Anticancer effect of lysine, proline, arginine, ascorbicacid and green tea extract on human renal adenocarcinoma line 786-0

Oncology Reports

Volumn 16, Issue 5, 2006, Pages 943-947

  Roomi, M Waheed ^a   Ivanov, Vadim ^a   Kalinovsky, Tatiana ^a   Niedzwiecki, Aleksandra ^a   Rath, Matthias ^a  

^a Matthias Rath Research Institute   (United States)

Author keywords

Arginine; Ascorbic acid; Green tea extract; Lysine; MMP 2; MMP 9; Nutrient mixture; Proline; Renal cancer

Indexed keywords

ANTINEOPLASTIC AGENT; ARGININE; ASCORBIC ACID; COLLAGEN; GELATINASE; GELATINASE A; GELATINASE B; GREEN TEA EXTRACT AR25; LAMININ; LYSINE; MATRIGEL; PLANT EXTRACT; PROLINE; PROTEOGLYCAN;

ARTICLE; CELL GROWTH; DRUG COMBINATION; DRUG EFFECT; ENZYMOLOGY; HUMAN; KIDNEY CARCINOMA; KIDNEY TUMOR; METABOLISM; PATHOLOGY; SECRETION; TEA; TUMOR CELL LINE;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; ARGININE; ASCORBIC ACID; CAMELLIA SINENSIS; CARCINOMA, RENAL CELL; CELL GROWTH PROCESSES; CELL LINE, TUMOR; COLLAGEN; DRUG COMBINATIONS; GELATINASES; HUMANS; KIDNEY NEOPLASMS; LAMININ; LYSINE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; PLANT EXTRACTS; PROLINE; PROTEOGLYCANS;

EID: 34548429401     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.16.5.943     Document Type: Article

References (35)

