A functional CD86 polymorphism associated with asthma and related allergic disorders

Journal of Medical Genetics

Volumn 44, Issue 8, 2007, Pages 509-515

  Corydon, Thomas Juhl ^a   Haagerup, Annette ^a,b   Jensen, Thomas Gryesten ^a,c   Binderup, Helle Glud ^a   Petersen, Mikkel Steen ^a   Kaltoft, Keld ^a   Vestbo, Jørgen ^d,e   Kruse, Torben Arvid ^f   Børglum, Anders Dupont ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b VIBORG HOSPITAL   (Denmark)

^c JOHN F KENNEDY INSTITUTE   (Denmark)

^d Kommunehospitalet ^*  (Denmark)

^e WYTHENSHAWE HOSPITAL   (United Kingdom)

^f ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; ASTHMA; ATOPIC DERMATITIS; CD86 GENE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; GENE EXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC CODE; GENETIC LINKAGE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MELANOMA CELL; MUTATOR GENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY MECHANISM; RHINITIS; T LYMPHOCYTE ACTIVATION;

AMINO ACID SUBSTITUTION; ANTIGENS, CD; ANTIGENS, CD86; ASTHMA; CELL LINE; CELL LINE, TUMOR; CHROMOSOMES, HUMAN, PAIR 3; CLONING, MOLECULAR; FEMALE; HUMANS; HYPERSENSITIVITY; LINKAGE (GENETICS); MALE; MELANOMA; POLYMORPHISM, GENETIC; SIBLINGS; T-LYMPHOCYTES; VARIATION (GENETICS);

EID: 34548263708     PISSN: 00222593     EISSN: None     Source Type: Journal    
DOI: 10.1136/jmg.2007.049536     Document Type: Article

References (45)

