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Volumn 19, Issue 3, 1998, Pages 203-209

Interaction of anti-HIV protease inhibitors with the multidrug transporter P-glycoprotein (P-gp) in human cultured cells

Author keywords

Bioavailability; Mdrl; Modulation; Nelfinavir; Ritonavir; Saquinavir

Indexed keywords

AZIDOPINE; CYTOCHROME P450; DAUNORUBICIN; DOXORUBICIN; GLYCOPROTEIN P; INDINAVIR; NELFINAVIR; PACLITAXEL; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; VALSPODAR; VINBLASTINE; VIRUS RNA;

EID: 0032211902     PISSN: 10779450     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042560-199811010-00001     Document Type: Article
Times cited : (143)

References (38)
  • 1
    • 0028868234 scopus 로고
    • Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine
    • Balani SK, Arison BH, Mathai L, et al. Metabolites of L-735,524, a potent HIV-1 protease inhibitor, in human urine. Drug Metab Dispos 1995;23:266-70.
    • (1995) Drug Metab Dispos , vol.23 , pp. 266-270
    • Balani, S.K.1    Arison, B.H.2    Mathai, L.3
  • 2
    • 0029872589 scopus 로고    scopus 로고
    • A 24-week open-label phase 1711 evaluation of the HIV protease inhibitor MK-639 (indinavir)
    • Stein DS, Fish DG, Bilello JA, Preston SL, Martineau GL, Drusano GL. A 24-week open-label phase 1711 evaluation of the HIV protease inhibitor MK-639 (indinavir). AIDS 1996;10:485-92.
    • (1996) AIDS , vol.10 , pp. 485-492
    • Stein, D.S.1    Fish, D.G.2    Bilello, J.A.3    Preston, S.L.4    Martineau, G.L.5    Drusano, G.L.6
  • 3
    • 0028806725 scopus 로고
    • A preliminary study of ritonavir, an inhibitor of HIV-1 protease. to treat HIV-1 infection
    • Markowitz M, Saag M, Powderly WG, et al. A preliminary study of ritonavir, an inhibitor of HIV-1 protease. to treat HIV-1 infection. N Engl J Med 1995;333:1534-9.
    • (1995) N Engl J Med , vol.333 , pp. 1534-1539
    • Markowitz, M.1    Saag, M.2    Powderly, W.G.3
  • 5
    • 13344275873 scopus 로고    scopus 로고
    • Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease
    • Patick AK, Mo H, Markowitz M, et al. Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob Agents Chemother 1996;40:292-7.
    • (1996) Antimicrob Agents Chemother , vol.40 , pp. 292-297
    • Patick, A.K.1    Mo, H.2    Markowitz, M.3
  • 6
    • 0030812875 scopus 로고    scopus 로고
    • Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro
    • Patick AK, Boritzki TJ, Bloom LA. Activities of the human immunodeficiency virus type 1 (HIV-1) protease inhibitor nelfinavir mesylate in combination with reverse transcriptase and protease inhibitors against acute HIV-1 infection in vitro. Antimicrob Agents Chemother 1997;41:2159-64.
    • (1997) Antimicrob Agents Chemother , vol.41 , pp. 2159-2164
    • Patick, A.K.1    Boritzki, T.J.2    Bloom, L.A.3
  • 7
    • 0029644513 scopus 로고
    • Safety and activity of saquinavir in HIV infection
    • Kitchen VS, Skinner C, Ariyoshi K. et al. Safety and activity of saquinavir in HIV infection. Lancet 1995;345:952-5.
    • (1995) Lancet , vol.345 , pp. 952-955
    • Kitchen, V.S.1    Skinner, C.2    Ariyoshi, K.3
  • 8
    • 2442723342 scopus 로고    scopus 로고
    • Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine
    • AIDS Clinical Trials Group
    • Collier AC, Coombs RW, Schoenfeld DA, et al. Treatment of human immunodeficiency virus infection with saquinavir, zidovudine, and zalcitabine. AIDS Clinical Trials Group. N Engl J Med 1996;334:1011-7.
    • (1996) N Engl J Med , vol.334 , pp. 1011-1017
    • Collier, A.C.1    Coombs, R.W.2    Schoenfeld, D.A.3
  • 9
    • 0028110476 scopus 로고
    • Use of proteinase inhibitors in clinical practice
    • Pollard RB. Use of proteinase inhibitors in clinical practice. Pharmacotherapy 1994;14(6 Part 2):21S-29S.
    • (1994) Pharmacotherapy , vol.14 , Issue.6 PART 2
    • Pollard, R.B.1
  • 10
    • 0029840569 scopus 로고    scopus 로고
    • Ritonavir
    • Lea AP, Faulds D. Ritonavir, Drugs 1996;52:541-6;547-8.
    • (1996) Drugs , vol.52 , pp. 541-546
    • Lea, A.P.1    Faulds, D.2
  • 11
    • 15444377672 scopus 로고    scopus 로고
    • Ordered accumulation of mutations in HIV protease confers resistance to ritonavir
    • Molla A, Korneyeva M, Gao Q, et al. Ordered accumulation of mutations in HIV protease confers resistance to ritonavir. Nat Med 1996;2:760-6.
    • (1996) Nat Med , vol.2 , pp. 760-766
