-
1
-
-
0043222419
-
Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor
-
Backbro, K., S. Lowgren, K. Osterlund, J. Atepo, T. Unge, J. Hulten, N. M. Bonham, W. Schaal, A. Karlen, and A. Hallberg. 1997. Unexpected binding mode of a cyclic sulfamide HIV-1 protease inhibitor. J. Med. Chem. 40:898-902.
-
(1997)
J. Med. Chem
, vol.40
, pp. 898-902
-
-
Backbro, K.1
Lowgren, S.2
Osterlund, K.3
Atepo, J.4
Unge, T.5
Hulten, J.6
Bonham, N.M.7
Schaal, W.8
Karlen, A.9
Hallberg, A.10
-
2
-
-
0028103275
-
-
Collaborative-Computational Project, Number 4. 1994. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50:760-763.
-
Collaborative-Computational Project, Number 4. 1994. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50:760-763.
-
-
-
-
3
-
-
0026579208
-
The HIV-1 protease as a therapeutic target for AIDS
-
Debouck, C. 1992. The HIV-1 protease as a therapeutic target for AIDS. AIDS Res. Hum. Retrovir. 8:153-164.
-
(1992)
AIDS Res. Hum. Retrovir
, vol.8
, pp. 153-164
-
-
Debouck, C.1
-
5
-
-
0025108755
-
Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution
-
Fitzgerald, P. M. D., B. M. McKeever, J. F. VanMiddlesworth, J. P. Springer, J. C. Heimbach, C. T. Leu, W. K. Herber, R. A. F. Dixon, and P. L. Darke. 1990. Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution. J. Biol. Chem. 265:14209-14219.
-
(1990)
J. Biol. Chem
, vol.265
, pp. 14209-14219
-
-
Fitzgerald, P.M.D.1
McKeever, B.M.2
VanMiddlesworth, J.F.3
Springer, J.P.4
Heimbach, J.C.5
Leu, C.T.6
Herber, W.K.7
Dixon, R.A.F.8
Darke, P.L.9
-
6
-
-
0000078168
-
O: A macromolecular modeling environment
-
C. Bugg and S. Ealick ed, Springer-Verlag Press, Berlin, Germany
-
Jones, T. A., M. Bergdoll, and M. Kjeldgaard. 1990. O: a macromolecular modeling environment, p. 189-195. In C. Bugg and S. Ealick (ed.), Crystallographic and modeling methods in molecular design. Springer-Verlag Press, Berlin, Germany.
-
(1990)
Crystallographic and modeling methods in molecular design
, pp. 189-195
-
-
Jones, T.A.1
Bergdoll, M.2
Kjeldgaard, M.3
-
7
-
-
0036147616
-
Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease
-
King, N. M., L. Melnick, M. Prabu-Jeyabalan, E. A. Nalivaika, S. S. Yang, Y. Gao, X. Nie, C. Zepp, D. L. Heefner, and C. A. Schiffer. 2002. Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease. Protein Sci. 11:418-429.
-
(2002)
Protein Sci
, vol.11
, pp. 418-429
-
-
King, N.M.1
Melnick, L.2
Prabu-Jeyabalan, M.3
Nalivaika, E.A.4
Yang, S.S.5
Gao, Y.6
Nie, X.7
Zepp, C.8
Heefner, D.L.9
Schiffer, C.A.10
-
8
-
-
6344231715
-
Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
-
King, N. M., M. Prabu-Jeyabalan, E. A. Nalivaika, P. Wigerinck, M. P. de Bethune, and C. A. Schiffer. 2004. Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor. J. Virol. 78:12012-12021.
-
(2004)
J. Virol
, vol.78
, pp. 12012-12021
-
-
King, N.M.1
Prabu-Jeyabalan, M.2
Nalivaika, E.A.3
Wigerinck, P.4
de Bethune, M.P.5
Schiffer, C.A.6
-
9
-
-
22544467240
-
Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex
-
Kumar, M., V. Prashar, S. Mahale, and M. V. Hosur. 2005. Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex. Biochem. J. 389:365-371.
-
(2005)
Biochem. J
, vol.389
, pp. 365-371
-
-
Kumar, M.1
Prashar, V.2
Mahale, S.3
Hosur, M.V.4
-
10
-
-
0025904209
-
Rigid protein motion as a model for crystallographic temperature factors
-
Kuriyan, J., and W. I. Weis. 1991. Rigid protein motion as a model for crystallographic temperature factors. Proc. Natl. Acad. Sci. USA 88:2773-2777.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 2773-2777
-
-
Kuriyan, J.1
Weis, W.I.2
-
11
-
-
34548147774
-
-
1 September, Patent W09419329-A
-
Lam, P. Y. S., P. K. Jadhav, C. J. Eyermann, C. N. Hodge, G. V. DeLucca, and J. D. Rodgers. 1 September 1994. Patent W09419329-A.
