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Volumn , Issue 13, 2007, Pages 2124-2126

Solvent-free basic or KF/alumina-assisted dehydrogenation of hydrazo compounds

Author keywords

Alumina; Azo compounds; Dehydrogenation; Hydrazo compounds; Solvent free

Indexed keywords

1,2 DIPHENYLHYDRAZINE; ALUMINUM OXIDE; AZO COMPOUND; AZOBENZENE; BENZENE DERIVATIVE; ORGANIC COMPOUND; ORGANIC SOLVENT; SODIUM HYDROXIDE; UNCLASSIFIED DRUG;

EID: 34548186227     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-984878     Document Type: Article
Times cited : (11)

References (33)
  • 5
    • 84890664985 scopus 로고    scopus 로고
    • Tanaka, K, Ed, Wiley-VCH: Weinheim
    • Solvent-Free Organic Synthesis; Tanaka, K., Ed.; Wiley-VCH: Weinheim, 2003.
    • (2003) Solvent-Free Organic Synthesis
  • 32
    • 34548147669 scopus 로고    scopus 로고
    • Basic alumina (lot 20), purchased from ICN, and KF/alumina (batch 16727CO), purchased from Aldrich, were used without further treatment.
    • Basic alumina (lot 20), purchased from ICN, and KF/alumina (batch 16727CO), purchased from Aldrich, were used without further treatment.
  • 33
    • 34548191469 scopus 로고    scopus 로고
    • Azo Compounds, Typical Procedure Hydrazobenzene (1a, 1 mmol) was measured into a 100 mL flask containing KF/alumina (0.5 g, The reaction mixture was stirred at 80°C for 30 min with blowing air under ambient pressure to obtain a red solid. Then, Et2O was added to the resulting mixture and filtered on a Büchner funnel to remove the alumina. The alumina was washed with Et2O and the combined filtrate was concentrated in vacuo. After purification by flash chromatography on silica gel eluting with EtOAc-hexane, azobenzene (2a) was obtained in a yield of 85, The reaction was also performed with 1a (10 mmol) and KF/alumina (5 g) following the same procedure except the reaction time. After a heating time of 45 min, 2a was obtained in a yield of 91% by passing through column of silica gel
    • 2O and the combined filtrate was concentrated in vacuo. After purification by flash chromatography on silica gel eluting with EtOAc-hexane, azobenzene (2a) was obtained in a yield of 85%. The reaction was also performed with 1a (10 mmol) and KF/alumina (5 g) following the same procedure except the reaction time. After a heating time of 45 min, 2a was obtained in a yield of 91% by passing through column of silica gel.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.