Expression of E-cadherin and α-, β- and γ-catenins in human bladder carcinomas: Are they good prognostic factors?

Invasion and Metastasis

Volumn 17, Issue 3, 1998, Pages 124-137

  Mialhe, Agnès ^a   Louis, Josette ^a   Montlevier, Sarah ^a   Peoch, Michel ^b   Pasquier, Dominique ^b   Bosson, Jean Luc ^b   Rambeaud, Jean Jacques ^b   Seigneurin, Daniel ^a  

^a INSTITUT ALBERT BONNIOT   (France)

^b GRENOBLE UNIVERSITY HOSPITAL   (France)

Author keywords

Bladder; Cancer; Catenins; E cadherin; Prognosis

Indexed keywords

ACTIN; ALPHA CATENIN; BETA CATENIN; UVOMORULIN;

ADULT; AGED; ARTICLE; BLADDER CANCER; BLADDER CARCINOGENESIS; BLADDER TUMOR; CANCER STAGING; CANCER SURVIVAL; CELL ADHESION; CYTOSKELETON; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROGNOSIS; PROTEIN EXPRESSION; TUMOR GROWTH; UROTHELIUM;

ADULT; AGED; ALPHA CATENIN; BETA CATENIN; CADHERINS; CYTOSKELETAL PROTEINS; DESMOPLAKINS; GAMMA CATENIN; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROGNOSIS; SURVIVAL ANALYSIS; TRANS-ACTIVATORS; URINARY BLADDER; URINARY BLADDER NEOPLASMS; UROTHELIUM;