-
(1994)
-
-
Lam, P.Y.S.1
Jadhav, P.K.2
Eyermann, C.J.3
Hodge, C.N.4
DeLucca, G.V.5
Rodgers, J.D.6
-
12
-
-
0028057975
-
Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors
-
Lam, P. Y. S., P. K. Jadhav, C. J. Eyermann, C. N. Hodge, Y. Ru, L. T. Bacheler, J. L. Meek, M. J. Otto, M. M. Rayner, Y. N. Wong, et al. 1994. Rational design of potent, bioavailable, nonpeptide cyclic ureas as HIV protease inhibitors. Science 263:380-384.
-
(1994)
Science
, vol.263
, pp. 380-384
-
-
Lam, P.Y.S.1
Jadhav, P.K.2
Eyermann, C.J.3
Hodge, C.N.4
Ru, Y.5
Bacheler, L.T.6
Meek, J.L.7
Otto, M.J.8
Rayner, M.M.9
Wong, Y.N.10
-
13
-
-
0034623020
-
Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples
-
Larder, B. A., K. Hertogs, S. Bloor, C. H. van den Eynde, W. DeCian, Y. Wang, W. W. Freimuth, and G. Tarpley. 2000. Tipranavir inhibits broadly protease inhibitor-resistant HIV-1 clinical samples. AIDS 14:1943-1948.
-
(2000)
AIDS
, vol.14
, pp. 1943-1948
-
-
Larder, B.A.1
Hertogs, K.2
Bloor, S.3
van den Eynde, C.H.4
DeCian, W.5
Wang, Y.6
Freimuth, W.W.7
Tarpley, G.8
-
16
-
-
84920325457
-
AMoRe: An automated package for molecular replacement
-
Navaza, J. 1994. AMoRe: an automated package for molecular replacement. Acta Crystallogr. D Biol. Crystallogr. A 50:157-163.
-
(1994)
Acta Crystallogr. D Biol. Crystallogr. A
, vol.50
, pp. 157-163
-
-
Navaza, J.1
-
17
-
-
0031059866
-
Processing of X-ray diffraction data collected in oscillation mode
-
Otwinowski, Z., and W. Minor. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:307-326.
-
(1997)
Methods Enzymol
, vol.276
, pp. 307-326
-
-
Otwinowski, Z.1
Minor, W.2
-
18
-
-
33645767675
-
Substrate envelope and drug resistance: Crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease
-
Prabu-Jeyabalan, M., N. M. King, E. A. Nalivaika, G. Heilek-Snyder, N. Cammack, and C. A. Schiffer. 2006. Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease. Antimicrob. Agents Chemother. 50:1518-1521.
-
(2006)
Antimicrob. Agents Chemother
, vol.50
, pp. 1518-1521
-
-
Prabu-Jeyabalan, M.1
King, N.M.2
Nalivaika, E.A.3
Heilek-Snyder, G.4
Cammack, N.5
Schiffer, C.A.6
-
19
-
-
0034283345
-
How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease
-
Prabu-Jeyabalan, M., E. Nalivaika, and C. A. Schiffer. 2000. How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease. J. Mol. Biol. 301:1207-1220.
-
(2000)
J. Mol. Biol
, vol.301
, pp. 1207-1220
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.2
Schiffer, C.A.3
-
20
-
-
0037223718
-
Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: Structural insights for better antiviral therapy
-
Prabu-Jeyabalan, M., E. A. Nalivaika, N. M. King, and C. A. Schiffer. 2003. Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy. J. Virol. 77:1306-1315.
-
(2003)
J. Virol
, vol.77
, pp. 1306-1315
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.A.2
King, N.M.3
Schiffer, C.A.4
-
21
-
-
0036121219
-
Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
-
Prabu-Jeyabalan, M., E. A. Nalivaika, and C. A. Schiffer. 2002. Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes. Structure 10:369-381.
-
(2002)
Structure
, vol.10
, pp. 369-381
-
-
Prabu-Jeyabalan, M.1
Nalivaika, E.A.2
Schiffer, C.A.3
-
22
-
-
3042554178
-
Peptidomimetic inhibitors of HIV protease
-
Randolph, J. T., and D. A. DeGoey. 2004. Peptidomimetic inhibitors of HIV protease. Curr. Top. Med. Chem. 4:1079-1095.
-
(2004)
Curr. Top. Med. Chem
, vol.4
, pp. 1079-1095
-
-
Randolph, J.T.1
DeGoey, D.A.2
-
23
-
-
0027263501
-
Regulation of HIV-1 and HIV-2 proteases with engineered amino acid substitutions
-
Rose, J. R., R. Salto, and C. S. Craik. 1993. Regulation of HIV-1 and HIV-2 proteases with engineered amino acid substitutions. J. Biol. Chem. 268:11939-11945.
