Akt and c-Jun N-terminal kinase are regulated in response to moderate noise exposure in the cochlea of guinea pigs

ORL

Volumn 69, Issue 5, 2007, Pages 277-282

  Selivanova, Oxana ^a   Brieger, Jürgen ^a,b   Heinrich, Ulf Rüdiger ^a   Mann, Wolf ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Akt; c Jun N terminal kinase; Cochlea; NF B; Noise exposure; Vascular endothelial growth factor

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; COCHLEA; COMPUTER ANALYSIS; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; ENZYME REGULATION; GUINEA PIG; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; NERVE CELL; NERVE FIBER; NOISE POLLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SCHWANN CELL; SPIRAL GANGLION; UPREGULATION;

ANIMALS; APOPTOSIS; COCHLEA; GUINEA PIGS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; NERVE FIBERS; NF-KAPPA B; NOISE; ONCOGENE PROTEIN V-AKT; ORGAN OF CORTI; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPIRAL GANGLION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34548456341     PISSN: 03011569     EISSN: None     Source Type: Journal    
DOI: 10.1159/000103871     Document Type: Article

References (15)

1. Selivanova O, Heinrich UR, Brieger J, Feltens R, Mann W: Fast alterations of vascular endothelial growth factor (VEGF) expression and its receptors (Flt-1, Flk-1 and Neuropilin) in the cochlea of guinea pigs after moderate noise exposure. Eur Arch Otorhinolaryngol 2007;264:121-128.
2. Plas DR, Thompson CB: Akt-dependent transformation: there is more to growth than just surviving. Oncogene 2005;24:7435-7442.
3. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999;399:601-605.
4. Hess A, Labbè D, Watanabe KI, Bloch W, Michel O: Evidence for an Akt-kinase/NO/cGMP pathway in the cochlea of guinea pigs. Eur Arch Otorhinolaryngol 2006;263:75-78.
5. Graham B, Gibson SB: The two faces of NFkappaB in cell survival responses. Cell Cycle 2005;4:1342-1345.
6. Bonny C, Borsello T, Zine A: Targeting the JNK pathway as a therapeutic protective strategy for nervous system diseases. Rev Neurosci 2005;16:57-67.
7. Pirvola U, Xing-Qun L, Virkkala J, Saarma M, Murakata C, Camoratto AM, Walton KM, Ylikoski J: Rescue of hearing, auditory hair cells, and neurons by CEP-1347/KT7515, an inhibitor of c-Jun N-terminal kinase activation. J Neurosci 2000;20:43-50.
8. Davis RJ: Signal transduction by the JNK group of MAP kinases. Cell 2000;103:239-252.
9. Maundrell K, Antonsson B, Magnenat E, Camps M, Muda M, Chabert C, Gillieron C, Boschert U, Vial-Knecht E, Martinou JC, Arkinstall S: Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac 1. J Cell Biol 1997;272:25238-25242.
10. Yamamoto K, Ichijo H, Korsmeyer SJ: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 1999;19:8469-8478.
11. Aoki H, Kang PM, Hampe J, Yoshimura K, Noma T, Matsuzaki M, Izumo S: Direct activation of mitochondrial apoptosis machinery by c-Jun N-terminal kinase in adult cardiac myocytes. J Biol Chem 2002;277:10244-10250.
12. Heinrich UR, Brieger J, Selivanova O, Feltens R, Eimermacher A, Schafer D, Mann WJ: COX-2 expression in the guinea pig cochlea is partly altered by moderate sound exposure. Neurosci Lett 2006;394:121-126.
13. Wang J, Van De Water TR, Bonny C, de Ribaupierre F, Puel JL, Zine A: A peptide inhibitor of c-Jun N-terminal kinase protects against both aminoglycoside and acoustic trauma-induced auditory hair cell death and hearing loss. J Neurosci 2003;23:8596-8607.
14. Zine A, Van de Water TR: The MAPK/JNK signalling pathway offers potential therapeutic targets for the prevention of acquired deafness. Curr Drug Targets CNS Neurol Disord 2004;3:325-332.
15. Bodmer D, Brors D, Bodmer M, Ryan AF: Rescue of auditory hair cells from ototoxicity by CEP-11 004, an inhibitor of the JNK signalling pathway. Laryngorhinootologie 2002;81:853-856.