    • Molla, A.1    Korneyeva, M.2    Gao, Q.3
  • 12
    • 0029926056 scopus 로고    scopus 로고
    • Reduced sensitivity to saquinavir: An update on genotyping from phase I/II trials
    • Jacobsen H, Haenggi M, Ott M, et al. Reduced sensitivity to saquinavir: an update on genotyping from phase I/II trials. Antiviral Res 1996;29:95-7.
    • (1996) Antiviral Res , vol.29 , pp. 95-97
    • Jacobsen, H.1    Haenggi, M.2    Ott, M.3
  • 13
    • 0028943992 scopus 로고
    • In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors
    • Condra JH, Schleif WA, Blahy OM, et al. In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors. Nature 1995;374:569-71.
    • (1995) Nature , vol.374 , pp. 569-571
    • Condra, J.H.1    Schleif, W.A.2    Blahy, O.M.3
  • 14
    • 1842284096 scopus 로고    scopus 로고
    • Clinical and virological responses to ritonavir, an inhibitor of HIV protease
    • abstract Mo.B. 1137. British Columbia, Canada
    • Korneyeva M, Molla A, Kempf D, et al. Clinical and virological responses to ritonavir, an inhibitor of HIV protease [abstract Mo.B. 1137]. Presented at the XI International Conference on AIDS, Vancouver, British Columbia, Canada, 1996.
    • (1996) XI International Conference on AIDS, Vancouver
    • Korneyeva, M.1    Molla, A.2    Kempf, D.3
  • 15
    • 0030059953 scopus 로고    scopus 로고
    • Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells
    • Schuetz EG, Beck WT, Schuetz JD. Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 1996;49:311-8.
    • (1996) Mol Pharmacol , vol.49 , pp. 311-318
    • Schuetz, E.G.1    Beck, W.T.2    Schuetz, J.D.3
  • 16
    • 0029028792 scopus 로고
    • Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: Implications for drug delivery and activity in cancer chemotherapy
    • Wacher VJ, Wu CY, Benet LZ. Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy. Mol Carcinog 1995;13:129-34.
    • (1995) Mol Carcinog , vol.13 , pp. 129-134
    • Wacher, V.J.1    Wu, C.Y.2    Benet, L.Z.3
  • 17
    • 0000712439 scopus 로고
    • Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites
    • Cordon-Cardo C, O'Brien JP, Casals D, et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 1989;86:695-8.
    • (1989) Proc Natl Acad Sci USA , vol.86 , pp. 695-698
    • Cordon-Cardo, C.1    O'Brien, J.P.2    Casals, D.3
  • 19
    • 0028923624 scopus 로고
    • Clinical studies with modulators of multidrug resistance
    • Fisher G and Sikic B, eds. Philadelphia: WB Saunders
    • Fisher G, Lum B, Sikic BI. Clinical studies with modulators of multidrug resistance. In Fisher G and Sikic B, eds. Drug resistance in clinical oncology and hematology. Philadelphia: WB Saunders, 1995:363-82.
    • (1995) Drug Resistance in Clinical Oncology and Hematology , pp. 363-382
    • Fisher, G.1    Lum, B.2    Sikic, B.I.3
  • 20
    • 0026570652 scopus 로고
    • The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo
    • Roninson IB. The role of the MDR1 (P-glycoprotein) gene in multidrug resistance in vitro and in vivo. Biochem Pharmacol 1992;43:95-102.
    • (1992) Biochem Pharmacol , vol.43 , pp. 95-102
    • Roninson, I.B.1
  • 21
    • 0029974821 scopus 로고    scopus 로고
    • Pharmacological considerations in the modulation of multidrug resistance
    • Fisher GA, Lum BL, Hausdorff J, Sikic, BI. Pharmacological considerations in the modulation of multidrug resistance. Eur J Cancer 1996;32A:1082-8.
    • (1996) Eur J Cancer , vol.32 A , pp. 1082-1088
    • Fisher, G.A.1    Lum, B.L.2    Hausdorff, J.3    Sikic, B.I.4
  • 22
    • 0028801904 scopus 로고
    • Inhibition of intestinal P-glycoprotein and effects on etoposide absorption
    • Leu BL, Huang JD. Inhibition of intestinal P-glycoprotein and effects on etoposide absorption. Cancer Chemother Pharmacol 1995;35:432-6.
    • (1995) Cancer Chemother Pharmacol , vol.35 , pp. 432-436
    • Leu, B.L.1    Huang, J.D.2
  • 23
    • 12644278301 scopus 로고    scopus 로고
    • Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine
    • Sparreboom A, van Asperen J, Mayer U, et al. Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestine. Proc Natl Acad Sci USA 1997;94:2031-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2031-2035
    • Sparreboom, A.1    Van Asperen, J.2    Mayer, U.3
  • 24
    • 0020559955 scopus 로고
    • Development and Characterization of a Human Sarcoma Cell Line, MES_SA, Sensitive to Multiple Drugs
