메뉴 건너뛰기




Volumn 81, Issue 17, 2007, Pages 9512-9518

Crystal structure of lysine sulfonamide inhibitor reveals the displacement of the conserved flap water molecule in human immunodeficiency virus type 1 protease

Author keywords

[No Author keywords available]

Indexed keywords

LYSINE; LYSINE SULFONAMIDE INHIBITOR; PEPTIDE DERIVATIVE; PROTEINASE; PROTEINASE INHIBITOR; SULFONAMIDE; UNCLASSIFIED DRUG; WATER;

EID: 34548154182     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00799-07     Document Type: Article
Times cited : (39)

References (31)
  • 2
    • 0028103275 scopus 로고    scopus 로고
    • Collaborative-Computational Project, Number 4. 1994. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50:760-763.
    • Collaborative-Computational Project, Number 4. 1994. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50:760-763.
  • 3
    • 0026579208 scopus 로고
    • The HIV-1 protease as a therapeutic target for AIDS
    • Debouck, C. 1992. The HIV-1 protease as a therapeutic target for AIDS. AIDS Res. Hum. Retrovir. 8:153-164.
    • (1992) AIDS Res. Hum. Retrovir , vol.8 , pp. 153-164
    • Debouck, C.1
  • 8
    • 6344231715 scopus 로고    scopus 로고
    • Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor
    • King, N. M., M. Prabu-Jeyabalan, E. A. Nalivaika, P. Wigerinck, M. P. de Bethune, and C. A. Schiffer. 2004. Structural and thermodynamic basis for the binding of TMC114, a next-generation human immunodeficiency virus type 1 protease inhibitor. J. Virol. 78:12012-12021.
    • (2004) J. Virol , vol.78 , pp. 12012-12021
    • King, N.M.1    Prabu-Jeyabalan, M.2    Nalivaika, E.A.3    Wigerinck, P.4    de Bethune, M.P.5    Schiffer, C.A.6
  • 9
    • 22544467240 scopus 로고    scopus 로고
    • Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex
    • Kumar, M., V. Prashar, S. Mahale, and M. V. Hosur. 2005. Observation of a tetrahedral reaction intermediate in the HIV-1 protease-substrate complex. Biochem. J. 389:365-371.
    • (2005) Biochem. J , vol.389 , pp. 365-371
    • Kumar, M.1    Prashar, V.2    Mahale, S.3    Hosur, M.V.4
  • 10
    • 0025904209 scopus 로고
    • Rigid protein motion as a model for crystallographic temperature factors
    • Kuriyan, J., and W. I. Weis. 1991. Rigid protein motion as a model for crystallographic temperature factors. Proc. Natl. Acad. Sci. USA 88:2773-2777.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 2773-2777
    • Kuriyan, J.1    Weis, W.I.2
  • 16
    • 84920325457 scopus 로고
    • AMoRe: An automated package for molecular replacement
    • Navaza, J. 1994. AMoRe: an automated package for molecular replacement. Acta Crystallogr. D Biol. Crystallogr. A 50:157-163.
    • (1994) Acta Crystallogr. D Biol. Crystallogr. A , vol.50 , pp. 157-163
    • Navaza, J.1
  • 17
    • 0031059866 scopus 로고    scopus 로고
    • Processing of X-ray diffraction data collected in oscillation mode
    • Otwinowski, Z., and W. Minor. 1997. Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 276:307-326.
    • (1997) Methods Enzymol , vol.276 , pp. 307-326
    • Otwinowski, Z.1    Minor, W.2
  • 18
    • 33645767675 scopus 로고    scopus 로고
    • Substrate envelope and drug resistance: Crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease
    • Prabu-Jeyabalan, M., N. M. King, E. A. Nalivaika, G. Heilek-Snyder, N. Cammack, and C. A. Schiffer. 2006. Substrate envelope and drug resistance: crystal structure of RO1 in complex with wild-type human immunodeficiency virus type 1 protease. Antimicrob. Agents Chemother. 50:1518-1521.
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1518-1521
    • Prabu-Jeyabalan, M.1    King, N.M.2    Nalivaika, E.A.3    Heilek-Snyder, G.4    Cammack, N.5    Schiffer, C.A.6
  • 19
    • 0034283345 scopus 로고    scopus 로고
    • How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease
    • Prabu-Jeyabalan, M., E. Nalivaika, and C. A. Schiffer. 2000. How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease. J. Mol. Biol. 301:1207-1220.
