Absence of ClC5 in knockout mice leads to glycosuria, impaired renal glucose handling and low proximal tubule GLUT2 protein expression

Cellular Physiology and Biochemistry

Volumn 20, Issue 5, 2007, Pages 455-464

  Souza Menezes, Jackson ^a,b   Morales, Marcelo M ^b   Tukaye, Deepali N ^a   Guggino, Sandra E ^a   Guggino, William B ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

ClC 5; Glucose homeostasis; Glucose transporters and insulin; Megalin; Proximal tubule

Indexed keywords

CLC 5 PROTEIN; GLUCOSE; GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 2; INSULIN; MEGALIN; MESSENGER RNA; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSE INTOLERANCE; GLUCOSURIA; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; KIDNEY CORTEX; KIDNEY PROXIMAL TUBULE; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE;

ANIMALIA; MUS;

EID: 34548334620     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107529     Document Type: Article

References (43)

1. Uchida S: In vivo role of CLC chloride channels in the kidney. Am.J.Physiol Renal Physiol 2000;279:F802-F808.
2. Silva IV, CebotaruV ,Wang H, Wang X.T, Wang SS, Guo G, Devuyst O, Thakker RV, Guggino WB, Guggino SE: The ClC-5 knockout mouse model of Dent's disease has renal hypercalciuria and increased bone turnover. J Bone Miner Res 2003;18:615-623.
3. Scheel O, Zdebik AA, Lourdel S, Jentsch TJ: Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins. Nature 2005;436:424-427.
4. Jentsch TJ: Chloride transport in the kidney: lessons from human disease and knockout mice. J Am Soc Nephrol 2005;16:1549-1561.
5. Gunther W, Luchow A, Cluzeaud F, Vandewalle A, Jentsch TJ: ClC-5, the chloride channel mutated in Dent's disease, colocalizes with the proton pump in endocytotically active kidney cells. Proc Natl Acad Sci USA 1998;95:8075-8080.
6. Dent CE, Friedman M: Hypercalcuric rickets associated with renal tubular damage. Arch Dis Child 1964;39:240-249.
7. Wang SS, Devuyst O, Courtoy PJ, Wang XT, Wang H, Wang Y, Thakker RV, Guggino S, Guggino WB: Mice lacking renal chloride channel, CLC-5, are a model for Dent's disease, a nephrolithiasis disorder associated with defective receptor-mediated endocytosis. Hum Mol Genet 2000;9:2937-2945.
8. Wrong O.M, Norden AG, Feest TG: Dent's disease; a familial proximal renal tubular syndrome with low-molecular-weight proteinuria, hypercalciuria, nephrocalcinosis, metabolic bone disease, progressive renal failure and a marked male predominance. QJM 1994;87:473-493.
9. Pook MA, Wrong O, Wooding C, Norden AG, Feest TG, Thakker RV: Dent's disease, a renal Fanconi syndrome with nephrocalcinosis and kidney stones, is associated with a microdeletion involving DXS255 and maps to Xp11.22. Hum Mol Genet 1993;2:2129-2134.
10. Christensen EI, Devuyst O, Dom G, Nielsen R, Van der SP, Verroust P, Leruth M, Guggino WB, Courtoy PJ: Loss of chloride channel ClC-5 impairs endocytosis by defective trafficking of megalin and cubilin in kidney proximal tubules. Proc Nat Acad Sci USA 2003;100:8472-8477.
11. Yanagida H, Ikeoka M, Kuwajima H, Wada N, Tabata N, Sugimoto K, Okada M, Takemura T: A boy with Japanese Dent's disease exhibiting abnormal calcium metabolism and osseous disorder of the spine: defective megalin expression at the brushborder of renal proximal tubules. Clin Nephrol 2004;62:306-312.
12. Urakami T, Kubota S, Nitadori Y, Harada K, Owada M, Kitagawa T: Annual incidence and clinical characteristics of type 2 diabetes in children as detected by urine glucose screening in the Tokyo metropolitan area. Diabetes Care 2005;28:1876-1881.
13. Simerville JA, Maxted WC, Pahira JJ: Urinalysis: a comprehensive review. Am Fam Physician 2005;71:1153-1162.
14. Vestri S, Okamoto MM, de Freitas HS, Parecida Dos SR, Nunes MT, Morimatsu M, Heimann JC, Machado UF: Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat. J Membr Biol 2001;182:105-112.
15. Berry GT, Baynes JW, Wells-Knecht KJ, Szwergold BS, Santer R: Elements of diabetic nephropathy in a patient with GLUT 2 deficiency. Mol Genet Metab 2005;86:473-477.
16. Lam PP, Leung YM, Sheu L, Ellis J, Tsushima RG, Osborne LR, Gaisano HY: Transgenic mouse overexpressing syntaxin-1A as a diabetes model. Diabetes 2005;54:2744-2754.
17. Nascimento DS, Reis CU, Goldenberg RC, Ortiga-Carvalho TM, Pazos-Moura CC, Guggino SE, Guggino WB, Morales MM: Estrogen modulates ClC-2 chloride channel gene expression in rat kidney. Pflugers Arch 2003;446:593-599.
