Structures of heparin-derived tetrasaccharide bound to cobra cardiotoxins: Heparin binding at a single protein site with diverse side chain interactions

Biochemistry

Volumn 46, Issue 35, 2007, Pages 9941-9952

  Tjong, Siu Cin ^a   Chen, Ting Shou ^a   Huang, Wei Ning ^b   Wu, Wen Guey ^a  

^a NATIONAL TSING HUA UNIVERSITY   (Taiwan)

^b YUANPEI UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

COBRA CARDIOTOXINS (CTXS); GLYCOSAMINOGLYCANS; SULFOGLYCOSPHINGOLIPID;

BINDING SITES; ENZYME ACTIVITY; LIGANDS; MOLECULAR STRUCTURE; MUSCLE; NUCLEOTIDES; PHOSPHATES; POLYPEPTIDES; TOXIC MATERIALS;

POLYSACCHARIDES;

COBROTOXIN; COBROTOXIN A1; COBROTOXIN A3; DEOXYADENOSINE TRIPHOSPHATE; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; HEPARIN; PHOSPHATE; SULFATIDE; TETRASACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL SURFACE; CHANNEL GATING; DIMERIZATION; ENZYME ACTIVITY; INTERNALIZATION; LIGAND BINDING; MUSCLE NECROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; SKELETAL MUSCLE; STRUCTURE ACTIVITY RELATION; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; COBRA CARDIOTOXIN PROTEINS; COBRA VENOMS; HEPARIN; HEPARITIN SULFATE; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEOTIDES; PHOSPHATES; POLYSACCHARIDES; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

NAJA ATRA;

EID: 34548491178     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700995v     Document Type: Article

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