    • (2000) J. Mol. Biol , vol.301 , pp. 1207-1220
    • Prabu-Jeyabalan, M.1    Nalivaika, E.2    Schiffer, C.A.3
  • 20
    • 0037223718 scopus 로고    scopus 로고
    • Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: Structural insights for better antiviral therapy
    • Prabu-Jeyabalan, M., E. A. Nalivaika, N. M. King, and C. A. Schiffer. 2003. Viability of a drug-resistant human immunodeficiency virus type 1 protease variant: structural insights for better antiviral therapy. J. Virol. 77:1306-1315.
    • (2003) J. Virol , vol.77 , pp. 1306-1315
    • Prabu-Jeyabalan, M.1    Nalivaika, E.A.2    King, N.M.3    Schiffer, C.A.4
  • 21
    • 0036121219 scopus 로고    scopus 로고
    • Substrate shape determines specificity of recognition for HIV-1 protease: Analysis of crystal structures of six substrate complexes
    • Prabu-Jeyabalan, M., E. A. Nalivaika, and C. A. Schiffer. 2002. Substrate shape determines specificity of recognition for HIV-1 protease: analysis of crystal structures of six substrate complexes. Structure 10:369-381.
    • (2002) Structure , vol.10 , pp. 369-381
    • Prabu-Jeyabalan, M.1    Nalivaika, E.A.2    Schiffer, C.A.3
  • 22
    • 3042554178 scopus 로고    scopus 로고
    • Peptidomimetic inhibitors of HIV protease
    • Randolph, J. T., and D. A. DeGoey. 2004. Peptidomimetic inhibitors of HIV protease. Curr. Top. Med. Chem. 4:1079-1095.
    • (2004) Curr. Top. Med. Chem , vol.4 , pp. 1079-1095
    • Randolph, J.T.1    DeGoey, D.A.2
  • 23
    • 0027263501 scopus 로고
    • Regulation of HIV-1 and HIV-2 proteases with engineered amino acid substitutions
    • Rose, J. R., R. Salto, and C. S. Craik. 1993. Regulation of HIV-1 and HIV-2 proteases with engineered amino acid substitutions. J. Biol. Chem. 268:11939-11945.
    • (1993) J. Biol. Chem , vol.268 , pp. 11939-11945
    • Rose, J.R.1    Salto, R.2    Craik, C.S.3
  • 25
    • 33646193492 scopus 로고    scopus 로고
    • New HIV protease inhibitors for drug-resistant viruses
    • Rusconi, S., and O. Vigano. 2006. New HIV protease inhibitors for drug-resistant viruses. Therapy 3:79-88.
    • (2006) Therapy , vol.3 , pp. 79-88
    • Rusconi, S.1    Vigano, O.2
  • 27
    • 0345358532 scopus 로고    scopus 로고
    • Lysine sulfonamides as novel HIV-protease inhibitors: Optimization of the Nepsilon-acyl-phenyl spacer
    • Stranix, B. R., G. Sauve, A. Bouzide, A. Cote, G. Sevigny, and J. Yelle. 2003. Lysine sulfonamides as novel HIV-protease inhibitors: optimization of the Nepsilon-acyl-phenyl spacer. Bioorg Med. Chem. Lett. 13:4289-4292.
    • (2003) Bioorg Med. Chem. Lett , vol.13 , pp. 4289-4292
    • Stranix, B.R.1    Sauve, G.2    Bouzide, A.3    Cote, A.4    Sevigny, G.5    Yelle, J.6
  • 28
    • 0025225682 scopus 로고
    • X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor
    • Swain, A. L., M. M. Miller, J. Green, D. H. Rich, J. Schneider, S. B. Kent, and A. Wlodawer. 1990. X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor. Proc. Natl. Acad. Sci. USA 87:8805-8809.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8805-8809
    • Swain, A.L.1    Miller, M.M.2    Green, J.3    Rich, D.H.4    Schneider, J.5    Kent, S.B.6    Wlodawer, A.7
  • 30
    • 0027218692 scopus 로고
    • Structure-based inhibitors of HIV-1 protease
    • Wlodawer, A., and J. W. Erickson. 1993. Structure-based inhibitors of HIV-1 protease. Annu. Rev. Biochem. 62:543-585.
    • (1993) Annu. Rev. Biochem , vol.62 , pp. 543-585
    • Wlodawer, A.1    Erickson, J.W.2
  • 31
    • 34548159810 scopus 로고    scopus 로고
    • The HIV-1 protease inhibitor PL-100 has a high genetic barrier and selects a novel pattern of mutations, abstr. 136
    • Wu, J. J., S. Dandachel, B. Stranix, C. Panchal, and M. A. Wainberg. 2006. The HIV-1 protease inhibitor PL-100 has a high genetic barrier and selects a novel pattern of mutations, abstr. 136. Antivir. Ther. 11:S152.
    • (2006) Antivir. Ther , vol.11
    • Wu, J.J.1    Dandachel, S.2    Stranix, B.3    Panchal, C.4    Wainberg, M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.