Posttransplant lymphoproliferative disorder in liver allograft biopsies: A comparison of three methods for the demonstration of Epstein-Barr virus

Human Pathology

Volumn 28, Issue 5, 1997, Pages 533-539

  Lones, Mark A ^b   Shintaku, I Peter ^b   Weiss, Lawrence M ^b   Thung, Swan N ^b   Nichols, W S ^b   Geller, Stephen A ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b NONE

Author keywords

EBER; Epstein Barr virus; latent membrane protein; liver allograft; posttransplant lymphoproliferative disorder

Indexed keywords

MEMBRANE PROTEIN; VIRUS CAPSID ANTIGEN; VIRUS PROTEIN; VIRUS RNA;

ARTICLE; CLINICAL ARTICLE; EPSTEIN BARR VIRUS; GRAFT FAILURE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFECTIOUS COMPLICATION; INTERMETHOD COMPARISON; LIVER BIOPSY; LIVER TRANSPLANTATION; LYMPHOPROLIFERATIVE DISEASE; POLYMERASE CHAIN REACTION; VIRUS DETECTION;

EID: 0031007049     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0046-8177(97)90074-5     Document Type: Article

References (39)

1. Snover DC: Liver transplantation, in Sale G (ed): The Pathology of Organ Transplantation. Boston, Butterworth, 1990, pp 103-132
2. Williams JW, Foster PF, Sankary HN: Role of liver allograft biopsy in patient management. Semin Liver Dis 12:60-72, 1992
3. Snover DC, Sibley RK, Freese OK, et al: Orthotopic liver transplantation: A pathological study of 63 serial liver biopsies from 17 patients with special reference to the diagnostic features and natural history of rejection. Hepatology 4:1212-1222, 1984
4. Snover DC: Problems in the interpretation of liver biopsies after liver transplantation. Am J Surg Pathol 13 :31-38, 1989 (suppl 1)
5. Demetris AJ, Qian SG, Sun H, et al: Liver allograft rejection: An overview of morphologic findings. Am J Surg Pathol 14:49-63, 1990 (suppl 1)
6. Randhawa PS, Markin RS, Starzl TE , et al: Epstein-Barr virus-associated syndromes in immunosuppressed liver transplant recipients: Clinical profile and recognition on routine allograft biopsy. Am J Surg Pathol 14:538-547, 1990
7. Markin RS, Wood RP, Shaw BW, et al: Immunohistologic identification of Epstein-Barr virus-induced hepatitis reactivation after OKT-3 therapy following orthotopic liver transplant. Am J Gastroenterol 85:1014-1018, 1990
8. Telenti A, Smith TF, Ludwig J, et al: Epstein-Barr virus and persistent graft dysfunction after liver transplantation. Hepatology 14:282-286, 1991
9. Howard TK, Klintmalm GBG, Stone MJ. et al: Lymphoproliferative disorder masquerading as rejection in liver transplant recipients - an early aggressive tumor with atypical presentation. Transplantation 53:1145-1147, 1992
10. Schmid M, Pirovino M, Altorfer J, et al: Acute hepatitis non-A, non-B: Are there any specific light microscopic features? Liver 2:61-67, 1982
11. Lefkowitch JH, Apfelbaum TF: Non-A, non-B hepatitis: Characterization of liver biopsy pathology. J Clin Gastroenterol 11:225-232, 1989
12. Scheuer PJ, Ashrafzadeh P, Sherlock S, et al: The pathology of hepatitis C. Hepatology 15:567-571, 1992
13. Bach N, Thung SN, Schaffner F: The histological features of chronic hepatitis C and autoimmune chronic hepatitis: A comparative analysis. Hepatology 15:572-577, 1992
14. Wright TL, Donegan E, Hsu HH, et al: Recurrent and acquired hepatitis C viral infection in liver transplant recipients. Gastroenterology 103:317-322, 1992
15. Petrovic LM, Villamil FG, Podesta LG, et al: Histopathologic analysis of recurrent hepatitis C following liver transplantation. Hepatology 18:71A, 1993
16. Mor E, Solomon H, Gibbs JF, et al: Acute cellular rejection following liver transplantation: Clinical pathologic features and effect on outcome. Semin Liver Dis 12:28-40,1992
17. Starzl TE, Nalesnik MA, Porter KA, et al: Reversibility of lymphomas and lymphoproliferative lesions developing under cyclosporine-steroid therapy. Lancet 1:583-587, 1984
18. Nalesnik MA, Jaffe R, Starzl TE, et al: The pathology of post transplant lymphoproliferative disorders occurring in the setting of cyclosporine A-prednisone immunosuppression. Am J Pathol 133:173-192, 1988