EID: 0008970384     PISSN: 02511789     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Rusciano D, Burger MM: Why do cancer cells metastasize into particular organs? BioEssays 1992;14:185-194.
2. Larue L, Antos C, Butz S, Huber O, Delmas V, Dominis M, Kemler R: A role for cadherins in tissue formation. Development 1996;122:3185-3194.
3. Vleminckx KL, Vakaet L, Mareel MM, Fiers W, van Roy FM: Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991;66:107-119.
4. Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, Löchner D, Birchmeier W: E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991;113:173-185.
5. Doki Y, Shiozaki H, Tahara H, Inoue M, Oka H, Ihara K, Kadowaki T, Takeichi M, Mori T: Correlation between E-cadherin expression and invasiveness in vitro in a human esophageal cancer cell line. Cancer Res 1993;53:3421-3426.
6. Rebel JMJ, Thijssen CDEM, Vermey M, Delouvée A, Zwarthoff EC, Van der Kwast TH: E-cadherin expression determines the mode of replacement of normal urothelium by human bladder carcinoma cells. Cancer Res 1994;54:5488-5492.
7. Gamallo C, Palacios J, Suarez A, Pizarro A, Navarro P, Quintanilla M, Cano A: Correlation of E-cadherin expression with differentiation grade and histological type breast carcinoma. Am J Pathol 1993;142:987-993.
8. Kadowaki T, Shiozaki H, Inoue M, Tamura S, Oka H, Doki Y, Iihara K, Matsui S, Iwazawa T, Nagafuchi A, Tsukita S, Mori T: E-cadherin and a-catenin expression in human esophageal cancer. Cancer Res 1994;54:291-296.
9. Gabbert HE, Mueller W, Schneiders A, Meier S, Moll R, Birchmeier W, Hommel G: Prognostic value of E-cadherin expression in 413 gastric carcinomas. Int J Cancer 1996;69:184-189.
10. Dorudi S, Sheffield JP, Poulsom R, Northover JMA, Hart IR: E-cadherin expression in colorectal cancer: An immunocytochemical and in situ hybridization study. Am J Pathol 1993;142:981-986.
11. Umbas R, Isaacs WB, Bringuier PP, Schaafsma HE, Karthaus HFM, Oosterhof GON, Debruyne FMJ, Schalken JA: Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer. Cancer Res 1994;54:3929-3933.
12. Ozawa M, Baribault H, Kemler R: The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species. EMBO J 1989;8:1711-1717.
13. Knudsen KA, Wheelock MJ: Plakoglobin, or an 83-kD homologue distinct from ß-catenin, interacts with E-cadherin and N-cadherin. J Cell Biol 1992;118:671-679.
14. 2+-dependent cell-cell adhesion. FEBS Lett 1994;355:195-200.
15. Aberle H, Schwartz H, Kemler R: Cadherin-catenin complex: Protein interactions and their implications for cadherin function. J Cell Biochem 1996;61:514-523.
16. Takayama T, Shiozaki H, Shibamoto S, Oka H, Kimura Y, Tamura S, Inoue M, Monden T, Ito F, Monden M: β-Catenin expression in human cancers. Am J Pathol 1996;148:39-46.
17. Takayama T, Shiozaki H, Inoue M, Tamura S, Oka H, Kadowaki T, Takatsuka Y, Nagafuchi A, Tsukita S, Mori T: Expression of E-cadherin and α-catenin molecules in human breast cancer tissues and association with clinicopathological features. Int J Oncol 1994;5:775-780.
18. Matsui S, Shiozaki H, Inoue M, Tamura S, Doki Y, Kadowaki T, Iwazawa T, Shimaya K, Nagafuchi A, Tsukita S, Mori T: Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer. Virchows Arch 1994;424:375-381.
19. Bringuier PP, Umbas R, Schaafsma HE, Karthaus HFM, Debruyne FMJ, Schalken JA: Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors. Cancer Res 1993;53:3241-3245.
20. Otto T, Birchmeier W, Schmidt U, Hinke A, Schipper J, Rübben H, Raz A: Inverse relation to E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas. Cancer Res 1994;54:3120-3123.
21. Hong RL, Pu YS, Hsieh TS, Chu JS, Lee WJ: Expressions of E-cadherin and exon V6-containing isoforms of CD44 and their prognostic values in human transitional cell carcinoma. J Urol 1995;153:2025-2028.
22. Syrigos KN, Krausz T, Waxman J, Pandha H, Rowlinson-Busza G, Verne J, Epenetos AA, Pignatelli M: E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: Correlation with histopathological grade, tumour stage and survival. Int J Cancer 1995;64:367-370.
23. Mialhe A, Louis J, Pasquier D, Rambeaud JJ, Seigneurin D: Expression of three cell adhesion molecules in bladder carcinomas: Correlation with pathological features. Anal Cell Pathol 1997;13:125-136.
24. cas) in bladder tumors. Cancer Res 1996;56:4154-4158.
25. Hermanek P, Sobin LH: UICC, TNM Classification of Malignant Tumors. Paris, Springer, 1988.
26. Kapprell HP, Cowin P, Franke WW: Biochemical characterization of the soluble form of the junctional plaque protein, plakoglobin, from different cell types. Eur J Biochem 1987;166:505-517.
27. Shimoyama Y, Hirohashi S, Hirano S, Noguchi M, Shimosato Y, Takeichi M, Abe O: Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res 1989;49:2128-2133.
28. Morton RA, Ewing CM, Nagafuchi A, Tsukita S, Isaacs WB: Reduction of E-cadherin levels and deletion of the α-catenin gene in human prostate cancer cells. Cancer Res 1993;53:3585-3590.
29. Shimoyama Y, Nagafuchi A, Fujita S, Gotoh M, Takeichi M, Tsukita S, Hirohashi S: Cadherin dysfunction in a human cancer cell line: Possible involvement of loss of α-catenin expression in reduced cell-cell adhesiveness. Cancer Res 1992;52:5770-5774.
30. Vermeulen SJ, Bruyneel EA, Bracke ME, Debruyne GK, Vennekens KM, Vleminckx KL, Berx GJ, van Roy FM, Mareel MM: Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells. Cancer Res 1995;55:4722-4728.
31. Oyama T, Kanai Y, Ochiai A, Akimoto S, Oda T, Yanagihara K, Nagafuchi A, Tsukita S, Shibamoto S, Ito F, Takeichi M, Matsuda H, Hirohashi S: A truncated β-catenin disrupts the interaction between E-cadherin and a-catenin: A cause of loss of intercellular adhesiveness in human cancer cell lines. Cancer Res 1994;54:6282-6287.
32. Brady-Kalnay SM, Rimm DL, Tonks NK: Receptor protein tyrosine phosphatase PTPμ associates with cadherins and catenins in vivo. J Cell Biol 1995;130:977-986.
33. Bussemakers MJG, Giroldi LA, van Bokhoven A, Schalken JA: Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: Characterization of the human E-cadhterin gene promoter. Biochem Biophys Res Commun 1994;203:1284-1290.
34. Dorudi S, Hanby AM, Poulson R, Northover J, Hart IR: Level of expression of E-cadherin mRNA in colorectal cancer correlates with clinical outcome. Br J Cancer 1995;71:614-616.
35. Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Höfler H: E-cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 1994;54:3845-3852.
36. Candidus S, Bischoff P, Becker KF, Höfler H: No evidence for mutations in the α- and β-catenin genes in human gastric and breast carcinomas. Cancer Res 1996;56:49-52.
37. cas associates with E-cadherin complexes. Mol Cell Biol 1994;14:8333-8342.
38. Su LK, Vogelstein B, Kinzler KW: Association of the APC tumor suppressor protein with catenins. Science 1993;262:1734-1737.