Cerebellar lesion studies of cognitive function in children and adolescents - Limitations and negative findings

Cerebellum

Volumn 6, Issue 3, 2007, Pages 242-253

  Frank, Benedikt ^a   Schoch, Beate ^a   Richter, Stefanie ^a,b   Frings, Markus ^a   Karnath, Hans Otto ^b   Timmann, Dagmar ^a  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

Attention; Language; Mutism; Non motor function; Visuospatial

Indexed keywords

APHASIA; ATTENTION DEFICIT DISORDER; CEREBELLUM INJURY; COGNITIVE DEFECT; DEPRESSION; DYSARTHRIA; DYSMETRIA; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; INTRACRANIAL HYPERTENSION; MOTOR DYSFUNCTION; MUTISM; POSTERIOR CRANIAL FOSSA SYNDROME; PRIORITY JOURNAL; REVIEW;

EID: 34548430575     PISSN: 14734222     EISSN: 14734230     Source Type: Journal    
DOI: 10.1080/14734220701297432     Document Type: Review

References (105)

1. Leiner HC, Leiner AL, Dow RS. Does the cerebellum contribute to mental skills? Behav Neurosci. 1986;100:443-54.
2. Schmahmann JD, Sherman JC. The cerebellar cognitive affective syndrome. Brain. 1998;121:561-79.
3. Chen SH, Desmond JE. Cerebrocerebellar networks during articulatory rehearsal and verbal working memory tasks. Neuroimage. 2005;24:332-8.
4. MacLeod CE, Zilles K, Schleicher A, Rilling JK, Gibson KR. Expansion of the neocerebellum in Hominoidea. J Hum Evol. 2003;44:401-29.
5. Ramnani N, Behrens TE, Johansen-Berg H, Richter MC, Pinsk MA, Andersson JL, et al. The evolution of prefrontal inputs to the cortico-pontine system: Diffusion imaging evidence from Macaque monkeys and humans. Cereb Cortex. 2006;16:811-8.
6. Ravizza SM, McCormick CA, Schlerf JE, Justus T, Ivry RB, Fiez JA. Cerebellar damage produces selective deficits in verbal working memory. Brain. 2006;129:306-20.
7. Schmahmann JD. Disorders of the cerebellum: Ataxia, dysmetria of thought and the cerebellar cognitive affective syndrome. J Neuropsychiatry Clin Neurosci. 2004;16:367-78.
8. Andreasen NC, Paradiso S, O'Leary DS. "Cognitive dysmetria" as an integrative theory of schizophrenia: A dysfunction in cortical-subcortical- cerebellar circuitry? Schizophr Bull. 1998;24:203-18.
9. Courchesne E. Brainstem, cerebellar and limbic neuroanatomical abnormalities in autism. Curr Opin Neurobiol. 1997;7:269-78.
10. Dennis M, Hetherington CR, Spiegler BJ, Barnes MA. Functional consequences of congenital cerebellar dysmorphologies and acquired cerebellar lesions of childhood. In: Broman SH, Fletcher JM, editors. The changing nervous system: Neurobehavioral consequences of early brain disorders. Oxford, UK: Oxford University Press, 1999. pp 172-98.
11. Konczak J, Schoch B, Dimitrova A, Gizewski E, Timmann D. Functional recovery of children and adolescents after cerebellar tumour resection. Brain. 2005;128:1428-41.
12. Schoch B, Konczak J, Dimitrova A, Gizewski ER, Wieland R, Timmann D. Impact of surgery and adjuvant therapy on balance function in children and adolescents with cerebellar tumours. Neuropediatrics (in press).
13. Ries LAG, Eisner MP, Kosary CL, Hankey BF, Miller BA, Clegg L, et al. SEER Cancer Statistics Review, 1975-2001. Bethesda, MD: http://seer.cancer.gov/ csr/1975_2001, 2004.
14. Ullrich NJ, Pomeroy SL. Pediatric brain tumors. Neurol Clin. 2003;21:897-913.
15. Duffner PK, Cohen ME, Thomas P. Late effects of treatment on the intelligence of children with posterior fossa tumors. Cancer. 1983;51:233-7.
16. Packer RJ, Sposto R, Atkins TE, Sutton LN, Bruce DA, Siegel KR, et al. Quality of life in children with primitive neuroectodermal tumors (medulloblastoma) of the posterior fossa. Pediatr Neurosci. 1987;13:169-75.
