Effects of soy phytoestrogens on the prostate

Prostate Cancer and Prostatic Diseases

Volumn 10, Issue 3, 2007, Pages 216-223

  Goetzl, M A ^a   VanVeldhuizen, P J ^a,b   Thrasher, J B ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGLYCONE; ALPHA TOCOPHEROL; ANTIANDROGEN; ANTIOXIDANT; BIOCHANIN A; DAIDZEIN; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLAV EIN; FORMONONETIN; GENISTIN; GLYCITEIN; GLYCOSIDE; GREEN TEA EXTRACT; ISOFLAVONE DERIVATIVE; LEGUME EXTRACT; LIGNAN; LYCOPENE; PHYTOESTROGEN; PLACEBO; PLANT EXTRACT; POLYSACCHARIDE; PROSTATE SPECIFIC ANTIGEN; SELENIUM; SILYMARIN; SOYBEAN PROTEIN; TESTOSTERONE; ULTRA SOY; UNCLASSIFIED DRUG; UNINDEXED DRUG; VENLAFAXINE;

APOPTOSIS; BONE METASTASIS; BREAST TENDERNESS; CANCER CELL; CANCER INHIBITION; CANCER RECURRENCE; CANCER RISK; CARCINOGENESIS; CELL CYCLE ARREST; CLINICAL TRIAL; DIARRHEA; DIET SUPPLEMENTATION; DRUG BLOOD LEVEL; DRUG CLASSIFICATION; DRUG DOSE INCREASE; DRUG EFFECT; DRUG EXCRETION; DRUG HALF LIFE; DRUG MECHANISM; DRUG MEGADOSE; DRUG SAFETY; DRUG STRUCTURE; DRUG TOLERABILITY; FOOD COMPOSITION; GYNECOMASTIA; HUMAN; LEGUME; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; REVIEW; RISK REDUCTION; SOYBEAN; TREATMENT DURATION; VASOMOTOR DISORDER;

ANIMALS; CLINICAL TRIALS; HUMANS; MALE; PHYTOESTROGENS; PROSTATE; PROSTATIC NEOPLASMS; SOYBEANS;

EID: 34548413287     PISSN: 13657852     EISSN: 14765608     Source Type: Journal    
DOI: 10.1038/sj.pcan.4500953     Document Type: Review

References (39)

