Regulation of GABAA-receptor surface expression with special reference to the involvement of GABARAP (GABAA receptor-associated protein) and PRIP (phospholipase C-related, but catalytically inactive protein)

Journal of Pharmacological Sciences

Volumn 104, Issue 4, 2007, Pages 285-292

  Kanematsu, Takashi ^a   Mizokami, Akiko ^a   Watanabe, Keiko ^a   Hirata, Masato ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Endocytosis; GABAA receptor; GABARAP (GABAA receptor associated protein); PRIP (phospholipase C related, but catalytically inactive protein); Trafficking

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BINDING PROTEIN; DIAZEPAM; FLUMAZENIL; GABA A RECEPTOR ASSOCIATED PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; MUSCIMOL; PROTEIN KINASE C; PROTEIN PRIP; PROTEIN TYROSINE KINASE; RECEPTOR SUBUNIT; THREONINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

CELL MEMBRANE; CELL SURFACE; CYTOPLASM; DRUG EFFECT; ENDOCYTOSIS; GABAERGIC TRANSMISSION; GOLGI COMPLEX; HUMAN; INTRACELLULAR TRANSPORT; NEUROTRANSMISSION; NONHUMAN; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE;

EID: 34548500128     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.CP0070063     Document Type: Review

References (40)

1. A receptors. Prog Neurobiol. 2002;67:113-159.
2. A receptor function. J Neurochem. 2007;100:279-294.
3. A receptor subtype in the brain is not lethal in mice. J Neurosci. 2001;2110:3409-3418.
4. Günther U, Benson J, Benke D, Fritschy JM, Reyes G, Knoflach F, et al. Benzodiazepine-insensitive mice generated by targeted disruption of the γ2 subunit gene of γ-aminobutyric acid type A receptors. Proc Natl Acad Sci U S A. 1995;92:7749-7753.
5. Homanics GE, DeLorey TM, Firestone LL, Quinlan JJ, Handforth A, Harrison NL, et al. Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior. Proc Natl Acad Sci U S A. 1997;94:4143-4148.
6. A receptor subtypes. Curr Top Med Chem. 2002;2:795-816.
7. A receptors and the cytoskeleton. Nature. 1999;397:69-72.
8. A receptors to the plasma membrane in neurons. J Neurosci. 2004;24:11429-11438.
9. A receptor cell-surface number in Xenopus laevis oocytes. Mol Pharmacol. 2005;68:152-159.
10. Chen C, Li JG, Chen Y, Huang P, Wang Y, Liu-Chen LY. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor. J Biol Chem. 2006;281:7983-7993.
11. A receptors. Mol Cell Neurosci. 2001;18:13-25.
12. O'Sullivan GA, Kneussel M, Elazar Z, Betz H. GABARAP is not essential for GABA receptor targeting to the synapse. Eur J Neurosci. 2005;22:2644-2648.
13. Kanematsu T, Takeya H, Watanabe Y, Ozaki S, Yoshida M, Koga T, et al. Putative inositol 1,4,5-trisphosphate binding proteins in rat brain cytosol. J Biol Chem. 1992;267:6518-6525.
14. Kanematsu T, Misumi Y, Watanabe Y, Ozaki S, Koga T, Iwanaga S, et al. A new inositol 1,4,5-trisphosphate binding protein similar to phospholipase C-δ1. Biochem J. 1996;313:319-325.
15. Hirata M, Kanematsu T, Takeuchi H, Yagisawa H. Pleckstrin homology domain as an inositol compound binding module. Jpn J Pharmacol. 1998;76:255-263.
16. A receptor function. EMBO J. 2002;21:1004-1011.
17. 2+ signaling and extension to neuroscience and beyond. Mol Cells. 2005;20:305-314.
18. A receptor phospho-dependent modulation is regulated by phospholipae C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J Neurosci. 2004;24:7074-7084.
19. Yoshimura K, Takeuchi H, Sato O, Hidaka K, Doira N, Terunuma M, et al. Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1α. J Biol Chem. 2001;276:17908-17913.
20. A receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying BDNF-dependent regulation of GABAergic inhibition. J Biol Chem. 2006;281:22180-22189.
21. A receptors to the cell surface. J Neurosci. 2007;27:1692-1701.
22. A receptor trafficking, channel activity, and functional plasticity of inhibitory synapses. Pharmacol Ther. 2004;102:195-221.
23. A synaptic responses by brain-derived neurotrophic factor (BDNF) in rat hippocampus. J Neurosci. 1997;17:2959-2966.
24. A receptor surface expression. Eur J Neurosci. 2001;13:1320-1328.
25. A receptor-mediated responses via postsynaptic mechanisms. J Physiol. 2003;548:711-721.
26. A receptor phosphorylation, activity, and cell-surface stability. J Neurosci. 2004;24:522-530.
27. Henneberger C, Juttner R, Rothe T, Grantyn R. Postsynaptic action of BDNF on GABAergic synaptic transmission in the superficial layers of the mouse superior colliculus. J Neurophysiol. 2002;88:595-603.
28. Hewitt SA, Bains JS. Brain-derived neurotrophic factor silences GABA synapses onto hypothalamic neuroendocrine cells through a postsynaptic dynamin-mediated mechanism. J Neurophysiol. 2006;95:2193-2198.
29. A receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition. Curr Opin Neurobiol. 2003;13:341-347.
30. Chapell R, Bueno OF, Alvarez-Hernandez X, Robinson LC, Leidenheimer NJ. Activation of protein kinase C induces γ-aminobutyric acid type A receptor internalization in Xenopus oocytes. J Biol Chem. 1998;273:32595-32601.
31. Filippova N, Sedelnikova A, Zong Y, Fortinberry H, Weiss DS. Regulation of recombinant γ-aminobutyric acid (GABA)(A) and GABA(C) receptors by protein kinase C. Mol Pharmacol. 2000;57:847-856.
32. A receptor assembly in mammalian cell lines and hippocampal neurons using γ2 subunit green fluorescent protein chimeras. Mol Cell Neurosci. 2000;16:440-452.
33. A receptors in HEK 293 cells. Biochemistry. 2001;40:14030-14036.
34. A receptor endocytosis and function is inhibited by mutation of a dileucine motif within the receptor β2 subunit. Neuropharmacology. 2005;48:181-194.
35. Connoly CN, Kittler JT, Thomas P, Uren JM, Brandon NJ, Smart TG, et al. Cell surface stability of γ-aminobutyric acid type A receptors. J Biol Chem. 1999;274:36565-36572.
36. A receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons. J Neurosci. 2000;20:7972-7977.
37. A receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the beta 2 subunit of the receptor. J Biol Chem. 2003;278:24046-24052.
38. A receptors regulates the efficacy of inhibitory synaptic transmission. Proc Natl Acad Sci U S A. 2005;102:14871-14876.
39. A receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J Neurosci. 2006;26:2513-2521.
40. A receptors mediated by clathrin and AP2 adaptor complex. J Neurochem. 2007;101:898-905.