-
(1993)
J. Biol. Chem
, vol.268
, pp. 11939-11945
-
-
Rose, J.R.1
Salto, R.2
Craik, C.S.3
-
24
-
-
0034053044
-
Susceptibility to PNU-140690 (Tipranavir) of human immunodeficiency virus type 1 isolates derived from patients with multidrug resistance to other protease inhibitors
-
Rusconi, S., S. La Seta Catamancio, P. Citterio, S. Kurtagic, M. Violin, C. Balotta, M. Moroni, M. Galli, and A. d'Arminio-Monforte. 2000. Susceptibility to PNU-140690 (Tipranavir) of human immunodeficiency virus type 1 isolates derived from patients with multidrug resistance to other protease inhibitors. Antimicrob Agents Chemother. 44:1328-1332.
-
(2000)
Antimicrob Agents Chemother
, vol.44
, pp. 1328-1332
-
-
Rusconi, S.1
La Seta Catamancio, S.2
Citterio, P.3
Kurtagic, S.4
Violin, M.5
Balotta, C.6
Moroni, M.7
Galli, M.8
d'Arminio-Monforte, A.9
-
25
-
-
33646193492
-
New HIV protease inhibitors for drug-resistant viruses
-
Rusconi, S., and O. Vigano. 2006. New HIV protease inhibitors for drug-resistant viruses. Therapy 3:79-88.
-
(2006)
Therapy
, vol.3
, pp. 79-88
-
-
Rusconi, S.1
Vigano, O.2
-
27
-
-
0345358532
-
Lysine sulfonamides as novel HIV-protease inhibitors: Optimization of the Nepsilon-acyl-phenyl spacer
-
Stranix, B. R., G. Sauve, A. Bouzide, A. Cote, G. Sevigny, and J. Yelle. 2003. Lysine sulfonamides as novel HIV-protease inhibitors: optimization of the Nepsilon-acyl-phenyl spacer. Bioorg Med. Chem. Lett. 13:4289-4292.
-
(2003)
Bioorg Med. Chem. Lett
, vol.13
, pp. 4289-4292
-
-
Stranix, B.R.1
Sauve, G.2
Bouzide, A.3
Cote, A.4
Sevigny, G.5
Yelle, J.6
-
28
-
-
0025225682
-
X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor
-
Swain, A. L., M. M. Miller, J. Green, D. H. Rich, J. Schneider, S. B. Kent, and A. Wlodawer. 1990. X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor. Proc. Natl. Acad. Sci. USA 87:8805-8809.
-
(1990)
Proc. Natl. Acad. Sci. USA
, vol.87
, pp. 8805-8809
-
-
Swain, A.L.1
Miller, M.M.2
Green, J.3
Rich, D.H.4
Schneider, J.5
Kent, S.B.6
Wlodawer, A.7
-
29
-
-
12944322516
-
Tipranavir (PNU-140690): A potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class
-
Turner, S. R., J. W. Strohbach, R. A. Tommasi, P. A. Aristoff, P. D. Johnson, H. I. Skulnick, L. A. Dolak, E. P. Seest, P. K. Tomich, M. J. Bohanon, M. M. Horng, J. C. Lynn, K. T. Chong, R. R. Hinshaw, K. D. Watenpaugh, M. N. Janakiraman, and S. Thaisrivongs. 1998. Tipranavir (PNU-140690): a potent, orally bioavailable nonpeptidic HIV protease inhibitor of the 5,6-dihydro-4-hydroxy-2-pyrone sulfonamide class. J. Med. Chem. 41:3467-3476.
-
(1998)
J. Med. Chem
, vol.41
, pp. 3467-3476
-
-
Turner, S.R.1
Strohbach, J.W.2
Tommasi, R.A.3
Aristoff, P.A.4
Johnson, P.D.5
Skulnick, H.I.6
Dolak, L.A.7
Seest, E.P.8
Tomich, P.K.9
Bohanon, M.J.10
Horng, M.M.11
Lynn, J.C.12
Chong, K.T.13
Hinshaw, R.R.14
Watenpaugh, K.D.15
Janakiraman, M.N.16
Thaisrivongs, S.17
-
30
-
-
0027218692
-
Structure-based inhibitors of HIV-1 protease
-
Wlodawer, A., and J. W. Erickson. 1993. Structure-based inhibitors of HIV-1 protease. Annu. Rev. Biochem. 62:543-585.
-
(1993)
Annu. Rev. Biochem
, vol.62
, pp. 543-585
-
-
Wlodawer, A.1
Erickson, J.W.2
-
31
-
-
34548159810
-
The HIV-1 protease inhibitor PL-100 has a high genetic barrier and selects a novel pattern of mutations, abstr. 136
-
Wu, J. J., S. Dandachel, B. Stranix, C. Panchal, and M. A. Wainberg. 2006. The HIV-1 protease inhibitor PL-100 has a high genetic barrier and selects a novel pattern of mutations, abstr. 136. Antivir. Ther. 11:S152.
-
(2006)
Antivir. Ther
, vol.11
-
-
Wu, J.J.1
Dandachel, S.2
Stranix, B.3
Panchal, C.4
Wainberg, M.A.5
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