PAX6 and SOX2-dependent regulation of the Sox2 enhancer N-3 involved in embryonic visual system development

Genes to Cells

Volumn 12, Issue 9, 2007, Pages 1049-1061

  Inoue, Masashi ^a   Kamachi, Yusuke ^a   Matsunami, Hideyuki ^b   Imada, Katsumi ^a,b   Uchikawa, Masanori ^a   Kondoh, Hisato ^a  

^a OSAKA UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DELTA CRYSTALLIN; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2;

ANIMAL TISSUE; ARTICLE; CHICKEN; CONTROLLED STUDY; DIENCEPHALON; EMBRYO; EMBRYO DEVELOPMENT; ENHANCER REGION; EYE DEVELOPMENT; GENE CONTROL; GENE EXPRESSION; GENE FUNCTION; GENE SEQUENCE; LENS; NONHUMAN; PHYLOGENY; PRIMORDIUM; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DNA INTERACTION; VISUAL SYSTEM; VISUAL THRESHOLD;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CHICK EMBRYO; DELTA-CRYSTALLINS; DNA-BINDING PROTEINS; EMBRYONIC INDUCTION; ENHANCER ELEMENTS (GENETICS); EPITHELIAL CELLS; EYE PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HMGB PROTEINS; HOMEODOMAIN PROTEINS; LENS, CRYSTALLINE; MICE; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; PAIRED BOX TRANSCRIPTION FACTORS; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SEQUENCE ALIGNMENT; TRANSCRIPTION FACTORS; TRANSFECTION;

EID: 34548417177     PISSN: 13569597     EISSN: 13652443     Source Type: Journal    
DOI: 10.1111/j.1365-2443.2007.01114.x     Document Type: Article

References (29)