17. Aarsen FK, van Dongen HR, Paquier PF, van Mourik M, Catsman-Berrevoets CE. Long-term sequelae in children after cerebellar astrocytoma surgery. Neurology. 2004;62:1311-6.
18. Riva D, Giorgi C. The cerebellum contributes to higher functions during development. Evidence from a series of children surgically treated for posterior fossa tumours. Brain. 2000;123:1051-61.
19. Steinlin M, Imfeld S, Zulauf P, Boltshauser E, Loevblad KO, Luethy AR, et al. Neuropsychological long-term sequelae after posterior fossa tumour resection during childhood. Brain. 2003;126:1998-2008.
20. Pollack IF, Polinko P, Albright AL, Towbin R, Fitz C. Mutism and pseudobulbar symptoms after resection of posterior fossa tumors in children: Incidence and pathophysiology. Neurosurgery. 1995;37:885-93.
21. Catsman-Berrevoets CE, Van Dongen HR, Mulder PG, Paz y Geuze D, Paquier PF, Lequin MH. Tumour type and size are high risk factors for the syndrome of "cerebellar" mutism and subsequent dysarthria. J Neurol Neurosurg Psychiatry. 1999;67:755-7.
22. Ozimek A, Richter S, Hein-Kropp C, Schoch B, Gorissen B, Kaiser O, et al. Cerebellar mutism - report of four cases. J Neurol. 2004;251:963-72.
23. Daum I, Ackermann H. Neuropsychological abnormalities in cerebellar syndromes - fact or fiction? Int Rev Neurobiol. 1997;41:455-71.
24. Glickstein M. Motor skills but not cognitive tasks. Trends Neurosci. 1993;16:450-1; discussion 3-4.
25. Glickstein M. Thinking about the cerebellum. Brain. 2006;129:288-90.
26. Globas C, Bosch S, Zuhlke C, Daum I, Dichgans J, Burk K. The cerebellum and cognition. Intellectual function in spinocerebellar ataxia type 6 (SCA6). J Neurol. 2003;250:1482-7.
27. Malm J, Kristensen B, Karlsson T, Carlberg B, Fagerlund M, Olsson T. Cognitive impairment in young adults with infratentorial infarcts. Neurology. 1998;51:433-40.
28. Ackermann H, Mathiak K, Ivry RB. Temporal organization of "Internal Speech" as a basic for cerebellar modulation of cognitive functions. Behav Cogn Neurosci Rev. 2004;3:14-22.
29. Manto MU, Pandolfo M. The cerebellum and its disorders. Cambridge: Cambridge University Press, 2002.
30. Timmann D, Diener HC. Coordination and ataxia. In: Goetz CG, Pappert EJ, editors. Textbook of clinical neurology. 3rd ed, Orlando: Saunders, (in press).
31. Grill J, Viguier D, Kieffer V, Bulteau C, Sainte-Rose C, Hartmann O, et al. Critical risk factors for intellectual impairment in children with posterior fossa tumors: The role of cerebellar damage. J Neurosurg. 2004;101:152-8.
32. Levisohn L, Cronin-Golomb A, Schmahmann JD. Neuropsychological consequences of cerebellar tumour resection in children. Cerebellar cognitive affective syndrome in a paediatric population. Brain. 2000;123:1041-50.
33. Ronning C, Sundet K, Due-Tonnessen B, Lundar T, Helseth E. Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood. Pediatr Neurosurg. 2005;41:15-21.
34. Scott RB, Stoodley CJ, Anslow P, Paul C, Stein JF, Sugden EM, et al. Lateralized cognitive deficits in children following cerebellar lesions. Dev Med Child Neurol. 2001;43:685-91.
35. Copeland DR, deMoor C, Moore BD 3rd, Ater JL. Neurocognitive development of children after a cerebellar tumor in infancy: A longitudinal study. J Clin Oncol. 1999;17:3476-86.
36. Riva D, Giorgi C, Nichelli F, Bulgheroni S, Massimino M, Cefalo G, et al. Intrathecal methotrexate affects cognitive function in children with medulloblastoma. Neurology. 2002;59:48-53.
37. Karatekin C, Lazareff JA, Asarnow RF. Relevance of the cerebellar hemispheres for executive functions. Pediatr Neurol. 2000;22:106-12.