1. Cookson WO, Moffatt MF. Genetics of asthma and allergic disease. Hum Mol Genet 2000;9:2359-64.
2. Mortz CG, Lauritsen JM, Bindslev-Jensen C andersen KE. Prevalence of atopic dermatitis, asthma, allergic rhinitis and hand and contact dermatitis in adolescents. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis. Br J Dermatol 2001;144:523-32.
3. Skadhauge LR, Christensen K, Kyvik KO, Sigsgaard T. Genetic and environmental influence on asthma: a population-based study of 11,688 Danish twin pairs. Eur Respir J 1999;13:8-14.
4. Palmer LJ, Burton PR, James AL, Musk AW, Cookson WO. Familial aggregation and heritability of asthma-associated quantitative traits in a population-based sample of nuclear families. Eur J Hum Genet 2000;8:853-60.
5. Hanson B, McGue M, Roitman-Johnson B, Segal NL, Bouchard TJ Jr, Blumenthal MN. Atopic disease and immunoglobulin E in twins reared apart and together. Am J Hum Genet 1991;48:873-9.
6. Lee YA, Wahn U, Kehrt R, Tarani L, Businco L, Gustafsson D andersson F, Oranje AP, Wolkertstorfer A, v Berg A, Hoffmann U, Kuster W, Wienker T, Ruschendorf F, Reis A. A major susceptibility locus for atopic dermatitis maps to chromosome 3q21. Nat Genet 2000;26:470-3.
7. Haagerup A, Bjerke T, Schiotz PO, Binderup HG, Dahl R, Kruse TA. Asthma and atopy - a total genome scan for susceptibility genes. Allergy 2002;57:680-6.
8. Haagerup A, Borglum AD, Binderup HG, Kruse TA. Fine-scale mapping of type I allergy candidate loci suggests central susceptibility genes on chromosomes 3q, 4q and Xp. Allergy 2004;59:88-94.
9. Kurz T, Altmueller J, Strauch K, Ruschendorf F, Heinzmann A, Moffatt MF, Cookson WO, Inacio F, Nurnberg P, Stassen HH, Deichmann KA. A genome-wide screen on the genetics of atopy in a multiethnic European population reveals a major atopy locus on chromosome 3q21.3. Allergy 2005;60:192-9.
10. Brasch-Andersen C, Haagerup A, Borglum AD, Vestbo J, Kruse TA. Highly significant linkage to chromosome 3q13.31 for rhinitis and related allergic diseases. J Med Genet 2006;43:e10.
11. Roitt I, Brostoff J, Male D. Immunology, 6th ed. London: Mosby, 2001.
12. Chambers CA, Allison JP. Co-stimulation in T cell responses. Curr Opin Immunol 1997;9:396-404.
13. Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med 1996;183:2533-40.
14. Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, Thompson CB, Griesser H, Mak TW. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 1995;270:985-8.
15. Umetsu DT, McIntire JJ, Akbari O, Macaubas C, DeKruyff RH. Asthma: an epidemic of dysregulated immunity. Nat Immunol 2002;3:715-20.
16. Horak E, Murr C, Streif W, Schroecksnadel K, Schennach H, Fuchs D. Association between neopterin in cord blood, urinary neopterin in early childhood and the development of atopic dermatitis, asthma and hay fever. Pediatr Allergy Immunol 2006;17:11-16.
17. Romagnani S. The role of lymphocytes in allergic disease. J Allergy Clin Immunol 2000;105:399-408.
18. Chen YQ, Shi HZ. CD28/OTA-4 - CD80/CD86 and ICOS-B7RP-1 costimulatory pathway in bronchial asthma. Allergy 2006;61:15-26.
19. Elias JA, Lee CG, Zheng T, Ma B, Homer RJ, Zhu Z. New insights into the pathogenesis of asthma. J Clin Invest 2003;111:291-7.
20. Natesan M, Razi-Wolf Z, Reiser H. Costimulation of IL-4 production by murine B7-1 and B7-2 molecules. J Immunol 1996;156:2783-91.
21. Kuchroo VK, Das MP, Brown JA, Ranger AM, Zamvil SS, Sobel RA, Weiner HL, Nabavi N, Glimcher LH. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: application to autoimmune disease therapy. Cell 1995;80:707-18.
22. Jirapongsananuruk O, Hofer MF, Trumble AE, Norris DA, Leung DY. Enhanced expression of B7.2 (CD86) in patients with atopic dermatitis: a potential role in the modulation of IgE synthesis, J Immunol 1998;160:4622-7.
23. Cazzola M, Polosa R. Anti-TNF-alpha and Th1 cytokine-directed therapies for the treatment of asthma. Curr Opin Allergy Clin Immunol 2006;6:43-50.
24. Bashian GG, Braun CM, Huang SK, Kagey-Sobotka A, Lichtenstein LM, Essayan DM. Differential regulation of human, antigen-specific Th1 and Th2 responses by the B-7 homologues, CD80 and CD86. Am J Respir Cell Mol Biol 1997;17:235-42.
25. Jellis CL, Wang SS, Rennert P, Borriello F, Sharpe AH, Green NR, Gray GS. Genomic organization of the gene coding for the costimulatory human B-lymphocyte antigen B7-2 (CD86). Immunogenetics 1995;42:85-9.
26. Vestbo J, Thomas W, the ASTHMAGEN group. Asthma and genes in a Danish population: Outline of an on-going study. Eur Respir Rev 2000;10:396-9.
27. Christensen U, Haagerup A, Binderup HG, Vestbo J, Kruse TA, Borglum AD. Family-based association analysis of the IL2 and IL15 genes in allergic disorders. Eur J Hum Genet 2006;14:227-35.
28. Yan K, Salome C, Woolcock AJ. Rapid method for measurement of bronchial responsiveness. Thorax 1983;38:760-5.
29. Sobel E, Lange K. Descent graphs in pedigree analysis: applications to haplotyping, location scores and marker-snaring statistics. Am J Hum Genet 1996;58:1323-37.
30. Abecasis GR, Cookson WO. GOLD - graphical overview of linkage disequilibrium. Bioinformatics 2000;16:182-3.
31. Spielman RS, Ewens WJ. A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test. Am J Hum Genet 1998;62:450-8.
32. Kaltoft K, Hansen BH, Pedersen CB, Pedersen S, Thestrup-Pedersen K. Common clonal chromosome aberrations in cytokine-dependent continuous human T-lymphocyte cell lines. Cancer Genet Cytogenet 1995;85:68-71.
33. Friedrich U, Houman M, Hansen BH, Kaltoft K. Microdissection and reverse painting in a melanoma cell line: a detailed description of structurally abnormal chromosomes. Cancer Genet Cytogenet 2001;125:5-9.
34. Morgenstern JP, Land H. Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line. Nucleic Acids Res 1990;18:3587-96.
35. Jensen TG, Sullivan DM, Morgan RA, Taichman LB, Nussenblatt RB, Blaese RM, Csaky KG. Retrovirus-mediated gene transfer of ornithine-delta- aminotransferase into keratinocytes from gyrate atrophy patients. Hum Gene Ther 1997;8:2125-32.
36. Corydon TJ, Bross P, Holst HU, Neve S, Kristiansen K, Gregersen N, Bolund L. A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization. Biochem J 1998;331:309-16.
37. Townsend SE, Allison JP. Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells. Science 1993;259:368-70.
38. Chamberlain RS, Carroll MW, Bronte V, Hwu P, Warren S, Yang JC, Nishimura M, Moss B, Rosenberg SA, Restifo NP. Costimulation enhances the active immunotherapy effect of recombinant anticancer vaccines. Cancer Res 1996;56:2832-6.
39. Marti WR, Zajac P, Spagnoli G, Heberer M, Oertli D. Nonreplicating recombinant vaccinia virus encoding human B-7 molecules elicits effective costimulation of naive and memory CD4+ T lymphocytes in vitro. Cell Immunol 1997;179:146-52.
40. Sad S, Marcotte R, Mosmann TR. Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines. Immunity 1995;2:271-9.
41. Muczynski KA anderson SK, Pious D. Discoordinate surface expression of IFN-gamma-induced HLA class II proteins in nonprofessional antigen-presenting cells with absence of DM and class II colocalization. J Immunol 1998;160:3207-16.
42. Stamper CC, Zhang Y, Tobin JF, Erbe DV, Ikemizu S, Davis SJ, Stahl ML, Seehra J, Somers WS, Mosyak L. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature 2001;410:608-11.
43. Mosmann TR, Coffman RL. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 1989;7:145-73.
44. Ip WK, Wong CK, Leung TF, Lam CW. Plasma concentrations of soluble CTLA-4, CD28, CD80 and CD86 costimulatory molecules reflect disease severity of acute asthma in children. Pediatr Pulmonol 2006;41:674-82.
45. Moser M. Regulation of Th1/Th2 development by antigen-presenting cells in vivo. Immunobiology 2001;204:551-7.