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Volumn 29, Issue 9, 2007, Pages 589-594

Molecular pathology and epidemiology of nephrogenic rests and Wilms tumors

Author keywords

Beckwith Wiedemann syndrome; H19; IGF2; Imprinting; WT1

Indexed keywords

SOMATOMEDIN B;

EID: 34548458923     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/01.mph.0000212981.67114.ec     Document Type: Review
Times cited : (33)

References (51)
  • 1
    • 0025271523 scopus 로고
    • Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumor
    • Beckwith JB, Kiviat NB, Bonadio JF. Nephrogenic rests, nephroblastomatosis, and the pathogenesis of Wilms' tumor. Pediatr Pathol. 1990;10:1-36.
    • (1990) Pediatr Pathol , vol.10 , pp. 1-36
    • Beckwith, J.B.1    Kiviat, N.B.2    Bonadio, J.F.3
  • 3
    • 0032476054 scopus 로고    scopus 로고
    • Nephrogenic rests and the pathogenesis of Wilms tumor: Developmental and clinical considerations
    • Beckwith JB. Nephrogenic rests and the pathogenesis of Wilms tumor: developmental and clinical considerations. Am J Med Genet. 1998;79:268-273.
    • (1998) Am J Med Genet , vol.79 , pp. 268-273
    • Beckwith, J.B.1
  • 4
    • 10744230832 scopus 로고    scopus 로고
    • Epigenetic differences between Wilms' tumours in white and east-Asian children
    • Fukuzawa R, Breslow NE, Morison IM, et al. Epigenetic differences between Wilms' tumours in white and east-Asian children. Lancet. 2004;363:446-451.
    • (2004) Lancet , vol.363 , pp. 446-451
    • Fukuzawa, R.1    Breslow, N.E.2    Morison, I.M.3
  • 5
    • 18244369516 scopus 로고    scopus 로고
    • Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1
    • Weksberg R, Nishikawa J, Caluseriu O, et al. Tumor development in the Beckwith-Wiedemann syndrome is associated with a variety of constitutional molecular 11p15 alterations including imprinting defects of KCNQ1OT1. Hum Mol Genet. 2001;10:2989-3000.
    • (2001) Hum Mol Genet , vol.10 , pp. 2989-3000
    • Weksberg, R.1    Nishikawa, J.2    Caluseriu, O.3
  • 6
    • 0347286871 scopus 로고    scopus 로고
    • Management of Wilms' tumour: Current practice and future goals
    • Kalapurakal JA, Dome JS, Perlman EJ, et al. Management of Wilms' tumour: current practice and future goals. Lancet Oncol. 2004;5:37-46.
    • (2004) Lancet Oncol , vol.5 , pp. 37-46
    • Kalapurakal, J.A.1    Dome, J.S.2    Perlman, E.J.3
  • 7
    • 0015295131 scopus 로고
    • Mutation and cancer: A model for Wilms' tumor of the kidney
    • Knudson AG Jr, Strong LC. Mutation and cancer: a model for Wilms' tumor of the kidney. J Natl Cancer Inst. 1972;48:313-324.
    • (1972) J Natl Cancer Inst , vol.48 , pp. 313-324
    • Knudson Jr, A.G.1    Strong, L.C.2
  • 8
    • 0028014420 scopus 로고
    • Uniparental disomy occurs infrequently in Wilms tumor patients
    • Grundy P, Wilson B, Telzerow P, et al. Uniparental disomy occurs infrequently in Wilms tumor patients. Am J Hum Genet. 1994;54:282-289.
    • (1994) Am J Hum Genet , vol.54 , pp. 282-289
    • Grundy, P.1    Wilson, B.2    Telzerow, P.3
  • 9
    • 0032797231 scopus 로고    scopus 로고
    • Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: Inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting
    • Dao D, Walsh CP, Yuan L, et al. Multipoint analysis of human chromosome 11p15/mouse distal chromosome 7: inclusion of H19/IGF2 in the minimal WT2 region, gene specificity of H19 silencing in Wilms' tumorigenesis and methylation hyper-dependence of H19 imprinting. Hum Mol Genet. 1999;8:1337-1352.
