The 14-3-3ζ-GPIb-IX-V complex as an antiplatelet target

Drug News and Perspectives

Volumn 20, Issue 5, 2007, Pages 285-292

  Andrews, Robert K ^a   Du, Xiaoping ^b   Berndt, Michael C ^a  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBOCYTIC AGENT; CALMODULIN; FUSICOCCIN; GLYCOPROTEIN; GLYCOPROTEIN1B IX V; ISOPROTEIN; NEW DRUG; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN 14 3 3ZETA; UNCLASSIFIED DRUG; PROTEIN 14 3 3; THROMBIN RECEPTOR;

AMINO ACID SEQUENCE; BINDING SITE; CELL CYCLE; DIMERIZATION; DRUG MECHANISM; DRUG SCREENING; HEART INFARCTION; HEMOSTASIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; REVIEW; RNA INTERFERENCE; STROKE; THROMBOCYTE ACTIVATION; THROMBOCYTE FUNCTION; THROMBOSIS; BIOLOGICAL MODEL; CHEMISTRY; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; THROMBOCYTE;

14-3-3 PROTEINS; AMINO ACID SEQUENCE; BINDING SITES; BLOOD PLATELETS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; PLATELET AGGREGATION INHIBITORS; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; PROTEIN BINDING;

EID: 34548426190     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2007.20.5.1120215     Document Type: Review

References (53)

