Modelling nicotine intake in smokers and snuff users using biological fluid nicotine metabolites

Biomarkers

Volumn 5, Issue 5, 2000, Pages 341-354

  Boswell, C ^a   Curvall, M ^a   Elswick R K , Jr ^a   Leyden, D ^a  

^a Philip Morris USA   (United States)

Author keywords

Cotinine; Glucuronide conjugates; Nicotine metabolites; Trans 3' hydroxycotinine

Indexed keywords

BIOLOGICAL MARKER; COTININE; NICOTINE;

ARTICLE; BODY FLUID; CIGARETTE SMOKING; DRUG BLOOD LEVEL; ENVIRONMENTAL EXPOSURE; HALF LIFE TIME; HUMAN; METABOLITE; MODEL; SAMPLING; SMOKELESS TOBACCO; URINALYSIS;

EID: 0033769702     PISSN: 1354750X     EISSN: None     Source Type: Journal    
DOI: 10.1080/135475000424357     Document Type: Article

References (24)

1. Oral mucosal changes and nicotine disposition in users of Swedish smokeless tobacco products: A comparative study
2. Reduction in nicotine intake and oral mucosal changes among users of Swedish oral moist snuff after switching to a low-nicotine product
3. The influence of cigarette consumption and smoking machine yields of tar and nicotine on the nicotine uptake and oral mucosal lesions in smokers
4. Pharmacokinetics and pharmacodynamics of nicotine
5. Cotinine as a biomarker of environmental tobacco smoke exposure
6. Individual differences in nicotine kinetics and metabolism in humans
7. Sources of variability in nicotine and cotinine levels with use of nicotine nasal spray, transdermal nicotine, and cigarette smoking
8. Validation of an assay for the determination of cotinine and 3-hydroxycotinine in human saliva using automated solid phase extraction and liquid chromatography with tandem mass-spectrometric detection
9. Nicotine uptake and metabolism in smokers
10. Poor metabolizers of nicotine and CYP2D6 polymorphism
11. CYP2D6 genotypes in cigarette smokers and non-tobacco users
12. Nicotine and metabolites: Analysis and levels in body fluids
13. The pharmacokinetics of cotinine in plasma and saliva from non-smoking healthy volunteers
14. Conjugation pathways in nicotine metabolism
15. Reliability of measurement
16. Determinants of plasma concentrations of nicotine and cotinine during cigarette smoking and transdermal nicotine treatment
17. Model-building strategies and methods for logistic regression
18. Personal exposure to environmental tobacco smoke: Salivary cotinine, airborne nicotine, and non-smoker misclassification
19. Plasma cotinine: Stability in smokers and validation of self-reported smoke exposure in nonsmokers
20. Criteria for choice of best model
21. Conference Summary Society for research on nicotine and tobacco
22. Examining the relation between the usual-brand nicotine yield, blood cotinine concentration and the nicotine 'compensation hypothesis'
23. Mathematical modelling of nicotine and cotinine as biological markers of environmental tobacco smoke exposure
24. Cotinine effects on nicotine metabolism