Single-blind, placebo-controlled pilot study of pregabalin for ataxia in cortical cerebellar atrophy

Acta Neurologica Scandinavica

Volumn 116, Issue 4, 2007, Pages 235-238

  Gazulla, J ^a,c   Benavente, I ^b  

^a HOSPITAL UNIVERSITARIO MIGUEL SERVET   (Spain)

^b HOSPITAL SAN JORGE   (Spain)

^c NONE   (Spain)

Author keywords

Ataxia; Cortical cerebellar atrophy; Placebo controlled; Pregabalin; Treatment

Indexed keywords

4 AMINOBUTYRIC ACID; ACETAZOLAMIDE; PLACEBO; PREGABALIN;

4 AMINOBUTYRIC ACID RELEASE; ADULT; AGED; ARTICLE; BRAIN ATROPHY; CEREBELLAR ATAXIA; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MALE; RATING SCALE; SCALE FOR THE ASSESSMENT AND RATING OF ATAXIA; SCORING SYSTEM; SIDE EFFECT; SINGLE BLIND PROCEDURE; THERAPY EFFECT; TREATMENT DURATION; TREATMENT OUTCOME; TREATMENT RESPONSE; VIDEORECORDING; WEIGHT GAIN;

ADULT; AGED; ANTICONVULSANTS; ATROPHY; CEREBELLAR ATAXIA; FEMALE; FOLLOW-UP STUDIES; GAMMA-AMINOBUTYRIC ACID; HUMANS; MALE; PILOT PROJECTS; RECOVERY OF FUNCTION; SINGLE-BLIND METHOD; TREATMENT OUTCOME;

EID: 34548490973     PISSN: 00016314     EISSN: 16000404     Source Type: Journal    
DOI: 10.1111/j.1600-0404.2007.00912.x     Document Type: Article

References (19)

1. Kanazawa I, Kwak S, Sasaki H et al. Studies on neurotransmitter markers and neuronal cell densities in the cerebellar system in olivopontocerebellar atrophy and cortical cerebellar atrophy. J Neurol Sci 1985 71 : 193 208.
2. Gazulla J, Errea JM, Benavente I, Tordesillas CJ. Treatment of ataxia in cortical cerebellar atrophy with the GABAergic drug gabapentin. Eur Neurol 2004 52 : 7 11.
3. 2- δ protein. J Med Chem 2005 48 : 2294 307.
4. Schmitz-Hübsch T, Tezenas du Montcel S, Baliko L et al. Scale for the assessment and rating of ataxia. Development of a new clinical scale. Neurology 2006 66 : 1717 20.
5. D'Adamo MC, Imbrici P, Pessia M. Episodic ataxias as ion channel diseases. In : Manto MU, Pandolfo M, eds. The cerebellum and its disorders. Cambridge : Cambridge University Press, 2002 562 72.
6. Selak I. Pregabalin Pfizer. Curr Opin Investig Drugs 2001 2 : 828 34.
7. Mirchandini GR, Abi Saab W, Mattson RH, Kocsis JD. Gabapentin and vigabatrin enhance GABA release in rat hippocampus in vivo. Epilepsia 1999 40 : 138.
8. Gong HC, Hang J, Kobler L, Li L, Su TZ. Tissue-specific expression and gabapentin-binding properties of calcium channel α2δ subunit subtypes. J Membrane Biol 2001 184 : 35 43.
9. Gao B, Sekido Y, Maximov A et al. Functional properties of a new voltage-dependent calcium channel α2δ auxiliary subunit gene (CACNA2D2). J Biol Chem 2000 275 : 12237 42.
10. Baloh RW, Yee RD, Honrubia V. Late cortical cerebellar atrophy. Clinical and oculographic features. Brain 1986 109 : 159 80.
11. Oppenheimer DR. Diseases of the basal ganglia, cerebellum and motor neurons. In : Adams JH, Corsellis JAN, Duchen LW, eds. Greenfield's neuropathology. London : Edward Arnold, 1982 699 747.
12. Plaitakis A, Berl S, Yahr MD. Neurological disorders associated with deficiency of glutamate dehydrogenase. Ann Neurol 1984 15 : 144 53.
13. Honnorat J, Saiz A, Giometto B et al. Cerebellar ataxia with anti-glutamic acid decarboxylase antibodies. Study of 14 patients. Arch Neurol 2001 58 : 225 30.
14. Ottersen OP, Walberg F. Neurotransmitters in the cerebellum. In : Manto MA, Pandolfo M, eds. The cerebellum and its disorders. Cambridge : Cambridge University Press, 2002 38 48.
15. Perry TL, Kish SJ, Hinton D, Hansen S, Becker LE, Gelfand EW. Neurochemical abnormalities in a patient with ataxia-telangiectasia. Neurology 1984 34 : 187 91.
16. Busiguina S, Fernández AM, Barrios V et al. Neurodegeneration is associated to changes in serum insulin-like growth factors. Neurobiol Dis 2000 7 : 657 65.
17. Schmitz-Hübsch T, Tezenas du Montcel S, Baliko L et al. Reliability and validity of the International Cooperative Ataxia Rating Scale (ICARS): A study in 156 spinocerebellar ataxia (SCA) patients. Mov Disord 2006 21 : 699 704.
18. Trouillas P, Takayanagi T, Hallett M et al. International Cooperative Ataxia Rating Scale for pharmacological assessment of the cerebellar syndrome. J Neurol Sci 1997 145 : 205 11.
19. Gazulla J, Benavente I, Sarasa M. Ataxia-telangiectasia del adulto. Observación clínica y terapéutica. Neurología 2006 21 : 447 51.