메뉴 건너뛰기




Volumn 45, Issue 6, 2007, Pages 761-769

Tipranavir: A new option for the treatment of drug-resistant HIV infection

Author keywords

[No Author keywords available]

Indexed keywords

ABACAVIR; AMPRENAVIR; ANTIARRHYTHMIC AGENT; ANTIHISTAMINIC AGENT; ANTIRETROVIRUS AGENT; DARUNAVIR; DIDANOSINE; EFAVIRENZ; ENFUVIRTIDE; ERGOT DERIVATIVE; ETRAVIRINE; GLYCOPROTEIN P; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYPERICUM PERFORATUM EXTRACT; LAMIVUDINE; LOPINAVIR; NEUROLEPTIC AGENT; NEVIRAPINE; PROTEINASE INHIBITOR; RIFABUTIN; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; SAQUINAVIR; SEDATIVE AGENT; STAVUDINE; TENOFOVIR; TIPRANAVIR; UNINDEXED DRUG; VIRUS RNA; ZIDOVUDINE;

EID: 34548534109     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/520847     Document Type: Review
Times cited : (29)

References (56)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella FJ Jr, Delaney KM, Moorman AC, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998; 338:853-60.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr, F.J.1    Delaney, K.M.2    Moorman, A.C.3
  • 2
    • 0343742642 scopus 로고    scopus 로고
    • Decline in deaths from AIDS due to new antiretrovirals
    • Hogg RS, O'Shaughnessy MV, Gataric N, et al. Decline in deaths from AIDS due to new antiretrovirals. Lancet 1997; 349:1294.
    • (1997) Lancet , vol.349 , pp. 1294
    • Hogg, R.S.1    O'Shaughnessy, M.V.2    Gataric, N.3
  • 3
    • 9844261693 scopus 로고    scopus 로고
    • Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres
    • Mouton Y, Alfandari S, Valette M, et al. Impact of protease inhibitors on AIDS-defining events and hospitalizations in 10 French AIDS reference centres. AIDS 1997; 11:F101-5.
    • (1997) AIDS , vol.11
    • Mouton, Y.1    Alfandari, S.2    Valette, M.3
  • 4
    • 0037119026 scopus 로고    scopus 로고
    • the HIV Outpatient Study Investigators. Durability and predictors of success of highly active antiretroviral therapy for ambulatory HIV-infected patients
    • Palella FJ, Chmiel JS, Mooreman AC, Holmberg SD; the HIV Outpatient Study Investigators. Durability and predictors of success of highly active antiretroviral therapy for ambulatory HIV-infected patients. AIDS 2002; 16:1617-26.
    • (2002) AIDS , vol.16 , pp. 1617-1626
    • Palella, F.J.1    Chmiel, J.S.2    Mooreman, A.C.3    Holmberg, S.D.4
  • 5
    • 0033587510 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy in a large urban clinic: Risk factors for virologic failure and adverse drug reactions
    • Lucas GM, Chaisson RE, Moore RD. Highly active antiretroviral therapy in a large urban clinic: risk factors for virologic failure and adverse drug reactions. Ann Intern Med 1999; 131:81-7.
    • (1999) Ann Intern Med , vol.131 , pp. 81-87
    • Lucas, G.M.1    Chaisson, R.E.2    Moore, R.D.3
  • 6
    • 0029909674 scopus 로고    scopus 로고
    • Structure-based design of HIV protease inhibitors: Sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors
    • Thaisrivongs S, Skulnick HI, Turner SR, et al. Structure-based design of HIV protease inhibitors: sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones as non-peptidic inhibitors. J Med Chem 1996; 39:4349-53.
    • (1996) J Med Chem , vol.39 , pp. 4349-4353
    • Thaisrivongs, S.1    Skulnick, H.I.2    Turner, S.R.3
  • 7
    • 0034623020 scopus 로고    scopus 로고
    • Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples
    • Larder BA, Hertogs K, Bloor S, et al. Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples. AIDS 2000; 14:1943-8.
    • (2000) AIDS , vol.14 , pp. 1943-1948
    • Larder, B.A.1    Hertogs, K.2    Bloor, S.3
  • 8
    • 1642418876 scopus 로고    scopus 로고
    • How flexible is tipranavir in complex with the HIV-1 protease active site?