38. Ackermann H, Wildgruber D, Daum I, Grodd W. Does the cerebellum contribute to cognitive aspects of speech production? A functional magnetic resonance imaging (fMRI) study in humans. Neurosci Lett. 1998;247:187-90.
39. Kagerer FA, Bracha V, Wunderlich DA, Stelmach GE, Bloedel JR. Ataxia reflected in the simulated movements of patients with cerebellar lesions. Exp Brain Res. 1998;121:125-34.
40. Richter S, Schoch B, Ozimek A, Gorissen B, Hein-Kropp C, Kaiser O, et al. Incidence of dysarthria in children with cerebellar tumors: a prospective study. Brain Lang. 2005;92:153-67.
41. Drepper J, Timmann D, Kolb FP, Diener HC. Non-motor associative learning in patients with isolated degenerative cerebellar disease. Brain. 1999;122:87-97.
42. Ravizza SM, Ivry RB. Comparison of the basal ganglia and cerebellum in shifting attention. J Cogn Neurosci. 2001;13:285-97.
43. Timmann D, Drepper J, Maschke M, Kolb FP, Boring D, Thilmann AF, et al. Motor deficits cannot explain impaired cognitive associative learning in cerebellar patients. Neuropsychologia. 2002;40:788-800.
44. Lehnung M, Leplow B, Ekroll V, Herzog A, Mehdorn M, Ferstl R. The role of locomotion in the acquisition and transfer of spatial knowledge in children. Scand J Psychol. 2003;44:79-86.
45. Riviere J, Lecuyer R. Spatial cognition in young children with spinal muscular atrophy. Dev Neuropsychol. 2002;21:273-83.
46. Francks C, Fisher SE, Marlow AJ, MacPhie IL, Taylor KE, Richardson AJ, et al. Familial and genetic effects on motor coordination, laterality, and reading-related cognition. Am J Psychiatry. 2003;160:1970-7.
47. Steinlin M, Styger M, Boltshauser E. Cognitive impairments in patients with congenital nonprogressive cerebellar ataxia. Neurology. 1999;53:966-73.
48. Richter S, Dimitrova A, Hein-Kropp C, Wilhelm H, Gizewski E, Timmann D. Cerebellar agenesis II: Motor and language functions. Neurocase. 2005;11:103-13.
49. Timmann D, Dimitrova A, Hein-Kropp C, Wilhelm H, Dorfler A. Cerebellar agenesis: Clinical, neuropsychological and MR findings. Neurocase. 2003;9:402-13.
50. Middleton FA, Strick PL. Cerebellar projections to the prefrontal cortex of the primate. J Neurosci. 2001;21:700-12.
51. Courchesne E, Allen G. Prediction and preparation, fundamental functions of the cerebellum. Learn Mem. 1997;4:1-35.
52. Akshoomoff NA, Courchesne E. A new role for the cerebellum in cognitive operations. Behav Neurosci. 1992;106:731-8.
53. Fiez JA, Petersen SE, Cheney MK, Raichle ME. Impaired non-motor learning and error detection associated with cerebellar damage. A single case study. Brain. 1992;115:155-78.
54. Schoch B, Gorißen B, Richter S, Ozimek A, Kaiser O, Dimitrova A, et al. Do children with focal cerebellar lesions show deficits in shifting attention? J Neurophysiol. 2004;92:1856-66.
55. Richter S, Kaiser O, Hein-Kropp C, Dimitrova A, Gizewski E, Beck A, et al. Preserved verb generation in patients with cerebellar atrophy. Neuropsychologia. 2004;42:1235-46.
56. Richter S, Schoch B, Kaiser O, Groetschel H, Hein-Kropp C, Maschke M, et al. Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect. J Neurophysiol. 2005;94:4108-20.
57. Thier P, Haarmeier T, Ignashchenkova A. The functional architecture of attention. Curr Biol. 2002;12:158-62.
58. Frings M, Maschke M, Timmann D. Cerebellum and cognition - viewed from philosophy of mind. Cerebellum. in press.
59. Akshoomoff NA, Courchesne E, Press GA, Iragui V. Contribution of the cerebellum to neuropsychological functioning: Evidence from a case of cerebellar degenerative disorder. Neuropsychologia. 1992;30:315-28.
60. Courchesne E, Townsend J, Akshoomoff NA, Saitoh O, Yeung-Courchesne R, Lincoln AJ, et al. Impairment in shifting attention in autistic and cerebellar patients. Behav Neurosci. 1994;108:848-65.