    • (1999) Hum Mol Genet , vol.8 , pp. 1337-1352
    • Dao, D.1    Walsh, C.P.2    Yuan, L.3
  • 10
    • 0029838115 scopus 로고    scopus 로고
    • Clinicopathologic correlates of loss of heterozygosity in Wilm's tumor: A preliminary analysis
    • Grundy P, Telzerow P, Moksness J, et al. Clinicopathologic correlates of loss of heterozygosity in Wilm's tumor: a preliminary analysis. Med Pediatr Oncol. 1996;27:429-433.
    • (1996) Med Pediatr Oncol , vol.27 , pp. 429-433
    • Grundy, P.1    Telzerow, P.2    Moksness, J.3
  • 11
    • 0023256838 scopus 로고
    • Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors
    • Schroeder WT, Chao LY, Dao DD, et al. Nonrandom loss of maternal chromosome 11 alleles in Wilms tumors. Am J Hum Genet. 1987;40:413-420.
    • (1987) Am J Hum Genet , vol.40 , pp. 413-420
    • Schroeder, W.T.1    Chao, L.Y.2    Dao, D.D.3
  • 12
    • 0023831210 scopus 로고
    • Genomic imprinting and carcinogenesis
    • Wilkins RJ. Genomic imprinting and carcinogenesis. Lancet. 1988;1:329-331.
    • (1988) Lancet , vol.1 , pp. 329-331
    • Wilkins, R.J.1
  • 14
    • 0025738681 scopus 로고
    • Uniparental paternal disomy in a genetic cancer-predisposing syndrome
    • Henry I, Bonaiti-Pellie C, Chehensse V, et al. Uniparental paternal disomy in a genetic cancer-predisposing syndrome. Nature. 1991;351:665-667.
    • (1991) Nature , vol.351 , pp. 665-667
    • Henry, I.1    Bonaiti-Pellie, C.2    Chehensse, V.3
  • 15
    • 0027793754 scopus 로고
    • Somatic mosaicism for partial paternal isodisomy in Wiedemann-Beckwith syndrome: A postfertilization event
    • Henry I, Puech A, Riesewijk A, et al. Somatic mosaicism for partial paternal isodisomy in Wiedemann-Beckwith syndrome: a postfertilization event. Eur J Hum Genet. 1993;1:19-29.
    • (1993) Eur J Hum Genet , vol.1 , pp. 19-29
    • Henry, I.1    Puech, A.2    Riesewijk, A.3
  • 16
    • 0025788974 scopus 로고
    • WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour
    • Pelletier J, Bruening W, Li FP, et al. WT1 mutations contribute to abnormal genital system development and hereditary Wilms' tumour. Nature. 1991;353:431-434.
    • (1991) Nature , vol.353 , pp. 431-434
    • Pelletier, J.1    Bruening, W.2    Li, F.P.3
  • 17
    • 0030889197 scopus 로고    scopus 로고
    • Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology
    • Schumacher V, Schneider S, Figge A, et al. Correlation of germ-line mutations and two-hit inactivation of the WT1 gene with Wilms tumors of stromal-predominant histology. Proc Natl Acad Sci U S A. 1997;94:3972-3977.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3972-3977
    • Schumacher, V.1    Schneider, S.2    Figge, A.3
  • 18
    • 0031686142 scopus 로고    scopus 로고
    • Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development
    • Charles AK, Brown KW, Berry PJ. Microdissecting the genetic events in nephrogenic rests and Wilms' tumor development. Am J Pathol. 1998;153:991-1000.
    • (1998) Am J Pathol , vol.153 , pp. 991-1000
    • Charles, A.K.1    Brown, K.W.2    Berry, P.J.3
  • 19
    • 0033566764 scopus 로고    scopus 로고
    • Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors
    • Koesters R, Ridder R, Kopp-Schneider A, et al. Mutational activation of the beta-catenin proto-oncogene is a common event in the development of Wilms' tumors. Cancer Res. 1999;59:3880-3882.
    • (1999) Cancer Res , vol.59 , pp. 3880-3882
    • Koesters, R.1    Ridder, R.2    Kopp-Schneider, A.3
  • 20
    • 0033677022 scopus 로고    scopus 로고
    • Frequent association of beta-catenin and WT1 mutations in Wilms tumors
    • Maiti S, Alam R, Amos CI, et al. Frequent association of beta-catenin and WT1 mutations in Wilms tumors. Cancer Res. 2000;60:6288-6292.
