The effect of digoxin on the quality of life in patients with heart failure

Journal of Cardiac Failure

Volumn 9, Issue 1, 2003, Pages 4-12

  Lader, Ellis ^a,f   Egan, Debra ^b   Hunsberger, Sally ^c   Garg, Rekha ^d   Czajkowski, Susan ^b   McSherry, Frances ^e  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d ELI LILLY AND COMPANY   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f Coop Studs Prog Coord Center ^*  (United States)

Author keywords

6 minute walk test; DIG trial; Exercise tolerance

Indexed keywords

DIGOXIN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EVALUATION; EXERCISE TOLERANCE; FEMALE; FOLLOW UP; HEALTH RELATED QUALITY OF LIFE MEASUREMENT; HEART EJECTION FRACTION; HEART FAILURE; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEASUREMENT; MINNESOTA LIVING WITH HEART FAILURE QUESTIONNAIRE; MULTICENTER STUDY; PERCEPTION; PRIORITY JOURNAL; QUALITY OF LIFE; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RATING SCALE; WALKING;

EID: 0037300641     PISSN: 10719164     EISSN: None     Source Type: Journal    
DOI: 10.1054/jcaf.2003.7     Document Type: Article

References (38)

1. American Heart Association. 2001 heart and stroke statistical update. American Heart Association, Dallas, TX, 2000.
2. Dracup K, Walden JA, Stevenson LW, Brecht M-L. Quality of life in patients with advanced heart failure. J Heart Lung Transplant 1992;11:273-279.
3. Hawthorne MH, Hixon ME. Functional status, mood disturbance and quality of life in patients with heart failure. Prog Cardiovasc Nursing 1994;9(1):22-32.
4. Rogers WJ, Johnstone DE, Yusuf S, Weiner DH, Gallagher P, Bittner VA, et al. Quality of life among 5025 patients with left ventricular dysfunction randomized between placebo and enalapril: the Studies of Left Ventricular Dysfunction. J Am Coll Cardiol 1994;23:393-400.
5. The CONSENSUS trial study group. Effects of enalapril on mortality in severe congestive heart failure: results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS). N Engl J Med 1987;316:1429-1435.
6. Gundersen T, Wiklund I, Swedberg K, Amtorp O, Remes J, Nilsson B. Effects of 12 weeks of ramipril treatment on the quality of life in patients with moderate congestive heart failure: results of a placebo-controlled trial. Cardiovasc Drugs Ther 1995;9:589-594.
7. MERIT-HF Study Group. Effects of controlled-release Metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure. The Metoprolol CR/XL Randomized Intervention Trial in Congestive Heart Failure. JAMA 2000;283:1295-1302.
8. The Digitalis Investigation Group. The effect of digoxin on mortality and morbidity in patients with congestive heart failure. N Engl J Med 1997;336:525-533.
9. Uretsky BF, Young JB, Shahidi FE, Yellen LG, Harrison MC, Jolly MK. Randomized study assessing the effect of digoxin withdrawal in patients with mild to moderate chronic congestive heart failure: results of the PROVED trial. J Am Coll Cardiol 1993;22:955-962.
10. Packer M, Gheorghiade M, Young JB, Costantini PJ, Adams KF, Cody RJ, et al. Withdrawal of digoxin from patients with chronic heart failure treated with angiotensin-converting-enzyme inhibitors. N Engl J Med 1993;329:1-7.
11. The Digitalis Investigation Group. Rationale, design, implementation, and baseline characteristics of patients in the DIG Trial: A large, simple, long-term trial to evaluate the effect of digitalis on mortality in heart failure. Cont Clin Trials 1996;17:77-97.
12. Guyatt GH, Thompson PJ, Berman LB, Sullivan MJ, Townsend M, Jones SL, et al. How should we measure function in patients with chronic heart and lung disease? J Chronic Dis 1985;38:517-524.
13. Ware JE Jr, Sherbourne CD. The MOS 36-item Short Form Health Survey (SF-36): 1. Conceptual framework and item selection. Med Care 1992;30:473-483.
14. Cantril H. The pattern of human concern. New Brunswick, NJ: Rutgers University, 1995.
15. Radloff LF. The CES-D scale: A self-report depression scale for research in the general population. Appl Psychol Measurement 1977;1:385-401.