    • Schake D. How flexible is tipranavir in complex with the HIV-1 protease active site? AIDS 2004; 18:579-80.
    • (2004) AIDS , vol.18 , pp. 579-580
    • Schake, D.1
  • 9
    • 12944322516 scopus 로고    scopus 로고
    • Tipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class
    • Turner SR, Strohbach JW, Tommasi RA, et al. Tipranavir (PNU-140690): a potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class. J Med Chem 1998; 41:3467-76.
    • (1998) J Med Chem , vol.41 , pp. 3467-3476
    • Turner, S.R.1    Strohbach, J.W.2    Tommasi, R.A.3
  • 10
    • 34548533025 scopus 로고    scopus 로고
    • Borin MT, Wang Y, Schneck DW, et al. Multiple-dose, safety, tolerance and pharmacokinetics of the protease inhibitor PNU-140690 in healthy volunteers [abstract 648]. In: Program and abstracts of the 5th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 1998.
    • Borin MT, Wang Y, Schneck DW, et al. Multiple-dose, safety, tolerance and pharmacokinetics of the protease inhibitor PNU-140690 in healthy volunteers [abstract 648]. In: Program and abstracts of the 5th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 1998.
  • 11
    • 1542409142 scopus 로고    scopus 로고
    • A 14-day dose-response study of the efficacy, safety, and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naive HIV-1 infected patients
    • McCallister S, Valdez H, Curry K, et al. A 14-day dose-response study of the efficacy, safety, and pharmacokinetics of the nonpeptidic protease inhibitor tipranavir in treatment-naive HIV-1 infected patients. J Acquir Immune Defic Syndr 2004; 35:376-82.
    • (2004) J Acquir Immune Defic Syndr , vol.35 , pp. 376-382
    • McCallister, S.1    Valdez, H.2    Curry, K.3
  • 12
    • 13844296701 scopus 로고    scopus 로고
    • Pharmacokinetic characterization of different dose combinations of coadministered tipranavir and ritonavir in healthy volunteers
    • MacGregor TR, Sabo JP, Norris SH, et al. Pharmacokinetic characterization of different dose combinations of coadministered tipranavir and ritonavir in healthy volunteers. HIV Clin Trials 2004; 5:371-82.
    • (2004) HIV Clin Trials , vol.5 , pp. 371-382
    • MacGregor, T.R.1    Sabo, J.P.2    Norris, S.H.3
  • 13
    • 34548531683 scopus 로고    scopus 로고
    • Yeni P, MacGregor T, Gathe J, et al. Correlation of viral load reduction and plasma levels in multiple protease inhibitor experienced patients taking tipranavir/ritonavir in a phase IIB trial: BI 1182.52 [abstract 528]. In: Program and abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2003.
    • Yeni P, MacGregor T, Gathe J, et al. Correlation of viral load reduction and plasma levels in multiple protease inhibitor experienced patients taking tipranavir/ritonavir in a phase IIB trial: BI 1182.52 [abstract 528]. In: Program and abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2003.
  • 14
    • 34548531480 scopus 로고    scopus 로고
    • Baldwin JR, Boron MT, Wang Y, Schneck DW, Hopkins NK. Effects of food and antacid on bioavailability of the protease inhibitor PNU-140690 in healthy volunteers [abstract 649]. In: Program and abstracts of the 5th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 1998.
    • Baldwin JR, Boron MT, Wang Y, Schneck DW, Hopkins NK. Effects of food and antacid on bioavailability of the protease inhibitor PNU-140690 in healthy volunteers [abstract 649]. In: Program and abstracts of the 5th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 1998.
  • 15
    • 34548523519 scopus 로고    scopus 로고
    • Aptivus [package insert, Ridgefield, Connecticut: Boehringer Ingelheim Pharmaceuticals. Revised 27 June 2006
    • Aptivus [package insert]. Ridgefield, Connecticut: Boehringer Ingelheim Pharmaceuticals. Revised 27 June 2006.