18. Stadie WC, Riggs BC: Microtome for the preparation of tissue slices for metabolic studies of surviving tissues in vitro. J Biol Chem 1944;154:687-690.
19. Baricault L, Galceran M, Ronco PM, Trugnan G, Verroust PJ: Unusual processing of GP280, a protein associated with the intermicrovillar areas of yolk sac epithelial cells: plasma membrane delivery of immature protein. Biochem Biophys Res Commun 1995;212:353-359.
20. Gekle M: Renal tubule albumin transport. Annu Rev Physiol 2005;67:573-594.
21. Kanai Y, Lee WS, You G, Brown D, Hediger MA: The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucose. J Clin Invest 1994;93:397-404.
22. Adachi T, Yasuda K, Okamoto Y, Shihara N, Oku A, Ueta K, Kitamura K, Saito A, Iwakura I, Yamada Y, Yano H, Seino Y, Tsuda K: T-1095, a renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic rats. Metabolism 2000;49:990-995.
23. Wright EM, Hirsch JR, Loo DD, Zampighi GA: Regulation of Na+/glucose cotransporters. J Exp Biol 1997;200:287-293.
24. Zimmet P, Magliano D, Matsuzawa Y, Alberti G, Shaw J: The metabolic syndrome: a global public health problem and a new definition. J Atheroscler Thromb 2005;12:295-300.
25. Haffner SM: The metabolic syndrome: inflammation, diabetes mellitus, and cardiovascular disease. Am J Cardiol 2006;97:3A-11A.
26. Barnett A: Prevention of loss of renal function over time in patients with diabetic nephropathy. Am J Med 2006;119:S40-S47.
27. Daneman D: Type 1 diabetes. Lancet 2006;367:847-858.
28. Barroso I: Genetics of Type 2 diabetes. Diabet Med 2005;22:517-535.
29. Tsakiris D. Ioannou ,K: An underdiagnosed type of diabetes: the MODY syndromes. Pathophysiology, clinical presentation and renal disease progression. J Nephrol 2004;17:637-641.
30. Marx J: Unraveling the causes of diabetes. Science 2002;296:686-689.
31. Rees DA, Alcolado JC: Animal models of diabetes mellitus. Diabet Med 2005;22:359-370.
32. Santer R, Steinmann B, Schaub J: Fanconi-Bickel syndrome-a congenital defect of facilitative glucose transport. Curr Mol Med 2002;2:213-227.
33. Magen D, Sprecher E, Zelikovic I, Skorecki K: A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduria. Kidney Int 2005;67:34-41.
34. Orlando RA, Rader K, Authier F, Yamazaki H, Posner BI, Bergeron JJ, Farquhar MG: Megalin is an endocytic receptor for insulin. J Am Soc Nephrol 1998;9:1759-1766.
35. Nielsen S: Sorting and recycling efficiency of apical insulin binding sites during endocytosis in proximal tubule cells. Am J Physiol 1993;264:C810-C822.
36. Nielsen S: Time course and kinetics of proximal tubular processing of insulin. Am J Physiol 2002;262:F813-F822.
37. Thevenod F: Ion channels in secretory granules of the pancreas and their role in exocytosis and release of secretory proteins. Am J Physiol Cell Physiol 2002;283:C651-C672.
38. Guillam MT, Hummler E, Schaerer E, Yeh JI, Birnbaum MJ, Beermann F, Schmidt A, Deriaz N, Thorens B: Early diabetes and abnormal postnatal pancreatic islet development in mice lacking Glut-2. Nat Genet1 997;17:327-330.
39. Sakamoto OSAM, Ogawa EISH, Ohura TOSH, Igarashi YUTA., Matsubara YOIC, Narisawa KUNI, Iinuma KAZU: Mutation Analysis of the GLUT2 Gene in Patients with Fanconi-Bickel Syndrome. Pediatr Res 2000;48:586-589.
40. Santer R, Kinner M, Lassen CL, Schneppenheim R, Eggert P, Bald M, Brodehl J, Daschner M, Ehrich JHH, Kemper M, Li Volti S, Neuhaus T, Skovby F, Swift PGF, Schaub J, Klaerke D: Molecular Analysis of the SGLT2 Gene in Patients with Renal Glucosuria. J Am Soc Nephrol 2003;14:2873-2882.
41. Zhao H, Yakar S, Gavrilova O, Sun H, Zhang Y, Kim H, Setser J, Jou W, LeRoith D: Phloridzin Improves Hyperglycemia But Not Hepatic Insulin Resistance in a Transgenic Mouse Model of Type 2 Diabetes. Diabetes 2004;53:2901-2909.
42. Oku A, Ueta K, Nawano M, Arakawa K, Kano-Ishihara T, Matsumoto M, Saito A, Tsujihara K, Anai M, Asano T: Antidiabetic effect of T-1095, an inhibitor of Na+-glucose cotransporter, in neonatally streptozotocin-treated rats. European Journal of Pharmacology 2000;391:183-192.
43. Navarro-Tableros V, Fiordelisio T, Hernandez-Cruz A, Hiriart M: Physiological development of insulin secretion, calcium channels and GLUT2 expression of pancreatic rat {beta}-cells. Am J Physiol Endocrinol Metab 2006