    • Harker WG, MacKintosh FR, Sikic BI. Development and Characterization of a Human Sarcoma Cell Line, MES_SA, Sensitive to Multiple Drugs. Cancer Res 1983;43:4943-50.
    • (1983) Cancer Res , vol.43 , pp. 4943-4950
    • Harker, W.G.1    MacKintosh, F.R.2    Sikic, B.I.3
  • 25
    • 0022352607 scopus 로고
    • Multidrug (pleiotropic) resistance in doxorubicin-selected variant, the human sarcoma cell line MES-SA
    • Harker WG, Sikic BI. Multidrug (pleiotropic) resistance in doxorubicin-selected variant, the human sarcoma cell line MES-SA. Cancer Res 1985;45:4091-6.
    • (1985) Cancer Res , vol.45 , pp. 4091-4096
    • Harker, W.G.1    Sikic, B.I.2
  • 26
    • 0024971222 scopus 로고
    • Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine
    • published erratum appears in J Biol Chem 1990;265:4172
    • Bruggemann EP, Germann UA, Gottesman MM, Pastan I. Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine. J Biol Chem 1989;264:15483-8 [published erratum appears in J Biol Chem 1990;265:4172].
    • (1989) J Biol Chem , vol.264 , pp. 15483-15488
    • Bruggemann, E.P.1    Germann, U.A.2    Gottesman, M.M.3    Pastan, I.4
  • 27
    • 0023226943 scopus 로고
    • Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers
    • Safa AR, Glover CJ, Sewell JL, Meyers MB, Biedler JL, Felsted RL. Identification of the multidrug resistance-related membrane glycoprotein as an acceptor for calcium channel blockers. J Biol Chem 1987;262:7884-8.
    • (1987) J Biol Chem , vol.262 , pp. 7884-7888
    • Safa, A.R.1    Glover, C.J.2    Sewell, J.L.3    Meyers, M.B.4    Biedler, J.L.5    Felsted, R.L.6
  • 28
    • 0028963760 scopus 로고
    • Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance
    • Jaffrezou JP, Chen G, Duran GE, et al. Inhibition of lysosomal acid sphingomyelinase by agents which reverse multidrug resistance. Biochim Biophys Acta 1995;1266:1-8.
    • (1995) Biochim Biophys Acta , vol.1266 , pp. 1-8
    • Jaffrezou, J.P.1    Chen, G.2    Duran, G.E.3
  • 29
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983;65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 30
    • 0022445670 scopus 로고
    • Rapid colimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability
    • Denizot F, Lang R. Rapid colimetric assay for cell growth and survival: Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability. J Immunol Methods 1986;89: 271-7.
    • (1986) J Immunol Methods , vol.89 , pp. 271-277
    • Denizot, F.1    Lang, R.2
  • 31
    • 0030057089 scopus 로고    scopus 로고
    • HIV therapeutics
    • Richman DD. HIV therapeutics. Science 1996;272:1886-8.
    • (1996) Science , vol.272 , pp. 1886-1888
    • Richman, D.D.1
  • 34
    • 0027181852 scopus 로고
    • Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators
    • Hunter J, Jepson MA, Tsuruo T, Simmons NL, Hirst BH. Functional expression of P-glycoprotein in apical membranes of human intestinal Caco-2 cells. Kinetics of vinblastine secretion and interaction with modulators. J Biol Chem 1993;268:14991-7.
    • (1993) J Biol Chem , vol.268 , pp. 14991-14997
    • Hunter, J.1    Jepson, M.A.2    Tsuruo, T.3    Simmons, N.L.4    Hirst, B.H.5
  • 36
    • 0026495375 scopus 로고
    • Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin
    • Evans CH, Baker PD. Decreased P-glycoprotein expression in multidrug-sensitive and -resistant human myeloma cells induced by the cytokine leukoregulin. Cancer Res 1992;52:5893-9.
    • (1992) Cancer Res , vol.52 , pp. 5893-5899
    • Evans, C.H.1    Baker, P.D.2
  • 37
    • 0025145490 scopus 로고
    • Human immunodeficiency virus 1-induced expression of p-glycoprotein
    • Gollapudi S, Gupta S. Human immunodeficiency virus 1-induced expression of p-glycoprotein. Biochem Biophys Res Commun 1990;171:1002-7.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 1002-1007
    • Gollapudi, S.1    Gupta, S.2
  • 38
    • 0022407895 scopus 로고
    • Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome
    • Ho DD, Rota TR, Schooley RT, et al. Isolation of HTLV-III from cerebrospinal fluid and neural tissues of patients with neurologic syndromes related to the acquired immunodeficiency syndrome. N Engl J Med 1985;313:1493-7.
    • (1985) N Engl J Med , vol.313 , pp. 1493-1497
    • Ho, D.D.1    Rota, T.R.2    Schooley, R.T.3


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