Randomized, double-blind, placebo-controlled crossover study in men with prostate cancer and rising PSA: Effectiveness of a dietary supplement

European Urology

Volumn 48, Issue 6, 2005, Pages 922-931

  Schröder, Fritz H ^a   Roobol, Monique J ^a   Boevé, Egbert R ^b   De Mutsert, Reneé ^c   Zuijdgeest Van Leeuwen, Sonja D ^c   Kersten, I ^a   Wildhagen, Mark F ^a   Van Helvoort, Ardy ^c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SINT FRANCISCUS GASTHUIS   (Netherlands)

^c NUMICO RESEARCH   (Netherlands)

Author keywords

Dietary supplement; Prevention; Prostate cancer; PSA doubling time; PSA slope

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BIOFLAVONOID; CALCIUM CARBONATE; CAROTENOID; COPPER; CROSCARMELLOSE SODIUM; CROSPOVIDONE; CYANOCOBALAMIN; FOLIC ACID; ISOFLAVONE; LYCOPENE; MAGNESIUM STEARATE; MANGANESE; MICROCRYSTALLINE CELLULOSE; PLACEBO; PROSOLV 90; PROSTATE SPECIFIC ANTIGEN; PYRIDOXINE; RIBOFLAVIN; SELENIUM; SILICON DIOXIDE; SILYMARIN; STEARIC ACID; UBIDECARENONE; UNCLASSIFIED DRUG; ZINC;

ADULT; AGED; ARTICLE; CANCER CHEMOTHERAPY; CANCER PREVENTION; CANCER RADIOTHERAPY; CLINICAL PROTOCOL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; FOLLOW UP; HUMAN; MALE; MEDICAL ETHICS; OBSERVATION; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATECTOMY; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SOYBEAN;

EID: 27844494837     PISSN: 03022838     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eururo.2005.08.005     Document Type: Article

References (38)