  • 16
    • 34548542195 scopus 로고    scopus 로고
    • Cooper C, van Heeswijk R, Bilodeau M, et al. The pharmacokinetics (PK) of single-dose and steady-state tipranavir/ritonavir (TPV/r) 500 mg/200 mg in subjects with mild or moderate hepatic impairment [abstract TuPe3.1B07]. In: Program and abstacts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
    • Cooper C, van Heeswijk R, Bilodeau M, et al. The pharmacokinetics (PK) of single-dose and steady-state tipranavir/ritonavir (TPV/r) 500 mg/200 mg in subjects with mild or moderate hepatic impairment [abstract TuPe3.1B07]. In: Program and abstacts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
  • 17
    • 34548527732 scopus 로고    scopus 로고
    • Wang Y, Daenzer C, Wood R, et al. The safety, efficacy and viral dynamics analysis of tipranavir, a new-generation protease inhibitor, in a phase II study in antiretroviral-naive HIV-1-infected patients [abstract 673]. In: Program and abstracts of the 7th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2000.
    • Wang Y, Daenzer C, Wood R, et al. The safety, efficacy and viral dynamics analysis of tipranavir, a new-generation protease inhibitor, in a phase II study in antiretroviral-naive HIV-1-infected patients [abstract 673]. In: Program and abstracts of the 7th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2000.
  • 18
    • 34548538158 scopus 로고    scopus 로고
    • Cooper D, Zajdenverg R, Ruxrungtham K, et al. Efficacy and safety of two doses of tipranavir/ritonavir versus lopinavir/ritonavir-based therapy in antiretroviral-naive patients: results of BI 1182.33 [abstract PL 13.4]. In: Program and abstracts of the 8th International Congress on Drug Therapy in HIV Infection. 2006.
    • Cooper D, Zajdenverg R, Ruxrungtham K, et al. Efficacy and safety of two doses of tipranavir/ritonavir versus lopinavir/ritonavir-based therapy in antiretroviral-naive patients: results of BI 1182.33 [abstract PL 13.4]. In: Program and abstracts of the 8th International Congress on Drug Therapy in HIV Infection. 2006.
  • 19
    • 34548538904 scopus 로고    scopus 로고
    • Neubacher D, Markowitz M, Slater L, Curry R, Kohlbrenner V, McCallister S. Long-term 80-week follow-up of highly treatment-experienced (HTE) patients on tipranavir-based antiretroviral therapy (BI 1182.2) [abstract 7.2/3]. In: Program and abstracts of the 9th European AIDS Conference. 2003.
    • Neubacher D, Markowitz M, Slater L, Curry R, Kohlbrenner V, McCallister S. Long-term 80-week follow-up of highly treatment-experienced (HTE) patients on tipranavir-based antiretroviral therapy (BI 1182.2) [abstract 7.2/3]. In: Program and abstracts of the 9th European AIDS Conference. 2003.
  • 20
    • 34548542624 scopus 로고    scopus 로고
    • Squires K, McCallister S, Lazzarin A, et al. Tipranavir/ritonavir (TPV/r) demonstrates a robust resistance profile in multiple protease inhibitor-experienced patients: correlation of baseline genotype and antiviral activity in BI 1182.52 [abstract 812]. In: Program and abstracts of the 2nd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2003.
    • Squires K, McCallister S, Lazzarin A, et al. Tipranavir/ritonavir (TPV/r) demonstrates a robust resistance profile in multiple protease inhibitor-experienced patients: correlation of baseline genotype and antiviral activity in BI 1182.52 [abstract 812]. In: Program and abstracts of the 2nd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2003.
  • 21
    • 34548539386 scopus 로고    scopus 로고
    • Gathe J, Kohlbrenner VM, Pierone G, et al. Tipranavir/ritonavir demonstrates potent efficacy in multiple protease inhibitor experienced patients: BI 1182.52 [abstract 179]. In: Program and abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2003.
    • Gathe J, Kohlbrenner VM, Pierone G, et al. Tipranavir/ritonavir demonstrates potent efficacy in multiple protease inhibitor experienced patients: BI 1182.52 [abstract 179]. In: Program and abstracts of the 10th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2003.