    • (2000) Cancer Res , vol.60 , pp. 6288-6292
    • Maiti, S.1    Alam, R.2    Amos, C.I.3
  • 21
    • 2642552403 scopus 로고    scopus 로고
    • Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway
    • Fukuzawa R, Heathcott RW, Sano M, et al. Myogenesis in Wilms' tumors is associated with mutations of the WT1 gene and activation of Bcl-2 and the Wnt signaling pathway. Pediatr Dev Pathol. 2004;7:125-137.
    • (2004) Pediatr Dev Pathol , vol.7 , pp. 125-137
    • Fukuzawa, R.1    Heathcott, R.W.2    Sano, M.3
  • 22
    • 9644265525 scopus 로고    scopus 로고
    • CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors
    • Li CM, Kim CE, Margolin AA, et al. CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors. Am J Pathol. 2004;165:1943-1953.
    • (2004) Am J Pathol , vol.165 , pp. 1943-1953
    • Li, C.M.1    Kim, C.E.2    Margolin, A.A.3
  • 23
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature. 2005;434:843-850.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 24
    • 85047699309 scopus 로고    scopus 로고
    • Loss of methylation at chromosome 11p15.5 is common in human adult tumors
    • Scelfo RA, Schwienbacher C, Veronese A, et al. Loss of methylation at chromosome 11p15.5 is common in human adult tumors. Oncogene. 2002;21:2564-2572.
    • (2002) Oncogene , vol.21 , pp. 2564-2572
    • Scelfo, R.A.1    Schwienbacher, C.2    Veronese, A.3
  • 25
    • 0026922595 scopus 로고
    • Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2
    • Zemel S, Bartolomei MS, Tilghman SM. Physical linkage of two mammalian imprinted genes, H19 and insulin-like growth factor 2. Nat Genet. 1992;2:61-65.
    • (1992) Nat Genet , vol.2 , pp. 61-65
    • Zemel, S.1    Bartolomei, M.S.2    Tilghman, S.M.3
  • 26
    • 0032878252 scopus 로고    scopus 로고
    • Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor
    • Frevel MA, Sowerby SJ, Petersen GB, et al. Methylation sequencing analysis refines the region of H19 epimutation in Wilms tumor. J Biol Chem. 1999;274:29331-29340.
    • (1999) J Biol Chem , vol.274 , pp. 29331-29340
    • Frevel, M.A.1    Sowerby, S.J.2    Petersen, G.B.3
  • 27
    • 0034713275 scopus 로고    scopus 로고
    • CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus
    • Hark AT, Schoenherr CJ, Katz DJ, et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature. 2000;405:486-489.
    • (2000) Nature , vol.405 , pp. 486-489
    • Hark, A.T.1    Schoenherr, C.J.2    Katz, D.J.3
  • 28
    • 0034713375 scopus 로고    scopus 로고
    • Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
    • Bell AC, Felsenfeld G. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature. 2000;405:482-485.
    • (2000) Nature , vol.405 , pp. 482-485
    • Bell, A.C.1    Felsenfeld, G.2
  • 29
    • 0027172683 scopus 로고
    • Relaxation of imprinted genes in human cancer
    • Rainier S, Johnson LA, Dobry CJ, et al. Relaxation of imprinted genes in human cancer. Nature. 1993;362:747-749.
    • (1993) Nature , vol.362 , pp. 747-749
    • Rainier, S.1    Johnson, L.A.2    Dobry, C.J.3
  • 30
    • 0027285258 scopus 로고
    • Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour
    • Ogawa O, Eccles MR, Szeto J, et al. Relaxation of insulin-like growth factor II gene imprinting implicated in Wilms' tumour. Nature. 1993;362:749-751.
    • (1993) Nature , vol.362 , pp. 749-751
    • Ogawa, O.1    Eccles, M.R.2    Szeto, J.3
  • 31
    • 0028356544 scopus 로고
    • Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour
    • Steenman MJ, Rainier S, Dobry CJ, et al. Loss of imprinting of IGF2 is linked to reduced expression and abnormal methylation of H19 in Wilms' tumour. Nat Genet. 1994;7:433-439.
    • (1994) Nat Genet , vol.7 , pp. 433-439
    • Steenman, M.J.1    Rainier, S.2    Dobry, C.J.3
  • 32
    • 0028227938 scopus 로고
    • Epigenetic lesions at the H19 locus in Wilms' tumour patients
    • Moulton T, Crenshaw T, Hao Y, et al. Epigenetic lesions at the H19 locus in Wilms' tumour patients. Nat Genet. 1994;7:440-447.