1. Moyad MA, editor. Urol Clin North Am 2002 Feb;29(1):1-168.
2. Moyad MA, editor. Urol Clin North Am 2004 May;31(2):195-330.
3. L.C. Clark, B. Dalkin, A. Krongrad, G.F. Combs Jr., B.W. Turnbull, and E.H. Slate Decreased incidence of prostate cancer with selenium supplementation: results of a double-blind cancer prevention trial BJU 81 1998 730 734
4. O.P. Heinonen, D. Albanes, J. Virtamo, P.R. Taylor, J.K. Huttunen, and A.M. Hartman Prostate cancer and supplementation with alpha-tocopherol and beta- carotene: incidence and mortality in a controlled trial J Natl Cancer Inst 90 1998 440 446
5. M.A. Moyad Selenium and vitamin E supplements for prostate cancer: evidence or embellishment? Urology 59 4 Suppl. 1 2002 Apr 9 19
6. O.W. Brawley, and H. Parnes Prostate cancer prevention trials in the USA Eur J Cancer 36 10 2000 Jun 1312 1315
7. E.A. Klein Clinical models for testing chemopreventative agents in prostate cancer and overview of SELECT: the Selenium and Vitamin E Cancer Prevention Trial Recent Results Cancer Res 163 2003 212 225 discussion 264-6
8. F.H. Schroder, R. Kranse, N. Barbet, W.C. Hop, A. Kandra, and M. Lassus Prostate-specific antigen: A surrogate endpoint for screening new agents against prostate cancer? Prostate 42 2 2000 Feb 1 107 115
9. G.N. Thalmann, R.A. Sikes, S.M. Chang, D.A. Johnston, A.C. von Eschenbach, and L.W. Chung Suramin-induced decrease in prostate-specific antigen expression with no effect on tumor growth in the LNCaP model of human prostate cancer J Natl Cancer Inst 88 12 1996 Jun 19 794 801
10. Kranse R, Dagnelie PC, Van Kemenade MC, De Jong FH, Blom JHM, Tijburg LBM, et al. Dietary intervention in prostate cancer patients - PSA response in a randomised, double-blind, placebo-controlled study. Int J Cancer 2004, in press.
11. J. Limpens, W.M. van Weerden, K. Kramer, D. Pallapies, U.C. Obermuller-Jevic, and F.H. Schroder Re: Prostate carcinogenesis in N-methyl-N-nitrosourea (NMU)-testosterone-treated rats fed tomato powder, lycopene, or energy-restricted diets J Natl Cancer Inst 96 7 2004 Apr 7 554 author reply 554-5
12. Schröder FH, Wildhagen MF. Uro-Oncology group Rotterdam; Erasmus MC and University, Rotterdam, Netherlands. ZD1839 (gefitinib) and hormone resistant (HR) prostate cancer - results of a double blind randomized placebo-controlled phase II study. ASCO 2004. abstract.
13. M. Hussain, M. Banerjee, F.H. Sarkar, Z. Djuric, M.N. Pollak, and D. Doerge Soy isoflavones in the treatment of prostate cancer Nutr Cancer 47 2 2003 111 117
14. O. Kucuk Chemoprevention of prostate cancer Cancer Metastasis Rev 21 2 2002 111 124
15. R.P. Singh, S. Dhanalakshmi, A.K. Tyagi, D.C. Chan, C. Agarwal, and R. Agarwal Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increases plasma insulin-like growth factor-binding protein-3 levels Cancer Res 62 11 2002 Jun 1 3063 3069
16. D. Urban The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen J Urol 165 1 2001 294 300
17. R.A. Jarred Induction of apoptosis in low to moderate-grade human prostate carcinoma by red clover-derived dietary isoflavones Cancer Epidemiol Biomarkers Prev 11 12 2002 1689 1696
18. O. Kucuk Phase II randomized clinical trial of lycopene supplementation before radical prostatectomy Cancer Epidemiol Biomarkers Prev 10 8 2001 861 868
19. M.S. Ansari, and N.P. Gupta A comparison of lycopene and orchidectomy vs orchidectomy alone in the management of advanced prostate cancer BJU Int 92 4 2003 375 378
20. B.G. Blijenberg, H. Lilja, H. Neels, and U.-H. Stenman Quality assessment for prostate-specific antigen (PSA) in relation to ERSPC: report of the PSA Committee BJUI 92 2 2003 66 70
21. Blijenberg BG, van Schaik RHN. Prostaat-specifiek antigeen (PSA) 1984-2004. Analyse 2004;maart: 45-48.
22. R.G. Uzzo, F.G. Brown, E.M. Horwitz, A. Hanlon, S. Mazzoni, and A. Konski Prevalence and patterns of self-initiated nutritional supplementation in men at high risk of prostate cancer BJU Int 93 2004 995 996
23. J. Eng, D. Ransum, M. Verhoef, E. Guns, J. Davison, and R. Gallagher A population-based survey of complementary and alternative medicine use in men recently diagnosed with prostate cancer Integr Cancer Ther 2 3 2003 212 216
24. P.C. Dagnelie, A.G. Schuurman, R.A. Goldbohm, and P.A. Van den Brandt Diet, anthropometric measures and prostate cancer risk: a review of prospective cohort and intervention studies BJU Int 93 8 2004 1139 1150
25. W.M. van Weerden, and J.C. Romijn Use of nude mouse xenograft models in prostate cancer research Prostate 43 4 2000 Jun 1 263 271
26. W.M. Van Weerden, C.M. De Ridder, C.A. Bolder, and M.F. Wildhagen Oral supplementation of Vitamin E and Lycopene reduces orthotopic growth of PC346C prostate tumors J Urol 169 4 2003 218
27. H. Adlercreutz Western diet and Western diseases: some hormonal and biochemical mechanisms and associations Scand J Clin Lab Invest 50 Suppl. 201 1990 3 23
28. P.J. Magee, and I.R. Rowland Phyto-oestrogens, their mechanism of action: current evidence for a role in breast and prostate cancer Br J Nutr 91 4 2004 513 531
29. H.S. Cross, E. Kallay, D. Lechner, W. Gerdenitsch, H. Adlerkreutz, and H.J. Armbrecht Phytoestrogens and Vitamin D metabolism: a new concept for prevention and therapy of colorectal, prostate cancer mammar carcinomas J Nutr 134 5 2004 1207S 1212S
30. S. Gao, G.Z. Liu, and Z. Wang Modulation of androgen receptor-dependent transcription by resveratrol and genistein in prostate cancer cells Prostate 59 2 2004 214 225
31. J.R. Zhou, L. Yu, Y. Zhong, R.L. Nassr, A.A. Franke, and S.M. Gaston Inhibition of orthotopic growth and metastasis of androgen-sensitive human prostate cancer tumors in mice by bioactive soybean components Prostate 53 2 2002 143 153
32. R.P. Singh, S. Dhanalakshmi, A.K. Tyagi, D.C. Chan, C. Agarwal, and R. Agarwal Dietary feeding of silibinin inhibits advance human prostate carcinoma growth in athymic nude mice and increasing plasma insulin-like growth factor-binding protein-3 levels Cancer Res 62 11 2002 3063 3069
33. E. Giovannucci Tomatoes, tomato-based products, lycopene and cancer: review of the epidemiologic literature JNCI 91 4 1999 317 331
34. P.R. Taylor, H.L. Parnes, and S.M. Lippman Science peels the onion of selenium effects on prostate carcinogenesis J Natl Cancer Inst 96 9 2004 645 647
35. G.F. Combs Status of selenium in prostate cancer prevention Br J Cancer 91 2 2004 195 199
36. H. Li, M.J. Stampfer, E.L. Giovannucci, J.S. Morris, W.C. Willett, and J.M. Gazia A prospective study of plasma selenium levels and prostate cancer risk J Natl Cancer Inst 96 9 2004 645 647
37. P.A. Van den Brandt, M.P. Zeegers, P. Bode, and R.A. Goldbohm Toenail selenium levels and the subsequent risk of prostate cancer: a prospective cohort study Cancer Epidemiol Biomarkers Prev 12 9 2003 866 871
38. J. Virtamo, P. Pietinen, J.K. huttunen, P. Korhonen, N. Malila, M.J. Virtanen ATB study group Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up JAMA 290 4 2003 476 485