  • 22
    • 34548526419 scopus 로고    scopus 로고
    • Cooper D, Hicks C, Cahn P, et al. 24-Week RESIST study analyses: the efficacy of tipranavir/ritonavir is superior to lopinavir/ritonavir, and the TPV/r treatment response is enhanced by inclusion of genotypically active antiretrovirals in the optimized background regimen [abstract 560]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
    • Cooper D, Hicks C, Cahn P, et al. 24-Week RESIST study analyses: the efficacy of tipranavir/ritonavir is superior to lopinavir/ritonavir, and the TPV/r treatment response is enhanced by inclusion of genotypically active antiretrovirals in the optimized background regimen [abstract 560]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
  • 23
    • 34548531187 scopus 로고    scopus 로고
    • Lazzarin A, Mukwaya G, Clumeck N, et al. Tipranavir/ritonavir (TPV/r) demonstrates superior treatment response to lopinavir/r (LPV/r), amprenavir/r (APV/r) or saquinavir/r (SQV/r) in PI-experienced patients from the TPV RESIST-1 and RESIST-2 trials [abstract WePe6.3C07]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
    • Lazzarin A, Mukwaya G, Clumeck N, et al. Tipranavir/ritonavir (TPV/r) demonstrates superior treatment response to lopinavir/r (LPV/r), amprenavir/r (APV/r) or saquinavir/r (SQV/r) in PI-experienced patients from the TPV RESIST-1 and RESIST-2 trials [abstract WePe6.3C07]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
  • 24
    • 34548525307 scopus 로고    scopus 로고
    • Tipranavir capsules, NDA 21-814. Applicant: Boehringer Ingelheim Pharmaceuticals. Antiviral Drugs Advisory Committee (AVDAC) briefing document, 19 April 2005. Available at: http://www.fda.gov/ohrms/dockets/ac/05/ briefing/2005-4139b1-02-boehringer.pdf. Accessed 15 March 2006.
    • Tipranavir capsules, NDA 21-814. Applicant: Boehringer Ingelheim Pharmaceuticals. Antiviral Drugs Advisory Committee (AVDAC) briefing document, 19 April 2005. Available at: http://www.fda.gov/ohrms/dockets/ac/05/ briefing/2005-4139b1-02-boehringer.pdf. Accessed 15 March 2006.
  • 25
    • 34548526072 scopus 로고    scopus 로고
    • Grinsztejn B, Hicks C, Cahn P, et al. Tipranavir/ritonavir (TPV/r) demonstrates superior immunologic response to comparator protease inhibitors (CPIs) in a PI-experienced population with advanced disease [abstract WePe16.7B07]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
    • Grinsztejn B, Hicks C, Cahn P, et al. Tipranavir/ritonavir (TPV/r) demonstrates superior immunologic response to comparator protease inhibitors (CPIs) in a PI-experienced population with advanced disease [abstract WePe16.7B07]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
  • 26
    • 33746576313 scopus 로고    scopus 로고
    • Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: An analysis of combined data from two randomised open-label trials
    • Hicks CB, Cahn P, Cooper DA, et al. Durable efficacy of tipranavir-ritonavir in combination with an optimised background regimen of antiretroviral drugs for treatment-experienced HIV-1-infected patients at 48 weeks in the Randomized Evaluation of Strategic Intervention in multi-drug reSistant patients with Tipranavir (RESIST) studies: an analysis of combined data from two randomised open-label trials. Lancet 2006; 368:466-75.
    • (2006) Lancet , vol.368 , pp. 466-475
    • Hicks, C.B.1    Cahn, P.2    Cooper, D.A.3
  • 27
    • 34548534798 scopus 로고    scopus 로고
    • Katlama C, Walmsley S, Hicks C, et al. Tipranavir achieves twice the rate of treatment response and prolongs durability of response vs. comparator PI in ART-experienced patients, independent of baseline CD4 cell count or viral load: week 48 RESIST 1 and 2 combined analyses [abstract 520]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
    • Katlama C, Walmsley S, Hicks C, et al. Tipranavir achieves twice the rate of treatment response and prolongs durability of response vs. comparator PI in ART-experienced patients, independent of baseline CD4 cell count or viral load: week 48 RESIST 1 and 2 combined analyses [abstract 520]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
  • 28
    • 34548538903 scopus 로고    scopus 로고
    • Schapiro J, Cahn P, Trottier B, et al. Effect of baseline genotype on response to tipranavir/ritonavir (TPV/r) compared with standard-of-care comparator (CPI/r) in treatment-experienced patients: the phase 3 RESIST-1 and -2 trials [abstract 104]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
    • Schapiro J, Cahn P, Trottier B, et al. Effect of baseline genotype on response to tipranavir/ritonavir (TPV/r) compared with standard-of-care comparator (CPI/r) in treatment-experienced patients: the phase 3 RESIST-1 and -2 trials [abstract 104]. In: Program and abstracts of the 12th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2005.
