Diversity of Helicobacter pylori cagA and vacA genes in Costa Rica: Its relationship with atrophic gastritis and gastric cancer

Helicobacter

Volumn 12, Issue 5, 2007, Pages 547-552

  Con, Sergio A ^a,b   Takeuchi, Hiroaki ^a   Valerín, Ana L ^b   Con Wong, Reinaldo ^b   Con Chin, Gil R ^b   Con Chin, Vicky G ^b   Nishioka, Mitsuaki ^a   Mena, Fernando ^c   Brenes, Fernando ^c   Yasuda, Nobufumi ^a   Araki, Keijiro ^a   Sugiura, Tetsuro ^a  

^a KOCHI UNIVERSITY   (Japan)

^b Centro Digestivo Doctores Con Mediplaza   (Costa Rica)

^c Laboratorio de Patología Mediplaza   (Costa Rica)

Author keywords

Atrophic gastritis; Costa Rica; Gastric cancer; Helicobacter pylori

Indexed keywords

BACTERIAL DNA; CAGA PROTEIN; GENOMIC DNA; VACUOLATING TOXIN;

ADULT; ARTICLE; ATROPHIC GASTRITIS; BACTERIAL COLONIZATION; BACTERIAL GENE; CANCER PATIENT; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION ANALYSIS; COSTA RICA; DISEASE ASSOCIATION; DNA EXTRACTION; FEMALE; GENETIC VARIABILITY; GENOTYPE; HELICOBACTER PYLORI; HUMAN; MALE; NONHUMAN; OUTCOME ASSESSMENT; POLYMERASE CHAIN REACTION; PREVALENCE; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; STOMACH; STOMACH CANCER;

ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; COSTA RICA; FEMALE; GASTRITIS, ATROPHIC; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PREVALENCE; STOMACH NEOPLASMS; VARIATION (GENETICS);

HELICOBACTER PYLORI;

EID: 34548176557     PISSN: 10834389     EISSN: 15235378     Source Type: Journal    
DOI: 10.1111/j.1523-5378.2007.00534.x     Document Type: Article

References (30)

1. Arents NL, Van Zwet AA, Thijs JC, et al. The importance of vacA, cagA, and iceA genotypes of Helicobacter pylori infection in peptic ulcer disease and gastroesophageal reflux disease. Am J Gastroenterol 2001 96 : 2603 8.
2. Blaser MJ. Ecology of Helicobacter pylori in the human stomach. J Clin Invest 1997 100 : 759 62.
3. Ashour AAR, Magalhaes PP, Mendes EN, et al. Distribution of vacA genotypes in Helicobacter pylori strains isolated from Brazilian adult patients with gastritis, duodenal ulcer or gastric carcinoma. FEMS Immunol Med Microbiol 2002 33 : 173 8.
4. Cover TL, Dooley CP, Blaser MJ. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 1990 58 : 603 10.
5. Van Doorn LJ, Figuereido C, Sanna R, et al. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology 1998 115 : 58 66.
6. Azuma T, Yamazaki S, Yamakawa A, et al. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J Infect Dis 2004 189 : 820 7.
7. Azuma T, Ohtani M, Yamazaki Y, et al. Meta-analysis of the relationship between CagA seropositivity and gastric cancer. Gastroenterology 2004 126 : 1926 7.
8. Hatakeyama M, Higashi H. Helicobacter pylori CagA: a new paradigm for bacterial carcinogenesis. Cancer Sci 2005 96 : 835 43.
9. Telford JL, Ghiara P, Dell'Orco M, et al. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 1994 79 : 1653 8.
10. Atherton JC, Cao P, Peek RM Jr., et al. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995 270 : 17771 7.
11. Covacci A, Censini S, Bugnoli M, et al. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc Natl Acad Sci USA 1993 90 : 5791 5.
12. Atherton JC, Peek RM Jr., Tham KT, et al. Clinical and pathological importance of heterogenity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997 112 : 92 9.
13. Van Doorn LJ, Figuereido C, Mégraud F, et al. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 1999 116 : 823 30.
14. Van Doorn LJ, Figuereido C, Rossau R, et al. Typing of Helicobacter pylori vacA gene and detection of cagA gene by PCR and reverse hybridization. J Clin Microbiol 1998 36 : 1271 6.
15. Ito Y, Azuma T, Ito S, et al. Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J Clin Microbiol 1997 35 : 1710 4.
16. Oleastro M, Gerhard M, Lopes AI, et al. Helicobacter pylori virulence genotypes in Portuguese children and adults with gastroduodenal pathology. Eur J Clin Microbiol Infect Dis 2003 22 : 85 91.
17. Yamaoka Y, Souchek J, Odenbreit S, et al. Discrimination between cases of duodenal ulcer and gastritis on the basis of putative virulence factors of Helicobacter pylori. J Clin Microbiol 2002, 2004 40 : 2244 6.
18. Kuroishi T, Hirose K, Takesaki T, et al. Cancer mortality statistics in 30 countries (1953-97). In : Tajima K, Kuroishi T, Oshima A, eds. Cancer Mortality and Morbidity Statistics: Japan and the World 2004. Tokyo and Basel : Japan Scientific Societies Press and Karger, 2004 165 9.
19. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process. First American Cancer Society Award Lecture on Cancer Epidemiology and Prevention. Cancer Res 1992 52 : 6735 40.
20. Dixon MF, Genta RM, Yardley J, et al. Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996 20 : 1161 81.
21. Yamaoka Y, Kodama T, Gutierrez O, et al. Relationship between Helicobacter pylori iceA, cagA, and vacA Status and Clinical Outcome: Studies in Four Different Countries. J Clin Microbiol 1999 37 : 2274 9.
22. Miehlke S, Kibler K, Kim JG, et al. Allelic variation in the cagA gene of Helicobacter pylori obtained from Korea compared to the United States. Am J Gastroenterol 1996 91 : 1322 5.
23. Martínez A, González C, Kawaguchi F, et al. Helicobacter pylori: cagA analysis and vacA genotyping in Chile. Detection of a s2/m1 strain. Rev Med Chil 2001 129 : 1147 53.
24. Warburton VJ, Everett S, Mapstone NP, et al. Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis. J Clin Pathol 1998 51 : 55 61.
25. Argent RH, Kidd M, Owen RJ, et al. Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 2004 127 : 514 23.
26. Occhialini A, Marais A, Urdachi M, et al. Composition and gene expression of the cag pathogenicity island in Helicobacter pylori strains isolated from gastric carcinoma and gastritis patients in Costa Rica. Infect Immun 2001 69 : 1902 8.
27. Zambon C-F, Navaglia F, Basso D, et al. Helicobacter pylori babA2, cagA, and s1 vacA genes work sinergistically in causing intestinal metaplasia. J Clin Pathol 2003 56 : 287 91.
28. Rad R, Dossumbekova A, Neu B, et al. Cytokine gene polymorphisms influence mucosal cytokine expression, gastric inflammation, and host specific colonization during Helicobacter pylori infection. Gut 2004 53 : 1082 9.
29. Morales-Espinosa R, Castillo-Rojas G, González-Valencia G, et al. Colonization of Mexican patients by multiple Helicobacter pylori strains with different vacA and cagA genotypes. J Clin Microbiol 1999 37 : 3001 4.
30. Yamaoka Y, Orito E, Mizokami M, et al. Helicobacter pylori in North and South America before Columbus. FEBS Lett 2002 517 : 180 4.