsen PE (1988) Relation of left ventricular function and Na,K-pump concentration in suspected idiopathic dilated cardiomyopathy. Am J Cardiol 61(15):1312-1315
22. Packer M, Gheorghiade M, Young JB, Costantini PJ, Adams KF, Cody RJ, Smith LK, Van Voorhees L, Gourley LA, Jolly MK (1993) Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. RADIANCE Study. N Engl J Med 329(1):1-7
23. Pocock SJ, Wang D, Pfeffer MA, Yusuf S, McMurray JJ, Swedberg KB, Ostergren J, Michelson EL, Pieper KS, Granger CB (2006) Predictors of mortality and morbidity in patients with chronic heart failure. Eur Heart J 27(1):65-75
24. Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM (2003) Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 289(7):871-878
25. Rathore SS, Wang Y, Krumholz HM (2002) Sex-based differences in the effect of digoxin for the treatment of heart failure. N Engl J Med 347(18):1403-1411
26. Redfors A (1971) The effect of different digoxin doses on subjective symptoms and physical working capacity in patients with atrial fibrillation. Acta Med Scand 190(4):307-320
27. Rosenbaum PR, Rubin DB (1983) The central role of the propensity score in observational studies for causal effects. Biometrika (70):41-55
28. Rubin DB (1997) Estimating causal effects from large data sets using propensity scores. Ann Intern Med 127(8 Pt 2):757-763
29. Ruelaz RA, Rahimtoola SH (2005) Was it digoxin toxicity?.very likely. J Card Fail 11(2):87-90
30. Spargias KS, Hall AS, Ball SG (1999) Safety concerns about digoxin after acute myocardial infarction. Lancet 354(9176):391-392
31. Steimer W, Muller C, Eber B (2002) Digoxin assays: frequent, substantial, and potentially dangerous interference by spironolactone, canrenone, and other steroids. Clin Chem 48(3):507-516
32. Stenestrand U, Tabrizi F, Lindback J, Englund A, Rosenqvist M, Wallentin L (2004) Comorbidity and myocardial dysfunction are the main explanations for the higher 1-year mortality in acute myocardial infarction with left bundle-branch block. Circulation 110(14):1896-1902
33. Stenestrand U, Wallentin L (2002) Early revascularisation and 1-year survival in 14-day survivors of acute myocardial infarction: a prospective cohort study. Lancet 359(9320):1805-1811
34. Stenestrand U, Wallentin L (2001) Early statin treatment following acute myocardial infarction and 1-year survival. JAMA 285(4):430-436
35. Stenestrand U, Wallentin L (2003) Fibrinolytic therapy in patients 75 years and older with ST-segment-elevation myocardial infarction: one-year follow-up of a large prospective cohort. Arch Intern Med 163(8):965-971
36. Tauke J, Goldstein S, Gheorghiade M (1994) Digoxin for chronic heart failure: a review of the randomized controlled trials with special attention to the PROVED (Prospective Randomized Study of Ventricular Failure and the Efficacy of Digoxin) and RADIANCE (Randomized Assessment of Digoxin on Inhibitors of the angiotensin Converting Enzyme) trials. Prog Cardiovasc Dis 37(1):49-58
37. Uretsky BF, Young JB, Shahidi FE, Yellen LG, Harrison MC, Jolly MK (1993) Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. PROVED Investigative Group. J Am Coll Cardiol 22(4):955-962
38. Wang PS, Schneeweiss S, Avorn J, Fischer MA, Mogun H, Solomon DH, Brookhart MA (2005) Risk of death in elderly users of conventional vs. atypical antipsychotic medications. N Engl J Med 353(22):2335-2341
39. Vardas PE, Kanoupakis EM, Kochiadakis GE, Simantirakis EN, Marketou ME, Chlouverakis GI (1998) Effects of long-term digoxin therapy on heart rate variability, baroreceptor sensitivity, and exercise capacity in patients with heart failure. Cardiovasc Drugs Ther 12(1):47-55
40. Wills P, Fastbom J, Claesson CB, Cornelius C, Thorslund M, Winblad B (1996) Use of cardiovascular drugs in an older Swedish population. J Am Geriatr Soc 44(1):54-60
41. Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, Kellen JC, Greene HL, Mickel MC, Dalquist JE, Corley SD (2002) A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 347(23):1825-1833