61. Bischoff-Grethe A, Ivry RB, Grafton ST. Cerebellar involvement in response reassignment rather than attention. J Neurosci. 2002;22:546-53.
62. Allen G, Buxton RB, Wong EC, Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science. 1997;275:1940-3.
63. Le TH, Pardo JV, Hu X. 4 T-fMRI study of nonspatial shifting of selective attention: Cerebellar and parietal contributions. J Neurophysiol. 1998;79:1535-48.
64. Wildgruber D, Ackermann H, Grodd W. Differential contributions of motor cortex, basal ganglia, and cerebellum to speech motor control: Effects of syllable repetition rate evaluated by fMRI. Neuroimage. 2001;13:101-9.
65. Helmuth LL, Ivry RB, Shimizu N. Preserved performance by cerebellar patients on tests of word generation, discrimination learning, and attention. Learn Mem. 1997;3:456-74.
66. Townsend J, Courchesne E, Covington J, Westerfield M, Harris NS, Lyden P, et al. Spatial attention deficits in patients with acquired or developmental cerebellar abnormality. J Neurosci. 1999;19:5632-43.
67. Townsend J, Courchesne E, Egaas B. Slowed orienting of covert visual-spatial attention in autism: Specific deficits associated with cerebellar and parietal abnormality. Dev Psychopathol. 1996;8:563-84.
68. Yamaguchi S, Tsuchiya H, Kobayashi S. Visuospatial attention shift and motor responses in cerebellar disorders. J Cogn Neurosci. 1998;10:95-107.
69. Golla H, Thier P, Haarmeier T. Disturbed overt but normal covert shifts of attention in adult cerebellar patients. Brain. 2005;128:1525-35.
70. Justus T. The cerebellum and English grammatical morphology: Evidence from production, comprehension, and grammaticality judgments. J Cogn Neurosci. 2004;16:1115-30.
71. Marien P, Engelborghs S, Fabbro F, De Deyn PP. The lateralized linguistic cerebellum: A review and a new hypothesis. Brain Lang. 2001;79:580-600.
72. Richter S, Gerwig M, Aslan B, Wilhelm H, Schoch B, Dimitrova A, et al. Cognitive functions in patients with MR-defined chronic focal cerebellar lesions. J Neurol. (in press).
73. Frank B, Schoch B, Hein-Kropp C, Dimitrova A, Hovel M, Ziegler W, et al. Verb generation in children and adolescents with acute cerebellar lesions. Neuropsychologia. 2007;45:977-88.
74. Fabbro F, Moretti R, Bava A. Language impairments in patients with cerebellar lesions. J Neuroling. 2000;13:173-88.
75. Gebhart AL, Petersen SE, Thach WT. Role of the posterolateral cerebellum in language. Ann NY Acad Sci. 2002;978:318-33.
76. Cappa SF, Binetti G, Pezzini A, Padovani A, Rozzini L, Trabucchi M. Object and action naming in Alzheimer's disease and frontotemporal dementia [see comment]. Neurology. 1998;50:351-5.
77. Peran P, Rascol O, Demonet JF, Celsis P, Nespoulous JL, Dubois B, et al. Deficit of verb generation in nondemented patients with Parkinson's disease. Mov Disord. 2003;18:150-6.
78. Cappa SF, Sandrini M, Rossini PM, Sosta K, Miniussi C. The role of the left frontal lobe in action naming: rTMS evidence. Neurology. 2002;59:720-3.
79. Hanakawa T, Immisch I, Toma K, Dimyan MA, Van Gelderen P, Hallett M. Functional properties of brain areas associated with motor execution and imagery. J Neurophysiol. 2003;89:989-1002.
80. Petersen SE, Fox PT, Posner ML, Mintun M, Raichle ME. Positron emission tomographic studies of the processing of single words. J Cogn Neurosci. 1989;1:153-70.
81. Raichle M, Fiez J, Videen T, MacLeod A, Fox P, Petersen S. Practice-related changes in human brain functional anatomy during nonmotor learning. Cereb Cortex. 1994;4:8-26.
