Interaction of human β1 thyroid hormone receptor and its mutants with DNA and retinoid X receptor β T3 response element-dependent dominant negative potency

Journal of Clinical Investigation

Volumn 92, Issue 4, 1993, Pages 1986-1993

  Meier, Christoph A ^a,b   Parkison, Clifford ^c   Chen, Angellee ^c   Ashizawa, Kiyoto ^c   Meier Heusler, Sibylle C ^a,b   Muchmore, Patricia ^a   Cheng, Sheue Yann ^c   Weintraub, Bruce D ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b University Hospital ^*  (Switzerland)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Dominant negative action; Generalized resis tance to thyroid hormone; Retinoid x receptor; T3 response element; Thyroid hormone receptor

Indexed keywords

LIOTHYRONINE; MUTANT PROTEIN; RECEPTOR SUBTYPE; THYROID HORMONE RECEPTOR;

ARTICLE; DNA BINDING; HELA CELL; HORMONE RECEPTOR INTERACTION; HORMONE RESISTANCE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMAL; BASE SEQUENCE; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CLONING, MOLECULAR; COMPARATIVE STUDY; GENETIC VECTORS; HUMAN; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, THYROID HORMONE; RECOMBINANT PROTEINS; RETINOIDS; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSLATION, GENETIC; TRIIODOTHYRONINE;

EID: 0027359451     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116793     Document Type: Article

References (8)

1. Usala, S. J., A. E. Bale, N. Gesundheit, C. Weinberger, R. W. Lash, F. E., Wondisford, O. W. McBride, and B. D. Weintrauh. 1988. Tight linkage between the syndrome of generalized thyroid hormone resistance and the human c-erbA-beta gene. Mol. Endocrinol. 2:1217-1220.
2. Sakurai, A., K. Takeda, K. Ain, P. Ceccarelli, A. Nakai, S. Seino, G. I. Bell, S. Refetoff, and L. J. DeGroot. 1989. Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor-beta. Proc. Natl. Acad. Sci. USA. 86:8977-8981.
3. Usala, S. J., G. E. Tennyson, A. E. Bale, R. W. Lash, N. Gesundheit, F. E. Wondisford, D. Accili, P. Hauser, and B. D. Weintraub. 1990. A base mutation of the c-erbA-beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance.-Molecular heterogeneity in two other kindreds. J. Clin. Invest. 85:93-100.
4. 125I)triiodothyronine to fibroblast nuclei. J. Endocrinol. Invest. 9:459-470.
5. Leid, M., P. Kastner, R. Lyons, H. Nakshatri, M. Saunders, T. Zachartwski, J. Y. Chen, A. Staub, J. M. Garnier, and S. Mader. 1992. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell. 68:377-395.
6. Hallenbeck, P. L., M. S. Marks, R. E. Lippoldt, K. Ozato, and V. M. Nikodem, 1992. Heterodimerization of thyroid hormone (TH) receptor with H-2RIIBP (RXRbeta) enhances DNA binding and TH-dependenl transonptional activation, Proc. Natl Acad Sci. USA. 89:5572-5576.
7. Zhang, X., B. Hoffmann, P. B. V. Tran, G. Graupner, and M. Pfahl, 1992. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (Lond.). 355:441-446.
8. Kliewer, S. A., K. Umesono, D. J. Mangelsdorf, and R. M. Evans. 1992. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling. Nature (Lond.). 355:446-449.