  • 29
    • 34548538159 scopus 로고    scopus 로고
    • Lazzarin A, Feinberg J, Kraft M, Hall D. Week 48 efficacy of TPV/r treatment is enhanced in patients with higher numbers of genotypically available background drugs in RESIST 1 and 2 [abstract P24]. In: Program and abstracts of the 8th International Congress on Drug Therapy in HIV Infection. 2006. Available at: http://www.abstracts2view.com/hiv/. Accessed 1 August 2007.
    • Lazzarin A, Feinberg J, Kraft M, Hall D. Week 48 efficacy of TPV/r treatment is enhanced in patients with higher numbers of genotypically available background drugs in RESIST 1 and 2 [abstract P24]. In: Program and abstracts of the 8th International Congress on Drug Therapy in HIV Infection. 2006. Available at: http://www.abstracts2view.com/hiv/. Accessed 1 August 2007.
  • 31
    • 34548537227 scopus 로고    scopus 로고
    • Valdez H, McCallister S, Kohlbrenner V, Mayers D. Tipranavir/ritonavir (TPV/r) 500 mg/200 mg BID drives week 24 viral load (VL) below 400 copies/mL when combined with a second active drug (T-20) in protease inhibitor experienced HIV+ patients [abstract WeOa0205]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
    • Valdez H, McCallister S, Kohlbrenner V, Mayers D. Tipranavir/ritonavir (TPV/r) 500 mg/200 mg BID drives week 24 viral load (VL) below 400 copies/mL when combined with a second active drug (T-20) in protease inhibitor experienced HIV+ patients [abstract WeOa0205]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
  • 32
    • 34548524857 scopus 로고    scopus 로고
    • Salazar JC, Cahn P, Della Negra M, et al. Predictors of response to TPV/r in pediatric patients: results of PACTG1051/BI1182.14 [abstract 733. In: Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2007.
    • Salazar JC, Cahn P, Della Negra M, et al. Predictors of response to TPV/r in pediatric patients: results of PACTG1051/BI1182.14 [abstract 733). In: Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2007.
  • 33
    • 34548529704 scopus 로고    scopus 로고
    • Pierone G, Drulak M, Arasteh K, et al. A long-term open-label rollover trial assessing the safety and tolerability of combination tipranavir and ritonavir (TPV/r) use in HIV-1-infected patients [Abstract WePe6.2C05]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
    • Pierone G, Drulak M, Arasteh K, et al. A long-term open-label rollover trial assessing the safety and tolerability of combination tipranavir and ritonavir (TPV/r) use in HIV-1-infected patients [Abstract WePe6.2C05]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2005.
  • 34
    • 34548529088 scopus 로고    scopus 로고
    • Nwando O, Themba B. An open-label steady state investigation of the pharmacokinetics (PK) of tipranavir (TPV) and ritonavir (RTV) and their effects on cytochrome P-450 (3A4) activity in normal healthy volunteers [abstract TuPe7.8C01]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment, Geneva: International AIDS Society, 2005.
    • Nwando O, Themba B. An open-label steady state investigation of the pharmacokinetics (PK) of tipranavir (TPV) and ritonavir (RTV) and their effects on cytochrome P-450 (3A4) activity in normal healthy volunteers [abstract TuPe7.8C01]. In: Program and abstracts of the 3rd IAS Conference on HIV Pathogenesis and Treatment, Geneva: International AIDS Society, 2005.
  • 35
    • 0032211902 scopus 로고    scopus 로고
    • Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells
    • Washington CB, Duran GE, Man MC, et al. Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells. J Acquir Immune Defic Syndr Hum Retrovirol 1998; 19:203-9.