82. Frings M, Dimitrova A, Schorn CF, Elles HG, Hein-Kropp C, Gizewski ER, et al. Cerebellar involvement in verb generation: An fMRI study. Neurosci Lett.2006;409:19-23.
83. Frank B, Schoch B, Hein-Kropp C, Hovel M, Gizewski E, Karnath HO, et al. Aphasia, neglect and extinction are no prominent clinical signs in children and adolescents with acute surgical cerebellar lesions. J Neurol Neurosurg Psychiatry. (submitted).
84. Riva D. The cerebellar contribution to language and sequential functions: Evidence from a child with cerebellitis. Cortex. 1998;34:279-87.
85. Gomez Beldarrain M, Garcia-Monco JC, Quintana JM, Llorens V, Rodeno E. Diaschisis and neuropsychological performance after cerebellar stroke. Eur Neurol. 1997;37:82-9.
86. Kalashnikova LA, Zueva YV, Pugacheva OV, Korsakova NK. Cognitive impairments in cerebellar infarcts. Neurosci Behav Physiol. 2005;35:773-9.
87. Silveri MC, Leggio MG, Molinari M. The cerebellum contributes to linguistic production: A case of agrammatic speech following a right cerebellar lesion. Neurology. 1994;44:2047-50.
88. Zettin M, Cappa SF, D'Amico A, Rago R, Perino C, Perani D, et al. Agrammatic speech production after a right cerebellar haemorrhage. Neurocase. 1997;3:375-80.
89. Gasparini M, Di Piero V, Ciccarelli O, Cacioppo MM, Pantano P, Lenzi GL. Linguistic impairment after right cerebellar stroke: A case report. Eur J Neurol. 1999;6:353-6.
90. Karnath HO, Zihl J. Disorders of spatial orientation. In: Brandt T, Caplan LR, Dichgans J, Diener HC, Kennard C, editors. Neurological disorders: Course and treatment. 2nd ed., San Diego: Academic Press, 2003. pp 277-86.
91. Karnath HO, Himmelbach M, Küker W. The cortical substrate of visual extinction. Neuroreport. 2003;14:437-42, Erratum 14:1189.
92. Silveri MC, Misciagna S, Terrezza G. Right side neglect in right cerebellar lesion. J Neurol Neurosurg Psychiatry. 2001;71:114-7.
93. Hildebrandt H, Spang K, Ebke M. Visuospatial hemi-inattention following cerebellar/brain stem bleeding. Neurocase. 2002;8:323-9.
94. Molinari M, Petrosini L, Misciagna S, Leggio MG. Visuospatial abilities in cerebellar disorder. J Neurosurg Psychiatry. 2004;75:235-40.
95. Neau J-P, Arroyo-Anollo E, Bonnaud V, Ingrand P, Gil R. Neuropsychological disturbances in cerebellar infarcts. Acta Neurol Scand. 2000;102:363-70.
96. Appollonio IM, Grafman J, Schwartz V, Massaquoi S, Hallett M. Memory in patients with cerebellar degeneration. Neurology. 1993;43:1536-44.
97. Dimitrov M, Grafman J, Kosseff P, Wachs J, Alway D, Higgins J, et al. Preserved cognitive processes in cerebellar degeneration. Behav Brain Res. 1996;79:131-5.
98. Ozgur BM, Berberian J, Aryan HE, Meltzer HS, Levy ML. The pathophysiologic mechanism of cerebellar mutism. Surg Neurol. 2006;66:18-25.
99. van Dongen HR, Catsman-Berrevoets CE, van Mourik M. The syndrome of 'cerebellar' mutism and subsequent dysarthria. Neurology. 1994;44:2040-6.
100. Gordon N. Speech, language, and the cerebellum. Eur J Disord Commun. 1996;31:359-67.
101. Murdoch BE, Hudson-Tennent LJ. Speech disorders in children treated for posterior fossa tumours: Ataxic and developmental features. Eur J Disord Commun. 1994;29:379-97.
102. Ackermann H, Ziegler W. Mutismus bei zentralmotorischen Störungen. Fortschr Neurol Psychiatr. 1994;62:337-44.
103. van Calenbergh F, van de Laar A, Plets C, Goffin J, Casaer P. Transient cerebellar mutism after posterior fossa surgery in children. Neurosurgery. 1995;37:894-8.
104. Huber W, Poeck K, Weniger D, Willmes K. Aachener Aphasie Test (AAT). Göttingen: Hogrefe, 1983.
105. Weintraub S, Mesulam MM. Mental state assessment of young and elderly adults in behavioral neurology. Philadelphia: F.A. Davis, 1985.