Regulation of nicotine-induced apoptosis of pulmonary artery endothelial cells by treatment of N-acetylcysteine and vitamin E

Human and Experimental Toxicology

Volumn 26, Issue 7, 2007, Pages 595-602

  Demiralay, Rezan ^a,c   Gursan N ^b   Erdem, H ^b  

^a SULEYMAN DEMIREL UNIVERSITY SCHOOL OF MEDICINE   (Turkey)

^b ATATURK UNIVERSITY   (Turkey)

^c Fatih M   (Turkey)

Author keywords

Apoptosis; Endothelial cells; N acetylcysteine; Nicotine; Pulmonary artery; Vitamin E

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; ANTIOXIDANT; MYELOPEROXIDASE; NICOTINE; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BLOOD VESSEL INJURY; CONTROLLED STUDY; CYTOPLASM; ENDOTHELIUM CELL; FEMALE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; STATISTICAL SIGNIFICANCE;

ACETYLCYSTEINE; ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; APOPTOSIS; ENDOTHELIAL CELLS; FEMALE; INJECTIONS, INTRAPERITONEAL; NICOTINE; NICOTINIC AGONISTS; PEROXIDASE; PULMONARY ARTERY; RATS; RATS, WISTAR; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VITAMIN E;

RATTUS; RATTUS NORVEGICUS;

EID: 34548389296     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1177/0960327106070079551     Document Type: Article

References (43)

