Erroneous laboratory results: What clinicians need to know

Clinical Medicine, Journal of the Royal College of Physicians of London

Volumn 7, Issue 4, 2007, Pages 357-361

  Ismail, Yasmin ^a   Ismail, Abbas A ^b   Ismail, Adel A A ^c  

^a Bristol Medical School   (United Kingdom)

^b STEPPING HILL HOSPITAL   (United Kingdom)

^c Department of Clinical Biochemistry and Chemical Endocrinology ^*  (United Kingdom)

Author keywords

Erroneous analytical results; Immunoassay; Interference; Laboratory tests; Wrong laboratory results

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; CREATINE KINASE; IMMUNOGLOBULIN M; RHEUMATOID FACTOR; THYROTROPIN; TROPONIN;

ACUTE CORONARY SYNDROME; ANGIOCARDIOGRAPHY; CLINICAL PRACTICE; DIAGNOSTIC ACCURACY; HUMAN; IMMUNOASSAY; IN VITRO STUDY; LABORATORY TEST; PATIENT CARE; QUALITY CONTROL; REVIEW; SCREENING TEST; UNITED KINGDOM;

EID: 34548179097     PISSN: 14702118     EISSN: None     Source Type: Journal    
DOI: 10.7861/clinmedicine.7-4-357     Document Type: Review

References (22)

1. Ismail AA, Shingler W, Seneviratne J, Burrows G. In vitro and in vivo haemolysis and potassium measurement. BMJ 2005;330:949.
2. Kricka LJ. Interference in immunoassays-still a threat. Clin Chem 2000;46:1037-8.
3. Ismail AAA, Barth JH. Wrong biochemistry results. BMJ 2001;323: 705-6.
4. Ismail AAA, Walker PL, Barth JH et al. Wrong biochemistry results: two case reports and observational study on 5310 patients on potentially misleading thyroid-stimulating hormone and gonadotropin immunoassay results. Clin Chem 2002;48:2023-9.
5. Ismail AAA, Walker PL, Cawood ML, Barth JH. Interference in immunoassay is an underestimated problem. Ann Clin Biochem 2002; 39:366-73.
6. Bjerner J, Nustad K, Norum LF, Olsen KH, Bomer OP. Immunometric assay interference: incidence and prevention. Clin Chem 2002;48:6: 13-21.
7. Weir DM, Stewart J. Antigens and antigen recognition. In: Immunology. Edinburgh: Churchill Livingstone, 1997:69.
8. Surks MI, Ortiz E, Daniels GH et al. Subclinical thyroid disease: Scientific review and guidelines for diagnosis and management. JAMA 2004;291:228-38.
9. Beastal GH, Beckett GJ, Franklyn J et al. UK guidelines for the use of thyroid function tests. London: British Thyroid Association, 2006. www.acb.org.uk or www.british-thyroid-association.org
10. Ismail AA, Snowden N. Autoantibodies and specific serum proteins in the diagnosis of rheumatological disorders. Ann Clin Biochem 1999; 36:565-78.
11. Teitsson I, Withrington RH, Seifert MH, Valdimarsson H. Prospective study of early rheumatoid arthritis. I. Prognostic value of IgA rheumatoid factor. Ann Rheum Dis 1984;43:673-8.
12. van Schaardenburg D, Lagaay AM, Otten HG, Breedveld FC. The relation between class-specific serum rheumatoid factors and age in the general population. Br J Rheumatol 1993;32:546-9.
13. Norden AGW, Jackson RA, Norden LE et al. Misleading results from immunoassays of serum free thyroxine in the presence of rheumatoid factor. Clin Chem 1997;43:957-62.
14. Krahn J, Parry DM, Laroux M, Dalton J. High percentage of false positive cardiac troponin I results in patients with rheumatoid factor. Clin Biochem 1998;44:2212-4.
15. McGinley PJ, Kilpatrick ES. Tumour markers; their use and misuse by clinicians. Ann Clin Biochem 2003;40:643-7.
16. Duffy MJ. Evidence for the clinical use of tumour markers. Ann Clin Biochem 2004;41:370-7.
17. Jones RG, Barth JH, Mitchell H. Tumour markers: same marker, different assay, different result. Clin Oncol 1999;11:221-2.
18. Antman E, Bassand J-P, Klein W et al. Myocardial infarction redefined - a consensus document of The Joint European Society of Cardiology/American College of Cardiology committee for the redefinition of myocardial infarction. The Joint European Society of Cardiology/American College of Cardiology Committee. J Am Coll Cardiol 2000;36:959-69.
19. Fitzmaurice TF, Brown C, Rifai N, Wu AHB, Yeo K-TJ. False increase of cardiac troponin I with heterophilic antibodies. Clin Chem 1998;44: 2212-4.
20. Eriksson S, Halenius H, Pulkki K, Hellman J, Pettersson K. Negative Interference in Cardiac Troponin I Immunoassays by Circulating Troponin Autoantibodies. Clin Chem 2005;51:839-47.
21. Kilpatrick ES, Pell AC, Pell JP. Was it a heart attack? BMJ 2002;324: 1216-6.
22. Collinson PO, Gaze DC, Morris F et al. Comparison of biomarker strategies for rapid rule out of myocardial infarction in the emergency department using ACC/ESC diagnostic criteria. Ann Clin Biochem 2006;43:273-80.