Distinct polymorphism of DBLα domain of the var gene in laboratory-cultured and clinical field isolates of Plasmodium falciparum malaria parasites

Current Science

Volumn 93, Issue 2, 2007, Pages 219-223

  Ozarkar, Aarti D ^a   Prakash, D ^b   Deobagkar, Dileep N ^a   Deobagkar, Deepti D ^a  

^a UNIVERSITY OF PUNE   (India)

^b NATIONAL CENTRE FOR CELL SCIENCE   (India)

Author keywords

Epidemiology; Malaria parasites; Size polymorphism; Var genes

Indexed keywords

PLASMODIUM FALCIPARUM;

EID: 34548308882     PISSN: 00113891     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Gardner, M. J. et al., Genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 2002, 419, 498-511.
2. Ganguly, N. K., Closing gaps to achieve the millennium development goals: Roles a medical research council can play - The Indian Experience. ICMR Bull., 2004, 34, 61-67.
3. Kirsten, F. and Qijun, C., Var genes, PfEMP1 and the human host. Mol. Biochem. Parasitol., 2004, 134, 3-9.
4. Idro, R., Jenkins, N. E. and Newton, C. R. J. C., Pathogenesis, clinical features and neurological outcome of cerebral malaria. Lancet Neurol., 2005, 4, 827-840.
5. Staalsoe, T., Shulman, C. E., Bulmer, J. N., Kawuondo, K., Marsh, K. and Hviid, L., Variant surface antigen-specific IgG and protection against clinical consequences of pregnancy-associated Plasmodium falciparum malaria. Lancet, 2004, 363, 283-289.
6. Horrocks, P., Pinches, R., Christodoulou, Z., Kyes, S. A. and Newbold, C. I., Variable var transition rates underlie antigenic variation in malaria. Proc. Natl. Acad. Sci. USA, 2004, 101, 11129-11134.
7. Qijun, C., Pettersson, F., Vogt, A. M., Schmidt, B., Ahuja, S., Liljeström, P. and Wahlgren, M., Immunization with PfEMP1-DBL1α generates antibodies that disrupt rosettes and protect against the sequestration of Plasmodium falciparum-infected erythrocytes. Vaccine, 2004, 22, 2701-2712.
8. Wooden, J. S., Kyes, S. and Sibley, C., PCR and strain identification in Plasmodium falciparum. Parasitol. Today, 1993, 9, 303-305.
9. Taylor, H. M., Kyes, S. A. and Newbold, C. I., Var gene diversity in Plasmodium falciparum is generated by frequent recombination events. Mol. Biochem. Parasitol., 2000, 110, 391-397.
10. Fowler, E. V., Peters, J. M., Gatton, M. L., Chen, N. and Cheng, Q., Genetic diversity of the DBLα region in Plasmodium falciparum var genes among Asian-Pacific isolates. Mol. Biochem. Parasitol., 2002, 120, 117-126.
11. Trager, W. and Jensen, J. B., Human malaria parasites in continuous culture. Science, 1976, 193, 673-686.
12. Lambros, C. and Vanderburg, J. P., Synchronization of Plasmodium falciparum erythrocytic stages in culture. J. Parasitol., 1979, 65, 113-139.
13. Arnot, D. E., Roper, C. and Bayoumi, R. A., Digital codes from hypervariable tandemly repeated DNA sequences in Plasmodium falciparum circumsporozoite genes can genetically barcode isolates. Mol. Biochem. Parasitol., 1993, 61, 15-24.
14. Ward, C. P., Clottey, G. T., Dorris, M., Ji, D.-D. and Arnot, D. E., Analysis of Plasmodium falciparum PfEMP-1/var genes suggests that recombination rearranges constrained sequences. Mol. Biochem. Parasitol., 1999, 102, 167-177.
15. Barnwell, J. W., Asch, A. S., Nachman, R. L., Yamaya, M., Aikawa, M. and Ingravallo, P., A human 88-kD membrane glycoprotein (CD36) functions in vitro as a receptor for a cytoadherence ligand on Plasmodium falciparum-infected erythrocytes. J. Clin. Invest., 1989, 84, 765-772.
16. Beeson, J. G. et al., Adhesion of Plasmodium falciparum-infected erythrocytes to hyaluronic acid in placental malaria. Nature Med., 2000, 6, 86-90.
17. Berendt, A. R. et al., Molecular mechanism of sequestration in malaria. Parasitology (Suppl.), 1994, 108, s19-s28.
18. Ockenhouse, C. F. et al., Human vascular endothelial cell adhesion receptors for Plasmodium falciparum-infected erythrocytes: Roles for endothelial leukocyte adhesion molecule 1 and vascular cell adhesion molecule 1. J. Exp. Med., 1992, 176, 1183-1189.
19. Truetiger, C. J., Heddini, A., Fernandez, V., Muller, W. A. and Wahlgren, M., PECAM-1/CD31, an endothelial receptor for binding Plasmodium falciparum-infected erythrocytes. Nature Med., 1997, 3, 1405-1408.
20. Kyes, S., Harding, R., Black, G., Craig, A. G., Peshu, N., Newbold, C. I. and Marsh, K., Limited spatial clustering of individual Plasmodium falciparum alleles in field isolates from coastal Kenya. Am. J. Trop. Med. Hyg., 1997, 57, 202-215.
21. Ikenoue, N., Kuwazu, S., Hatabu, T., Villacorte, E. A., Rivera, P. T. and Kano, S., PCR amplification, sequencing, and comparison of the var/PfEMP-1 gene from the blood of patients with falciparum malaria in Philippines. Southeast Asian J. Trop. Med. Public Health, 2002, 33, 8-13.
22. Kirchgatter, K., Mosbach, R. and delPortillo, H. A., Plasmodium falciparum DBL-1 var sequence analysis in field isolates from Brazil. Exp. Parasitol., 2000, 95, 154-157.
23. Bull, P. C. et al., Plasmodium falciparum variant surface antigen expression patterns during malaria. PLoS Pathogens, 2005, 1, e26.
24. Tami, A., Ord, R., Geoffrey, A. T. and Sutherland, C. J., Sympatric Plasmodium falciparum isolates from Venezuela have structured var gene repertoires. Malaria J., 2003, 2, 1-6.
25. Smith, J. D., Gamain, B., Baruch, D. and Kyes, S., Decoding the language of var genes and Plasmodium falciparum sequestration. Trends Parasitol., 2001, 17, 538-545.