Endothelial cell nitric oxide synthase in peritumoral microvessels is a favorable prognostic indicator in premenopausal breast cancer patients

Clinical Cancer Research

Volumn 5, Issue 5, 1999, Pages 1093-1097

  Mortensen, Kirsten ^a,b   Holck, Susanne ^c   Christensen, Ib Jarle ^d   Skouv, Jan ^e   Hougaard, David M ^a   Blom, Jens ^a   Larsson, Lars Inge ^a,b  

^a STATENS SERUM INSTITUT   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c HILLERØD HOSPITAL   (Denmark)

^d FINSEN LABORATORY   (Denmark)

^e Exiqon AS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE SYNTHASE;

ARTICLE; BREAST CANCER; CANCER INVASION; CANCER RECURRENCE; CANCER SURVIVAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; PRIORITY JOURNAL; PROGNOSIS;

ADULT; BREAST NEOPLASMS; CAPILLARIES; CARCINOMA, DUCTAL, BREAST; DISEASE-FREE SURVIVAL; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; ISOENZYMES; LIFE TABLES; LYMPHATIC METASTASIS; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PREMENOPAUSE; PROGNOSIS; RANDOM ALLOCATION; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 0032900871     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other diseases. Nat. Med., 1: 27-31, 1995.
2. Nicolson, G. L. Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metastasis Rev., 7: 143-148, 1989.
3. Kong, L. P., Dunn, G. D., Keefer, L. K., and Korthuis, R. J. Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules. Clin. Exp. Metastasis, 14: 335-343, 1996.
4. Ziche, M., Morbidelli, L., Choudhuri, R., Zhang, H-T., Donnini, S., and Granger, H. J. Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Invest., 99: 2625-2634, 1997.
5. Li, L., Kilbourn, R. G., Adams, J., and Fidler, I. J. Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res., 51: 2531-2535, 1991.
6. Moncada, S., and Higgs, A. The L-arginine-nitric oxide pathway. N. Engl. J Med., 329: 2002-2012, 1993.
7. Moncada, S., Palmer, R. M. J., and Higgs, E. A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43: 109-142, 1991.
8. Umansky, V., Bucur, M., Schirrmacher, V., and Rocha, M. Activated endothelial cells induce apoptosis in lymphoma cells: role of nitric oxide. Int. J. Oncol., 10: 465-471, 1997.
9. Ambs, S., Hussain, S. P., and Harris, C. C. Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression. FASEB J., 11: 443-448, 1997.
10. Ho, Y-S., Wang, Y-J., and Lin, J-K. Induction of p53 and p21/ WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells. Mol. Carcinogenesis, 16: 20-31, 1996.
11. Messmer, U. K., Ankarcrona, M., Nicotera, P., and Brune, B. p53 expression in nitric oxide-induced apoptosis. FEBS Lett., 355: 23-26, 1994.
12. Sandoval, M., Liu, X., Oliver, P. D., Zhang, X-J., Clark, D. A., and Miller, M. J. S. Nitric oxide induces apoptosis in a human colonic epithelial cell line T84. Mediators Inflammation, 4: 248-250, 1995.
13. Mannick, J. B., Asano, K., Izumi, K., Kieff, E., and Stamler, J. S. Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell, 79: 1137-1146, 1994.
14. Pennova, N., Kuzin, B., Robers, I., O'Kane, C., and Enikolopov, G. Nitric oxide, cell multiplication and cell survival. Cold Spring Harbor Symp. Quant. Biol., 61: 417-426, 1996.
15. Polte, T., Oberle, S., and Schröder, H. Nitric oxide protects endothelial cells from tumor necrosis factor-α-mediated cytotoxicity: possible involvement of cyclic GMP. FEBS Lett., 409: 46-48, 1997.
16. Inoue, W., Venema, R. C., Sayegh, H. S., Ohara, Y., Murphy, I. J., and Harrison, D. G. Molecular regulation of the bovine endothelial cell nitric oxide synthase by transforming growth factor β1. Arterioscler. Thromb. Vasc. Biol., 15: 1255-1261, 1995.
17. Farhat, M. Y., Larigne, M. C., and Ramwell, P. W. The vascular protective effects of estrogen. FASEB J., 10: 615-624, 1996.
18. Uematzu, M., Ohara, Y., Naras, J. P., Nishida, K., Murphy, T. J., Alexander, R. W., Nerem, R. M., and Harrison, D. G. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am. J. Physiol., 269: C1371-C1378, 1995.
19. Larsson, L-I. Immunocytochemistry. Theory and Practice. Boca Raton, FL: CRC Press Inc., 1988.
20. Fox, S. B., Leek, R. D., Weekes, M. P., Whitehouse, R. M., Gatter, K. C., and Harris, A. L. Quantitation and prognostic value of breast cancer angiogenesis. Comparison of microvessel density, Chalkley count and computer image analysis. J. Pathol., 177: 275-283, 1995.
21. Weidner, N., Semple, J. P., Welch, W. R., and Folkman, J. Tumour angiogenesis and metastasis: correlation in invasive breast carcinoma. N. Engl. J. Med., 324: 1-8, 1991.
22. Andersen, K. W., and Mouridsen, H. T. Danish Breast Cancer Cooperative Group (DBCG). A description of the register of the nation-wide programme for primary breast cancer. Acta Oncol., 27: 627-647, 1988.
23. Elston, C. W., and Ellis, I. O. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up. Histopathology, 19: 403-410, 1991.
24. Tschugguel, W., Knogler, W., Czerwenkz, K., Mildner, M., Weninger, W., Zeillinger, R., and Huber, J. C. Presence of endothelial calcium-dependent nitric oxide synthase in breast apocrine metaplasia. Br. J. Cancer, 74: 1423-1426, 1996.
25. Zeillinger, R., Tantscher, E., Schneeberger, C., Tschuggued, W., Eder, S., Sliutz, G., and Huber, J. C. Simultaneous expression of nitric oxide synthase and estrogen receptor in human breast cancer cell lines. Breast Cancer Res. Treat., 40: 205-207, 1996.
26. Wong, X. L., Sim, A. S., Badenkop, R. F., McCredie, R. M., and Wilken, D. E. L. A smoking-dependent risk of coronary artery disease associated with a polymorphism of the endothelial nitric oxide synthase gene. Nat. Med., 2: 41-45, 1996.
27. Ohhashi, T., and Yokoyama, S. Nitric oxide and the lymphatic system. Jpn. J. Physiol., 44: 727-342, 1994.
28. Marchetti, C., Casasco, A., DiNucci, A., Reguzzoni, M., Rosso, S., Piovella, F., Calligaro, A., and Polak, J. M. Endothelin and nitric oxide synthase in lymphatic endothelial cells: immunolocalization in vivo and in vitro. Anat. Rec., 248: 490-497, 1997.