1. Barbera JA, Peinado VI, Santos S et al. Reduced expression of endothelial nitric oxide synthase in pulmonary arteries of smokers. American Journal of Respiratory and Critical Care Medicine 2001; 164: 709-13.
2. Su Y, Cao W, Han Z, Block ER. Cigarette smoke extract inhibits angiogenesis of pulmonary artery endothelial cells: the role of calpain. American Journal of Physiology, Lung Cellular and Molecular Physiology 2004; 287: 794-800.
3. Villablanca AC. Nicotine stimulates DNA synthesis and proliferation in vascular endothelial cells in vitro. Journal of Applied Physiology 1998; 84: 2089-98.
4. Santos S, Peinado VI, Ramirez J et al. Characterization of pulmonary vascular remodelling in smokers and patients with mild COPD. European Respiratory Journal 2002; 19: 632-38.
5. Sun YP, Zhu BQ, Browne AE et al. Nicotine does not influence arterial lipid deposits in rabbits exposed to second-hand smoke. Circulation 2001; 104: 810-14.
6. Tithof PK, Elgayyar M, Schuller HM et al. 4-(methylnisrosaminol)- 1-(3-pyridyl)-1-butanone, a nicotine derivative, induces apoptosis of endothelial cells. American Journal of Physiology, Heart and Circulatory Physiology 2001; 281: 1946-54.
7. Mayhan WG, Sharpe GM. Chronic exposure to nicotine alters endothelium-dependent arteriolar dilatations: effect of superoxide dismutase. Journal of Applied Physiology 1999; 86: 112611-34.
8. Wang JF, Zhang X, Groopman JE. Activation of vascular endothelial growth factor receptor -3 and its downstream signaling promote cell survival under oxidative stress. The Journal of Biological Chemistry 2004; 279: 27088-97.
9. Lum H, Roebuck KA. Oxidant stress and endothelial cell dysfunction. American Journal of Physiology, Cell Physiology 2001; 280: 719-41.
10. Babior BM. Phagocytes and oxidative stress. The American Journal of Medicine 2000; 109: 33-44.
11. Sikora L, Rao SP, Sriramarao P. Selectin-dependent rolling and adhesion of leukocytes in nicotine-exposed microvessels of lung allografts. American Journal of Physiology, Lung Cellular and Molecular Physiology 2003; 285: 654-63.
12. Albaugh G, Kann B, Strande L et al. Nicotine induces endothelial TNF-alpha expression, which mediates growth retardation in vitro. Journal of Surgical Research 2001; 99: 381-84.
13. Blesa S, Cortijo J, Mata M et al. Oral N-acetylcysteine attenuates the rat pulmonary inflammatory response to antigen. European Respiratory Journal 2003; 21: 394-400.
14. De Flora S, Izzotti A, Albini A et al. Antigenetoxic and cancer preventive mechanisms of N-acetyl-L-cysteine. In Kelloff GJ, Hawk ET, Sigman CC eds. Cancer chemoprevention, Vol. 1: Promising cancer chemopreventive agents. The Humana Press Inc., 2004: 37-67.
15. Minko T, Stefanov A, Pozharov V. Lung edema clearence: 20 years of progress selected contribution: lung hypoxia: antioxidant and antiapoptotic effects of liposomal α-tocopherol. Journal of Applied Physiology 2002; 93: 1550-60.
16. Helen A, Krishnakumar K, Vijayammal PL, Augusti KT. A comparative study of antioxidants S-allylcysteine sulfoxide and vitamin E on the damages induced by nicotine in rats. Pharmacology 2003; 67: 113-17.
17. Wang HC, Shun CT, Hsu SM et al. Fas/Fas ligand pathway is involved in the resolution of type II pneumocyte hyperplasia after acute lung injury: evidence from a rat model. Critical Care Medicine 2002; 30: 1528-34.
18. D'Agostini F, Balansky RM, Izzotti A et al. Modulation of apoptosis by cigarette smoke and cancer chemopreventive agents in the tract of rats. Carcinogenesis 2001; 22: 375-80.
19. Yang LL, Ji XP, Liu Z. Effects of hypercapnia on nuclear factor-kappaB and tumor necrosis factor-alpha in acute lung injury models. Chinese Medical Journal 2004; 117: 1859-61.
20. Coimbra R, Melbostad H, Loomis W et al. LPS-induced acute lung is attenuated by phosphodiesterase inhibition: effects on proinflammatory mediators, metalloproteinases, NF-kappaB, and ICAM-1 expression. Journal of Trauma 2006; 60: 115-25.
21. Wright JL, Tai H, Churg A. Cigarette smoke induces persisting increases of vasoactive mediators in pulmonary arteries. American Journal of Respiratory Cell and Molecular Biolology 2004; 31: 501-09.
22. Kuo WH, Chen JH, Lin HH et al. Induction of apoptosis in the lung tissue from rats exposed to cigarette smoke involves P38/JNK MAKP pathway. Chemico-Biological Interactions 2005; 155: 31-42.
23. Gomes HC, Campos JHO, Ferreira LM, Kobayashi LA. Experimental model to study the effect of nicotine in a random skin flap, in a rat. Acta Cirurgica Brasileira 2004; 19: 65-68.
24. Qin F, Shite J, Liang CS. Antioxidants attenuate myocyte apoptosis and improve cardiac function in CHF: association with changes in MAKP pathways. American Journal of Physiology, Heart and Circulatory Physiology 2003; 285: 822-32.
25. Fiordaliso F, Bianchi R, Staszewsky L et al. Antioxidant treatment attenuates hyperglycemia-induced cardiomycyte death in rats. Journal of Molecular and Cellular Cardiology 2004; 37: 959-68.
26. Tousoulis D, Antoniades C, Tentolouris C et al. Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers. Atherosclerosis 2003; 170: 261-67.
27. Pober JS. Activation and injury of endothelial cells by cytokines. Pathologie-Biologie 1998; 46: 159-63.
28. Petrache I, Birukav K, Zaiman AL et al. Caspase-dependent cleavage of myosin light chain kinase (MLCK) is involved in TNF-α-mediated bovine pulmonary endothelial cell apoptosis. The FASEB Journal 2003; 17: 407-16.
29. Peinado VI, Barbera JA, Abate P et al. Inflammatory reaction in pulmonary muscular arteries of patients with mild chronic obstructive pulmonary disease. American Journal of Respiratory Critical Care Medicine 1999; 159: 1605-11.
30. Sasayama S, Okada M, Matsumori A. Chemokines and cardiovascular diseases. Cardiovascular Research 2000; 14: 267-69.
31. Rahman A, Kefer J, Bando M et al. E-selectin expression in human endothelial cells by TNF-α-induced oxidant generation and NF-κB activation. The American Journal of Physiology 1998; 275: 533-44.
32. Devaraj S, Jialal I. Alpha-tocopherol decreases tumor necrosis factor-alpha mRNA and protein from activated human monocytes by inhibition of 5-lipoxygenase. Free Radical Biology and Medicine 2005; 38: 1212-20.
33. Naidu BV, Farivar AS, Woolley SM et al. Chemokine response of pulmonary artery endothelial cells to hypoxia and reoxygenation. Journal of Surgical Research 2003; 114: 163-71.
34. Blackwell TS, Blackwell TR, Holden EP, Cristman BW, Cristman JW. In vivo antioxidant treatment supresses nuclear factor-kappaB activation and neutrophilic lung inflammation. Journal of Immunology 1996; 157: 1630-37.
35. Hughes G, Murphy MP, Ledgerwood EC. Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor-kappaB to modulate tumour necrosis factor-induced apoptosis evidence from mitochondria-targeted antioxidants. The Biochemical Journal 2005; 389: 83-89.
36. Abid MR, Guo S, Minami T et al. Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 2004; 24: 294-300.
37. Taraseviciene-Stewart L, Kasahara Y, Alger L et al. Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent endothelial cell proliferation and severe pulmonary hypertension. The FASEB Journal 2001; 15: 427-38.
38. Tuder RM, Cool CD, Yeager M et al. The pathobiology of pulmonary hypertension. Endothelium. Clinics in Chest Medicine 2001; 22: 405-18.
39. Kranenburg AR, de Boer WI, Alagappan VK et al. Enhanced bronchial expression of vascular endothelial growth factor and receptors (Flk-1 and Flt-1) in patients with chronic obstructive pulmonary disease. Thorax 2005; 60: 106-13.
40. Conklin B, Zhao W, Zhong DS, Chen C. Nicotine and cotinine up-regulate vascular endothelial growth factor expression in endothelial cells. American Journal of Pathology 2002; 160: 413-18.
41. Quinn TP, Soiter SJ, Ramer K et al. A receptor for vascular endothelial growth factor that stimulates endothelial apoptosis. Cancer Research 2001; 61; 8629-37.
42. Hoshikawa Y, Ono S, Suzuki S et al. Generation of oxidative stress contributes to the development of pulmonary hypertension induced by hypoxia. Journal of Applied Physiology 2001; 90: 1299-306.
43. Nespereira B, Perez-Ilzarbe M, Fernandez P et al. Vitamins C and E downregulate vascular VEGF and VEGFR-2 expression in apolipoprotein-E-deficient mice. Atherosclerosis 2003; 171: 67-73.