Is lipid bilayer binding a common property of inhibitor cysteine knot ion-channel blockers?

Biophysical Journal

Volumn 93, Issue 4, 2007, Pages

  Posokhov, Yevgen O ^a   Gottlieb, Philip A ^b   Morales, Michael J ^b   Sachs, Frederick ^b   Ladokhin, Alexey S ^a  

^a UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOLYTE; GLYCYLSERYLASPARTYLASPARTYLCYSTEINYLGLYCYLLYSYLLEUCYLPHENYLAL ANYLSERYLGLYCYLCYSTEINYLASPARTYLTHREONYLASPARAGINYLALANYLAS PARTYLCYSTEINYLCYSTEINYLGLUTAMYLGLYCYLTYROSYLVALYLCYSTEINYLARGINYLLEUCYL TRYPTOPHYLCYSTEINYLLYSYLLEUCYLASPARTYLTRYPTOPHAN; INHIBITOR CYSTEINE KNOT ION CHANNEL BLOCKER; ION TRANSPORT AFFECTING AGENT; LIPID; PEPTIDE DERIVATIVE; POTASSIUM CHANNEL BLOCKING AGENT; TYROSYLCYSTEINYLGLUTAMINYLLYSYLTRYPTOPHYLMETHIONYLTRYPTOPHYL THREONYLCYSTEINYLASPARTYLGLUTAMYLGLUTAMYLARGINYLLYSYLCYSTEINYLCYSTEINYL GLUTAMYLGLYCYLLEUCYLVALYLCYSTEINYLARGINYLLEUCYLTRYPTOPHYLCYSTEINYLLYSYL LYSYLLYSYLISOLEUCYLGLUTAMYLTRYPTOPHAN; UNCLASSIFIED DRUG;

ARTICLE; BINDING KINETICS; CELL VOLUME; CHANNEL GATING; COMPLEX FORMATION; DRUG BINDING; DRUG MECHANISM; ELECTRICITY; HYDROPHOBICITY; LIPID BILAYER; LIPID MEMBRANE; LIPID VESICLE; MEMBRANE BINDING; MEMBRANE BIOLOGY; MOLECULAR INTERACTION; PARTITION COEFFICIENT; STRUCTURE ACTIVITY RELATION; SURFACE PROPERTY;

EID: 34548214197     PISSN: 00063495     EISSN: None     Source Type: Journal    
DOI: 10.1529/biophysj.107.112375     Document Type: Article

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