Differential contribution of sodium channel subtypes to action potential generation in unmyelinated human C-type nerve fibers

Anesthesiology

Volumn 107, Issue 3, 2007, Pages 495-501

  Lang, Philip M ^a,b   Hilmer, Verena B ^a   Grafe, Peter ^a  

^a Department of Anesthesiology ^*

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

LIDOCAINE; MEXILETINE; SODIUM CHANNEL; TETRODOTOXIN;

ACTION POTENTIAL; ARTICLE; CELL MEMBRANE; CELL TYPE; COMPUTER PROGRAM; CONTROLLED STUDY; HUMAN; HUMAN CELL; NERVE CELL STIMULATION; NONMYELINATED NERVE; PERIPHERAL NERVE; PRIORITY JOURNAL;

ACTION POTENTIALS; ANESTHETICS, LOCAL; ANTI-ARRHYTHMIA AGENTS; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HUMANS; LIDOCAINE; MEMBRANE POTENTIALS; MEXILETINE; NERVE FIBERS, UNMYELINATED; SENSORY THRESHOLDS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS; TETRODOTOXIN;

EID: 34548218773     PISSN: 00033022     EISSN: 15281175     Source Type: Journal    
DOI: 10.1097/01.anes.0000278862.77981.c8     Document Type: Article

References (43)