1. Aitken, A. 14-3-3 proteins: A historic-overview. Semin Cancer Biol 2006, 16: 162-72.
2. Kroll, M.H., Hellums, J.D., McIntire, L.V., Schafer, A.I. and Moake, J.L. Platelets and shear stress. Blood 1996, 88: 1525-41.
3. Andrews, R.K., Gardiner, E.E., Shen, Y., Whisstock, J.C. and Berndt, M.C. Molecules in focus: Glycoprotein Ib-IX-V. Int J Biochem Cell Biol 2003, 35: 1170-4.
4. Andrews, R.K., Berndt, M.C. and López, J.A. The glycoprotein Ib-LX-V complex. In: Platelets, 2nd edition, A. Michelson (Ed.), Academic Press: San Diego 2006, 145-63.
5. Kjarland, E., Keen, T.J. and Kleppe, R. Does isoform diversity explain functional differences in the 14-3-3 protein family? Curr Pharmaceut Biotech 2006, 7: 217-23.
6. MacKintosh, C. Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochem J 2004, 381: 329-42.
7. Hermeking, H. The 14-3-3 cancer connection. Nat Reviews 2003, 3: 931-43.
8. Du, X., Fox, J.E. and Pei, S. Identification of a binding sequence for the 14-3-3 protein within the cytoplasmic domain of the adhesion receptor, platelet glycoprotein Ibα. J Biol Chem 1996, 271: 7362-7.
9. Andrews, R.K., Harris, S.J., McNally, T. and Berndt, M.C. Binding of purified 14-3-3ζ signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein Ib-IX-V complex. Biochemistry 1998, 37: 638-47.
10. Calverley, D.C., Kavanagh, T.J. and Roth, G.J. Human signaling protein 14-3-3ζ interacts with platelet glycoprotein Ib subunits Ibα and Ibβ. Blood 1998, 91: 1295-303.
11. Bodnar, R.J., Gu, M., Li, Z., Englund, G.D. and Du, X. The cytoplasmic domain of the platelet glycoprotein Ibα is phosphorylated at serine 609. J Biol Chem 1999, 274: 33474-9.
12. 3 using a reconstituted mammalian cell expression model. J Cell Biol 1999, 147: 1085-96.
13. Feng, S., Christodoulides, N., Resendiz, J.C., Berndt, M.C. and Kroll, M.H. Cytoplasmic domains of GPIbα and GPIbβ regulate 14-3-3ζ binding to GPIb/IX/V. Blood 2000, 95: 551-7.
14. Mangin, P., David, T., Lavaud, V. et al. Identification of a novel 14-3-3ζ binding site within the cytoplasmic tail of platelet glycoprotein Ibα. Blood 2004, 104: 420-7.
15. Dai, K., Bodnar, R., Berndt, M.C. and Du, X. A critical role for 14-3-3ζ protein in regulating the VWF binding function of platelet glycoprotein Ib-IX and its therapeutic implications. Blood 2005, 106: 1975-81.
16. Liu, D., Bienkowska, J., Petosa, C., Collier, R.J., Fu, H. and Liddington, R. Crystal structure of the ζ isoform of the 14-3-3 protein. Nature 1995, 376: 191-4.
17. Xiao, B., Smerdon, S.J., Jones, D.H. et al. Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. Nature 1995, 376: 188-91.
18. Petosa, C., Masters, S.C., Bankston, L.A. et al. 14-3-3ζ binds a phosphorylated Raf peptide and an unphosphorylated peptide via its conserved amphipathic groove. J Biol Chem 1998, 273: 16305-10.
19. Gardino, A.K., Smerdon, S.J. and Yaffe, M.B. Structural determinants of 14-3-3 binding specificities and regulation of subcellular localization of 14-3-3 ligand complexes: A comparison of the X-ray crystal structures of all human 14-3-3 isoforms. Sem Cancer Biol 2006, 16: 173-82.
20. Woodcock, J.M., Murphy, J., Stomski, F.C., Berndt, M.C. and Lopez, A.F. The dimeric versus monomeric status of 14-3-3ζ is controlled by phosphorylation of Ser58 at the dimer interface. J Biol Chem 2003, 278: 36323-7.
21. Gu, Y.M., Jin, Y.H., Choi, J.K., Baek, K.H., Yeo, C.Y. and Lee, K.Y. Protein kinase A phosphorylates and regulates dimerization of 14-3-3ε. FEBS Lett 2006, 580: 305-10.
22. Muslin, A. J., Tanner, J.W., Allen, P.M. and Shaw, A.S. Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine. Cell 1996, 84: 889-97.
23. Wang, B., Yang, H., Liu, Y.C. et al. Isolation of high-affinity peptide antagonists of 14-3-3 proteins by phage display. Biochemistry 1999, 38: 12499-504.
24. Arthur, J.F., Matzaris, M., Gardiner, E.E. et al. Glycoprotein (GP)VI is associated with GPIb-IX-V on the membrane of resting and activated platelets. Thromb Haemostas 2005, 93: 716-23.
25. Fox, J.E.B. and Berndt, M.C. Cyclic AMP-dependent phosphorylation of glycoprotein Ib inhibits collagen-induced polymerization of actin in platelets. J Biol Chem 1989, 264: 9520-6.
26. Bodnar, R.J., Xi, X., Li, Z., Berndt, M.C. and Du, X. Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser166 of glycoprotein Ibβ. J Biol Chem 2002, 277: 47080-7.
27. David, T., Ohlmann, P., Eckly, A. et al. Inhibition of adhesive and signaling functions of the platelet GPIb-V-IX complex by a cell penetrating GPIbα peptide. J Thromb Haemost 2006, 4: 2645-55.
28. Kanaji, T., Russell, S., Cunningham, J., Izuhara, K., Fox, J.E. and Ware, J. Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibα. Blood 2004, 104: 3161-8.
