Epstein-Barr virus hepatitis: Diagnostic value of in situ hybridization, polymerase chain reaction, and immunohistochemistry on liver biopsy from immunocompetent patients

American Journal of Surgical Pathology

Volumn 31, Issue 9, 2007, Pages 1403-1409

  Suh, Namsoo ^a   Liapis, Helen ^a   Misdraji, Joseph ^c   Brunt, Elizabeth M ^b   Wang, Hanlin L ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Epstein Barr virus hepatitis; Immunohistochemistry; In situ hybridization; Liver biopsy; Polymerase chain reaction

Indexed keywords

ADULT; AGED; ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; EPSTEIN BARR VIRUS; FEMALE; HEPATITIS C; HUMAN; HUMAN TISSUE; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER BIOPSY; LIVER SINUSOID; MALE; POLYMERASE CHAIN REACTION; VIRUS DETECTION;

ADULT; AGED; BIOPSY; DNA, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; FEMALE; HEPATITIS, VIRAL, HUMAN; HERPESVIRUS 4, HUMAN; HUMANS; IMMUNOCOMPETENCE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LIVER; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREDICTIVE VALUE OF TESTS; RNA, VIRAL; UNITED STATES; VIRAL ENVELOPE PROTEINS;

EID: 34548238367     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/PAS.0b013e31802ffdd5     Document Type: Article

References (25)

1. Barkholt L, Reinholt FP, Teramoto N, et al. Polymerase chain reaction and in situ hybridization of Epstein-Barr virus in liver biopsy specimens facilitate the diagnosis of EBV hepatitis after liver transplantation. Transplant Int. 1998;11:336-344.
2. Belhadj K, Reyes F, Farcet JP, et al. Hepatosplenic γδ T-cell lymphoma is a rare clinicopathologic entity with poor outcome: report on a series of 21 patients. Blood. 2003;102:4261-4269.
3. Crum NF. Epstein Barr virus hepatitis: case series and review. South Med J. 2006;99:544-547.
4. Edoute Y, Baruch Y, Lachter J, et al. Severe cholestatic jaundice induced by Epstein-Barr virus infection in the elderly. J Gastroenterol Hepatol. 1998;13:821-824.
5. Farcet JP, Gaulard P, Marolleau JP, et al. Hepatosplenic T-cell lymphoma: sinusal/sinusoidal localization of malignant cells expressing the T-cell receptor gamma delta. Blood. 1990;75:2213-2219.
6. Gershburg E, Pagano JS. Epstein-Barr virus infections: prospects for treatment. J Antimicrob Chemother. 2005;56:277-281.
7. Hinedi TB, Koff RS. Cholestatic hepatitis induced by Epstein-Barr virus infection in an adult. Dig Dis Sci. 2003;48:539-541.
8. Hughes J, Weston S, Bennetts B, et al. The application of a PCR technique for the detection of immunoglobulin heavy chain gene rearrangements in fresh or paraffin-embedded skin tissue. Pathology. 2001;33:222-225.
9. Kimura H, Nagasaka T, Hoshino Y, et al. Severe hepatitis caused by Epstein-Barr virus without infection of hepatocytes. Hum Pathol. 2001;32:757-762.
10. Kojima K, Nagayama R, Hirama S, et al. Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly. J Gastroenterol. 1999;34:706-712.
11. Lones MA, Shintaku IP, Weiss LM, et al. Posttransplant lymphoproliferative disorder in liver allograft biopsies: a comparison of three methods for the demonstration of Epstein-Barr virus. Hum Pathol. 1997;28:533-539.
12. Markin RS. Manifestations of Epstein-Barr virus-associated disorders in liver. Liver. 1994;14:1-13.
13. Mendez-Sanchez N, Aguilar-Dominguez C, Chavez-Tapia NC, et al. Hepatic manifestations of Epstein-Barr viral infection. Ann Hepatol. 2005;4:205-209.
14. Nobili V, Comparcola D, Sartorelli MR, et al. Autoimmune hepatitis type 1 after Epstein-Barr virus infection. Pediatr Infect Dis J. 2003;22:387.
15. Palanduz A, Yildirmak Y, Telhan L, et al. Fulminant hepatic failure and autoimmune hemolytic anemia associated with Epstein-Barr virus infection. J Infect. 2002;45:96-98.
16. Papatheodoridis GV, Delladetsima JK, Kavallierou L, et al. Fulminant hepatitis due to Epstein-Barr virus infection. J Hepatol. 1995;23:348-350.
17. Rogers BB, Conlin C, Timmons CF, et al. Epstein-Barr virus PCR correlated with viral histology and serology in pediatric liver transplant patients. Pediatr Pathol Lab Med. 1997;17:391-400.
18. Sevilla J, del Carmen Escudero M, Jimenez R, et al. Severe systemic autoimmune disease associated with Epstein-Barr virus infection. J Pediatr Hematol Oncol. 2004;26:831-833.
19. Shaukat A, Tsai HT, Rutherford R, et al. Epstein-Barr virus induced hepatitis: an important cause of cholestasis. Hepatol Res. 2005;33:24-26.
20. Thompson MP, Kurzrock R. Epstein-Barr virus and cancer. Clin Cancer Res. 2004;10:803-821.
21. Vento S, Cainelli F. Is there a role for viruses in triggering autoimmune hepatitis? Autoimmun Rev. 2004;3:61-69.
22. Vento S, Guella L, Mirandola F, et al. Epstein-Barr virus as a trigger for autoimmune hepatitis in susceptible individuals. Lancet. 1995;346:608-609.
23. Wagner HJ, Bein G, Bitsch A, et al. Detection and quantification of latently infected B lymphocytes in Epstein-Barr virus-seropositive, healthy individuals by polymerase chain reaction. J Clin Microbiol. 1992;30:2826-2829.
24. Williams H, Crawford DH. Epstein-Barr virus: the impact of scientific advances on clinical practice. Blood. 2006;107:862-869.
25. Young LS, Rickinson AB. Epstein-Barr virus: 40 years on. Nat Rev Cancer. 2004;4:757-768.