Blockade action of ketanserin and increasing effect of potassium ion on Kv1.3 channels expressed in Xenopus oocytes

Pharmacological Research

Volumn 56, Issue 2, 2007, Pages 148-154

  Wang, Xianpei ^a   Liao, Yuhua ^a   Zou, Anruo ^a   Li, Lu ^a   Tu, Danna ^a  

^a Department of Cardiology   (China)

Author keywords

Channel kinetics; Immunomodulation; Ketanserin; Kv1.3 potassium channel; Potassium ion

Indexed keywords

KETANSERIN; POTASSIUM CHANNEL KV1.3; POTASSIUM ION;

ACCELERATION; ANIMAL CELL; ARTICLE; CHRONOPHARMACOLOGY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; FEMALE; MICROELECTRODE; NONHUMAN; OOCYTE; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; VOLTAGE CLAMP; XENOPUS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ION CHANNEL GATING; KETANSERIN; KINETICS; KV1.3 POTASSIUM CHANNEL; MEMBRANE POTENTIALS; OOCYTES; POTASSIUM; POTASSIUM CHANNEL BLOCKERS; XENOPUS LAEVIS;

EID: 34548164825     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2007.05.002     Document Type: Article

References (26)

1. van Schie D.L., de Jeu R.M., Steyn D.W., Odendaal H.J., and van Geijn H.P. The optimal dosage of ketanserin for patients with severe hypertension in pregnancy. Eur J Obstet Gynecol Reprod Biol 102 (2002) 161-166
2. Geerling R.A., de Bruin R.W., Scheringa M., Bonthuis F., IJzermans J.N., and Marquet R.L. Ketanserin reduces graft arteriosclerosis after allogeneic aorta transplantation in rats. J Cardiovasc Pharmacol 27 (1996) 307-311
3. Zhang Z.H., Boutjdir M., and el-Sherif N. Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes. Circ Res 75 (1994) 711-721
4. Le Grand B., Marty A., Colpaert F.C., and John G.W. Ketanserin inhibits the transient outward current in rabbit ventricular myocytes. J Cardiovasc Pharmacol 25 (1995) 341-344
5. Ju J.M., Hwang J.H., Piao L.H., Park H.W., Park J.S., Shin D.H., et al. Ketanserin, a 5-HT2 antagonist, directly inhibits the ATP-sensitive potassium channel in mouse ventricular myocytes. J Cardiovasc Pharmacol 47 (2006) 96-102
6. Panyi G., Vamosi G., Bodnar A., Gaspar R., and Damjanovich S. Looking through ion channels: recharged concepts in T-cell signaling. Trends Immunol 25 (2004) 565-569
7. Mourre C., Chernova M.N., Martin-Eauclaire M.F., Bessone R., Jacquet G., Gola M., et al. Distribution in rat brain of binding sites of kaliotoxin, a blocker of Kv1.1 and Kv1.3 alpha-subunits. J Pharmacol Exp Ther 291 (1999) 943-952
8. Xu J., Wang P., Li Y., Li G., Kaczmarek L.K., Wu Y., et al. The voltage-gated potassium channel Kv1.3 regulates peripheral insulin sensitivity. Proc Natl Acad Sci USA 101 (2004) 3112-3117
9. + channels as targets for specific immunomodulation. Trends Pharmacol Sci 25 (2004) 280-289
10. + channel expression during B cell differentiation: implications for immunomodulation and autoimmunity. J Immunol 173 (2004) 776-786
11. Krasznai Z. Ion channels in T cells: from molecular pharmacology to therapy. Arch Immunol Ther Exp (Warsz) 53 (2005) 127-135
12. Levite M., Cahalon L., Peretz A., Hershkoviz R., Sobko A., Ariel A., et al. Extracellular K(+) and opening of voltage-gated potassium channels activate T cell integrin function: physical and functional association between Kv1.3 channels and beta1 integrins. J Exp Med 191 (2000) 1167-1176
13. Wagner C.A., Friedrich B., Setiawan I., Lang F., and Broer S. The use of Xenopus laevis oocytes for the functional characterization of heterologously expressed membrane proteins. Cell Physiol Biochem 10 (2000) 1-12
14. Sigel E., and Minier F. The Xenopus oocyte: system for the study of functional expression and modulation of proteins. Mol Nutr Food Res 49 (2005) 228-234
15. Marom S., and Levitan I.B. State-dependent inactivation of the Kv3 potassium channel. Biophys J 67 (1994) 579-589
16. + in recovery from C-type inactivation. Biophys J 71 (1996) 3157-3166
17. Heinemann S.H., Rettig J., Graack H.R., and Pongs O. Functional characterization of Kv channel beta-subunits from rat brain. J Physiol 493 Pt 3 (1996) 625-633
18. Hahn S.J., Wang L.Y., and Kaczmarek L.K. Inhibition by nystatin of Kv1.3 channels expressed in Chinese hamster ovary cells. Neuropharmacology 35 (1996) 895-901
19. + channel from human T lymphocytes. FEBS Lett 303 (1992) 229-232
20. Blomeley C., and Bracci E. Excitatory effects of serotonin on rat striatal cholinergic interneurones. J Physiol 569 (2005) 715-721
21. Hanff L.M., Visser W., Steegers E.A., and Vulto A.G. Population pharmacokinetics of ketanserin in pre-eclamptic patients and its association with antihypertensive response. Fundam Clin Pharmacol 19 (2005) 585-590
22. Poulopoulou C., Markakis I., Davaki P., Nikolaou C., Poulopoulos A., Raptis E., et al. Modulation of voltage-gated potassium channels in human T lymphocytes by extracellular glutamate. Mol Pharmacol 67 (2005) 856-867
23. + current in adult rat ventricular myocytes. J Pharmacol Exp Ther 265 (1993) 1450-1459
24. + channel. Proc Natl Acad Sci USA 89 (1992) 2466-2470
25. Lopez-Barneo J., Hoshi T., Heinemann S.H., and Aldrich R.W. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors Channels 1 (1993) 61-71
26. Mandal K., Jahangiri M., and Xu Q. Autoimmune mechanisms of atherosclerosis. Handb Exp Pharmacol (2005) 723-743