19. Locker J, Nalesnik M: Molecular genetic analysis of lymphoid tumors arising after organ transplantation. Am J Pathol 135:977-987, 1989
20. Seiden MV, Sklar J: Molecular genetic analysis of post-transplant lymphoproliferative disorders. Hematol Oncol Clin North Am 7:447-465, 1993
21. Alshak N, Jiminez AM, Gedebou M, et al: Epstein-Barr virus infection in liver transplantation patients: Correlation of histopathology and semiquantitative Epstein-Barr virus-DNA recovery using polymerase chain reaction. HUM PATHOL 24:1306-1312, 1993
22. Higuchi R: Rapid, efficient DNA extraction for PCR from cells or blood. Amplifications: A forum for PCR users. Perkin-Elmer Cetus Newsletter, May 2, 1989
23. Innis MA, Gelfand DH: Optimization of PCRs, in Innis MA, Gelfand DH, Sninsky JJ, et al (eds): PCR Protocols: A Guide to Methods and Applications. New York, Academic, 1990, pp 3-12
24. Telenti A, Marshall WF, Smith TF: Detection of Epstein-Barr virus by polymerase chain reaction. J Clin Microbiol 28:2187-2190, 1990
25. Miller G, Lipman M: Release of infectious Epstein-Barr virus by transformed Marmocet leukocytes. Proc Natl Acad Sci U S A 70:190-194, 1973
26. Chang KL, Chen YY, Shibata D, et al: Description of an in situ hybridization methodology for detection of Epstein-Barr virus RNA in paraffin-embedded tissues, with a survey of normal and neoplastic tissues. Diagn Mol Pathol 1:246-255, 1992
27. Howe JG, Steit JA: Localization of Epstein-Barr virus-encoded small RNA's by in situ hybridization. Proc Natl Acad Sci U S A 83:9006-9010, 1986
28. Rooney C, Howe JG, Speck SH, et al: Influences of Burkitt's lymphoma and primary B cells on latent gene expression by the non immortalizing P3J-HR-1 strain of Epstein-Barr virus. J Virol 63:1531-1539, 1989
29. Weiss LM, Mohaved LA, Chen YY, et al: Detection of immunoglobulin light-chain mRNA in lymphoid tissues using a practical in situ hybridization method. Am J Pathol 137:979-988, 1990
30. Weiss LM, Chen YY, Liu XF, et al: Epstein-Barr virus and Hodgkin's disease: a correlative in situ hybridization and polymerase chain reaction study. Am J Pathol 139:1259-1265, 1991
31. Weiss LM, Chen YY: Effect of different fixatives on the detection of nucleic acids from paraffin-embedded tissues by in situ hybridization using oligonucleotide probes. J Histochem Cytochem 39: 1237-1242, 1991
32. Pinkus GS, Lones MA, Shintaku IP, et al: Immunohistochemical detection of Epstein-Barr virus encoded latent membrane protein in Reed-Sternberg cells and variants of Hodgkin's Disease. Mod Pathol 7:454-461, 1994
33. Montone KT, Friedman H, Hodinka RL, et al: In situ hybridization for Epstein-Barr virus NotI repeats in post transplant lymphoproliferative disorder. Mod Pathol 5:292-302, 1992
34. Randhawa PS, Jaffe R, Demetris AJ, et al: Expression of Epstein-Barr virus-encoded small RNA (by the EBER-1 gene) in liver specimens from transplant recipients with post-transplantation lymphoproliferative disease. N EnglJ Med 327:1710-1714, 1992
35. Lones MA, Mishalani S, Shintaku IP, et al: Changes in tonsils and adenoids in children with post-transplant lymphoproliferative disorder: Report of three cases with early involvement of Waldeyer's ring. HUM PATHOL 26:525-530, 1995
36. Ritter JH, Wick MR: Post-transplant lymphoproliferative disorders versus severe rejection: The importance of CD20, CD43, and Epstein-Barr virus latent membrane protein. Mod Pathol 7:119A, 1994
37. Poterucha JJ, Rakela J, Lumeng L, et al: Diagnosis of chronic hepatitis C after liver transplantation by the detection of viral sequences with polymerase chain reaction. Hepatology 15:42-45, 1992
38. Penn I: The changing pattern of post transplant malignancies. Transplant Proc 23:1101-1103, 1991
39. Renard TH, Andrews WS, Foster ME: Relationship between OKT3 administration, EBV seroconversion, and the lymphoproliferative syndrome in pediatric liver transplant recipients. Transplant Proc 23:1473-1476, 1991