Exploiting temperature-dependent substrate promiscuity for nucleoside analogue activation by thymidine kinase from Thermotoga maritima

Journal of the American Chemical Society

Volumn 129, Issue 28, 2007, Pages 8714-8715

  Lutz, Stefan ^a   Lichter, Joseph ^a   Liu, Lingfeng ^a  

^a EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 DIOXOLANE DERIVATIVE; 2',3' DIDEOXYTHYMIDINE; 2',3' DIDEOXYURIDINE; CLEVUDINE; DEOXYURIDINE; DIOXOLANE THYMIDINE; FLOXURIDINE; NUCLEOSIDE ANALOG; STAVUDINE; THYMIDINE; THYMIDINE KINASE; UNCLASSIFIED DRUG; URIDINE; ZIDOVUDINE; NUCLEOSIDE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CATALYST; CRYSTALLOGRAPHY; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SUBSTRATE COMPLEX; GENE ISOLATION; HYDROGEN BOND; NONHUMAN; REACTION TIME; TEMPERATURE DEPENDENCE; THERMOTOGA MARITIMA; ENZYME SPECIFICITY; ENZYMOLOGY; KINETICS; METABOLISM; PHOSPHORYLATION; TEMPERATURE;

KINETICS; NUCLEOSIDES; PHOSPHORYLATION; SUBSTRATE SPECIFICITY; TEMPERATURE; THERMOTOGA MARITIMA; THYMIDINE KINASE;

EID: 34548461275     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0734391     Document Type: Article

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