Syncytin-A mediates the formation of syncytiotrophoblast involved in mouse placental development

Cellular Physiology and Biochemistry

Volumn 20, Issue 5, 2007, Pages 517-526

  Gong, Rui ^a   Huang, Liqin ^a   Shi, Jian ^a   Luo, Kan ^a   Qiu, Gang ^a   Feng, Huixing ^a   Tien, Po ^a   Xiao, Gengfu ^a  

^a WUHAN UNIVERSITY   (China)

Author keywords

Endogenous retrovirus; Fusion; Placental development; Syncytin A; Syncytiotrophoblast cell

Indexed keywords

ANTIBODY; ANTISENSE OLIGONUCLEOTIDE; FIBROBLAST GROWTH FACTOR 4; MESSENGER RNA; PROTEIN; SYNCYTIN A; UNCLASSIFIED DRUG; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUSION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; IMMUNOFLUORESCENCE TEST; INHIBITION KINETICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PLACENTA DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STEM CELL; SYNCYTIOTROPHOBLAST;

EID: 34548366444     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107535     Document Type: Article

References (33)

1. Boeke JD, Stoye JP: Retrotransposons, endogenous retroviruses, and the evolution of retroelements; in Coffin JM, Hughes SH, Varmus HE (eds): Retroviruses. New York, Cold Spring Harbor Laboratory Press, 1997, pp 343-435.
2. Bannert N, Kurth R: Retroelements and the human genome: new perspectives on an old relation. Proc Natl Acad Sci U S A 2004;5:14572-14579.
3. Lander ES, Linton LM, Birren B, Nusbaum C, Zody MC, Baldwin J, Devon K, Dewar K, Doyle M, FitzHugh W, et al.: Initial sequencing and analysis of the human genome. Nature 2001;409:860-921.
4. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, et al.: Initial sequencing and comparative analysis of the mouse genome. Nature 2002;420:520-562.
5. Mi S, Lee X, Li X, Veldman GM, Finnerty H, Racie L, LaVallie E, Tang XY, Edouard P, Howes S, Keith JC Jr, McCoy JM: Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 2000;403:785-789.
6. Frendo JL, Olivier D, Cheynet V, Blond JL, Bouton O, Vidaud M, Rabreau M, Evain-Brion D, Mallet F: Direct involvement of HERV-W Env glycoprotein in human trophoblast cell fusion and differentiation. Mol Cell Biol 2003;23:3566-3574.
7. Mallet F, Bouton O, Prudhomme S, Cheynet V, Oriol G, Bonnaud B, Lucotte G, Duret L, and Mandrand B: The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology. Proc Natl Acad Sci U S A 2004;101:1731-1736.
8. Dunlap KA, Palmarini M, Varela M, Burghardt RC, Hayashi K, Farmer JL, Spencer TE: Endogenous retroviruses regulate periimplantation placental growth and differentiation. Proc Natl Acad Sci U S A 2006;103:14390-14395.
9. Rossant J, Cross JC: Placental development: lessons from mouse mutants. Nat Rev Genet 2001;2:538-548.
10. Cross JC: Genetic insights into trophoblast differentiation and placental morphogenesis. Semin Cell Dev Biol 2000;11:105-113.
11. Cross JC, Baczyk D, Dobric N, Hemberger M, Hughes M, Simmons DG, Yamamoto H, Kingdom JC: Genes, development and evolution of the placenta. Placenta 2003;24:123-130.
12. Basyuk E, Cross JC, Corbin J, Nakayama H, Hunter P, Nait-Oumesmar B, Lazzarini RA: Murine Gcm1 gene is expressed in a subset of placental trophoblast cells. Dev Dyn 1999;214:303-311.
13. Anson-Cartwright L, Dawson K, Holmyard D, Fisher SJ, Lazzarini RA, Cross JC. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Nat Genet 2001;25:311-314.
14. Stecca B, Nait-Oumesmar B, Kelley KA, Voss AK, Thomas T, Lazzarini RA: Gcm1 expression defines three stages of chorioallantoic interaction during placental development. Mech Dev 2002;115:27-34.
15. Hughes M, Dobric N, Scott IC, Su L, Starovic M, St-Pierre B, Egan SE, Kingdom JC, Cross JC: The Hand1, Stra13 and Gcm1 transcription factors override FGF signaling to promote terminal differentiation of trophoblast stem cells. Dev Biol 2004;271:26-37.