1. Jemal A, Siegal R, Ward E, Murray T, Xu J, Smigal C et al. Cancer Statistics, 2006. CA Cancer J Clin 2006; 56: 106-130.
2. Parkin DM, Whelan SL, Ferlay J, Teppo L, Thomas DB (eds). Cancer Incidence in Five Continents, Vol VIII. International Agency for Research on Cancer: Lyon. IARC Scientific Publication no. 155, 2002.
3. Ho SY, Schooling M, Hui LL, McGhee SM, Mak KH, Lam TH. Soy consumption and mortality in Hong Kong: Proxy-reported case-control study of all older adult deaths in 1998. Prev Med 2006; 43: 20-26.
4. Hebert JR, Hurley JG, Olendzki BC, Teas J, Ma Y, Hampl JS. Nutritional and socioeconomic factors in relation to prostate cancer mortality: A cross-national study. J Natl Cancer Inst 1998; 90: 1637-1647.
5. Thrasher JB. Prostate cancer: Causes, risk factors, and prevention. In: Medical Education Collaborative (ed.) New Frontiers in the Diagnosis and Treatment of Prostate Diseases. Medical Education Collaborative: Golden, 1999, pp 8-19.
6. Yan L, Spitznagel EL. Meta-analysis of soy food and risk of prostate cancer in men. Int J Cancer 2005; 117: 667-669.
7. Adlercreutz CH, Goldin BR, Gorbach SL, Hockerstedt KA, Watanabe S, Hamalainen EK et al. Soybean phytoestrogen intake and cancer risk. J Nutr 1995; 125 (3 Suppl): 757S-770S.
8. Usui T. Pharmaceutical prospects of phytoestrogens. Endocr J 2006; 53: 7-20.
9. Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 1999; 129: 1628-1635.
10. Mazur WM, Duke JA, Wahala K, Rasku S, Adlercreutz H. Isoflavonoids and lignans in legumes: Nutritional and Health Aspects in Humans. J Nutr Biochem 1998; 9: 193-200.
11. Reinli K, Block G. Phytoestrogen content of foods-a compendium of literature values. Nutr Cancer 1996; 26: 123-148.
12. Bektic J, Guggenberger R, Eder IE, Pelzer AE, Berger AP, Bartsch G et al. Molecular effects of the isoflavonoid genistein in prostate cancer. Clin Prostate Cancer 2005; 4: 124-129.
13. Bingham SA, Atkinson C, Liggins J, Bluck L, Coward A. Phyto-oestrogens: Where are we now? Br J Nutr 1998; 79: 393-406.
14. Messina M, Kucuk O, Lampe JW. An overview of the health effects of isoflavones with an emphasis on prostate cancer risk and prostate-specific antigen levels. J AOAC Int 2006; 89: 1121-1134.
15. Daskivich TJ, Oh WK. Recent progress in hormonal therapy for advanced prostate cancer. Curr Opin Urol 2006; 16: 173-178.
16. Imamov O, Lopatkin NA, Gustafsson JA. Estrogen receptor beta in prostate cancer. N Engl J Med 2004; 351: 2773-2774.
17. Shen JC, Klein RD, Wei Q, Guan Y, Contois JH, Wang TT et al. Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells. Mol Carcinog 2000; 29: 92-102.
18. Davis JN, Singh B, Bhuivan M, Sarkar FH. Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells. Nutr Cancer 1998; 32: 123-131.
19. Kyle E, Neckers L, Takimoto C, Curt G, Bergan R. Genistein-induced apoptosis of prostate cancer cells is preceded by a specific decrease in focal adhesion kinase activity. Mol Pharmacol 1997; 51: 193-200.
20. Sarkar FH, Li Y. Mechanisms of cancer chemoprevention by soy isoflavone genistein. Cancer Metastasis Rev 2002; 21: 265-280.
21. Handayani R, Rice L, Cui Y, Medrano TA, Samedi VG, Baker HV et al. Soy isoflavones alter expression of genes associated with cancer progression, including interleukin-8, in androgen-independent PC-3 human prostate cancer cells. J Nutr 2006; 136: 75-82.
22. Kim SJ, Uehara H, Karashima T, Mccarty M, Shih N, Fidler IJ. Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice. Neoplasia 2001; 3: 33-42.
23. Li Y, Che M, Bhagat S, Ellis K-L, Kucuk O, Doerge DR et al. Regulation of Gene Expression and Inhibition of Experimental Prostate Cancer Bone Metastasis by Dietary Genistein. Neoplasia 2004; 6 354-363.
24. Bektic J, Berger AP, Pfeil K, Dobler G, Bartsch G, Klocker H. Androgen receptor regulation by physiological concentrations of the isoflavonoid genistein in androgen-dependent LNCaP cells is mediated by estrogen receptor beta. Eur Urol 2004; 45: 245-251.
25. Yu L, Blackburn GL, Zhou JR. Genistein and daidzein down-regulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells. J Nutr 2003; 133: 389-392.
26. Zhou JR, Gugger ET, Tanaka T, Guo Y, Blackburn GL, Clinton SK. Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. J Nutr 1999; 129: 1628-1635.
27. Fritz WA, Wang J, Eltoum I-E, Lamartiniere CA. Dietary genistein down-regulates androgen and estrogen receptor expression in the rate prostate. Mol Cell Endocrinol 2002; 186: 89-99.
28. Adams KF, Chen C, Newton KM, Potter JD, Lampe JW. Soy isoflavones do not modulate prostate-specific antigen concentrations in older men in a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 2004; 13: 644-648.
29. Jenkins DJ, Kendall CW, D'Costa MA, Jackson CJ, Vidgen E, Singer W et al. Soy consumption and phytoestrogens: Effect on serum prostate specific antigen when blood lipids and oxidized low-density lipoprotein are reduced in hyperlipidemic men. J Urol 2003; 169: 507-511.
30. deVere White RW, Hackman RM, Soares SE, Beckett LA, Li Y, Sun B. Effects of a genistein-rich extract on PSA levels in men with a history of prostate cancer. Urology 2004; 63: 259-263.
31. Fischer L, Mahoney C, Jeffcoat AR, Koch MA, Thomas BE, Valentine JL et al. Clinical characteristics and pharmacokinetics of purified soy isoflavones: Multiple-dose administration to men with prostate neoplasia. Nutr Cancer 2004; 48: 160-170.
32. Dalais FS, Meliala A, Wattanapenpaiboon N, Frydenberg M, Suter DA, Thomson WK et al. Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer. Urology 2004; 64: 510-515.
33. Schroder FH, Roobol MJ, Boeve ER, deMutsert R, Zuijdgeest-van Leeuwen SD, Kersten I et al. Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: effectiveness of a dietary supplement. Eur Urol 2005; 48: 922-930.
34. Jacobsen BK, Knutsen SF, Fraser GE. Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (US). Cancer Causes Control 1998; 9: 553-557.
35. Kolonel LN, Hankin JH, Whittemore AS, Wu AH, Gallagher RP, Wilkens LR et al. Vegetables, fruits, legumes and prostate cancer: A multiethnic case-control study. Cancer Epidemiol Biomarkers Prev 2000; 9 795-804.
36. Yan L, Spitznagel EL. Meta-analysis of soy food and risk of prostate cancer in men. Int J Cancer 2005; 117: 667-669.
37. VanVeldhuizen PJ, Thrasher JB, Gibanananda R, Cherian R, Ward J, Holzbeierlein JM et al. Dose effect of soy supplementation in prostate cancer: A pilot study. Oncol Rep 2006; 16: 1221-1224.
38. Thompson IM, Goodman PJ, Tangen CM, Lucia MS, Miller GJ, Ford LG et al. The influence of finasteride on the development of prostate cancer. NEJM 2003; 349: 215-224.
39. Lieberman R. Evolving strategies for prostate cancer chemoprevention trials. World J Urol 2003; 21: 3-8.