1. + channels in pain pathways. Trends Pharmacol Sci 2001; 22:27-31
2. Lai J, Hunter JC, Porreca F: The role of voltage-gated sodium channels in neuropathic pain. Curr Opin Neurobiol 2003; 13:291-7
3. Wood JN, Boorman JP, Okuse K, Baker MD: Voltage-gated sodium channels and pain pathways. J Neurobiol 2004; 61:55-71
4. Rush AM, Cummins TR, Waxman SG: Multiple sodium channels and their roles in electrogenesis within dorsal root ganglion neurons. J Physiol 2007; 579:1-14
5. Catterall WA, Goldin AL, Waxman SG: International Union of Pharmacology: XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels. Pharmacol Rev 2005; 57:397-409
6. Yang Y, Wang Y, Li S, Xu Z, Li H, Ma L, Fan J, Bu D, Liu B, Fan Z, Wu G, Jin J, Ding B, Zhu X, Shen Y: Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia. J Med Gen 2004; 41:171-4
7. Cox JJ, Reimann F, Nicholas AK, Thornton G, Roberts E, Springell K, Karbani G, Jafri H, Mannan J, Raashid Y, Al Gazali L, Hamamy H, Valente EM, Gorman S, Williams R, McHale DP, Wood JN, Gribble FM, Woods CG: An SCN9A channelopathy causes congenital inability to experience pain. Nature 2006; 444:894-8
8. Klugbauer N, Lacinova L, Flockerzi V, Hofmann F: Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells. EMBO J 1995; 14: 1084-90
9. Cummins TR, Howe JR, Waxman SG: Slow closed-state inactivation: A novel mechanism underlying ramp currents in cells expressing the hNE/PN1 sodium channel. J Neurosci 1998; 18:9607-19
10. Quasthoff S, Grosskreutz J, Schroder JM, Schneider U, Grafe P: Calcium potentials and tetrodotoxin-resistant sodium potentials in unmyelinated C fibres of biopsied human sural nerve. Neurosci 1995; 69:955-65
11. Grosskreutz J, Quasthoff S, Kuhn M, Grafe P: Capsaicin blocks tetrodotoxin-resistant sodium potentials and calcium potentials in unmyelinated C fibres of biopsied human sural nerve in vitro. Neurosci Lett 1996; 208:49-52
12. Waxman SG: Neurobiology: A channel sets the gain on pain. Nature 2006; 444:831-2
13. Legroux-Crespel E, Sassolas B, Guillet G, Kupfer I, Dupre D, Misery L: Treatment of familial erythermalgia with the association of lidocaine and mexiletine. Ann Dermatol Venereol 2003; 130:429-33
14. Jang HS, Jung D, Kim S, Jo J, Lee J, Kim M, Oh C, Kwon K: A case of primary erythromelalgia improved by mexiletine. Br J Dermatol 2004; 151:708-10
15. Nathan A, Rose JB, Guite JW, Hehir D, Milovcich K: Primary erythromelalgia in a child responding to intravenous lidocaine and oral mexiletine treatment. Pediatrics 2005; 115:e504-7
16. Bostock H, Cikurel K, Burke D: Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 1998; 21:137-58
17. Burke D, Kiernan MC, Bostock H: Excitability of human axons. Clin Neurophysiol 2001; 112:1575-85
18. Grafe P, Quasthoff S, Grosskreutz J, Alzheimer C: Function of the hyperpolarization-activated inward rectification in nonmyelinated peripheral rat and human axons. J Neurophysiol 1997; 77:421-6
19. Lang PM, Tracey DJ, Irnich D, Sippel W, Grafe P: Activation of adenosine and P2Y receptors by ATP in human peripheral nerve. Naunyn Schmiedebergs Arch Pharmacol 2002; 366:449-57
20. Lang PM, Burgstahler R, Sippel W, Irnich D, Schlotter-Weigel B, Grafe P: Characterization of neuronal nicotinic acetylcholine receptors in the membrane of unmyelinated human C-fiber axons by in vitro studies. J Neurophysiol 2003; 90:3295-303
21. Rogers M, Tang L, Madge DJ, Stevens EB: The role of sodium channels in neuropathic pain. Semin Cell Dev Biol 2006; 17:571-81
22. Torebjörk E, Schmelz M: Single-unit recordings of afferent human peripheral nerves by microneurography, Peripheral Neuropathy, 4th edition. Edited by Dyck PJ, Thomas PK. Philadelphia, Elsevier Saunders, 2005, pp 1003-14
23. Mayer C, Quasthoff S, Grafe P: Confocal imaging reveals activity-dependent intracellular Ca2+ transients in nociceptive human C fibres. Pain 1999; 81:317-22
24. Bickel A, Butz M, Schmelz M, Handwerker HO, Neundörfer B: Density of sympathetic axons in sural nerve biopsies of neuropathy patients is related to painfulness. Pain 2000; 84:413-9
25. Rush AM, Dib-Hajj SD, Liu S, Cummins TR, Black JA, Waxman SG: A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons. Proc Natl Acad Sci U S A 2006; 103:8245-50
26. Brock JA, McLachlan EM, Belmonte C: Tetrodotoxin-resistant impulses in single nociceptor nerve terminals in guinea-pig cornea. J Physiol 1998; 512:211-7
27. Strassman AM, Raymond SA: Electrophysiological evidence for tetrodotoxin-resistant sodium channels in slowly conducting dural sensory fibers. J Neurophysiol 1999; 81:413-24
28. Jeftinija S: The role of tetrodotoxin-resistant sodium channels of small primary afferent fibers. Brain Res 1994; 639:125-34
29. Steffens H, Eek B, Trudrung P, Mense S: Tetrodotoxin block of A-fibre afferents from skin and muscle: A tool to study pure C-fibre effects in the spinal cord. Pflugers Arch 2003; 445:607-13
30. Akopian AN, Sivilotti L, Wood JN: A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature 1996; 379:257-62
31. Sangameswaran L, Delgado SG, Fish LM, Koch BD, Jakeman LB, Stewart GR, Sze P, Hunter JC, Eglen RM, Herman RC: Structure and function of a novel voltage-gated, tetrodotoxin-resistant sodium channel specific to sensory neurons. J Biol Chem 1996; 271:5953-6
32. Renganathan M, Cummins TR, Waxman SG: Contribution of Na(v)1.8 sodium channels to action potential electrogenesis in DRG neurons. J Neurophysiol 2001; 86:629-40
33. Herzog RI, Cummins TR, Ghassemi F, Dib-Hajj SD, Waxman SG: Distinct repriming and closed-state inactivation kinetics of Nav1.6 and Nav1.7 sodium channels in mouse spinal sensory neurons. J Physiol 2003; 551:741-50
34. Toledo-Aral JJ, Moss BL, He ZJ, Koszowski AG, Whisenand T, Levinson SR, Wolf JJ, Silos-Santiago I, Halegoua S, Mandel G: Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons. Proc Natl Acad Sci U S A 1997; 94:1527-32
35. Blair NT, Bean BP: Role of tetrodotoxin-resistant Na+ current slow inactivation in adaptation of action potential firing in small-diameter dorsal root ganglion neurons. J Neurosci 2003; 23:10338-50
36. 2+ current in the action potentials of nociceptive sensory neurons. J Neurosci 2002; 22:10277-90
37. Tanelian DL, Brose WG: Neuropathic pain can be relieved by drugs that are use-dependent sodium channel blockers: Lidocaine, carbamazepine, and mexiletine. ANESTHESIOLOGY 1991; 74:949-51
38. Tremont-Lukats IW, Challapalli V, McNicol ED, Lau J, Carr DB: Systemic administration of local anesthetics to relieve neuropathic pain: A systematic review and meta-analysis. Anesth Analg 2005; 101:1738-49
39. Gottrup H, Bach FW, Juhl G, Jensen TS: Differential effect of ketamine and lidocaine on spontaneous and mechanical evoked pain in patients with nerve injury pain. ANESTHESIOLOGY 2006; 104:527-36
40. Catterall W, Mackie K: Local anesthetics, Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 10th edition. Edited by Hardman JG, Limbird LE. New York, McGraw-Hill, 2000, pp 367-84
41. Tanelian DL, Maciver MB: Analgesic concentrations of lidocaine suppress tonic A-delta and C fiber discharges produced by acute injury. ANESTHESIOLOGY 1991; 74:934-6
42. Chevrier P, Vijayaragavan K, Chahine M: Differential modulation of Nav1.7 and Nav1.8 peripheral nerve sodium channels by the local anesthetic lidocaine. Br J Pharmacol 2004; 142:576-84
43. Kiernan MC, Burke D, Andersen KV, Bostock H: Multiple measures of axonal excitability: A new approach in clinical testing. Muscle Nerve 2000; 23:399-409