    • (1994) Nat Genet , vol.7 , pp. 440-447
    • Moulton, T.1    Crenshaw, T.2    Hao, Y.3
  • 33
    • 4444365791 scopus 로고    scopus 로고
    • Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome
    • Sparago A, Cerrato F, Vernucci M, et al. Microdeletions in the human H19 DMR result in loss of IGF2 imprinting and Beckwith-Wiedemann syndrome. Nat Genet. 2004;36:958-960.
    • (2004) Nat Genet , vol.36 , pp. 958-960
    • Sparago, A.1    Cerrato, F.2    Vernucci, M.3
  • 34
    • 20144363310 scopus 로고    scopus 로고
    • Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor
    • Prawitt D, Enklaar T, Gartner-Rupprecht B, et al. Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor. Proc Natl Acad Sci U S A. 2005;102:4085-4090.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 4085-4090
    • Prawitt, D.1    Enklaar, T.2    Gartner-Rupprecht, B.3
  • 35
    • 0035393429 scopus 로고    scopus 로고
    • Loss of imprinting of insulinlike growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site
    • Cui H, Niemitz EL, Ravenel JD, et al. Loss of imprinting of insulinlike growth factor-II in Wilms' tumor commonly involves altered methylation but not mutations of CTCF or its binding site. Cancer Res. 2001;61:4947-4950.
    • (2001) Cancer Res , vol.61 , pp. 4947-4950
    • Cui, H.1    Niemitz, E.L.2    Ravenel, J.D.3
  • 36
    • 0029956737 scopus 로고    scopus 로고
    • Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity
    • Wang WH, Duan JX, Vu TH, et al. Increased expression of the insulin-like growth factor-II gene in Wilms' tumor is not dependent on loss of genomic imprinting or loss of heterozygosity. J Biol Chem. 1996;271:27863-27870.
    • (1996) J Biol Chem , vol.271 , pp. 27863-27870
    • Wang, W.H.1    Duan, J.X.2    Vu, T.H.3
  • 37
    • 0030973543 scopus 로고    scopus 로고
    • Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis
    • Okamoto K, Morison IM, Taniguchi T, et al. Epigenetic changes at the insulin-like growth factor II/H19 locus in developing kidney is an early event in Wilms tumorigenesis. Proc Natl Acad Sci U S A. 1997;94:5367-5371.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 5367-5371
    • Okamoto, K.1    Morison, I.M.2    Taniguchi, T.3
  • 38
    • 0031956224 scopus 로고    scopus 로고
    • Insulin-like growth factor 2 and overgrowth: Molecular biology and clinical implications
    • Morison IM, Reeve AE. Insulin-like growth factor 2 and overgrowth: molecular biology and clinical implications. Mol Med Today. 1998;4:110-115.
    • (1998) Mol Med Today , vol.4 , pp. 110-115
    • Morison, I.M.1    Reeve, A.E.2
  • 39
    • 0027465535 scopus 로고
    • Genetic mosaicism in normal tissues of Wilms' tumour patients
    • Chao LY, Huff V, Tomlinson G, et al. Genetic mosaicism in normal tissues of Wilms' tumour patients. Nat Genet. 1993;3:127-131.
    • (1993) Nat Genet , vol.3 , pp. 127-131
    • Chao, L.Y.1    Huff, V.2    Tomlinson, G.3
  • 40
    • 0006059376 scopus 로고    scopus 로고
    • Perilobar nephrogenic rests are associated with epigenetic changes at the IGF2/H19 locus in developing kidney
    • Becroft D, Okamoto K, Morison I, et al. Perilobar nephrogenic rests are associated with epigenetic changes at the IGF2/H19 locus in developing kidney. Pediatr Dev Pathol. 1998;1:251.
    • (1998) Pediatr Dev Pathol , vol.1 , pp. 251
    • Becroft, D.1    Okamoto, K.2    Morison, I.3
  • 41
    • 0035930134 scopus 로고    scopus 로고
    • Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor
    • Ravenel JD, Broman KW, Perlman EJ, et al. Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. J Natl Cancer Inst. 2001;93:1698-1703.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 1698-1703
    • Ravenel, J.D.1    Broman, K.W.2    Perlman, E.J.3
  • 42
    • 0026691721 scopus 로고
    • A third Wilms' tumor locus on chromosome 16q
    • Maw MA, Grundy PE, Millow LJ, et al. A third Wilms' tumor locus on chromosome 16q. Cancer Res. 1992;52:3094-3098.
