Is there a role for viruses in triggering autoimmune hepatitis?

Autoimmunity Reviews

Volumn 3, Issue 1, 2004, Pages 61-69

  Vento, Sandro ^a,c   Cainelli, Francesca ^b  

^a UNIVERSITY OF VERONA   (Italy)

^b Specialist in Infectious Diseases   (Italy)

^c NONE   (Italy)

Author keywords

Autoimmune hepatitis; Epstein Barr virus; Hepatitis A virus; Measles virus; Suppressor T lymphocytes

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; BACTERIAL ANTIGEN; CYTOCHROME P450 2D6; IMMUNOSUPPRESSIVE AGENT;

AUTOIMMUNE HEPATITIS; CLINICAL FEATURE; CYTOMEGALOVIRUS; DISEASE PREDISPOSITION; EPSTEIN BARR VIRUS; GENETIC PREDISPOSITION; HEPATITIS A VIRUS; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HEPATITIS G VIRUS; HERPES SIMPLEX VIRUS 1; HUMAN; HUMAN T CELL LEUKEMIA VIRUS 1; HUMAN T CELL LEUKEMIA VIRUS 2; IMMUNE DEFICIENCY; IMMUNOPATHOGENESIS; IMMUNOSUPPRESSIVE TREATMENT; LIVER INJURY; MEASLES VIRUS; MOLECULAR MIMICRY; NONHUMAN; PATHOGENESIS; REVIEW; SALMONELLA TYPHIMURIUM; TREATMENT OUTCOME; VIRUS INDUCTION; VIRUS INFECTION;

EID: 1042302181     PISSN: 15689972     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1568-9972(03)00053-3     Document Type: Review

References (39)