16. Dupressoir A, Marceau G, Vernochet C, Benit L, Kanellopoulos C, Sapin V, Heidmann T: Syncytin-A and syncytin-B, two fusogenic placenta-specific murine envelope genes of retroviral origin conserved in Muridae. Proc Natl Acad Sci U S A 2005;102:725-730.
17. Peng X, Pan J, Gong R, Liu Y, Kang S, Feng H, Qiu G, Guo D, Tien P, Xiao G: Functional characterization of syncytin-A, a newly murine endogenous virus envelope protein. Implication for its fusion mechanism. J Biol Chem 2007;282:381-389.
18. Tanaka S, Kunath T, Hadjantonakis AK, Nagy A, Rossant J: Promotion of trophoblast stem cell proliferation by FGF4. Science 1998;282:2072-2075.
19. Kunath T, Rossant J: Mouse trophoblast stem cells; in Soares MJ, Hunt JS (eds): Placenta and Trophoblast. Totowa, Humana Press, 2005, pp 123-146.
20. Alsat E, Haziza J, Evain-Brion D: Increase in epidermal growth factor receptor and its messenger ribonucleic acid levels with differentiation of human trophoblast cells in culture. J Cell Physiol 1993;154:122-128.
21. Alsat E, Haziza J, Scippo ML, Frankenne F, Evain-Brion D: Increase in epidermal growth factor receptor and its mRNA levels by parathyroid hormone (1-34) and parathyroid hormone-related protein (1-34) during differentiation of human trophoblast cells in culture. J Cell Biochem 1993;53: 32-42.
22. Morrish DW, Linetsky E, Bhardwaj D, Li H, Dakour J, Marsh RG, Paterson MC, Godbout R: Identification by subtractive hybridization of a spectrum of novel and unexpected genes associated with in vitro differentiation of human cytotrophoblast cells. Placenta 1996;17:431-441.
23. Garcia-Lloret MI, Morrish DW, Wegmann TG, Honore L, Turner AR, Guilbert LJ: Demonstration of functional cytokine-placental interactions: CSF-1 and GM-CSF stimulate human cytotrophoblast differentiation and peptide hormone secretion. Exp Cell Res 1994; 214:46-54.
24. Robinson BG, Emanuel RL, Frim DM, Majzoub JA: Glucocorticoid stimulates expression of corticotropin-releasing hormone gene in human placenta. Proc Natl Acad Sci U S A 1988;85:5244-5248.
25. Cronier L, Guibourdenche J, Niger C, Malassine A: Oestradiol stimulates morphological and functional differentiation of human villous cytotrophoblast. Placenta 1999;20:669-676.
26. Shi QJ, Lei ZM, Rao CV, Lin J: Novel role of human chorionic gonadotropin in differentiation of human cytotrophoblasts. Endocrinology 1993;132:1387-1395.
27. Cronier L, Bastide B, Herve JC, Deleze J, Malassine A: Gap junctional communication during human trophoblast differentiation: influence of human chorionic gonadotropin. Endocrinology 1994;135:402-408.
28. Gong R, Peng X, Kang S, Feng H, Huang J, Zhang W, Lin D, Tien P, Xiao G: Structural characterization of the fusion core in syncytin, envelope protein of human endogenous retrovirus family W. Biochem Biophys Res Commun 2005;331:1193-1200.
29. Voisset C, Blancher A, Perron H, Mandrand B, Mallet F, Paranhos-Baccala G: Phylogeny of a novel family of human endogenous retrovirus sequences, HERV-W, in humans and other primates. AIDS Res Hum Retroviruses 1999;15:1529-1533.
30. Lee X, Keith JC Jr, Stumm N, Moutsatsos I, McCoy JM, Crum CP, Genest D, Chin D, Ehrenfels C, Pijnenborg R, van Assche FA, Mi S: Downregulation of placental syncytin expression and abnormal protein localization in pre-eclampsia. Placenta 2001;22:808-812.
31. Knerr I, Beinder E, Rascher W: Syncytin, a novel human endogenous retroviral gene in human placenta: evidence for its dysregulation in preeclampsia and HELLP syndrome. Am J Obstet Gynecol 2002;186:210-213.
32. Kudo Y, Boyd CA, Sargent IL, Redman CW: Hypoxia alters expression and function of syncytin and its receptor during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia. Biochim Biophys Acta 2003;1638:63-71.
33. Knerr I, Weigel C, Linnemann K, Dotsch J, Meissner U, Fusch C, Rascher W: Transcriptional effects of hypoxia on fusogenic syncytin and its receptor ASCT2 in human cytotrophoblast BeWo cells and in ex vivo perfused placental cotyledons. Am J Obstet Gynecol 2003;189:583-588.