Fusaristatins A and B, two new cyclic lipopeptides from an endophytic Fusarium sp.

Journal of Antibiotics

Volumn 60, Issue 5, 2007, Pages 309-316

  Shiono, Yoshihito ^a   Tsuchinari, Mio ^a   Shimanuki, Keiko ^a   Miyajima, Takeshi ^a   Murayama, Tetsuya ^a   Koseki, Takuya ^a   Laatsch, Hartmut ^b   Funakoshi, Takayuki ^c   Takanami, Koji ^d   Suzuki, Keitarou ^d  

^a YAMAGATA UNIVERSITY   (Japan)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

^c KYUSHU UNIVERSITY OF NURSING AND SOCIAL WELFARE   (Japan)

^d KUMAMOTO UNIVERSITY   (Japan)

Author keywords

Fusaristatins A and B; Fusarium sp.; Lipopeptides; Topoisomerase inhibitor

Indexed keywords

CAMPTOTHECIN; ETOPOSIDE; FLUOROURACIL; FUSARISTATIN A; FUSARISTATIN B; LIPOPEPTIDE; NATURAL PRODUCT; TOPOSTATIN; UNCLASSIFIED DRUG; YM 170320; ANTINEOPLASTIC ANTIBIOTIC; DEPSIPEPTIDE; DNA TOPOISOMERASE; DNA TOPOISOMERASE (ATP HYDROLYSING); ENZYME INHIBITOR;

ANTIMICROBIAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; ENDOPHYTE; FUNGUS CULTURE; FUSARIUM; HUMAN; HUMAN CELL; IC 50; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; BACTERIUM; CELL PROLIFERATION; CHEMISTRY; CULTURE MEDIUM; DRUG ANTAGONISM; DRUG EFFECT; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FERMENTATION; FUNGUS; INFRARED SPECTROPHOTOMETRY; ISOLATION AND PURIFICATION; MAACKIA; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; TUMOR CELL LINE; ULTRAVIOLET SPECTROPHOTOMETRY;

FUNGI; FUSARIUM SP.;

ANTIBIOTICS, ANTINEOPLASTIC; BACTERIA; CELL LINE, TUMOR; CELL PROLIFERATION; CULTURE MEDIA; DEPSIPEPTIDES; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FERMENTATION; FUNGI; FUSARIUM; HUMANS; MAACKIA; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, INFRARED; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 34548409109     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.1038/ja.2007.39     Document Type: Article

References (11)

1. Gunatilaka AAL. Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implications of their occurrence. J Nat Prod 69: 509-526 (2006)
2. Shiono Y, Murayama T, Takahashi K, Okada K, Katohda S, Ikeda M. Three oxygenated cyclohexenone derivatives, produced by an endophytic fungus. Biosci Biotechnol Biochem 69: 287-292 (2005)
3. Shiono Y, Murayama T. New eremophilane-type sesquiterpenoids, eremoxylarins A and B from xylariaceous endophytic fungus YUA-026. Z Naturforsch 60b: 885-890 (2005)
4. Shiono Y. Anthracobic acids A and B, two polyketides, produced by an endophytic fungus Anthracobia sp. Chem Biodivers 3: 217-223 (2006)
5. Suzuki K, Nagao K, Monnai Y, Yagi A, Uyeda M. Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. I. Taxonomy, fermentation, isolation and biological activities. J Antibiot 51: 991-998 (1998)
6. Suzuki K, Yahara S, Kido Y, Nagao K, Hatano Y, Uyeda M. Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. II. Physico-chemical properties and structure elucidation. J Antibiot 51: 999-1003 (1998)
7. Suzuki K, Yamaizumi M, Tateishi S, Monnai Y, Uyeda M. Topostatin, a novel inhibitor of topoisomerases I and II produced by Thermomonospora alba strain No. 1520. III. Inhibitory properties. J Antibiot 52: 460-465 (1999)
8. Li TK, Liu LF. Tumor cell death induced by topoisomerase-targeting drugs. Ann Rev Pharmacol Toxicol 41: 53-77 (2001)
9. Yamashita Y, Kawada S, Fujii N, Nakano H. Induction of mammalian DNA topoisomerase II dependent DNA cleavage by antitumor antibiotic streptonigrin. Cancer Res 50: 5841-5844 (1990)
10. Hsiang YH, Hertzberg R, Hecht S, Lui LF. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J Biol Chem 260: 14873-14878 (1985)
11. Sugawara T, Tanaka A, Tanaka K, Nagai K, Suzuki K, Suzuki T. YM-170320, a novel lipopeptide antibiotic inducing morphological change of colonies in a mutant of Candida tropicalis pK233. J Antibiot 51: 435-438 (1998)