1. Aota, S., Nakajima, N., Sakamoto, R., Watanabe, S., Ibaraki, N. & Okazaki, K. (2003) Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene. Dev. Biol. 257, 1-13.
2. Campbell, R.E., Tour, O., Palmer, A.E., Steinbach, P.A., Baird, G.S., Zacharias, D.A. & Tsien, R.Y. (2002) A monomeric red fluorescent protein. Proc. Natl. Acad. Sci USA 99, 7877-7882.
3. Czerny, T. & Busslinger, M. (1995) DNA-binding and transactivation properties of Pax-6: Three amino acids in the paired domain are responsible for the different sequence recognition of Pax-6 and BSAP (Pax-5). Mol. Cell. Biol. 15, 2858-2871.
4. Epstein, J., Cai, J., Glaser, T., Jepeal, L. & Maas, R. (1994) Identification of a Pax paired domain recognition sequence and evidence for DNA-dependent conformational changes. J. Biol. Chem. 269, 8355-8361.
5. Fitzpatrick, D.R. & van Heyningen, V. (2005) Developmental eye disorders. Curr. Opin. Genet. Dev. 15, 348-353.
6. Gehring, W.J. & Ikeo, K. (1999) Pax 6: Mastering eye morphogenesis and eye evolution. Trends Genet. 15, 371-377.
7. Glaser, T., Walton, D.S. & Maas, R.L. (1992) Genomic structure, evolutionary conservation and aniridia mutations in the human PAX6 gene. Nat. Genet. 2, 232-239.
8. Goto, K., Okada, T.S. & Kondoh, H. (1990) Functional cooperation of lens-specific and nonspecific elements in the δ 1-crystallin enhancer. Mol. Cell. Biol. 10, 958-964.
9. Hamburger, V. & Hamilton, H.L. (1992) A series of normal stages in the development of the chick embryo. 1951. Dev. Dyn. 195, 231-272.
10. Hever, A.M., Williamson, K.A. & van Heyningen, V. (2006) Developmental malformations of the eye: The role of PAX6, SOX2 and OTX2. Clin. Genet. 69, 459-470.
11. Hill, R.E., Favor, J., Hogan, B.L., Ton, C.C., Saunders, G.F., Hanson, I.M., Prosser, J., Jordan, T., Hastie, N.D. & van Heyningen, V. (1991) Mouse small eye results from mutations in a paired-like homeobox-containing gene. Nature 354, 522-525.
12. Kamachi, Y., Cheah, K.S. & Kondoh, H. (1999) Mechanism of regulatory target selection by the SOX high-mobility-group domain proteins as revealed by comparison of SOX1/2/3 and SOX9. Mol. Cell. Biol. 19, 107-120.
13. Kamachi, Y. & Kondoh, H. (1993) Overlapping positive and negative regulatory elements determine lens-specific activity of the δ1-crystallin enhancer. Mol. Cell. Biol. 13, 5206-5215.
14. Kamachi, Y., Uchikawa, M., Collignon, J., Lovell-Badge, R. & Kondoh, H. (1998) Involvement of Sox1, 2 and 3 in the early and subsequent molecular events of lens induction. Development 125, 2521-2532.
15. Kamachi, Y., Uchikawa, M., Tanouchi, A., Sekido, R. & Kondoh, H. (2001) Pax6 and SOX2 form a co-DNA-binding partner complex that regulates initiation of lens development. Genes Dev. 15, 1272-1286.
16. Kondoh, H. (1999) Transcription factors for lens development assessed in vivo. Curr. Opin. Genet. Dev. 9, 301-308.
17. Kondoh, H., Uchikawa, M. & Kamachi, Y. (2004) Interplay of Pax6 and SOX2 in lens development as a paradigm of genetic switch mechanisms for cell differentiation. Int. J. Dev. Biol. 48, 819-827.
18. Li, H.S., Yang, J.M., Jacobson, R.D., Pasko, D. & Sundin, O. (1994) Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate: Implications for stepwise determination of the lens. Dev. Biol. 162, 181-194.
19. Matsumata, M., Uchikawa, M., Kamachi, Y. & Kondoh, H. (2005) Multiple N-cadherin enhancers identified by systematic functional screening indicate its Group B1 SOX-dependent regulation in neural and placodal development. Dev. Biol. 286, 601-617.
20. Okuda, Y., Yoda, H., Uchikawa, M., Furutani-Seiki, M., Takeda, H., Kondoh, H. & Kamachi, Y. (2006) Comparative genomic and expression analysis of group B1 sox genes in zebrafish indicates their diversification during vertebrate evolution. Dev. Dyn. 235, 811-825.
21. Ragge, N.K., Lorenz, B., Schneider, A., Bushby, K., de Sanctis, L., de Sanctis, U., Salt, A., Collin, J.R., Vivian, A.J., Free, S.L., Thompson, P., Williamson, K.A., Sisodiya, S.M., van Heyningen, V. & Fitzpatrick, D.R. (2005) SOX2 anophthalmia syndrome. Am. J. Med. Genet. 135A, 1-7.
22. Rex, M., Orme, A., Uwanogho, D., Tointon, K., Wigmore, P.M., Sharpe, P.T. & Scotting, P.J. (1997) Dynamic expression of chicken Sox2 and Sox3 genes in ectoderm induced to form neural tissue. Dev. Dyn. 209, 323-332.
23. Schedl, A., Ross, A., Lee, M., Engelkamp, D., Rashbass, P., van Heyningen, V. & Hastie, N.D. (1996) Influence of PAX6 gene dosage on development: Overexpression causes severe eye abnormalities. Cell 86, 71-82.
24. Takemoto, T., Uchikawa, M., Kamachi, Y. & Kondoh, H. (2006) Convergence of Wnt and FGF signals in the genesis of posterior neural plate through activation of the Sox2 enhancer N-1. Development 133, 297-306.
25. Taranova, O.V., Magness, S.T., Fagan, B.M., Wu, Y., Surzenko, N., Hutton, S.R. & Pevny, L.H. (2006) SOX2 is a dose-dependent regulator of retinal neural progenitor competence. Genes Dev. 20, 1187-1202.
26. Uchikawa, M., Ishida, Y., Takemoto, T., Kamachi, Y. & Kondoh, H. (2003) Functional analysis of chicken Sox2 enhancers highlights an array of diverse regulatory elements that are conserved in mammals. Dev. Cell 4, 509-519.
27. Uchikawa, M., Takemoto, T., Kamachi, Y. & Kondoh, H. (2004) Efficient identification of regulatory sequences in the chicken genome by a powerful combination of embryo electroporation and genome comparison. Mech. Dev. 121, 1145-1158.
28. Uwanogho, D., Rex, M., Cartwright, E.J., Pearl, G., Healy, C., Scotting, P.J. & Sharpe, P.T. (1995) Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an interactive role in neuronal development. Mech. Dev. 49, 23-36.
29. van Heyningen, V. & Williamson, K.A. (2002) PAX6 in sensory development. Hum. Mol. Genet. 11, 1161-1167.