    • (1992) Cancer Res , vol.52 , pp. 3094-3098
    • Maw, M.A.1    Grundy, P.E.2    Millow, L.J.3
  • 43
    • 0036778642 scopus 로고    scopus 로고
    • Chromosome arm 16q in Wilms tumors: Unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene
    • Yeh A, Wei M, Golub SB, et al. Chromosome arm 16q in Wilms tumors: unbalanced chromosomal translocations, loss of heterozygosity, and assessment of the CTCF gene. Genes Chromosomes Cancer. 2002;35:156-163.
    • (2002) Genes Chromosomes Cancer , vol.35 , pp. 156-163
    • Yeh, A.1    Wei, M.2    Golub, S.B.3
  • 44
    • 17644407707 scopus 로고    scopus 로고
    • Association of chromosome arm 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor
    • Mummert SK, Lobanenkov VA, Feinberg AP. Association of chromosome arm 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. Genes Chromosomes Cancer. 2005;43:155-161.
    • (2005) Genes Chromosomes Cancer , vol.43 , pp. 155-161
    • Mummert, S.K.1    Lobanenkov, V.A.2    Feinberg, A.P.3
  • 45
    • 0023737555 scopus 로고
    • Parkin D, Stiller C, Draper G, et al, eds, Lyon: IARC Scientific Publications;
    • Parkin D, Stiller C, Draper G, et al, eds. International Incidence of Childhood Cancer. Lyon: IARC Scientific Publications; 1988.
    • (1988) International Incidence of Childhood Cancer
  • 46
    • 0025612034 scopus 로고
    • International variations in the incidence of childhood renal tumours
    • Stiller CA, Parkin DM. International variations in the incidence of childhood renal tumours. Br J Cancer. 1990;62:1026-1030.
    • (1990) Br J Cancer , vol.62 , pp. 1026-1030
    • Stiller, C.A.1    Parkin, D.M.2
  • 47
    • 33646568520 scopus 로고    scopus 로고
    • Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulinlike growth factor-II in Wilms tumor
    • Watanabe N, Nakadate H, Haruta M, et al. Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulinlike growth factor-II in Wilms tumor. Genes Chromosomes Cancer. 2006;45:592-601.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 592-601
    • Watanabe, N.1    Nakadate, H.2    Haruta, M.3
  • 48
    • 9744222638 scopus 로고    scopus 로고
    • Epigenotyping as a tool for the prediction of tumor risk and tumor type in patients with Beckwith-Wiedemann syndrome (BWS)
    • Bliek J, Gicquel C, Maas S, et al. Epigenotyping as a tool for the prediction of tumor risk and tumor type in patients with Beckwith-Wiedemann syndrome (BWS). J Pediatr. 2004;145:796-799.
    • (2004) J Pediatr , vol.145 , pp. 796-799
    • Bliek, J.1    Gicquel, C.2    Maas, S.3
  • 49
    • 34548443977 scopus 로고    scopus 로고
    • Kobayashi Y, Hata J-I, Sasaki Y, eds. Shouni Geka Byourigaku (Pediatric Surgical Pathology). In: Kobayashi Y, ed. Malformation Syndromes and Pediatric Tumors. 1st ed. Tokyo: Bunkodo; 1995.
    • Kobayashi Y, Hata J-I, Sasaki Y, eds. Shouni Geka Byourigaku (Pediatric Surgical Pathology). In: Kobayashi Y, ed. Malformation Syndromes and Pediatric Tumors. 1st ed. Tokyo: Bunkodo; 1995.
  • 50
    • 0037436509 scopus 로고    scopus 로고
    • Loss of IGF2 imprinting: A potential marker of colorectal cancer risk
    • Cui H, Cruz-Correa M, Giardiello FM, et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science. 2003;299:1753-1755.
    • (2003) Science , vol.299 , pp. 1753-1755
    • Cui, H.1    Cruz-Correa, M.2    Giardiello, F.M.3
  • 51
    • 0037112364 scopus 로고    scopus 로고
    • Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2
    • Cui H, Onyango P, Brandenburg S, et al. Loss of imprinting in colorectal cancer linked to hypomethylation of H19 and IGF2. Cancer Res. 2002;62:6442-6446.
    • (2002) Cancer Res , vol.62 , pp. 6442-6446
    • Cui, H.1    Onyango, P.2    Brandenburg, S.3


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