-
1
-
-
0029838307
-
DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata
-
Pommier Y., Kohlhagen G., Bailly C., Waring M., Mazumder A., and Kohn K.W. DNA sequence- and structure-selective alkylation of guanine N2 in the DNA minor groove by ecteinascidin 743, a potent antitumor compound from the Caribbean tunicate Ecteinascidia turbinata. Biochemistry 35 41 (1996) 13303-13309
-
(1996)
Biochemistry
, vol.35
, Issue.41
, pp. 13303-13309
-
-
Pommier, Y.1
Kohlhagen, G.2
Bailly, C.3
Waring, M.4
Mazumder, A.5
Kohn, K.W.6
-
2
-
-
0033566150
-
Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove
-
Zewail-Foote M., and Hurley L.H. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J Med Chem 42 14 (1999) 2493-2497
-
(1999)
J Med Chem
, vol.42
, Issue.14
, pp. 2493-2497
-
-
Zewail-Foote, M.1
Hurley, L.H.2
-
3
-
-
0032844806
-
Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA
-
Bonfanti M., La Valle E., Fernandez Sousa Faro J.M., et al. Effect of ecteinascidin-743 on the interaction between DNA binding proteins and DNA. Anticancer Drug Des 14 3 (1999) 179-186
-
(1999)
Anticancer Drug Des
, vol.14
, Issue.3
, pp. 179-186
-
-
Bonfanti, M.1
La Valle, E.2
Fernandez Sousa Faro, J.M.3
-
4
-
-
17944374027
-
Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair
-
Takebayashi Y., Pourquier P., Zimonjic D.B., et al. Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair. Nat Med 7 8 (2001) 961-966
-
(2001)
Nat Med
, vol.7
, Issue.8
, pp. 961-966
-
-
Takebayashi, Y.1
Pourquier, P.2
Zimonjic, D.B.3
-
5
-
-
0035281641
-
Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors
-
Taamma A., Misset J.L., Riofrio M., et al. Phase I and pharmacokinetic study of ecteinascidin-743, a new marine compound, administered as a 24-hour continuous infusion in patients with solid tumors. J Clin Oncol 19 5 (2001) 1256-1265
-
(2001)
J Clin Oncol
, vol.19
, Issue.5
, pp. 1256-1265
-
-
Taamma, A.1
Misset, J.L.2
Riofrio, M.3
-
6
-
-
0035281734
-
Ecteinascidin-743: a marine-derived compound in advanced, pretreated sarcoma patients-preliminary evidence of activity
-
Delaloge S., Yovine A., Taamma A., et al. Ecteinascidin-743: a marine-derived compound in advanced, pretreated sarcoma patients-preliminary evidence of activity. J Clin Oncol 19 5 (2001) 1248-1255
-
(2001)
J Clin Oncol
, vol.19
, Issue.5
, pp. 1248-1255
-
-
Delaloge, S.1
Yovine, A.2
Taamma, A.3
-
7
-
-
0036239748
-
Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study
-
van Kesteren C., Twelves C., Bowman A., et al. Clinical pharmacology of the novel marine-derived anticancer agent Ecteinascidin 743 administered as a 1- and 3-h infusion in a phase I study. Anticancer Drugs 13 4 (2002) 381-393
-
(2002)
Anticancer Drugs
, vol.13
, Issue.4
, pp. 381-393
-
-
van Kesteren, C.1
Twelves, C.2
Bowman, A.3
-
8
-
-
0036154945
-
A phase I and pharmacokinetic study of ecteinascidin-743 on a daily × 5 schedule in patients with solid malignancies
-
Villalona-Calero M.A., Eckhardt S.G., Weiss G., et al. A phase I and pharmacokinetic study of ecteinascidin-743 on a daily × 5 schedule in patients with solid malignancies. Clin Cancer Res 8 1 (2002) 75-85
-
(2002)
Clin Cancer Res
, vol.8
, Issue.1
, pp. 75-85
-
-
Villalona-Calero, M.A.1
Eckhardt, S.G.2
Weiss, G.3
-
9
-
-
0035127175
-
Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies
-
Ryan D.P., Supko J.G., Eder J.P., et al. Phase I and pharmacokinetic study of ecteinascidin 743 administered as a 72-hour continuous intravenous infusion in patients with solid malignancies. Clin Cancer Res 7 2 (2001) 231-242
-
(2001)
Clin Cancer Res
, vol.7
, Issue.2
, pp. 231-242
-
-
Ryan, D.P.1
Supko, J.G.2
Eder, J.P.3
-
10
-
-
2342461682
-
Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy
-
Garcia-Carbonero R., Supko J.G., Manola J., et al. Phase II and pharmacokinetic study of ecteinascidin 743 in patients with progressive sarcomas of soft tissues refractory to chemotherapy. J Clin Oncol 22 8 (2004) 1480-1490