    • (1998) J Acquir Immune Defic Syndr Hum Retrovirol , vol.19 , pp. 203-209
    • Washington, C.B.1    Duran, G.E.2    Man, M.C.3
  • 36
    • 34548534345 scopus 로고    scopus 로고
    • Walmsley S, Leith J, Katlama C, et al. Pharmacokinetics and safety of tipranavir/ritonavir (TPV/r) alone or in combination with saquinavir (SQV), amprenavir (APV), or lopinavir (LPV): interim analysis of BI1182.51 [abstract WeOrB1236]. In: Program and abstracts of the 15th International AIDS Conference. Geneva: International AIDS Society, 2004.
    • Walmsley S, Leith J, Katlama C, et al. Pharmacokinetics and safety of tipranavir/ritonavir (TPV/r) alone or in combination with saquinavir (SQV), amprenavir (APV), or lopinavir (LPV): interim analysis of BI1182.51 [abstract WeOrB1236]. In: Program and abstracts of the 15th International AIDS Conference. Geneva: International AIDS Society, 2004.
  • 37
    • 34548525441 scopus 로고    scopus 로고
    • Roszko PJ, Curry K, Brazina B, et al. Standard doses of efavirenz (EFV), zidovudine (ZDV), tenofovir (TDF), and didanosine (ddI) may be given with tipranavir/ritonavir (TPV/r) [abstract 812]. In: Program and abstracts of the 2nd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2003.
    • Roszko PJ, Curry K, Brazina B, et al. Standard doses of efavirenz (EFV), zidovudine (ZDV), tenofovir (TDF), and didanosine (ddI) may be given with tipranavir/ritonavir (TPV/r) [abstract 812]. In: Program and abstracts of the 2nd IAS Conference on HIV Pathogenesis and Treatment. Geneva: International AIDS Society, 2003.
  • 38
    • 34548524737 scopus 로고    scopus 로고
    • Philips L, Borin MT, Hopkins NK, Daenzer CL, Wang Y. The pharmacokinetics of nucleoside reverse transcriptase inhibitors when coadministered with the HIV protease inhibitor tipranavir in HIV-1 infected patients [abstract 81]. In: Program and abstracts of the 7th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2000.
    • Philips L, Borin MT, Hopkins NK, Daenzer CL, Wang Y. The pharmacokinetics of nucleoside reverse transcriptase inhibitors when coadministered with the HIV protease inhibitor tipranavir in HIV-1 infected patients [abstract 81]. In: Program and abstracts of the 7th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2000.
  • 40
    • 34548533487 scopus 로고    scopus 로고
    • Schöller M, Kraft M, Hoetelmans R, et al. Significant decrease in TMC125 exposures when co-administered with tipranavir boosted with ritonavir in healthy subjects [abstract 583]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2006.
    • Schöller M, Kraft M, Hoetelmans R, et al. Significant decrease in TMC125 exposures when co-administered with tipranavir boosted with ritonavir in healthy subjects [abstract 583]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2006.
  • 41
    • 34548535711 scopus 로고    scopus 로고
    • Gonzalez De Requena D, Calcagno A, Bonora S, et al. Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide [abstract 579]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2006.
    • Gonzalez De Requena D, Calcagno A, Bonora S, et al. Unexpected drug-drug interaction between tipranavir/ritonavir and enfuvirtide [abstract 579]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2006.
  • 42
    • 34548537457 scopus 로고    scopus 로고
    • Van Heeswijk R, Sabo JP, MacGregor T, et al. The effect of tipranavir/ritonavir 500mg/200mg bid (TPV/r) on the pharmacokinetics of fluconazole in healthy volunteers [abstract 20]. In: Program and abstracts of the 5th International Workshop on Clinical Pharmacology in HIV Therapy. 2004. Available at: http://www.hivpresentation.com. Accessed 1 August 2007.
    • Van Heeswijk R, Sabo JP, MacGregor T, et al. The effect of tipranavir/ritonavir 500mg/200mg bid (TPV/r) on the pharmacokinetics of fluconazole in healthy volunteers [abstract 20]. In: Program and abstracts of the 5th International Workshop on Clinical Pharmacology in HIV Therapy. 2004. Available at: http://www.hivpresentation.com. Accessed 1 August 2007.
