An increase in DNA double-strand breaks, induced by Ku70 depletion, is associated with human papillomavirus 16 episome loss and de novo viral integration events

Journal of Pathology

Volumn 213, Issue 1, 2007, Pages 27-34

  Winder, D M ^a,b   Pett, M R ^a   Foster, N ^a   Shivji, M K K ^a   Herdman, M T ^a   Stanley, M A ^b   Venkitaraman, A R ^a,b   Coleman, N ^a,b  

^a HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Cervix; DNA repair; Double strand breaks; Episome; Human papillomavirus; Integration; Ku70

Indexed keywords

CELL DNA; DOUBLE STRANDED DNA; KU ANTIGEN; SMALL INTERFERING RNA; VIRUS DNA;

ARTICLE; CARCINOGENESIS; CELL LINE; CHROMOSOMAL INSTABILITY; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; EPISOME; FEMALE; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; HYPOTHESIS; KERATINOCYTE; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DEPLETION; UTERINE CERVIX CARCINOMA; VIRUS DNA CELL DNA INTERACTION;

ANTIGENS, NUCLEAR; BASE SEQUENCE; CELL LINE, TUMOR; CERVICAL INTRAEPITHELIAL NEOPLASIA; CHROMOSOMAL INSTABILITY; DNA BREAKS, DOUBLE-STRANDED; DNA, VIRAL; DNA-BINDING PROTEINS; FEMALE; GENE DELETION; GENOME, VIRAL; HUMAN PAPILLOMAVIRUS 16; HUMANS; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; PAPILLOMAVIRUS INFECTIONS; POLYMERASE CHAIN REACTION; RESTRICTION MAPPING; RNA INTERFERENCE; RNA, SMALL INTERFERING; UTERINE CERVICAL NEOPLASMS; VIRUS INTEGRATION;

EID: 34548445995     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2206     Document Type: Article

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