-
(2004)
J Clin Oncol
, vol.22
, Issue.8
, pp. 1480-1490
-
-
Garcia-Carbonero, R.1
Supko, J.G.2
Manola, J.3
-
11
-
-
1542398698
-
Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients
-
Yovine A., Riofrio M., Blay J.Y., et al. Phase II study of ecteinascidin-743 in advanced pretreated soft tissue sarcoma patients. J Clin Oncol 22 5 (2004) 890-899
-
(2004)
J Clin Oncol
, vol.22
, Issue.5
, pp. 890-899
-
-
Yovine, A.1
Riofrio, M.2
Blay, J.Y.3
-
12
-
-
20044372153
-
Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial
-
Le Cesne A., Blay J.Y., Judson I., et al. Phase II study of ET-743 in advanced soft tissue sarcomas: a European Organisation for the Research and Treatment of Cancer (EORTC) soft tissue and bone sarcoma group trial. J Clin Oncol 23 3 (2005) 576-584
-
(2005)
J Clin Oncol
, vol.23
, Issue.3
, pp. 576-584
-
-
Le Cesne, A.1
Blay, J.Y.2
Judson, I.3
-
13
-
-
24944460785
-
Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: multicenter phase II and pharmacokinetic study
-
Garcia-Carbonero R., Supko J.G., Maki R.G., et al. Ecteinascidin-743 (ET-743) for chemotherapy-naive patients with advanced soft tissue sarcomas: multicenter phase II and pharmacokinetic study. J Clin Oncol 23 24 (2005) 5484-5492
-
(2005)
J Clin Oncol
, vol.23
, Issue.24
, pp. 5484-5492
-
-
Garcia-Carbonero, R.1
Supko, J.G.2
Maki, R.G.3
-
14
-
-
0043073206
-
Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma
-
Laverdiere C., Kolb E.A., Supko J.G., et al. Phase II study of ecteinascidin 743 in heavily pretreated patients with recurrent osteosarcoma. Cancer 98 4 (2003) 832-840
-
(2003)
Cancer
, vol.98
, Issue.4
, pp. 832-840
-
-
Laverdiere, C.1
Kolb, E.A.2
Supko, J.G.3
-
15
-
-
0036189675
-
Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas
-
Van Glabbeke M., Verweij J., Judson I., and Nielsen O.S. Progression-free rate as the principal end-point for phase II trials in soft-tissue sarcomas. Eur J Cancer 38 4 (2002) 543-549
-
(2002)
Eur J Cancer
, vol.38
, Issue.4
, pp. 543-549
-
-
Van Glabbeke, M.1
Verweij, J.2
Judson, I.3
Nielsen, O.S.4
-
16
-
-
0033941746
-
Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: a trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group
-
Le Cesne A., Judson I., Crowther D., et al. Randomized phase III study comparing conventional-dose doxorubicin plus ifosfamide versus high-dose doxorubicin plus ifosfamide plus recombinant human granulocyte-macrophage colony-stimulating factor in advanced soft tissue sarcomas: a trial of the European Organization for Research and Treatment of Cancer/Soft Tissue and Bone Sarcoma Group. J Clin Oncol 18 14 (2000) 2676-2684
-
(2000)
J Clin Oncol
, vol.18
, Issue.14
, pp. 2676-2684
-
-
Le Cesne, A.1
Judson, I.2
Crowther, D.3
-
17
-
-
4043125603
-
Randomized phase II study of trabectedin (ET-743) given by two different dosing schedules in patients (pts) with leiomyosarcomas (LMS) or liposarcomas (LPS) refractory to conventional doxorubicin and ifosfamide chemotherapy
-
Samuels B., Rushing D., Chawla S., et al. Randomized phase II study of trabectedin (ET-743) given by two different dosing schedules in patients (pts) with leiomyosarcomas (LMS) or liposarcomas (LPS) refractory to conventional doxorubicin and ifosfamide chemotherapy. J Clin Oncol 22 (2004) 14S
-
(2004)
J Clin Oncol
, vol.22
-
-
Samuels, B.1
Rushing, D.2
Chawla, S.3
-
18
-
-
0000183433
-
Identification of biochemical parameters that predict the onset of severe toxicities in patients treated with ET-743
-
Gomez J., Lazaro L., Guzman C., et al. Identification of biochemical parameters that predict the onset of severe toxicities in patients treated with ET-743. Proc Am Soc Clin Oncol 19 (2000) 187a
-
(2000)
Proc Am Soc Clin Oncol
, vol.19
-
-
Gomez, J.1
Lazaro, L.2
Guzman, C.3
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