  • 43
    • 34548541950 scopus 로고    scopus 로고
    • Van Heeswijk R, Sabo JP, MacGregor T, et al. The pharmacokinetic interaction between single-dose rifabutin and steady state tipranavir/ritonavir 500mg/200mg (TPV/r) in healthy volunteers abstract A-456]. In: Program and abstracts of the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Alexandria, VA: American Society for Microbiology, 2004.
    • Van Heeswijk R, Sabo JP, MacGregor T, et al. The pharmacokinetic interaction between single-dose rifabutin and steady state tipranavir/ritonavir 500mg/200mg (TPV/r) in healthy volunteers (abstract A-456]. In: Program and abstracts of the 44th Interscience Conference on Antimicrobial Agents and Chemotherapy. Alexandria, VA: American Society for Microbiology, 2004.
  • 44
    • 34548535495 scopus 로고    scopus 로고
    • Doyon L, Tremblay C, Wardrop E, et al. Characterization of HIV-1 isolates showing decreased susceptibility to tipranavir and their inhibition by tipranavir containing drug mixtures [abstract 12]. In: Program and abstracts of the 12th International HIV Drug Resistance Workshop. College Park, GA: Informed Horizons, 2003.
    • Doyon L, Tremblay C, Wardrop E, et al. Characterization of HIV-1 isolates showing decreased susceptibility to tipranavir and their inhibition by tipranavir containing drug mixtures [abstract 12]. In: Program and abstracts of the 12th International HIV Drug Resistance Workshop. College Park, GA: Informed Horizons, 2003.
  • 46
    • 34548536312 scopus 로고    scopus 로고
    • Mayers D, Leith J, Valdez H, et al. Impact of three or four protease mutations at codons 33, 82, 84 and 90 on 2 week virological responses to tipanavir, lopinavir, amprenavir and saquinavir all boosted by ritonavir in phase 2B trial BI 1182.51 [abstract 147]. In: Program and abstracts of the 13th International HIV Drug Resistance Workshop. College Park, GA: Informed Horizons, 2004.
    • Mayers D, Leith J, Valdez H, et al. Impact of three or four protease mutations at codons 33, 82, 84 and 90 on 2 week virological responses to tipanavir, lopinavir, amprenavir and saquinavir all boosted by ritonavir in phase 2B trial BI 1182.51 [abstract 147]. In: Program and abstracts of the 13th International HIV Drug Resistance Workshop. College Park, GA: Informed Horizons, 2004.
  • 47
    • 34548528605 scopus 로고    scopus 로고
    • Hall D, McCallister S, Neubacher D, Kraft M, Mayers DL. Characterisation of treatment-emergent resistance mutations in two phase II studies of tipranavir (TPV) [abstract 13]. In: Program and abstracts of the 12th International HIV Drug Resistance Workshop. College Park, GA: Informed Horizons, 2003.
    • Hall D, McCallister S, Neubacher D, Kraft M, Mayers DL. Characterisation of treatment-emergent resistance mutations in two phase II studies of tipranavir (TPV) [abstract 13]. In: Program and abstracts of the 12th International HIV Drug Resistance Workshop. College Park, GA: Informed Horizons, 2003.
  • 48
    • 33750338185 scopus 로고    scopus 로고
    • Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir
    • Baxter JD, Schapiro JM, Boucher CAB, et al. Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol 2006; 80:10794-801.
    • (2006) J Virol , vol.80 , pp. 10794-10801
    • Baxter, J.D.1    Schapiro, J.M.2    Boucher, C.A.B.3
  • 49
    • 34548541277 scopus 로고    scopus 로고
    • Scherer J, Kohlbrenner VM, Hall DB, et al. Mutations associated with cross-resistance to tipranavir in patients previously treated with two or more protease inhibitors. In: Program and abstracts of the 5th European HIV Drug Resistance Workshop. 2007. Available at: http://www.natap.org. Accessed 30 March 2007.
    • Scherer J, Kohlbrenner VM, Hall DB, et al. Mutations associated with cross-resistance to tipranavir in patients previously treated with two or more protease inhibitors. In: Program and abstracts of the 5th European HIV Drug Resistance Workshop. 2007. Available at: http://www.natap.org. Accessed 30 March 2007.
  • 50
    • 34548532353 scopus 로고    scopus 로고
    • Parkin NT, Chappey C. Protease mutations associated with higher or lower than expected tipranavir susceptibility based on the TPV mutation score [abstract 637]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2006.