1. American Cancer Society: Cancer Facts and Figures 2005. Atlanta, GA: American Cancer Society, 2005.
2. Motzer RJ: Renal cell carcinoma: a priority malignancy for development and study of novel therapies. J Clin Oncol 21: 1193-1194, 2003.
3. Bui MH, Zisman A, Pantuck AJ, Han KR, Wieder J and Belldegrun AS: Prognostic factors and molecular markers for renal cell carcinoma. Expert Rev Anticancer Ther 1: 565-575, 2001. (Pubitemid 34679448)
4. Chae EJ, Kim JK, Kim SH, Bae SJ and Cho KS: Renal cell carcinoma: analysis of post-operative recurrence patterns. Radiology 234: 189-196, 2005.
5. Peeters CF, De Geus LF, Westphal JR, et al: Decrease in circulating anti-angiogenic factors (angiostatin and endostatin) after surgical removal of primary colorectal carcinoma coincides with increased metabolic activity of liver metastases. Surgery 137: 246-249, 2005. (Pubitemid 40174436)
6. Scharovsky OG, Binda MM, Rozados VR, Bhagat S, Cher ML and Bonfil RD: Angiogenic and antiangiogenic balance regulates concomitant antitumoral resistance. Clin Exp Metastasis 21: 177-183, 2004. (Pubitemid 38988091)
7. Wolchok JD and Motzer RJ: Management of renal cell carcinoma. Oncology 14: 29-36, 2000.
8. Motzer RJ, Mazumdar M, Bacik J, Berg W, Amsterdam A and Ferrara J: Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma. J Clin Oncol 17: 2530-2540, 1999. (Pubitemid 29368255)
9. Curran S and Murray GI: Matrix metalloproteinases in tumour invasion and metastasis. J Pathol 189: 300-308, 1999. (Pubitemid 29489213)
10. Lein M, Jung K, Laube C, et al: Matrix-metalloproteinases and their inhibitors in plasma and tumor tissue of patients with renal cell carcinoma. Int J Cancer 85: 801-804, 2000. (Pubitemid 30131469)
11. Kamiya N, Kishimoto T, Suzuki H, et al: Increased in situ gelatinolytic activity in renal cell tumor tissues correlates with tumor size, grade and vessel invasion. Int J Cancer 106: 480-485, 2003. (Pubitemid 36966203)
12. Rath M and Pauling L: Plasmin-induced proteolysis and the role of apoprotein(a), lysine and synthetic analogs. Orthomol Med 7: 17-23, 1992.
13. Netke SP, Roomi MW, Ivanov V, Niedzwiecki A and Rath M: A specific combination of ascorbic acid, lysine, proline and green tea extract inhibits proliferation and extracellular matrix invasion of various human cancer cell lines. Research communications in pharmacology and toxicology: Emerging Drugs 2: 37-50, 2003.
14. Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: Antitumor effect of nutrient synergy on human osteosarcoma cells U-2OS, MNNG-HOS and Ewing's sarcoma SK-ES.1. Oncol Rep 13: 253-257, 2005.
15. Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: Synergistic effect of combination of lysine, proline, arginine, ascorbic acid and epigallocatechin gallate on colon cancer cell line HCT 116. JANA 7: 40-43, 2004.
16. Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human colon cancer cell HCT 116 xenografts in nude mice: evaluation of tumor growth and immunohistochemistry. Oncol Rep 13: 421-425, 2005.
17. Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: In vivo antitumor effect of ascorbic acid, lysine, proline and green tea extract on human prostate cancer PC-3 xenografts in nude mice: evaluation of tumor growth and immunohistochemistry. In vivo 19: 179-183, 2005.
18. Roomi MW, Ivanov V, Kalinovsky T, Niedzwiecki A and Rath M: Modulation of N-methyl-N-nitrosourea induced mammary tumors in Sprague-Dawley rats by combination of lysine, proline, arginine, ascorbic acid and green tea extract. Breast Cancer Res 7: R291-R295, 2005.
19. Kawakami S, Kageyama Y, Fujii Y, et al: Inhibitory effects of N-acetyl cysteine on invasion and MMP 9 production of T24 human bladder cancer cells. Anticancer Res 21: 213-219, 2001.
20. Morini M, Cai T, Aluigi MG, et al: The role of the thiol N-acetyl cysteine in the prevention of tumor invasion and angiogenesis. Int J Biol Markers 14: 268-271, 1999. (Pubitemid 30064181)
21. Yoon SO, Kim MM and Chung AS: Inhibitory effects of selenite on invasion of HT 1080 tumor cells. J Biol Chem 276: 20085-20092, 2001.
22. Chen Q, Espey MG, Krishna MC, et al: Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a prodrug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci USA 102: 13604-13609, 2005. (Pubitemid 41420895)
23. Hare Y: Green tea: Health Benefits and Applications. Marcel Dekker (ed). Basel, 2001.
24. Cooke JP and Dzau VJ: Nitric oxide synthase: Role in the genesis of vascular disease. Annu Rev Med 48: 489-509, 1997. (Pubitemid 27101848)
25. Roomi MW, Ivanov V, Niedzwiecki A and Rath M: Synergistic antitumor effect of ascorbic acid, lysine, proline and epigallocatechin gallate on human fibrosarcoma cells HT-1080. Ann Cancer Res Ther 12: 1-2, 2004.
26. Kallakury BV, Karikehalli S, Haholu A, Sheehan CE, Azumi N and Ross JS: Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res 7: 3113-3119, 2001. (Pubitemid 32963832)
27. Foda HD and Zucker S: Matrix metalloproteinases in cancer invasion, metastasis and angiogenesis. Drug Discov Today 6: 478-482, 2001. (Pubitemid 32422151)
28. Ha HY, Moon HB, Nam MS, et al: Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice. Cancer Res 61: 984-990, 2001.
29. Naidu KA, Karl RC and Coppola D: Antiproliferative and proapoptotic effect of ascorbyl stearate in human pancreatic cancer cells: association with decreased expression of insulin-like growth factor 1 receptor. Dig Dis Sci 48: 230-237, 2003. (Pubitemid 36232786)
30. Anthony HM and Schorah CJ: Severe hypovitaminosis C in lung-cancer patients: the utilization of vitamin C in surgical repair and lymphocyte related host resistance. Br J Cancer 46: 354-367, 1982. (Pubitemid 12029882)
31. Metz N, Lobstein A, Schneider Y, et al: Suppression of azoxymethane-induced preneoplastic lesions and inhibition of cyclooxygenase-2 activity in the colonic mucosa of rats drinking a crude green tea extract. Nutr Cancer 38: 60-64, 2000. (Pubitemid 32377944)
32. Koh WS, Lee SJ, Lee H, et al: Differential effects and transport kinetics of ascorbate derivatives in leukemic cell lines. Anticancer Res 8: 2487-2493, 1998. (Pubitemid 28386538)
33. Nunez C, Ortiz de Apodaca Y and Ruiz A: Ascorbic acid in the plasma and blood cells of women with breast cancer. The effect of consumption of food with an elevated content of this vitamin. Nutr Hosp 10: 368-372, 1995.
34. Kurbacher CM, Wagner U, Kolster B, et al: Ascorbic acid (vitamin C) improves the antineoplastic activity doxorubicin, cisplatin and paclitaxel in human breast carcinoma cells in vitro. Cancer Lett 103: 183-189, 1996. (Pubitemid 26147697)
35. Garbisa S, Sartor L, Biggin S, Salvato B, Benelli R and Albini A: Tumor gelatinases and invasion inhibited by the green tea flavanol epigallocatechin-3-gallate. Cancer 91: 822-832, 2001. (Pubitemid 32173309)