29. Feng, S., Christodoulides, N. and Kroll, M.H. The glycoprotein Ib/IX complex regulates cell proliferation. Blood 1999, 93: 4256-63.
30. Dong, J.-F., Li, C.O., Sae-Tung, G., Hyun, W., Afshar-Kharghan, V. and Lopez, J.A. The cytoplasmic domain of glycoprotein (GP)Ibα constrains the lateral diffusion of the GPIb-IX complex and modulates von Willebrand factor binding. Biochemistry 1997, 36: 12421-7.
31. Perrault, C., Mangin, P., Santer, M. et al. Role of the intracellular domains of GPIb in controlling the adhesive properties of the platelet GPIb/V/IX complex. Blood 2003, 101: 3477-84.
32. Garcia, A., Senis, Y.A., Antrobus, R. et al. A global proteomics approach identifies novel phosphorylated signaling proteins in GPVI-activated platelets: Involvement of G6f, a novel platelet Grb2-binding membrane adapter. Proteomics 2006, 6: 5332-543.
33. Bialkowska, K., Zaffran, Y., Meyer, S.C. and Fox, J.E.B. 14-3-3ζ mediates integrin-induced activation of Cdc42 and Rac. Platelet glycoprotein Ib-IX regulates integrin-induced signaling by sequestering 14-3-3ζ. J Biol Chem 2003, 278: 33342-50.
34. Wheeler-Jones, C.P., Learmonth, M.P., Martin, H. and Aitken, A. Identification of 14-3-3 proteins in human platelets: Effects of synthetic peptides on protein kinase C activation. Biochem J 1996, 315: 41-7.
35. Kawamoto, Y., Akiguchi, I., Tomimoto, H., Shirakashi, Y., Honjo, Y. and Budka, H. Upregulated expression of 14-3-3 proteins in astrocytes from human cerebrovascular ischemic lesions. Stroke 2006, 37: 830-5.
36. Gardiner, E.E., Arthur, J.F., Berndt, M.C. and Andrews, R.K. Role of calmodulin in platelet receptor function. Current Med Chem Cardiovasc Hematolog Agents 2005, 3: 173-9.
37. Luk, S.C., Ngai, S.M., Tsui, S.K., Fung, K.P., Lee, C.Y. and Wave, M.M. In vivo and in vitro association of 14-3-3ε isoform with calmodulin: Implication for signal transduction and cell proliferation. J Cell Biochem 1999, 73: 31-5.
38. Beguin, P., Mahalakshmi, R.N., Nagashima, K. et al. Roles of 14-3-3 and calmodulin binding in subcellular localization and function of the small G-protein Rem2. Biochem J 2005, 390: 67-75.
39. Beguin, P., Mahalakshmi, R.N., Nagashima, K. et al. 14-3-3 and calmodulin control subcellular distribution of Kir/Gem and its regulation of cell shape and calcium channel activity. J Cell Sci 2005, 118: 1923-34.
40. 2+ channel regulation. J Mol Biol 2006, 355: 34-46.
41. Andrews, R.K., Munday, A.D., Mitchell, C.A. and Berndt, M.C. Interaction of calmodulin with the cytoplasmic domain of the platelet membrane GPIb-IX-V complex. Blood 2001, 98: 681-7.
42. Gardiner, E.E., Arthur, J.F., Kahn, M.L., Berndt, M.C. and Andrews, R.K. Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinase. Blood 2004, 104: 3611-7.
43. Wurtele, M., Jelich-Ottmann, C., Wittinghofer, A. and Oecking, C. Structural view of a fungal toxin acting on a 14-3-3 regulatory complex. EMBO J 2003, 22: 987-94.
44. Yasmin, L., Jansson, A.L., Panahandeh, T., Palmer, R.H., Francis, M.S. and Hallberg, B. Delineation of exoenzyme S residues that mediate the interaction 14-3-3 and its biological activity. FEBS J 2006, 273: 638-46.
45. Tzivion, G., Luo, Z. and Avruch, J. A dimeric 14-3-3 protein is an essential cofactor for Raf kinase activity. Nature 1998, 394: 88-92.
46. Catassi, A., Cesario, A., Arzani, D. et al. Characterization of apoptosis induced by marine natural products in non small cell lung cancer A549 cells. Cell Mol Life Sci 2006, 63: 2377-86.
47. Han, B., Xie, H., Chen, Q. and Zhang, J.-T. Sensitizing hormone-refractory prostate cancer cells to drug treatment by targeting 14-3-3σ. Mol Cancer Ther 2006, 5: 903-12.
48. Steinacker, P., Schwarz, P., Reim, K. et al. Unchanged survival rates of 14-3-3γ knockout mice after inoculation with pathological prion protein. Mol Cell Biol 2005, 25: 1339-46.
49. Ballif, B.A., Cao, Z., Schwartz, D., Carraway, K.L. and Gygi, S.P. Identification of 14-3-3ε substrates from embryonic murine brain. J Proteome Res 2006, 5: 2372-9.
50. Angrand, P.O., Segura, I., Volkel, P. et al. Transgenic mouse proteomics identifies new 14-3-3 associated proteins involved in cytoskeletal rearrangements and cell signaling. Mol Cell Proteomics 2006, 5: 2211-27.
51. Jin, J., Smith, F.D., Stark, C. et al. Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. Curr Biol 2004, 14: 1436-50.
52. Meek, S.E., Lane, W.S. and Piwnica-Worms, H. Comprehensive proteomic analysis of interphase and mitotic 14-3-3-binding proteins. J Biol Chem 2004, 279: 32046-54.
53. Wu, M., Coblitz, B., Shikano, S. et al. Phospho-specific recognition by 14-3-3 proteins and antibodies monitored by a high throughput label-free optical biosensor. FEBS Lett 2006, 580: 5681-9.