Effect of chronic infusion of olanzapine and clozapine on food intake and body weight gain in male and female rats

Life Sciences

Volumn 81, Issue 12, 2007, Pages 1024-1030

  Choi, SuJean ^a   DiSilvio, Briana ^a   Unangst, JayLynn ^a   Fernstrom, John D ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Body weight; Clozapine; Food intake; Olanzapine; Pharmacokinetics; Rat

Indexed keywords

CLOZAPINE; OLANZAPINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MINIPUMP; NONHUMAN; RAT; SEX DIFFERENCE; WEIGHT GAIN;

ANIMALS; ANTIPSYCHOTIC AGENTS; BENZODIAZEPINES; CLOZAPINE; EATING; FEMALE; MALE; RATS; RATS, SPRAGUE-DAWLEY; WEIGHT GAIN;

RATTUS;

EID: 34548542060     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2007.08.009     Document Type: Article

References (30)

1. Aichhorn W., Whitworth A.B., Weiss E.M., and Marksteiner J. Second-generation antipsychotics: is there evidence for sex differences in pharmacokinetic and adverse effect profiles?. Drug Safety 29 (2006) 587-598
2. Albaugh V.L., Henry C.R., Bello N.T., Hajnal A., Lynch S.L., Halle B., and Lynch C.J. Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity 14 (2006) 36-51
3. Allison D.B., and Casey D.E. Antipsychotic-induced weight gain: a review of the literature. Journal of Clinical Psychiatry 62 Suppl 7 (2001) 22-31
4. Allison D.B., Mentore J.L., Heo M., Chandler L.P., Cappelleri J.C., Infante M.C., and Weiden P.J. Antipsychotic-induced weight gain: a comprehensive research synthesis. American Journal of Psychiatry 156 (1999) 1686-1696
5. Arjona A.A., Zhang S.X., Adamson B., and Wurtman R.J. An animal model of antipsychotic-induced weight gain. Behavioural Brain Research 152 (2004) 121-127
6. Baldessarini R.J., Centorrino F., Flood J.G., Volpicelli S.A., Huston-Lyons D., and Cohen B.M. Tissue concentrations of clozapine and its metabolites in the rat. Neuropsychopharmacology 9 (1993) 117-124
7. 2 dopamine receptors involved?. Pharmacology, Biochemistry and Behavior 27 (1987) 399-405
8. Baptista T., Mata A., Teneud L., de Quijada M., Han H.W., and Hernandez L. Effects of long-term administration of clozapine on body weight and food intake in rats. Pharmacology, Biochemistry and Behavior 45 (1993) 51-54
9. Baptista T., Contreras Q., Teneud L., Albornoz M.A., Acosta A., Paez X., de Quijada M., Lacruz A., and Hernandez L. Mechanism of the neuroleptic-induced obesity in female rats. Progress in Neuro-Psychopharmacology & Biological Psychiatry 22 (1998) 187-198
10. Basson B.R., Kinon B.J., Taylor C.C., Szymanski K.A., Gilmore J.A., and Tollefson G.D. Factors influencing acute weight change in patients with schizophrenia treated with olanzapine, haloperidol, or risperidone. Journal of Clinical Psychiatry 62 (2001) 231-238
11. Benvenga M.J. Can Clinical Weight Gain Produced by Atypical Antipsychotic Agents be Modelled in the Rat? (2002), Society for Neuroscience, Washington DC Abstract 707.4
12. Bhana N., Foster R.H., Olney R., and Plosker G.L. Olanzapine: an updated review of its use in the management of schizophrenia. Drugs 61 (2001) 111-161
13. Byerly M.J., and Devane C.L. Pharmacokinetics of clozapine and risperidone: a review of recent literature. Journal of Clinical Psychopharmacology 16 (1996) 177-187
14. Callaghan J.T., Bergstrom R.F., Ptak L.R., and Beasley C.M. Olanzapine: pharmacokinetic and pharmacodynamic profile. Clinical Pharmacokinetics 37 (1999) 177-193
15. Chiu J.A., and Franklin R.B. Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detection. Journal of Pharmaceutical and Biomedical Analysis 14 (1996) 609-615
16. Cooper G.D., Pickavance L.C., Wilding J.P., Harrold J.A., Halford G., and Goudie A.J. Effects of olanzapine in male rats: enhanced adiposity in the absence of hyperphagia, weight gain or metabolic abnormalities. Journal of Psychopharmacology 21 (2006) 405-413
17. de Leon J., Diaz F.J., Josiassen R.C., Cooper T.B., and Simpson G.M. Weight gain during a double-blind multidosage clozapine study. Journal of Clinical Psychopharmacology 27 (2007) 22-27
18. Frankenburg F.R., Zanarini M.C., Kando J., and Centorrino F. Clozapine and body mass change. Biological Psychiatry 43 (1998) 520-524
19. Freedman R. Schizophrenia. New England Journal of Medicine 349 (2003) 1738-1749
20. Ganguli R. Weight gain associated with antipsychotic drugs. Journal of Clinical Psychiatry 60 Suppl 21 (1999) 20-24
21. Goudie A.J., Smith J., and Halford J. Characterization of olanzapine-induced weight gain in rats. Journal of Psychopharmacology 16 (2002) 291-296
22. Greenwood-Smith C., Lubman D.I., and Castle D.J. Serum clozapine levels: a review of their clinical utility. Journal of Psychopharmacology 17 (2003) 234-238
23. Minet-Ringuet J., Even P.C., Goubern M., Tome D., and deBeaurepaire R. Long term treatment with olanzapine mixed with the food in male rats induces body fat deposition with no increase in body weight and no thermogenic alteration. Appetite 46 (2006) 254-262
24. Minet-Ringuet J., Even P.C., Lacroix M., Tome D., and deBeaurepaire R. A model for antipsychotic-induced obesity in the male rat. Psychopharmacology 187 (2006) 447-454
25. Olesen O.V., and Linnet K. Determination of olanzapine in serum by high-performance liquid chromatography using ultraviolet detection considering the easy oxidability of the compound and the presence of other psychotropic drugs. Journal of Chromatography. B, Biomedical Sciences and Applications 714 (1998) 309-315
26. Perry P.J., Lund B.C., Sanger T., and Beasley C. Olanzapine plasma concentrations and clinical response: acute phase results of the North American Olanzapine Trial. Journal of Clinical Psychopharmacology 21 (2001) 14-20
27. Pouzet B., Mow T., Kreilgard M., and Velschow S. Chronic treatment with antipsychotics in rats as a model for antipsychotic-induced weight gain in human. Pharmacology, Biochemistry and Behavior 75 (2003) 133-140
28. Schulte P. What is an adequate trial with clozapine?: therapeutic drug monitoring and time to response in treatment-refractory schizophrenia. Clinical Pharmacokinetics 42 (2003) 607-618
29. Volpicelli S.A., Centorrino F., Puopolo P.R., Kando J., Frankenburg F.R., Baldessarini R.J., and Flood J.G. Determination of clozapine, norclozapine, and clozapine-N-oxide in serum by liquid chromatography. Clinical Chemistry 39 (1993) 1656-1659
30. Weiss U., Marksteiner J., Kemmler G., Saria A., and Aichhorn W. Effects of age and sex on olanzapine plasma concentrations. Journal of Clinical Psychopharmacology 25 (2005) 570-574