16. Spielberger CD, Gorsuch RL, Lushene RE. Manual for the State-Trait Anxiety Inventory. Paolo Alto, CA, Consulting Psychologists Press, 1970.
17. Spielberger CD, Jacobs G, Russell S, Crane R. Assessment of anger: The State-Trait Anger Scale. In Butcher JN, Spielberger CD, eds: Advances in personality assessment. Hillsdale, NJ, Lawrence Erlbaum, 1983.
18. Rector TS, Kubo SH, Cohn JN. Patients' self-assessment of their congestive heart failure. Part 2: Content, reliability and validity of a new measure: The Minnesota Living With Heart Failure Questionnaire. Heart Fail October/November 1987;198-209.
19. Garg R, Czajkowski S, Hunsberger S, Homey A. Assessment of health-related quality of life and six-minute walk tests in the DIG Study. Second Annual Symposium of Contributed Papers on Quality of Life Evaluation (DIA Meeting), October 1994, Charleston, SC.
20. Hollander M, Wolfe, DA. Nonparametric statistical methods. New York, John Wiley & Sons, 1973.
21. nd ed. New York, Springer Verlag, 1981.
22. Lehmann EL. Nonparametrics: Statistical methods based on ranks. Oakland, CA, Holden-Day, 1975.
23. SAS Institute Inc. SAS language: Reference, version 6. Cary, NC, SAS Institute, Inc, 1990.
24. Little RJA, Rubin, DB. Statistical analysis with missing data. New York, John Wiley & Sons, 1987.
25. Wiklund I, Waagstein F, Swedberg K, Hjalmarsson A. Quality of life on treatment with metoprolol in dilated cardiomyopathy: Results from the MDC trial. Cardiovasc Drugs Ther 1996;10:361-368.
26. Bristow MR, Gilbert EM, Abraham WT, Adams KF, Fowler MB, Hershberger RE, et al. Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure. MOCHA investigators. Circulation 1996;94:2807-2816.
27. Cohn JN, Archibald DG, Ziesche S. Effect of vasodilator therapy on mortality in congestive heart failure: Results of the Veterans Administration Cooperative Study. N Engl J Med 1986;314:1547-1552.
28. Rector TS, Johnson G, Dunkman WB, for the V-HeFT VA Cooperative Studies Group. Evaluation of patients with heart failure of the effects of enalapril compared with hydralazine plus isosorbide dinitrate on quality of life. Circulation 1993;87 (suppl VI):71-77.
29. Blackwood R, Mayou RA, Gamham JC, Armstrong C, Bryant B. Exercise capacity and quality of life in the treatment of heart failure. Clin Pharmacol Ther 1990;48: 325-332.
30. Braunholtz DA, Edwards SJ, Lilford RJ. Are randomized clinical trials good for us (in the short term)? Evidence for a "trial effect." J Clin Epidemiol 2001;54: 217-224.
31. Cowley AJ, Skene AM. Treatment of severe heart failure: quantity or quality of life? Trial of enoximone. Enoximone Investigators. Br Heart J 1994;72:226-230.
32. Lee C, Johnson RA, Bingham, GB et al. Heart failure in outpatients. N Engl J Med 1982;306:699-705.
33. Captopril-digoxin multicenter research group. Comparative effects of therapy with captopril and digoxin in patients with mild to moderate heart failure. JAMA 1988;259:539-544.
34. Gheorghiade M, St. Clair J, Beller GA. Hemodynamic effects of intravenous digoxin in patients with severe heart failure initially treated with diuretics and vasodilators. JACC 1987;9:849-857.
35. Ferguson DW, Berg WJ, Sanders JS, Roach PJ, Kempf JS, Kienzle MG. Sympathoinhibitory responses to digitalis glycosides in heart failure: Direct evidence from sympathetic neural recordings. Circulation 1989;80:65-77.
36. Wang W, Chen JW, Zucker I. Carotid sinus baroreceptor sensitivity in experimental heart failure. Circulation 1990; 81:1959-1966.
37. Franciosa JA, Park M, Levine TB. Lack of correlation between exercise capacity and indexes of resting left ventricular performance in heart failure. Am J Cardiol 1981;47:33-39.
38. Young JB, Gheorghiade M, Packer M, Uretsky B, Hull H, on behalf of the PROVED and RADIANCE investigators. Are low serum levels of digoxin effective in chronic heart failure? J Am Coll Cardiol 1993;21:378A.