    • Parkin NT, Chappey C. Protease mutations associated with higher or lower than expected tipranavir susceptibility based on the TPV mutation score [abstract 637]. In: Program and abstracts of the 13th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2006.
  • 51
    • 33845925741 scopus 로고    scopus 로고
    • Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients
    • Naeger LK, Struble KA. Food and Drug Administration analysis of tipranavir clinical resistance in HIV-1-infected treatment-experienced patients. AIDS 2007; 21:179-85.
    • (2007) AIDS , vol.21 , pp. 179-185
    • Naeger, L.K.1    Struble, K.A.2
  • 52
    • 34548524980 scopus 로고    scopus 로고
    • Marcelin AG, Masquelier B, Descamps D, et al. Mutations associated to response to boosted tipranavir in HIV-1 infected protease inhibitor-experienced patients [abstract 612]. In: Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2007.
    • Marcelin AG, Masquelier B, Descamps D, et al. Mutations associated to response to boosted tipranavir in HIV-1 infected protease inhibitor-experienced patients [abstract 612]. In: Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections. Alexandria, VA: Foundation for Retrovirology and Human Health, 2007.
  • 53
    • 34548544708 scopus 로고    scopus 로고
    • Bacheler L, Vermeiren H, Winters B, et al. Clinically relevant phenotypic resistance and cross-resistance to tipranavir among recent routine clinical isolates. In: Program and abstracts of the 4th European HIV Drug Resistance Workshop. 2006. Available at: http://www.hivpresentations.org. Accessed 13 May 2006.
    • Bacheler L, Vermeiren H, Winters B, et al. Clinically relevant phenotypic resistance and cross-resistance to tipranavir among recent routine clinical isolates. In: Program and abstracts of the 4th European HIV Drug Resistance Workshop. 2006. Available at: http://www.hivpresentations.org. Accessed 13 May 2006.
  • 54
    • 34548544585 scopus 로고    scopus 로고
    • Van der Borght K, Winters B, Van Craenenbroeck E, et al. Correlation of resistance algorithms for tipranavir susceptibility with response to tipranavir containing regimens in the RESIST trials. In: Program and abstracts of the 5th European HIV Drug Resistance Workshop. 2007. Available at: http://www.natap.org. Accessed 30 March 2007.
    • Van der Borght K, Winters B, Van Craenenbroeck E, et al. Correlation of resistance algorithms for tipranavir susceptibility with response to tipranavir containing regimens in the RESIST trials. In: Program and abstracts of the 5th European HIV Drug Resistance Workshop. 2007. Available at: http://www.natap.org. Accessed 30 March 2007.
  • 55
    • 34548525564 scopus 로고    scopus 로고
    • De Meyer S, Cao-Van K, Lathouwers E, et al. Phenotypic and genotypic profiling of TMC114, lopinavir and tipranavir against PI-resistant HIV-1 clinical isolates [abstract 42]. In: Program and abstracts of the 4th European HIV Drug Resistance Workshop. 2006. Available at: http://www. hivpresentations.org. Accessed 13 May 2006.
    • De Meyer S, Cao-Van K, Lathouwers E, et al. Phenotypic and genotypic profiling of TMC114, lopinavir and tipranavir against PI-resistant HIV-1 clinical isolates [abstract 42]. In: Program and abstracts of the 4th European HIV Drug Resistance Workshop. 2006. Available at: http://www. hivpresentations.org. Accessed 13 May 2006.
  • 56
    • 34548535266 scopus 로고    scopus 로고
    • Elston RC, Kuritzkes DR, Bethell R. An investigation into the influence of the tipranavir-associated V82L/T mutations on the susceptibility to darunavir and brecanavir. In: Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections [abstract 602]. Alexandria, VA: Foundation for Retrovirology and Human Health, 2007.
    • Elston RC, Kuritzkes DR, Bethell R. An investigation into the influence of the tipranavir-associated V82L/T mutations on the susceptibility to darunavir and brecanavir. In: Program and abstracts of the 14th Conference on Retroviruses and Opportunistic Infections [abstract 602]. Alexandria, VA: Foundation for Retrovirology and Human Health, 2007.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.