Syncytin and cancer cell fusions

TheScientificWorldJournal

Volumn 7, Issue , 2007, Pages 1193-1197

  Larsson, Lars Inge ^a   Bjerregaard, Bolette ^a   Wulf Andersen, Linda ^a   Talts, Jan Fredrik ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BREAST CANCER; CANCER CELL; CARCINOGENICITY; CELL FUSION; CELL INTERACTION; ENDOTHELIUM CELL; GENE; GENE EXPRESSION; GENETIC CODE; HUMAN; IN SITU HYBRIDIZATION; NONHUMAN; SYNCYTIN 1 GENE;

ANIMALS; BREAST NEOPLASMS; CATTLE; CELL FUSION; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE PRODUCTS, ENV; HUMANS; PREGNANCY PROTEINS;

EID: 34548228595     PISSN: None     EISSN: 1537744X     Source Type: Journal    
DOI: 10.1100/tsw.2007.212     Document Type: Article

References (26)

1. Ogle, B.M., Cascalho, M., and Platt, J.F. (2005) Biological implications of cell fusion. Nature Reviews Mol. Cell Biol. 6, 567-575.
2. Duelli, D., and Lazebnik, Y. (2003) Cell fusion: a hidden enemy? Cancer Cell 3, 445-448.
3. Mortensen, K., Lichtenberg, J., Thomsen, P.D., and Larsson, L.-I. (2004) Spontaneous fusion between cancer cells and endothelial cells. Cell. Mol. Life Sci. 61, 2125-2131.
4. Pawelek, J.M. (2005) Tumour-cell fusion as a source of myeloid traits in cancer. Lancet Oncology 6, 988-993.
5. Goldenberg, D.M., Pavia, R.A., and Tsao, M.C. (1974) In vivo hybridisation of human tumor and normal hamster cells. Nature 250, 649-651.
6. Harris, H., Miller, O.J., Klein, G., Worst, P., and Tachibana, T. (1969) Suppression of malignancy by cell fusion. Nature 223, 363-368.
7. Wiener, F., Klein, G., and Harris, H. (1974) The analysis of malignancy by cell fusion. V. Further evidence of the ability of normal diploid cells to suppress malignancy. J. Cell Sci. 15, 177-183.
8. Stanbridge, E.J. (1976) Suppression of malignancy in human cells. Nature 260, 17-20.
9. Kohler, G. and Milstein, C. (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256, 495-497.
10. Larizza, L., Schirrmacher, V., Graf, L., Pfluger, E., Peres-Martinez, M., and Stohr, M. (1984) Suggestive evidence that the highly metastatic variant ESb of the T-cell lymphoma Eb is derived from spontaneous fusion with a host macrophage. Int. J. Cancer 34, 699-702.
11. Munzarova, M., Lauerova, L., and Capkova, J. (1992) Are advanced malignant melanoma cells hybrids between melanocytes and macrophages? Melanoma Res. 2, 127-129.
12. Duelli, D.M., Hearn, S., Myers, M.P., and Lazebnik, Y. (2005) A primate virus generates transformed human cells by fusion. J. Cell Biol. 171, 493-503.
13. Bjerregaard, B., Holck, S., Christensen, I. J., and Larsson, L.-I. (2006) Syncytin is involved in breast cancer-endothelial cell fusions. Cell. Mol. Life Sci. 63, 1906-1911.
14. Mallet, F., Bouton, O., Prudhomme, S., Cheynet, V., Oriol, G., Bonnaud, B., Lucotte, G., Duret, L., Mandrand, B. (2004) The endogenous retroviral locus ERVWE1 is a bona fide gene involved in hominoid placental physiology. Proc. Natl. Acad. USA 101, 1731-1736.
15. Blond J. L., Lavillette D., Cheynet V., Bouton O., Oriol G., Chapel-Fernandes, S. Mandrand, B., Mallet, F., and Cosset, F.L. (2000) An envelope glycoprotein of the human endogenous retrovirus HERV-W is expressed in the human placenta and fuses cells expressing the type D mammalian retrovirus receptor. J. Virol. 74, 3321-3329.
16. Mi, S., Lee, X., Li, X., Veldman, G.M., Finnerty, H., Racie, L., LaVallie, E., Tang, X.Y., Edouard, P., Howes, S., Keith Jr,, J.C., and McCoy, J.M.(2000) Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 403, 785-789.
17. Lavillette, D., Marin, M., Ruggieri, A., Mallet, F., Cosset, F.L., and Kabat, D. (2000) The envelope glycoprotein of human endogenous retrovirus type W uses a divergent family of amino acid transporters/cell surface receptors. J. Virol. 76, 6442-6452.
18. Antony, J.M., van Marle, G., Opii, W., Butterfield, D.A., Mallet, F., Yong, V.W. Wallace, J.L., Deacon, R.M., Warren, K., and Power, C. (2004) Human endogenous retrovirus glycoprotein-mediated induction of redox reactants causes oligodendrocyte death and demyelination. Nature Neurosci. 7, 1088-1095.
19. Strick, R., Ackermann, S., Langbein, M., Swiatek, J., Schubert, S.W., Hashemolhosseini, S., Koscheck, T., Fasching, P.A., Schild, R.L., Beckmann, M.W., and Strissel, P.L. (2007) Proliferation and cell-cell fusion of endometrial carcinoma are induced by the human endogenous retroviral syncytin-1 and regulated by TGF-beta. J. Mol. Med. 85, 23-38.
20. Blaise, S., de Parseval, N., Benit, L., and Heidmann, T. (2003) Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution. Proc. Natl. Acad. Sci. USA 100, 13013-13018.
21. Dupressoir, A., Marceau, G., Vermochet, C., Benit, L., Kanellopoulos, C., Sapin, V., and Heidmann, T. (2005) Syncytin- A and syncytin-B, two fusogenic placenta-specific murine envelope gtenes of retroviral origin conserved in Muridae. Proc. Natl. Acad. Sci. USA 102: 725-730.
22. Larsson, L.-I., Holck, S., and Christensen, I.J. (2007) Prognostic role of syncytin expression in breast cancer. Human Pathol. 38, 726-731.
23. Chen, C.P., Wang, K.G., Chen, C.Y., Yu, C., Chuang, H.C., and Chen, H. (2006) Altered placental syncytin and its receptor ASCT2 expression in placental development and pre-eclampsia. BJOG 113: 152-158.
24. Mortensen, K., Holck, S., Christensen, I.J., Skouv, J., Hougaard, D.M., Blom, J., and Larsson, L.I. (1999) Endothelial cell nitric oxide synthase expression in peritumoral microvessels is a favourable prognostic indicator in breast cancer Clin. Cancer Res. 5, 1093-1097.
25. Mortensen, K., Christensen, I.B., Nielsen, H.J., Hansen, U., and Larsson, L.-I. (2004) A high frequency of peritumoral microvessels expressing endothelial cell nitric oxide synthase is a favorable prognostic factor in cancer of the colon. Cancer Lett. 216, 109-114.
26. Qiu, H., Orr, F.W., Jensen, D., Wang, H.H., McIntosh, A.R., Hasinoff, B.B., Nance, D.M., Polypas, S., Qi, K., Song, C., Muschel, R.J., and Al-Mehdi, A.B. (2003) Arrest of B16 melanoma cells in the mouse pulmonary microcirculation induces endothelial nitric oxide synthase-dependent nitric oxide release that is cytotoxic to the tumor cells. Am. J. Pathol. 162, 403-412.