1. Vento S., Eddleston A. Autoimmunity and liver diseases. Popper H., Schaffner F. Progress in liver diseases, vol. IX. 1990;335-343 WB Saunders, Philadelphia.
2. O'Brien C.J., Vento S., Donaldson P.T., et al. Cell-mediated immunity and suppressor T cell defects to liver-derived antigens in families of patients with autoimmune chronic active hepatitis. Lancet. 1:1986;350-353.
3. Montano L., Aranguibel F., Boffill M., Goodall A.H., Janossy G., Thomas H.C. An analysis of the composition of the inflammatory infiltrate in autoimmune and HBV-induced chronic liver disease. Hepatology. 3:1983;292-297.
4. Mizuno M., Brown W.R., Vierling J.M. Ultrastructural immunocytochemical localization of the asialoglycoprotein receptor in rat hepatocytes. Gastroenterology. 87:1984;763-769.
5. Vento S., O'Brien C.J., McFarlane I.G., Williams R., Eddleston A.L.W.F. T-cell inducers of suppressor lymphocytes control liver-directed autoreactivity. Lancet. 1:1987;886-888.
6. Christie K.E., Haukenes G. Measles virus-specific IgM antibodies in sera from patients with chronic active hepatitis. J Med Virol. 12:1983;267-272.
7. Robertson D.A.F., Zhang S.L., Guy E.C., Wright R. Persistent measles virus genome in autoimmune chronic active hepatitis. Lancet. 2:1987;9-11.
8. Mieli-Vergani G., Sutherland S., Mowat A.P. Measles and autoimmune chronic active hepatitis. Lancet. 2:1989;688.
9. Vento S., Cainelli F., Ferraro T., Concia E. Autoimmune hepatitis type 1 after measles. Am J Gastroenterol. 91:1996;2618-2619.
10. Vento S., Garofano T., Di Perri G., Dolci L., Concia E., Bassetti D. Identification of hepatitis A virus as a trigger for autoimmune chronic hepatitis type 1 in susceptible individuals. Lancet. 337:1991;1183-1187.
11. Vento S., McFarlane B.M., McSorley C.G., et al. Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. J Clin Lab Immunol. 25:1988;1-7.
12. Vallbracht A., Maier K., Stierhof Y.D., Wiedmann K.H., Flehmig B., Fleischer B. Liver-derived cytotoxic T cells in hepatitis A virus infection. J Infect Dis. 160:1989;209-217.
13. Rahaman S.M., Chira P., Koff R.S. Idiopathic autoimmune chronic hepatitis triggered by hepatitis A. Am J Gastroenterol. 89:1994;106-108.
14. Huppertz H.I., Treichel U., Gassel A.M., Jeschke R., Meyer zum Buschenfelde K.H. Autoimmune hepatitis following hepatitis A virus infection. J Hepatol. 23:1995;204-208.
15. Tong M.J., El-Farra N.S., Grew M.I. Clinical manifestations of hepatitis A: recent experience in a community teaching hospital. J Infect Dis. 171:1995;S15-S18.
16. Hilzenrat N., Zilberman D., Klein T., Zur B., Sikuler E. Autoimmune hepatitis in a genetically susceptible patient. Is it triggered by acute viral hepatitis A? Dig Dis Sci. 44:1999;1950-1952.
17. Ramonet M.D., Gomez S., Morise S., et al. Acute hepatitis A virus (HAV). Association with fulminant hepatic failure (FHF) and autoimmune hepatitis (AIH) in pediatric population. J Pediatr Gastroenterol Nutr. 31:(suppl 2):2000;s116-s117.
18. Teixeira M.R. Jr., Weller I.V., Murray A., et al. The pathology of hepatitis A in man. Liver. 2:1982;53-60.
19. Sciot R., Van den Oord J.J., De Wolf-Peeters C., Desmet V.J. In situ characterisation of the (peri)portal inflammatory infiltrate in acute hepatitis A. Liver. 6:1986;331-336.
20. Fainboim L., Canero Velasco M.C., Marcos C.Y., et al. Protracted, but not acute, hepatitis A virus infection is strongly associated with HLA-DRB1*1301, a marker for pediatric autoimmune hepatitis. Hepatology. 33:2001;1512-1517.
21. Vento S., Guella L., Mirandola F., et al. Epstein-Barr virus as a trigger for autoimmune hepatitis in susceptible individuals. Lancet. 346:1995;608-609.
22. Aceti A., Mura M.S., Babudieri S., Bacciu S.A. A young woman with hepatitis after a sore throat. Lancet. 346:1995;1603.
23. Kojima K., Nagayama R., Hirama S., et al. Epstein-Barr virus infection resembling autoimmune hepatitis with lactate dehydrogenase and alkaline phosphatase anomaly. J Gastroenterol. 34:1999;706-712.
24. Nobili V., Comparcola D., Sartorelli M.R., Devito R., Marcellini M. Autoimmune hepatitis type 1 after Epstein-Barr virus infection. Pediatr Infect Dis J. 22:2003;387.
25. Manns M.P., Griffin K.J., Sullivan K.F., Johnson E.F. LKM-1 autoantibodies recognize a short linear sequence in P450IID6, a cytochrome P-450 monooxygenase. J Clin Invest. 88:1991;1370-1378.
26. Klein R., Zanger U.M., Berg T., Hopf U., Berg P.A. Overlapping but distinct specificities of anti-liver-kidney microsome antibodies in autoimmune hepatitis type II and hepatitis C revealed by recombinant native CYP2D6 and novel peptide epitopes. Clin Exp Immunol. 118:1999;290-297.
27. Kerkar N., Mahmoud A., Muratori L., et al. New viral triggers of autoreactivity to cytochrome P4502D6, the target of liver kidney microsomal autoantibody. J Hepatol. 30:(suppl 1):1999;58.
28. Gueguen M., Boniface O., Bernard O., Clerc F., Cartwright T., Alvarez F. Identification of the main epitope on human cytochrome P450 IID6 recognized by anti-liver kidney microsome antibody. J Autoimmun. 4:1991;607-615.
29. Lenzi M., Ballardini G., Fusconi M., et al. Type 2 autoimmune hepatitis and hepatitis C virus infection. Lancet. 335:1990;258-259.
30. Manns M., Koletzko S., Lohr H., et al. Discordant manifestation of LKM-1 antibody positive autoimmune hepatitis in identical twins. Hepatology. 12:1990;840.
31. Dalekos G.N., Wedemeyer H., Obermayer-Straub P., et al. Epitope mapping of cytochrome P4502D6 autoantigen in patients with chronic hepatitis C during α interferon treatment. J Hepatol. 30:1999;366-375.
32. Gregorio G.V., Bracken P., Mieli-Vergani G., Vergani D. Prevalence of antibodies to hepatitis C and herpes simplex virus type 1 is not increased in children with liver kidney microsomal type 1 autoimmune hepatitis. J Pediatr Gastroenterol Nutr. 23:1996;534-537.
33. Vento S., Cainelli F., Renzini C., Concia E. Autoimmune hepatitis type 2 induced by HCV and persisting after viral clearance. Lancet. 350:1997;1298-1299.
34. Laskus T., Slusarczyk J. Autoimmune chronic active hepatitis developing after acute type B hepatitis. Dig Dis Sci. 34:1989;1294-1297.
35. Becheur H., Valla D., Loriot M.A., Attar A., Bloch F., Petite J.P. Concurrent emergence of hepatitis B e antigen-negative hepatitis B virus variant and autoimmune hepatitis cured by adenine arabinoside monophosphate. Dig Dis Sci. 43:1998;2479-2482.
36. Nishiguchi S., Enomoto M., Shiomi S., et al. GB virus C and TT virus infections in Japanese patients with autoimmune hepatitis. J Med Virol. 66:2002;258-262.
37. Tribl B., Schoniger-Hekele M., Petermann D., Bakos S., Penner E., Muller C. Prevalence of GBV-C/HGV-RNA, virus genotypes, and anti-E2 antibodies in autoimmune hepatitis. Am J Gastroenterol. 94:1999;3336-3340.
38. Heringlake S., Tillmann H.L., Cordes-Temme P., Trautwein C., Hunsmann G., Manns M.P. GBV-C/HGV is not the major cause of autoimmune hepatitis. J Hepatol. 25:1996;980-984.
39. Shibata M., Wang R.Y.H., Yoshiba M., Shih J.W.K., Alter H.J., Mitamura K. The presence of a newly identified infectious agent (SEN virus) in patients with liver diseases and in blood donors in Japan. J Infect Dis. 184:2001;400-404.